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#34238972   2021/07/08 To Up

Exosomal hsa_circRNA_104484 and hsa_circRNA_104670 may serve as potential novel biomarkers and therapeutic targets for sepsis.

In order to explore the role of exosomal circRNAs in the occurrence and development of sepsis, we looked for potential diagnostic markers to accurately identify sepsis and to lay a molecular basis for precise treatment. Ultracentrifugation was used to extract exosomes from the serum of patients with sepsis and healthy individuals. Then, changes in circRNA expression in exosomes were studied by circRNA microarray analysis. Gene ontology (GO) analysis and Kyoto City Encyclopaedia of Genes and Genomes (KEGG) pathway analysis were used to annotate the biological functions and pathways of genes, and a circRNA-miRNA-mRNA regulatory network was constructed. In the microarray analysis, 132 circRNAs were significantly differentially expressed, including 80 and 52 that were upregulated and downregulated, respectively. RT-qPCR verified the results of microarray analysis: hsa_circRNA_104484 and hsa_circRNA_104670 were upregulated in sepsis serum exosomes. ROC analysis showed that hsa_circRNA_104484 and hsa_circRNA_104670 in serum exosomes have the potential to be used as diagnostic markers for sepsis. The circRNA-miRNA-mRNA network predicted the potential regulatory pathways of differentially expressed circRNAs. There are differences in the expression of circRNA in serum exosomes between patients with sepsis and healthy individuals, which may be involved in the occurrence and development of the disease. Among them, elevations in hsa_circRNA_104484 and hsa_circRNA_104670 could be used as novel diagnostic biomarkers and molecular therapeutic targets.
Chang Tian, Jiaying Liu, Xin Di, Shan Cong, Min Zhao, Ke Wang

1098 related Products with: Exosomal hsa_circRNA_104484 and hsa_circRNA_104670 may serve as potential novel biomarkers and therapeutic targets for sepsis.

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#33902476   2021/04/26 To Up

Diagnostic value of neutrophil CD64, procalcitonin, and interleukin-6 in sepsis: a meta-analysis.

The aim of the study was to conduct a meta-analysis to evaluate the accuracy of neutrophil CD64, procalcitonin (PCT), and interleukin-6 (IL-6) as markers for the diagnosis of sepsis in adult patients.
Shan Cong, Tiangang Ma, Xin Di, Chang Tian, Min Zhao, Ke Wang

1967 related Products with: Diagnostic value of neutrophil CD64, procalcitonin, and interleukin-6 in sepsis: a meta-analysis.

1 mg 0.1 mg 1-8 Sample Kit100.00 ug10 mg1 mg100.00 ug10 mg100.00 ug1 mg2ug

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#32905294   2020/08/01 To Up

Real-world treatment patterns and survival in stage IV non-small-cell lung cancer in Canada.

Almost half of all patients with non-small-cell lung cancer (nsclc) present with stage iv disease. The objective of the present study was to characterize treatment patterns and survival outcomes in patients with advanced nsclc.
S J Seung, M Hurry, R N Walton, W K Evans

1639 related Products with: Real-world treatment patterns and survival in stage IV non-small-cell lung cancer in Canada.



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#32905267   2020/08/01 To Up

Retrospective cohort study of unresectable stage III non-small-cell lung cancer in Canada.

The management of unresectable stage iii non-small-cell lung cancer (nsclc) is complex and best determined through multidisciplinary consultation. A longitudinal, population-level study was carried out to describe the management approach and outcomes of treatment in the real-world setting in Ontario.
S J Seung, M Hurry, R N Walton, W K Evans

1291 related Products with: Retrospective cohort study of unresectable stage III non-small-cell lung cancer in Canada.



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#31708661   2019/10/01 To Up

The generation of two specific cancer costing algorithms using Ontario administrative databases.

Cancer treatment and management have become increasingly economically burdensome. Consequently, to help with planning health service delivery, it is vital to understand the associated costs. Administrative databases can be used to help understand and generate real-world system-level costs. Using databases to generate costs can take one of two approaches: top-down or bottom-up. Top-down approaches disaggregate the total health care spending from a global health care budget by sector and provider. A bottom-up approach begins with individual-level health care use and its costs, which are then aggregated.
N Mittmann, S Y Cheng, N Liu, S J Seung, F E Saxena, C DeAngelis, N J Look Hong, C C Earle, M C Cheung, N Leighl, N Coburn, W K Evans

1333 related Products with: The generation of two specific cancer costing algorithms using Ontario administrative databases.

2 Pieces/Box2 Pieces/Box 6 ml Ready-to-use

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#31043811   2019/04/01 To Up

Cost-of-illness study for non-small-cell lung cancer using real-world data.

With recent advances in the treatment of non-small-cell lung cancer (nsclc) and current fiscal constraints within publicly funded health care systems, understanding the real-world economic effect of lung cancer management has become important. The objective of the present study was to determine the costs and resources used in the management of nsclc cohorts in Ontario.
S J Seung, M Hurry, S Hassan, R N Walton, W K Evans

2519 related Products with: Cost-of-illness study for non-small-cell lung cancer using real-world data.



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#30923418   2018/09/27 To Up

Building Word Knowledge, Learning Strategies, and Metacognition with the Word-Knowledge E-Book.

Many children fail to comprehend what they read because they do not monitor their understanding, which requires making accurate judgements of what they know and then employing repair strategies when comprehension fails. Relying on research from learning science and cognitive and developmental psychology, we developed the Word Knowledge e-Book (WKe-Book) to improve children's calibration of their word knowledge, strategy use, and word knowledge overall; skills which are associated with reading comprehension. The WKe-Book, which is read on a tablet computer, is a choose-your-own adventure book where choices require choosing between two rare words (e.g., cogitate vs. procrastinate). Depending on the word chosen, the story follows a different plot. There are also embedded comprehension questions where students receive immediate feedback with consequences for incorrect answers, such as being sent back to reread a few pages. In a randomized controlled trial, we tested whether students ( = 603 in 25 third through fifth grade classrooms in Arizona in the US) reading the WKe-Book would demonstrate improved word knowledge, strategy use, and word knowledge calibration. Classrooms were randomly assigned to read the WKe-Book immediately (treatment) or later (delayed-treatment control), and within classrooms, students were randomly assigned to either participate in a 15-minute weekly book club (book club treatment) or to read the WKe-Book independently with no book club (no book club control). Results revealed a significant treatment effect of the WKe-Book on students' word knowledge, word knowledge calibration, and strategy use, which predicted student performance on standardized reading comprehension and vocabulary measures. The effects were greater for students who participated in weekly book clubs compared to students in the no book club control. These findings suggest that the affordances offered by technology, which are unavailable in paper-based books, can support students' development of metacognition, including word knowledge calibration, strategy use, and word learning skills.
Carol McDonald Connor, Stephanie L Day, Elham Zargar, Taffeta S Wood, Karen S Taylor, Masha R Jones, Jin Kyoung Hwang

2133 related Products with: Building Word Knowledge, Learning Strategies, and Metacognition with the Word-Knowledge E-Book.

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#30711537   2019/01/31 To Up

CircRNAs and lung cancer: Biomarkers and master regulators.

CircRNAs are a class of competitive, endogenous, non-coding RNAs with closed-loop structures. High-throughput sequencing indicates that circRNAs are ubiquitously expressed in many eukaryotes. Biological functions of circRNAs include interaction with proteins and regulation of gene transcription, translation, and miRNA sponge activity. These functions suggest that circRNAs may be useful as novel biomarkers for disease diagnosis and prognosis. Lung cancer is known worldwide as the most common malignant tumor. It is also the main cause of cancer-related death. In recent years, it has become increasingly evident that circRNAs are involved in the proliferation, migration, and invasion of lung cancer cells. Differentially expressed circRNAs may be used as non-invasive diagnostic and prognostic markers for lung cancer. Therefore, they are considered a research hotspot for lung cancer studies. This article is a systematic review of mechanisms underlying the action, diagnosis, clinical aspects, and drug resistance of circRNAs in lung cancer.
Xin Di, Xin Jin, Ranwei Li, Min Zhao, Ke Wang

1544 related Products with: CircRNAs and lung cancer: Biomarkers and master regulators.

100ug1,000 tests200ug2.5 mg1 mg1000 tests

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#30513826   2018/12/02 To Up

Broccoli Fluorets: Split Aptamers as a User-Friendly Fluorescent Toolkit for Dynamic RNA Nanotechnology.

RNA aptamers selected to bind fluorophores and activate their fluorescence offer a simple and modular way to visualize native RNAs in cells. Split aptamers which are inactive until the halves are brought within close proximity can become useful for visualizing the dynamic actions of RNA assemblies and their interactions in real time with low background noise and eliminated necessity for covalently attached dyes. Here, we design and test several sets of F30 Broccoli aptamer splits, that we call fluorets, to compare their relative fluorescence and physicochemical stabilities. We show that the splits can be simply assembled either through one-pot thermal annealing or co-transcriptionally, thus allowing for direct tracking of transcription reactions via the fluorescent response. We suggest a set of rules that enable for the construction of responsive biomaterials that readily change their fluorescent behavior when various stimuli such as the presence of divalent ions, exposure to various nucleases, or changes in temperature are applied. We also show that the strand displacement approach can be used to program the controllable fluorescent responses in isothermal conditions. Overall, this work lays a foundation for the future development of dynamic systems for molecular computing which can be used to monitor real-time processes in cells and construct biocompatible logic gates.
Morgan Chandler, Tatiana Lyalina, Justin Halman, Lauren Rackley, Lauren Lee, Dylan Dang, Weina Ke, Sameer Sajja, Steven Woods, Shrija Acharya, Elijah Baumgarten, Jonathan Christopher, Emman Elshalia, Gabriel Hrebien, Kinzey Kublank, Saja Saleh, Bailey Stallings, Michael Tafere, Caryn Striplin, Kirill A Afonin

2072 related Products with: Broccoli Fluorets: Split Aptamers as a User-Friendly Fluorescent Toolkit for Dynamic RNA Nanotechnology.

50 assays100Tests100 reactions100 tests96 Tests1,000 tests

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#30350316   2019/01/24 To Up

Kimchi extracts as inhibitors of colour deterioration and lipid oxidation in raw ground pork meat during refrigerated storage.

Kimchi is a Korean, traditional fermented food made from Korean cabbage, radish, fermented jeotgal, ginger, garlic, and red pepper powder. It is a good source of natural antioxidants such as phenolic compounds, flavonoids, vitamins, and carotenoids. In this study, the antioxidant effects of various kimchi extracts on raw ground pork during refrigerated storage were investigated. Raw ground pork samples were treated with ascorbic acid, butylated hydroxyl toluene, baechu kimchi extract (BKE), gat kimchi extract (GKE), puchu kimchi extract (PKE), and white kimchi extract (WKE) and compared with raw ground pork without antioxidant treatment (NC).
Mi-Ai Lee, Tae-Kyung Kim, Ko-Eun Hwang, Yun-Jeong Choi, Sung-Hee Park, Cheon-Jei Kim, Yun-Sang Choi

2914 related Products with: Kimchi extracts as inhibitors of colour deterioration and lipid oxidation in raw ground pork meat during refrigerated storage.

400Tests0.1ml (1mg/ml)100 μg100 tests100 assays100 assays48 assays 6 inhibitors100 assays96 assays 8 inhibitors

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