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           Search results for: (2R)-2-Amino-1,2,3,4-tetrahydro-5,8-dimethoxy-2-naphthalenecarboxylic Acid Methyl Ester-13C C1313CH19NO4 CAS:    

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Palladium-catalyzed decarboxylative ortho-amidation of O-methyl ketoximes with oxamic acids.

The first palladium-catalyzed ortho-amidation of ketoximes has been developed with readily available, easy to handle and environment-friendly N,N-disubstituted oxamic acids as the amidation sources. When N-monosubstituted oxamic acids are used as the substrates, the formed ortho-amidated ketoximes undergo further intramolecular cyclization to provide 3-methyleneisoindolinones.

2013 related Products with: Palladium-catalyzed decarboxylative ortho-amidation of O-methyl ketoximes with oxamic acids.

2-Amino-5-(methyl-d3)-pyr removed without changing MUP, disodium salt [4 Met 1H-Benzimidazole-5-carbox 5 Methylcytidine CAS Numb N-Benzyloxycarbonyl-L-lys 5 Methylisoxazole 4 carbo 5-(Acetylamino)-5-deoxy-D 2 Chloro 3 nitro 4 picoli 1-(Benzyl-d5)-4-[(6-benzy β-[(Acetyloxy)methyl]-3- L Isoleucine methyl ester

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Tropane alkaloids biosynthesis involves an unusual type III polyketide synthase and non-enzymatic condensation.

The skeleton of tropane alkaloids is derived from ornithine-derived N-methylpyrrolinium and two malonyl-CoA units. The enzymatic mechanism that connects N-methylpyrrolinium and malonyl-CoA units remains unknown. Here, we report the characterization of three pyrrolidine ketide synthases (PYKS), AaPYKS, DsPYKS, and AbPYKS, from three different hyoscyamine- and scopolamine-producing plants. By examining the crystal structure and biochemical activity of AaPYKS, we show that the reaction mechanism involves PYKS-mediated malonyl-CoA condensation to generate a 3-oxo-glutaric acid intermediate that can undergo non-enzymatic Mannich-like condensation with N-methylpyrrolinium to yield the racemic 4-(1-methyl-2-pyrrolidinyl)-3-oxobutanoic acid. This study therefore provides a long sought-after biosynthetic mechanism to explain condensation between N-methylpyrrolinium and acetate units and, more importantly, identifies an unusual plant type III polyketide synthase that can only catalyze one round of malonyl-CoA condensation.

2716 related Products with: Tropane alkaloids biosynthesis involves an unusual type III polyketide synthase and non-enzymatic condensation.

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Enhanced isolation of lipids from microalgal biomass with high water content for biodiesel production.

In present study, lipids were extracted from unbroken microalga Chlorella vulgaris with high water content (50% microalgal solution) through three-phase partitioning (TPP). The method was found to extract around 15.9% of total lipid transformable to methyl esters (LTMEs) from unbroken microalgal cells which is two times of Bligh and Dyer method. We investigated the effects of various parameters on TPP performance and were optimised through response surface methodology. The results indicated that incubation duration, temperature and extraction time were positively correlated with LTME extraction efficiency. The optimum temperature was 60 °C, incubation duration was 120 min, extraction time was 60 min, ratio of solvent to DKP was 1:1. The FAME yield was calculated as 12.05% and major fatty acids together accounted for 71.33% which indicated the great potential of the proposed lipid extraction procedure for microalga-based biodiesel production.

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Variation of Interfacial Interactions in PCBM-like Electron-Transporting Compounds for Perovskite Solar Cells.

The synthesis, characterization, and incorporation of phenyl-C-butyric acid methyl ester (PCBM)-like derivatives as electron transporting materials (ETMs) in inverted perovskite solar cells (PSCs) are reported. These compounds have the same structure except for the ester substituent, which was varied from methyl to phenyl to thienyl and to pyridyl. The three latter derivatives performed better than PCBM in PSCs, mainly attributed to the specific interactions of the fullerenes with the perovskite layer, as evidenced by X-ray photoelectron spectroscopy (XPS) and steady-state and time-resolved photoluminescence (SS- and TRPL) measurements. The experimental results were fully supported by density functional theory (DFT) calculations, which showed that the strongest interactions were exhibited by the compound possessing the pyridyl substituent.

2854 related Products with: Variation of Interfacial Interactions in PCBM-like Electron-Transporting Compounds for Perovskite Solar Cells.

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Discovery of New Selective Butyrylcholinesterase (BChE) Inhibitors with Anti-Aβ Aggregation Activity: Structure-Based Virtual Screening, Hit Optimization and Biological Evaluation.

In this study, a series of selective butyrylcholinesterase (BChE) inhibitors was designed and synthesized from the structural optimization of hit , a 4-((3,4-dihydroisoquinolin-2(1)-yl)methyl)benzoic acid derivative identified by virtual screening our compound library. The in vitro enzyme assay results showed that compounds ((4-((3,4-dihydroisoquinolin-2(1)-yl)methyl)phenyl)(pyrrolidin-1-yl)methanone) and (-(2-bromophenyl)-4-((3,4-dihydroisoquinolin-2(1)-yl)methyl)benzamide) displayed improved BChE inhibitory activity and good selectivity towards BChE versus AChE. Their binding modes were probed by molecular docking and further validated by molecular dynamics simulation. Kinetic analysis together with molecular modeling studies suggested that these derivatives could target both the catalytic active site (CAS) and peripheral anionic site (PAS) of BChE. In addition, the selected compounds and displayed anti-Aβ aggregation activity in a dose-dependent manner, and they did not show obvious cytotoxicity towards SH-SY5Y neuroblastoma cells. Also, both compounds showed significantly protective activity against Aβ-induced toxicity in a SH-SY5Y cell model. The present results provided a new valuable chemical template for the development of selective BChE inhibitors.

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Ethanol induced jasmonate pathway promotes astaxanthin hyperaccumulation in Haematococcus pluvialis.

Haematococcus pluvialis is a main biological resource for the antioxidant astaxanthin production, however, potential modulators and molecular mechanisms underpinning astaxanthin accumulation remain largely obscured. We discovered that provision of ethanol (0.4%) significantly triggered the cellular astaxanthin content up to 3.85% on the 4th day of treatment. Amongst, 95% of the accumulated astaxanthin was esterified, particularly enriched with monoesters. Ultrastructural analysis revealed that ethanol altered cell wall structure and physiological properties. Antioxidant analyses revealed that astaxanthin accumulation offset the ethanol induced oxidative stress. Ethanol treatment reduced carbohydrates while increased lipids and jasmonic acid production. Transcriptomic analysis uncovered that ethanol orchestrated the expression of crucial genes involved in carotenogenesis, e.g. PSY, BKT and CRTR-b were significantly upregulated. Moreover, methyl jasmonic acid synthesis was induced and played a major role in regulating the carotenogenic genes. The findings uncovered the novel viewpoint in the intricate transcriptional regulatory mechanisms of astaxanthin biosynthesis.

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Inhibition of juvenile hormone synthesis in mosquitoes by the methylation inhibitor 3-deazaneplanocin A (DZNep).

Juvenile hormone (JH), synthesized by the corpora allata (CA), controls development and reproduction in mosquitoes through its action on thousands of JH-responsive genes. These JH-dependent processes can be studied using tools that increase or decrease JH titers in vitro and in vivo. Juvenile hormone acid methyl transferase (JHAMT) is a critical JH biosynthetic enzyme. JHAMT utilizes the methyl donor S-adenosyl-methionine (SAM) to methylate farnesoic acid (FA) into methyl farnesoate (MF), releasing the product S-adenosyl-L-homocysteine (AdoHcy), which inhibits JHAMT. S-adenosyl-homocysteine hydrolase (SAHH) catalyzes AdoHcy hydrolysis to adenosine and homocysteine, alleviating AdoHcy inhibition of JHAMT. 3-deazaneplanocin A (DZNep), an analog of adenosine, is an inhibitor of SAHH, and an epigenetic drug for cancer therapy. We tested the effect of DZNep on in vitro JH synthesis by CA of mosquitoes. DZNep inhibited JH synthesis in a dose-response fashion. Addition of MF, but not of FA relieved the inhibition, demonstrating a direct effect on JHAMT. In vivo experiments, with addition of DZNep to the sugar ingested by mosquitoes, resulted in a dose-response decrease in JH synthesis and JH hemolymphatic titers, as well as expression of early trypsin, a JH-dependent gene. Our studies suggest that DZNep can be employed to lower JH synthesis and titer in experiments evaluating JH-controlled processes in mosquitoes.

1427 related Products with: Inhibition of juvenile hormone synthesis in mosquitoes by the methylation inhibitor 3-deazaneplanocin A (DZNep).

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Self-Healable Polyelectrolytes with Mechanical Enhancement for Flexible and Durable Supercapacitors.

The practical application of advanced personalized electronics is inseparable from flexible, durable, and even self-healable energy storage devices. However, the mechanical and self-healing performance of supercapacitors is still limited at present. Herein, highly transparent, stretchable, and self-healable poly(2-acrylamido-2-methyl-1-propanesulfonic acid) (PAMPSA)/poly(vinyl alcohol) (PVA)/LiCl polyelectrolytes were facilely prepared by one-step radical polymerization. The cooperation of PAMPSA and PVA significantly increased the mechanical and self-healing capacity of the polyelectrolyte, which exhibited superior stretchability of 938 %, stress of 112.68 kPa, good electrical performance (ionic conductivity up to 20.6 mS cm ), and high healing efficiency of 92.68 % after 24 h. After assembly with polypyrrole-coated single-walled carbon nanotubes, the resulting as-prepared supercapacitor had excellent electrochemical properties with high areal capacitance of 297 mF cm at 0.5 mA cm and good rate capability (218 mF cm at 5 mA cm ). Besides, after cutting in two the supercapacitor recovered 99.2 % of its original specific capacitance after healing for 24 h at room temperature. The results also showed negligible change in the interior contact resistance of the supercapacitor after ten cutting/healing cycles. The present work provides a possible solution for the development of smart and durable energy storage devices with low cost for next-generation intelligent electronics.

2433 related Products with: Self-Healable Polyelectrolytes with Mechanical Enhancement for Flexible and Durable Supercapacitors.

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Amplification of lysozyme signal detected in capillary electrophoresis using mixed polymer brushes coating with switchable properties.

In this work, a mixed polymer brushes based on poly(2-methyl-2-oxazoline) (PMOXA) and poly(acrylic acid) (PAA) coated capillary with switchable protein adsorption/desorption properties was developed and applied for on-line extraction and preconcentration of lysozyme. The study of electroosmotic flow (EOF) and fluorescence microscope showed that the inner surface charge of PMOXA/PAA mixed brush coated capillary displayed the switchable behavior toward the change of pH value and ionic strength (I), and PMOXA/PAA mixed brushes coated capillary could adsorb high amounts of lysozyme at pH 7 (I = 10 M), and the most of adsorbed lysozyme could then be desorbed at pH 3 (I = 10 M). Subsequently, this coated capillary with switchable lysozyme adsorption/desorption ability was applied for on-line extraction and preconcentration of lysozyme during capillary electrophoresis (CE) performance. Under the process of on-line preconcentration, the detection signal (peak area) of lysozyme obtained in PMOXA/PAA coated capillary was 26 times that obtained in bare capillary under normal CE while the contour chain length of PAA was 1.56 times that of PMOXA. Moreover, the value of low detection limit (LOD) of lysozyme using above coated capillary under on-line preconcentration method reached to 4.5 × 10 mg/mL, and 1 × 10-fold sensitivity enhancement was realized for lysozyme as compared with the bare capillary under normal CE.

1991 related Products with: Amplification of lysozyme signal detected in capillary electrophoresis using mixed polymer brushes coating with switchable properties.

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Tailoring of carbonized polypyrrole nanotubes core by different polypyrrole shells for oxygen reduction reaction selectivity modification.

By using methyl orange template, polypyrrole nanotubes were obtained by the oxidative polymerization of pyrrole. The nanotubes were carbonized in inert atmosphere to nitrogen-enriched carbon nanotubes. These were subsequently coated with 20 wt% of polypyrrole prepared in the absence or the presence of anionic dyes (methyl orange or Acid Blue 25). The morphology of all the samples was examined by the electron microscopies, FTIR and Raman spectroscopies. Moreover, X-ray photoelectron spectroscopy and elemental analysis were used to prove the chemical structure and the successful coating process. Electron paramagnetic resonance analysis was used to calculate the spin concentrations. Significant impact of coating method is evidenced with neat polypyrrole coating providing a two-fold capacitance increase compared to uncoated nanotubes, while coating in the presence of Acid Blue 25 decreasing it slightly. With respect to oxygen reduction reaction, coatings irreversibly transformed in the first few cycles in the presence of the products of O reduction, presumably hydrogen peroxide, altering the oxygen reduction mechanism. This transformation allows the tailoring of the polymeric shell, over ORR active carbonaceous core, and tuning of the catalyst selectivity and optimization of materials performance for a given application - from alkaline fuel cells to hydrogen peroxide generation.

2051 related Products with: Tailoring of carbonized polypyrrole nanotubes core by different polypyrrole shells for oxygen reduction reaction selectivity modification.

Lymphoma array, together Colon moderately differen Breast invasive ductal ca Stomach poorly differenti Colon well differentiated Growth Differentiation Fa Colon poorly differentiat Multiple lung carcinoma ( Mouse PAI-1 (wild type ac Bladder cancer and normal Esophagus cancer mid dens Malignant melanoma tissue

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