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Search results for: (S)-3-Benzyloxycarbonyl-5-oxo-4-oxazolidinepropanoic Acid C14H15NO6 CAS: 23632-67-9

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#33078809   2020/10/20 To Up

Chronic n-3 fatty acid intake enhances insulin response to oral glucose and elevates GLP-1 in high-fat diet-fed obese mice.

n-3 polyunsaturated fatty acids (PUFA) can exert beneficial effects on glucose homeostasis, especially in obese rodents. Gut incretin hormones regulate glucose and lipid homeostasis, but their involvement in the above effects is not entirely clear. This study aims to assess the effects of chronic n-3 PUFA administration on the insulin and incretin responses in C57BL/6N obese male mice subjected to oral glucose tolerance test (oGTT) after 8 weeks of feeding a corn-oil-based high-fat diet (cHF). The weight gain and adiposity were partially reduced in mice fed cHF in which some of the corn oil was replaced with n-3 PUFA concentrate containing ∼60% DHA and EPA in a 3 : 1 ratio. In addition, these mice had improved glucose tolerance, which was consistent with an increased insulin response to oral glucose and plasma glucagon-like peptide-1 (GLP-1) levels. While the stimulatory effects of n-3 PUFA on GLP-1 levels could not be attributed to changes in intestinal or plasma dipeptidyl peptidase-4 activity, their beneficial effects on glucose tolerance were abolished when mice were pretreated with the GLP-1 receptor antagonist exendin 9-39. Moreover, chronic n-3 PUFA intake prevented the detrimental effects of cHF feeding on glucose-stimulated insulin secretion in the pancreatic islets. Collectively, our data suggest that n-3 PUFA may modulate postprandial glucose metabolism in obese mice through a GLP-1-based mechanism. The significance of these findings in terms of the effective DHA and EPA ratio of the n-3 PUFA concentrate as well as the effect of n-3 PUFA in humans requires further research.
Jana Pavlisova, Olga Horakova, Veronika Kalendova, Jana Buresova, Kristina Bardova, Blanka Holendova, Lydie Plecita-Hlavata, Sarka Vackova, Jindra Windrichova, Ondrej Topolcan, Jan Kopecky, Martin Rossmeisl

1495 related Products with: Chronic n-3 fatty acid intake enhances insulin response to oral glucose and elevates GLP-1 in high-fat diet-fed obese mice.

100ug 100ul 100ul100tests96tests100g100gm100ug100ug Lyophilized 25 G

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#33076153   2020/09/08 To Up

Large volume sample stacking of antiepileptic drugs in counter current electrophoresis performed in PAMAPTAC coated capillary.

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Petr Tůma, Tomáš Hložek, Blanka Sommerová, Dušan Koval

1703 related Products with: Large volume sample stacking of antiepileptic drugs in counter current electrophoresis performed in PAMAPTAC coated capillary.

16 Arrays/Slide32-50 Sample Kit500 samples8 Sample Kit8 Sample Kit32-50 Sample Kit-32-50 Sample Kit96 samples

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#33075563   2020/10/16 To Up

S100A11 Promotes Liver Steatosis via FOXO1-Mediated Autophagy and Lipogenesis.

Non-alcoholic fatty liver disease (NAFLD) is becoming a severe liver disorder worldwide. Autophagy plays a critical role in liver steatosis. However, the role of autophagy in NAFLD remains exclusive and under debate. In this study, we investigated the role of S100 calcium binding protein A11 (S100A11) in the pathogenesis of hepatic steatosis.
Linqiang Zhang, Zhiguo Zhang, Chengbin Li, Tingting Zhu, Jing Gao, Hu Zhou, Yingzhuan Zheng, Qing Chang, Mingshan Wang, Jieyu Wu, Liyuan Ran, Yingjie Wu, Huilai Miao, Xiaoju Zou, Bin Liang

1931 related Products with: S100A11 Promotes Liver Steatosis via FOXO1-Mediated Autophagy and Lipogenesis.

N/A N/A 1 kit10 mg50μg/vial100 ug/vial 5 G100|uI x 10 vials

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#33074314   2020/10/19 To Up

TransCirc: an interactive database for translatable circular RNAs based on multi-omics evidence.

TransCirc (https://www.biosino.org/transcirc/) is a specialized database that provide comprehensive evidences supporting the translation potential of circular RNAs (circRNAs). This database was generated by integrating various direct and indirect evidences to predict coding potential of each human circRNA and the putative translation products. Seven types of evidences for circRNA translation were included: (i) ribosome/polysome binding evidences supporting the occupancy of ribosomes onto circRNAs; (ii) experimentally mapped translation initiation sites on circRNAs; (iii) internal ribosome entry site on circRNAs; (iv) published N-6-methyladenosine modification data in circRNA that promote translation initiation; (v) lengths of the circRNA specific open reading frames; (vi) sequence composition scores from a machine learning prediction of all potential open reading frames; (vii) mass spectrometry data that directly support the circRNA encoded peptides across back-splice junctions. TransCirc provides a user-friendly searching/browsing interface and independent lines of evidences to predicte how likely a circRNA can be translated. In addition, several flexible tools have been developed to aid retrieval and analysis of the data. TransCirc can serve as an important resource for investigating the translation capacity of circRNAs and the potential circRNA-encoded peptides, and can be expanded to include new evidences or additional species in the future.
Wendi Huang, Yunchao Ling, Sirui Zhang, Qiguang Xia, Ruifang Cao, Xiaojuan Fan, Zhaoyuan Fang, Zefeng Wang, Guoqing Zhang

2172 related Products with: TransCirc: an interactive database for translatable circular RNAs based on multi-omics evidence.

1 ml0.1 ml100ug100 TESTS 100ul500 100ug100ugTwo 96-Well Microplate Ki0.2 mg100.00 ug0.1ml (1mg/ml)

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#33073835   2020/10/19 To Up

Human metabolite-derived alkylsuccinate/dilinoleate copolymers: from synthesis to application.

The advances in polymer chemistry have allowed the preparation of biomedical polymers using human metabolites as monomers that can hold unique properties beyond the required biodegradability and biocompatibility. Herein, we demonstrate the use of endogenous human metabolites (succinic and dilinoleic acids) as monomeric building blocks to develop a new series of renewable resource-based biodegradable and biocompatible copolyesters. The novel copolyesters were characterized in detail employing several standard techniques, namely 1H NMR, 13C NMR, and FTIR spectroscopy and SEC, followed by an in-depth thermomechanical and surface characterization of their resulting thin films (DSC, TGA, DMTA, tensile tests, AFM, and contact angle measurements). Also, their anti-fungal biofilm properties were assessed via an anti-fungal biofilm assay and the biological properties were evaluated in vitro using relevant human-derived cells (human mesenchymal stem cells and normal human dermal fibroblasts). These novel highly biocompatible polymers are simple and cheap to prepare, and their synthesis can be easily scaled-up. They presented good mechanical, thermal and anti-fungal biofilm properties while also promoting cell attachment and proliferation, outperforming well-known polymers used for biomedical applications (e.g. PVC, PLGA, and PCL). Moreover, they induced morphological changes in the cells, which were dependent on the structural characteristics of the polymers. In addition, the obtained physicochemical and biological properties can be design-tuned by the synthesis of homo- and -copolymers through the selection of the diol moiety (ES, PS, or BS) and by the addition of a co-monomer, DLA. Consequently, the copolyesters presented herein have high application potential as renewable and cost-effective biopolymers for various biomedical applications.
Alessandro Jäger, Ricardo K Donato, Magdalena Perchacz, Katarzyna Z Donato, Zdeněk Starý, Rafał Konefał, Magdalena Serkis-Rodzeń, Maria G Raucci, Alexandre M Fuentefria, Eliézer Jäger

2526 related Products with: Human metabolite-derived alkylsuccinate/dilinoleate copolymers: from synthesis to application.

100ul 100ul 100ul 100ul 100ul 100ul1mg100ug Lyophilized50ul100ug Lyophilized 100ul 100ul

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#33069789   2020/10/15 To Up

Discovery and Proteomics Analysis of Effective Compounds in Valeriana jatamansi Jones for the Treatment of Anxiety.

Zhizhu Xiang (ZZX for short) is the root and rhizome of Valeriana jatamansi Jones, which is a Traditional Chinese Medicine (TCM) used to treat various mood disorders for more than 2,000 years, especially anxiety. However, there have been few investigations to clarify the compounds in ZZX for the treatment of anxiety.
Shao-Nan Wang, Zi-Wei Yao, Cheng-Bowen Zhao, Yong-Sheng Ding, Jing-Luo, Li-Hua Bian, Qiu-Yu Li, Xiao-Mei Wang, Jin-Li Shi, Jian-You Guo, Chun-Guo Wang

1646 related Products with: Discovery and Proteomics Analysis of Effective Compounds in Valeriana jatamansi Jones for the Treatment of Anxiety.

5 Inhibitors 1 G 5 G 1 G 5 G1

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#33069232   2020/10/17 To Up

Improved thermostability of creatinase from Alcaligenes Faecalis through non-biased phylogenetic consensus-guided mutagenesis.

Enzymatic quantification of creatinine has become an essential method for clinical evaluation of renal function. Although creatinase (CR) is frequently used for this purpose, its poor thermostability severely limits industrial applications. Herein, we report a novel creatinase from Alcaligenes faecalis (afCR) with higher catalytic activity and lower K value, than currently used creatinases. Furthermore, we developed a non-biased phylogenetic consensus method to improve the thermostability of afCR.
Xue Bai, Daixi Li, Fuqiang Ma, Xi Deng, Manjie Luo, Yan Feng, Guangyu Yang

2561 related Products with: Improved thermostability of creatinase from Alcaligenes Faecalis through non-biased phylogenetic consensus-guided mutagenesis.

1Up to 200 ml cultures10x96, 2.0ml cultures10, 10ml whole blood 5 G

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#33068968   2020/10/07 To Up

Inhibition of the newly discovered β‑carbonic anhydrase from the protozoan pathogen Trichomonas vaginalis with inorganic anions and small molecules.

The protozoan pathogen Trichomonas vaginalis encodes two carbonic anhydrases (CAs, EC 4.2.1.1) belonging to the β-class. One of these enzymes, T. vaginalis carbonic anhydrase 1 (TvaCA1), was recently cloned and characterized by our group, and its X-ray crystal structure reported. No inhibitors of this enzyme were reported up until now. Here we investigated the inhibition of TvaCA1 with inorganic anions and small molecules and observed that thiocyanate, cyanide, selenite, selenocyanate and divanadate are sub-millimolar inhibitors, whereas sulfamide, sulfate, phenylboronic acid and phenylarsonic acid are micromolar inhibitors. Finding effective TvaCA1 inhibitors may be useful for developing new antiprotozoan drugs.
Linda J Urbański, Andrea Angeli, Vesa P Hytönen, Anna Di Fiore, Seppo Parkkila, Giuseppina De Simone, Claudiu T Supuran

1856 related Products with: Inhibition of the newly discovered β‑carbonic anhydrase from the protozoan pathogen Trichomonas vaginalis with inorganic anions and small molecules.

100 U 100 G 100ul100.00 ul1200 units100 500IUmin 2 cartons

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