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Analysis of circulating tumor DNA does not improve the clinical management of patients with locally advanced and metastatic papillary thyroid carcinoma.Circulating cell-free tumor DNA (ctDNA) in plasma is a promising noninvasive instrument for cancer monitoring. Detection of BRAFon ctDNA of patients with papillary thyroid carcinoma (PTC) may represent an indicator of tumor aggressiveness and progression.
1178 related Products with: Analysis of circulating tumor DNA does not improve the clinical management of patients with locally advanced and metastatic papillary thyroid carcinoma.Breast cancer and matched Breast cancer tissue arra Breast cancer tissue arra Breast cancer tissue arra Breast cancer tissue arra Advanced colon tumor tiss Colon cancer tissue array Colon cancer tissue array Mid advanced stage kidney Kidney cancer tissue arra Lung cancer tissue array Multiple organ tumor tiss
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Segmentation of gray matter, white matter, and CSF with fluid and white matter suppression using MP2RAGE.MP2RAGE can generate uniform T-weighted images, which have been used for brain segmentation. However, there remain concerns about carrying out fast brain segmentation.
1004 related Products with: Segmentation of gray matter, white matter, and CSF with fluid and white matter suppression using MP2RAGE.Cycloheximide ; Appearanc Cycloheximide ; Appearanc Dexamethasone ; Appearanc Dexamethasone ; Appearanc Etoposide ; Appearance Wh Etoposide ; Appearance Wh Androgen Receptor (Phosph Androgen Receptor (Phosph Caspase-3 Inhibitor Q-DEV Caspase-3 Inhibitor Q-DEV Caspase-3 Inhibitor Q-DEV Rabbit Anti-Human Androge
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Effects of Montmorency tart cherry (L. Prunus Cerasus) consumption on nitric oxide biomarkers and exercise performance.The purpose of this study was to investigate the effects of Montmorency tart cherry juice (MC) on nitric oxide (NO) biomarkers, vascular function and exercise performance. In a randomized, double blind, placebo (PLA) - controlled, crossover study, 10 trained cyclists (mean ± SD; V̇O59.0 ± 7.0 ml/kg/min) acutely ingested 30 mL of either MC or PLA following dietary restrictions of polyphenol-rich compounds, and completed 6 min moderate- and severe-intensity cycling bouts 1.5 h post ingestion on two occasions for each experimental condition. The severe-intensity cycling test was continued to exhaustion on one occasion and immediately followed by a 60 s all-out sprint on the other occasion. Blood pressure, pulse wave measures, tissue oxygenation index and plasma nitrite concentration were assessed pre and 1.5 h post ingestion. Time to exhaustion was not different between conditions (P > 0.05), but peak power over the first 20 s (363 ± 42 vs. 330 ± 26 W) and total work completed during the 60 s all-out sprint (21 ± 3 vs. 19 ± 3 kJ) were 10% higher in the MC trial compared to the PLA trial (P < 0.05). Systolic blood pressure was 5 ± 2 mmHg lower 1.5 h post MC supplementation compared to PLA supplementation (P < 0.05). There were no differences in pulse wave measures, plasma nitrite concentration or tissue oxygenation between the MC and PLA trials (P > 0.05). These results suggest that acute supplementation with MC can lower blood pressure and improve some aspects of exercise performance, specifically end-sprint performance, in trained cyclists. This article is protected by copyright. All rights reserved.
1812 related Products with: Effects of Montmorency tart cherry (L. Prunus Cerasus) consumption on nitric oxide biomarkers and exercise performance.Rat inducible nitric oxid QuantiChrom™ Nitric Oxi QuantiChrom™ Nitric Oxi EnzyChrom™ Nitric Oxide Nitric Oxide Colorimteric Nitric Oxide Fluorometric Nitric Oxide Colorimetric Rabbit Anti-Nitric Oxide Rabbit Anti-Nitric Oxide Rabbit Anti-Nitric Oxide Nitric Oxide Synthase, mo Bcl-2 Oncoprotein; Clone
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Clinical Prospective Study on the Use of Subcutaneous Carboxytherapy in the Treatment of Diabetic Foot Ulcer.Diabetic footfoot ulcer (DFU) is a serious complication of diabetes mellitus, and possibly the major morbidity of the diabetic foot. It is the most common foot injury in diabetic patients and can lead to lower-extremity amputation. Management of DFU requires a systematic knowledge of the major risk factors for amputation, frequent routine evaluation, scrupulous preventive maintenance, and correction of peripheral arterial insufficiency. Carboxytherapy refers to the subcutaneous injection of CO2 to improve the microcirculation and promote wound-healing by stimulating the microcirculation. Since optimal ulcer-healing requires adequate tissue perfusion, it is considered that carboxytherapy could be useful in the treatment of DFU. The present prospective clinical study included 40 patients with different sizes and types of chronic DFU. In addition to cleaning of the wound, antibiotics and debridement as necessary, the treatment protocol included blood sugar control, medication, healthy habits, no weight-bearing, and carboxytherapy. The results showed that this treatment that included carboxytherapy promoted wound-healing and prevented amputation. These positive effects should be confirmed through a complete study that includes different clinical and instrumental parameters.
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Estradiol: A Steroid with Multiple Facets.Seventy-five glorious years have passed since estradiol was discovered by Edward Doisy. From discovery in the ovaries to delineation of diverse physiological effects, research on estrogens has covered a lot of ground. Estrogen receptors that mediate estrogenic effects, have been detected not only in reproductive organs, but also in other body organs. Estrogen receptors function either as conventional transcription factors or as rapid signal transducers. These different modes of action are opted by estrogens to elicit an array of reproductive and non-reproductive functions. It is well established that estrogens promote cell proliferation in various tissues and hence are also linked to carcinogenesis. Anti-estrogens are being used as adjunct therapies for cancers since several years. On the other hand, estrogen-based strategies are used to alleviate adverse effects of menopause. Apart from estrogens synthesized in various organs, exposure to environmental estrogens can also impact physiology. Thus, too much or too less of estrogens can tip the balance and lead to unfavorable consequences. Multiple estrogen receptors with their tissue- or cell type-specific expression eliciting dose-dependent effects make it perplexing to 'unify' estrogenic actions in diverse tissues/organs. This warrants more research on estrogen-mediated effects and their regulation in somatic and reproductive tissues. This review presents physiological and pathological aspects of estrogens thus highlighting the good, bad, and ugly facets of estrogens.
Estradiol 6 antibody, Mon Estradiol 6 antibody, Mon Estradiol 6,17b antibody, steroidogenic acute regul Cell Meter™ Caspase 3 7 Steroid AccuBind™ ELISA AEE-788 Mechanisms: Multi 17β-Acetyl-estradiol 3-( 17-O-Acetyl-3-O-methyl-6- 17-O-Acetyl-3-O-methyl 17 Obesity (Human) Quantitat Obesity (Human) Quantitat
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Dual p16 and Ki-67 Expression in Liquid-Based Cervical Cytological Samples Compared to Pap Cytology Findings, Biopsies, and HPV Testing in Cervical Cancer Screening: A Diagnostic Accuracy Study.Our objective was to verify the sensitivity and specificity of dual immunocytochemistry staining for p16 and Ki-67 in liquid-based samples (the "dual" assay) for cervical lesion screening, compared to biopsy findings and human papillomavirus (HPV) DNA molecular detection.
1636 related Products with: Dual p16 and Ki-67 Expression in Liquid-Based Cervical Cytological Samples Compared to Pap Cytology Findings, Biopsies, and HPV Testing in Cervical Cancer Screening: A Diagnostic Accuracy Study.Breast cancer tissue arra Cervical cancer tissue ar High density cervical can Uterine cervical cancer a Cervical cancer survey ti Uterine cervical cancer t Cervical cancer tissue ar Tissue array of uterine c Cervical cancer test tiss Cervical cancer tissue ar Homogenizer for 24 sample Top five cancer tissue ar
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A Comprehensive Assessment of the Role of miRNAs as Biomarkers in Gastroenteropancreatic Neuroendocrine Tumors.A key issue in neuroendocrine neoplasia management is the identification of blood signatures that specifically define the activity of a cancer or local tumor microenvironment. MicroRNAs (miRNAs) may represent such a candidate. To evaluate their clinical utility as biomarkers in gastroenteropancreatic neuroendocrine tumors (GEP-NETs), we assessed their expression in tissue and blood.
2994 related Products with: A Comprehensive Assessment of the Role of miRNAs as Biomarkers in Gastroenteropancreatic Neuroendocrine Tumors.EMAP-II Inhibitor Z-ASTD- EMAP-II Inhibitor Z-ASTD- EMAP II Inhibitor Z ASTD EMAP II Inhibitor Z ASTD Amplite™ Fluorimetric H Amplite™ Intracellular Amplite™ Fluorimetric P Amplite™ Fluorimetric A Cell Meter™ Intracellul Cell Meter™ Fluorimetri Cell Meter™ Fluorimetri Alkaline Phospatase (ALP)
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Wnt-Responsive Odontoblasts Secrete New Dentin after Superficial Tooth Injury.The objective of our experiments was to identify new therapeutic strategies to stimulate dentin formation in an adult tooth. To address this objective, we evaluated dentin production in 2 acute trauma models: one involving a pulp exposure and the other involving a superficial dentin injury. Molecular, cellular, and histologic analyses revealed that in response to a severe injury, where the pulp is exposed to the oral cavity, cell death is rampant and the repair response initiates from surviving pulp cells and, to a lesser extent, surviving odontoblasts. When an injury is superficial, as in the case of a dentin injury model, then disturbances are largely confined to pulp tissue immediately underneath the damaged dentin tubules. We found that the pulp remained vital and innervated; primary odontoblasts upregulated HIF1α; and the rate of mineralization was significantly increased. A tamoxifen-inducible Axin2; R26Rreporter strain was then used to demonstrate that a population of long-lived Wnt-responsive odontoblasts, which secreted dentin throughout the life of the animal, were responsible for depositing new dentin in response to a superficial injury. Amplifying Wnt signaling in the pulp stimulates dentin secretion, and in the dentin injury model, we show that a liposomal formulation of human WNT3A protein passes through dentinal tubules and is capable of upregulating Wnt signaling in the pulp. These data provide strong proof of concept for a therapeutic pulp-capping material to stimulate Wnt signaling in odontoblasts and thus improve the pulp repair response.
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Alpha B-crystallin promotes the invasion and metastasis of gastric cancer via NF-κB-induced epithelial-mesenchymal transition.Alpha B-crystallin (CRYAB) is overexpressed in a variety of cancers. However, little is known about its specific function and regulatory mechanism in gastric cancer. Here, we first explore the role of CRYAB in gastric cancer progression and metastasis. The expression of CRYAB was determined by western blot and immunohistochemistry in gastric cancer tissues. Besides, methods including stably transfected against CRYAB into gastric cancer cells, western blot, migration and invasion assays in vitro and metastasis assay in vivo were also conducted. The expression of CRYAB is up-regulated in gastric cancer tissues compared with matched normal tissues. High expression level of CRYAB is closely correlated with cancer metastasis and shorter survival time in patients with gastric cancer. Additionally, CRYAB silencing significantly suppresses epithelial-mesenchymal transition (EMT), migration and invasion of gastric cancer cells in vitro and in vivo, whereas CRYAB overexpression dramatically reverses these events. Mechanically, CRYAB facilitates gastric cancer cells invasion and metastasis via nuclear factor-κ-gene binding (NF-κB)-regulated EMT. These findings suggest that CRYAB expression predicts a poor prognosis in patients with gastric cancer. Besides, CRYAB contributes to gastric cancer cells migration and invasion via EMT, mediated by the NF-κB signalling pathway, thus possibly providing a novel therapeutic target for gastric cancer.
2291 related Products with: Alpha B-crystallin promotes the invasion and metastasis of gastric cancer via NF-κB-induced epithelial-mesenchymal transition.Rat Mesenchymal Cells Mid advanced stage bladde Breast cancer tissue arra Middle advanced stage bre Middle advanced stage bre Colon cancer tissue array Colorectal (colon and rec Colorectal (colon and rec Mid advanced stage uterin Mouse Anti-Human Crystall Middle advanced stage eso Esophagus cancer with mat
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Oligodendrocyte gene expression is reduced by and influences effects of chronic social stress in mice.Oligodendrocyte gene expression is down-regulated in stress-related neuropsychiatric disorders, including depression. In mice, chronic social stress (CSS) leads to depression-relevant changes in brain and emotional behavior, and the present study demonstrates the involvement of oligodendrocytes in this model. In C57BL/6 (BL/6) mice, RNA-sequencing was conducted with prefrontal cortex, amygdala and hippocampus from CSS and controls; a gene enrichment database for neurons, astrocytes and oligodendrocytes was used to identify cell origin of affected genes, and cell deconvolution was applied. To assess the potential causal contribution of reduced oligodendrocyte gene expression to CSS effects, mice heterozygous for the oligodendrocyte gene cyclic nucleotide phosphodiesterase (Cnp1) on a BL/6 background were studied; a 2 genotype (WT, Cnp1) x 2 environment (control, CSS) design was used to investigate effects on emotional behaviour and amygdala microglia. In BL/6 mice, in prefrontal cortex and amygdala tissue comprising gray and white matter, CSS down-regulated expression of multiple oligodendroycte genes encoding myelin and myelin-axon-integrity proteins, and cell deconvolution identified a lower proportion of oligodendrocytes in amygdala. Quantification of oligodendrocyte proteins in amygdala gray matter did not yield evidence for reduced translation, suggesting that CSS impacts primarily on white matter oligodendrocytes or the myelin transcriptome. In Cnp1 mice, social interaction was reduced by CSS in Cnp1mice specifically; using IBA1 expression, microglia activity was increased additively by Cnp1and CSS in amygdala gray and white matter. This study provides back-translational evidence that oligodendrocyte changes are relevant to the pathophysiology and potentially the treatment of stress-related neuropsychiatric disorders.
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