Only in Titles

Search results for: ∆2-Androstene-1α,17β-diol� Acetate C21H32O3 CAS: 5846-70-8

paperclip

#33949602   2021/05/05 To Up

The effect of deoxyfluorination and -acylation on the cytotoxicity of -acetyl-D-gluco- and D-galactosamine hemiacetals.

Fully acetylated deoxyfluorinated hexosamine analogues and non-fluorinated 3,4,6-tri-O-acylated N-acetyl-hexosamine hemiacetals have previously been shown to display moderate anti-proliferative activity. We prepared a set of deoxyfluorinated GlcNAc and GalNAc hemiacetals that comprised both features: O-acylation at the non-anomeric positions with an acetyl, propionyl and butanoyl group, and deoxyfluorination at selected positions. Determination of the in vitro cytotoxicity towards the MDA-MB-231 breast cancer and HEK-293 cell lines showed that deoxyfluorination enhanced cytotoxicity in most analogues. Increasing the ester alkyl chain length had a variable effect on the cytotoxicity of fluoro analogues, which contrasted with non-fluorinated hemiacetals where butanoyl derivatives had always higher cytotoxicity than acetates. Reaction with 2-phenylethanethiol indicated that the recently described S-glyco-modification is an unlikely cause of cytotoxicity.
Vojtěch Hamala, Lucie Červenková Šťastná, Martin Kurfiřt, Petra Cuřínová, Martin Balouch, Roman Hrstka, Petr Voňka, Jindřich Karban

2204 related Products with: The effect of deoxyfluorination and -acylation on the cytotoxicity of -acetyl-D-gluco- and D-galactosamine hemiacetals.

25 mg100 mg10 mg10 mg25 mg25 mg25 mg50 mg 100ul100ug

Related Pathways

paperclip

Error loading info... Pleas try again later.
paperclip

#33922451   2021/04/23 To Up

Phenolic Compounds from Are Characterized by Their Antioxidant, Anti-Inflammatory and Hepatoprotective Activities.

has been traditionally used for the treatment of various diseases due to its different pharmacological activities. However, the active compounds responsible for its potentially specific activities have rarely been explored. To this end, the ethyl acetate (EA) fraction was screened out and selected for further phytochemical isolation because of its promising activities in preliminary 2,2-diphenyl-1-picrylhydrazyl (DPPH), ferric reducing antioxidant power (FRAP) and COX-2 inhibition assays. As a result, 10 compounds (-), including a new one (), were isolated, with eight of these being identified as phenolic compounds, as expected. Compound possessed an IC value of 16.5 ± 1.2 µM, which was lower than that of positive control (vitamin C, 25.5 ± 0.3 µM) in the DPPH assay, and compounds , , and showed better total antioxidant capacity than vitamin C in the FRAP assay. Meanwhile, compounds - and also had IC values of less than 1.0 µM, which was even better than the positive control indomethacin in the COX-2 inhibition assay. In this context, compounds and were further evaluated to exhibit clear hepatoprotective activities by improving the L02 cell viability and reducing ROS production using a HO-induced L02 cell injury model. This study provides initial evidence revealing the most potent phenolic compounds from the root bark of responsible for its antioxidant, anti-inflammatory and hepatoprotective activities.
Ye Liu, Yongli Zhang, Felix Wambua Muema, Festus Kimutai, Guilin Chen, Mingquan Guo

1770 related Products with: Phenolic Compounds from Are Characterized by Their Antioxidant, Anti-Inflammatory and Hepatoprotective Activities.

1000 100 μg1000 TESTS/0.65ml100.00 ul100ul0.1 mg100ul1 ml200 25 Tests1 mg100ug Lyophilized

Related Pathways

paperclip

#33901894   2021/04/08 To Up

Integrative effect of citrate on Cr(Ⅵ) and total Cr removal using a sulfate-reducing bacteria consortium.

In controlling toxic Cr(Ⅵ) pollution, the sulfate-reducing bacteria (SRB) method-a bioresource technology-is considered more sustainable and stable than synthetic technologies; however, its mechanisms of metal removal are unclear. This study investigated the mechanism of the use of citrate as a carbon source in an SRB bioreactor for Cr(Ⅵ) removal by disassemble or simulation approach. We show that citrate can mask toxicity, whereby the IC value (inhibitory concentration affecting 50% of the test population) of citrate was higher than that of lactate, and that citrate can also protect water systems from oxidation. The anti-oxidation rate of citrate ranged from 76.00% to 90.92%; whereas for citrate‒Cr(Ⅲ), the oxidation rate was only 0.185%-0.587%. Citrate can up-regulate microbial genes and functions, causing acetate and sulfide (NaFeS) accumulation. Acetate addition promoted Cr adsorption by sulfide (mainly NaFeS) and promoted sulfide sedimentation. Moreover, in addition to Cr(Ⅵ) reduction and Cr(Ⅲ)‒sulfide generation, the addition of sulfide promoted sedimentation; the correlation coefficient between the sedimentation coefficient and the sulfur content was r = -0.88877 at p < 0.01. Therefore, citrate had a systemic radiative effect on every aspect of the SRB‒citrate system model for Cr(Ⅵ) removal. In addition to the reduction in the former simple model, an integrative effect (including adsorption, sedimentation, and metabolism) was combined with NaFeS for Cr removal, which was regulated by the SRB‒citrate system. Exploration and understanding of these mechanisms promote SRB‒citrate methods to be wider implications in practice.
Wenzhi Gu, Decong Zheng, Daping Li, Cuicui Wei, Xu Wang, Qingzhuoma Yang, Chang Tian, Mengyao Cui

1316 related Products with: Integrative effect of citrate on Cr(Ⅵ) and total Cr removal using a sulfate-reducing bacteria consortium.

1KG100.00 ul100ug100ug Lyophilized100 Plates96 tests100ug1 g100ug1 kg100 ul

Related Pathways

paperclip

#33875129   // To Up

Increased Production of Short-Chain Fatty Acids in Microbacteria Fermentation Treated by Fullerenols.

Fullerenol nanoparticles were found to significantly modulate the gut microbiota and selectively enrich the short-chain fatty acids (SCFAs) production by adjusting the gut microbacteria in mice models. In this research, we screened the from seven strains and investigated the interactions and mechanism between the and fullerenol NPs fermentation. The results shows that fullerenol NPs increased the amounts of acetate and butyrate of without significant bacteria growth in the complete medium. The activities of the butyryl-CoA: acetate CoA transferase (BUT), which are the main pathway to produce butyrate, were reduced while the activities of the butyrate kinase (BUK) were enhanced simultaneously. Surprisingly, fullerenol NPs promoted the growth of and in low glucose medium, but they could not be direct carbon source in the culture. Moreover, when cocultured with and the bifidobacterial strains in fullerenols, the biomass and acetate production of were markedly increased while butyrate was decreased significantly.
Hui Sun, Jiaxin Zhang, Jianglong Kong, Hui Yuan, Yuelan Liang, Kui Chen, Xue Bai, Yanan Chang, Juan Li, Gengmei Xing

1454 related Products with: Increased Production of Short-Chain Fatty Acids in Microbacteria Fermentation Treated by Fullerenols.

96 tests1 mg1,000 tests1mg100ug10 96tests100ug2 10 2 Pieces/Box10mg

Related Pathways

paperclip

#33845069   2021/04/14 To Up

RIFM fragrance ingredient safety assessment, lavandulyl acetate, CAS Registry Number 25905-14-0.


A M Api, D Belsito, S Biserta, D Botelho, M Bruze, G A Burton, J Buschmann, M A Cancellieri, M L Dagli, M Date, W Dekant, C Deodhar, A D Fryer, S Gadhia, L Jones, K Joshi, M Kumar, A Lapczynski, M Lavelle, I Lee, D C Liebler, H Moustakas, M Na, T M Penning, G Ritacco, J Romine, N Sadekar, T W Schultz, D Selechnik, F Siddiqi, I G Sipes, G Sullivan, Y Thakkar, Y Tokura

1601 related Products with: RIFM fragrance ingredient safety assessment, lavandulyl acetate, CAS Registry Number 25905-14-0.

25 G 1KG 100 G 5 G 1 G 100 G 5 G 1KG 1KG 1KG 100 G 100 G

Related Pathways

    No related Items
paperclip

#33804242   2021/03/15 To Up

Antioxidant and Antiproliferative Potentials of and Its Bioactive Polyphenol Metabolites.

Delile (Moraceae), a reputed plant that is used in herbal medicine, is of high medicinal and nutritional value in local communities primarily ascribed to its phytochemical profile. Currently, there are hardly any fine details on the chemical profiling and pharmacological evaluation of this species. In this study, the flavonoids and phenolics contents of the ethanol extracts and four extracted fractions (petroleum ether (PE), ethyl acetate (EA), -butanol, and water) of the stem bark of were firstly quantified. Further, their antioxidant and antiproliferative potentials were also evaluated. The quantitative determination indicated that the EA and -butanol fractions possessed the highest total flavonoids/phenolics levels of 274.05 ± 0.68 mg RE/g and 78.87 ± 0.97 mg GAE/g, respectively. Similarly, for the 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2'-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), and ferric-reducing antioxidant power (FRAP) assays, the EA fraction exhibited high potency in both DPPH and ABTS scavenging activities with IC values of 0.23 ± 0.03 mg/mL, 0.22 ± 0.03 mg/mL, and FRAP potential of 2.81 ± 0.01 mg Fe/g, respectively. Furthermore, the EA fraction displayed high cytotoxicity against human lung (A549) and colon (HT-29) cancer cells. Additionally, the liquid chromatography coupled with electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) was employed in order to characterize the chemical constituents of the EA fraction of stem bark. Our findings revealed 16 compounds from the EA fraction that were possibly responsible for the strong antioxidant and anti-proliferative properties. This study provides edge-cutting background information on the exploitation of as a potential natural antioxidant and anti-cancer remedy.
Moses Mutuse Mutungi, Felix Wambua Muema, Festus Kimutai, Yong-Bing Xu, Hui Zhang, Gui-Lin Chen, Ming-Quan Guo

1382 related Products with: Antioxidant and Antiproliferative Potentials of and Its Bioactive Polyphenol Metabolites.

10 mg1000 tests100ug25 mg200 10 mg100ug500 mg 5 G1000 TESTS/0.65ml 5 G100ul

Related Pathways

paperclip

Error loading info... Pleas try again later.
paperclip

#33760301   2021/03/24 To Up

Comparison of the Sensititre YeastOne ® and CLSI M38-A2 Microdilution Methods in Determining the Activity of Nine Antifungal Agents against Dermatophytes.

Dermatophytes are the most common fungal pathogens causing superficial infections in humans with a high prevalence worldwide. The treatment of these infections is based on the use of topical and systemic antifungal agents. A convenient method with a high predictive value for testing the susceptibilities of dermatophytes is necessary.
Wenqian Chang, Fangfang Bao, Zhenzhen Wang, Hong Liu, Furen Zhang

2269 related Products with: Comparison of the Sensititre YeastOne ® and CLSI M38-A2 Microdilution Methods in Determining the Activity of Nine Antifungal Agents against Dermatophytes.

1500 Units1 ml

Related Pathways

    No related Items
paperclip

#33755112   // To Up

Combined effects of 3-nitrooxypropanol and canola oil supplementation on methane emissions, rumen fermentation and biohydrogenation, and total tract digestibility in beef cattle.

The individual and combined effects of 3-nitrooxypropanol (3-NOP) and canola oil (OIL) supplementation on enteric methane (CH4) and hydrogen (H2) emissions, rumen fermentation and biohydrogenation, and total tract nutrient digestibility were investigated in beef cattle. Eight beef heifers (mean body weight ± SD, 732 ± 43 kg) with ruminal fistulas were used in a replicated 4 × 4 Latin square with a 2 (with and without 3-NOP) × 2 (with and without OIL) arrangement of treatments and 28-d periods (13 d adaption and 15 d measurements). The four treatments were: control (no 3-NOP, no OIL), 3-NOP (200 mg/kg dry matter [DM]), OIL (50 g/kg DM), and 3-NOP (200 mg/kg DM) plus OIL (50 g/kg DM). Animals were fed restrictively (7.6 kg DM/d) a basal diet of 900 g/kg DM barley silage and 100 g/kg DM supplement. 3-NOP and OIL decreased (P < 0.01) CH4 yield (g/kg DM intake) by 31.6% and 27.4%, respectively, with no 3-NOP × OIL interaction (P = 0.85). Feeding 3-NOP plus OIL decreased CH4 yield by 51% compared with control. There was a 3-NOP × OIL interaction (P = 0.02) for H2 yield (g/kg DM intake); the increase in H2 yield (P < 0.01) due to 3-NOP was less when it was combined with OIL. There were 3-NOP × OIL interactions for molar percentages of acetate and propionate (P < 0.01); individually, 3-NOP and OIL decreased acetate and increased propionate percentages with no further effect when supplemented together. 3-NOP slightly increased crude protein (P = 0.02) and starch (P = 0.01) digestibilities, while OIL decreased the digestibilities of DM (P < 0.01) and neutral detergent fiber (P < 0.01) with no interactions (P = 0.15 and 0.10, respectively). 3-NOP and OIL increased (P = 0.04 and P < 0.01, respectively) saturated fatty acid concentration in rumen fluid, with no interaction effect. Interactions for ruminal trans-monounsaturated fatty acids (t-MUFA) concentration and percentage were observed (P = 0.02 and P < 0.01); 3-NOP had no effect on t-MUFA concentration and percentage, while OIL increased the concentration (P < 0.01) and percentage (P < 0.01) of t-MUFA but to a lesser extent when combined with 3-NOP. In conclusion, the CH4-mitigating effects of 3-NOP and OIL were independent and incremental. Supplementing ruminant diets with a combination of 3-NOP and OIL may help mitigate CH4 emissions, but the decrease in total tract digestibility due to OIL may decrease animal performance and needs further investigation.
Xiu Min Zhang, Megan L Smith, Robert J Gruninger, Limin Kung, Diwakar Vyas, Sean M McGinn, Maik Kindermann, Min Wang, Zhi Liang Tan, Karen A Beauchemin

2586 related Products with: Combined effects of 3-nitrooxypropanol and canola oil supplementation on methane emissions, rumen fermentation and biohydrogenation, and total tract digestibility in beef cattle.

10 mg 5 G2.5 mg100ug1 mg1000 TESTS/0.65ml50 ug 1,000 tests100ul100 mg1000 tests

Related Pathways