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Search results for: p16

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#33661190   // To Up

Targeting the IL-2 inducible kinase in melanoma; a phase 2 study of ibrutinib in systemic treatment-refractory distant metastatic cutaneous melanoma: preclinical rationale, biology, and clinical activity (NCI9922).

IL-2 inducible kinase (ITK) is highly expressed in metastatic melanomas and its inhibition suppresses melanoma cell proliferation. We hypothesize that ibrutinib has a direct antitumor effect in melanoma cell lines and that treatment of metastatic melanomas with ibrutinib induces antitumor responses.
Stergios J Moschos, Zeynep Eroglu, Nikhil I Khushalani, Kari L Kendra, George Ansstas, Gino K In, Peng Wang, Glenn Liu, Frances A Collichio, Paul B Googe, Craig C Carson, Karen McKinnon, Hsing-Hui Wang, Nana Nikolaishvilli-Feinberg, Anastasia Ivanova, Christy C Arrowood, Nancy Garrett-Mead, Kathleen C Conway, Sharon N Edmiston, David W Ollila, Jonathan S Serody, Nancy E Thomas, S Percy Ivy, Lokesh Agrawal, Elizabeth C Dees, James L Abbruzzese

2165 related Products with: Targeting the IL-2 inducible kinase in melanoma; a phase 2 study of ibrutinib in systemic treatment-refractory distant metastatic cutaneous melanoma: preclinical rationale, biology, and clinical activity (NCI9922).

250ul

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#33660890   2021/03/04 To Up

Evaluation of HPV and EBV in OSCC and the Expression of p53, p16, E-cadherin, COX-2, MYC and MLH1.

This study aimed to evaluate the presence of Human Papillomavirus(HPV) and Epstein-Barr virus (EBV) and the expression of p53, p16, E-cadherin, COX-2, MLH1 and MYC in oral squamous cell carcinoma(OSCC).
Marcos Antonio Pereira de Lima, Roberta Barroso Cavalcante, Cláudio Gleidiston Lima da Silva, Renato Luiz Maia Nogueira, Geamberg Einstein Cruz Macedo, Lara Eduardo de Galiza, Juliana Viana Pinheiro, Pedro Hugo Bezerra Maia Filho, Sarah Ferreira Santos, Silvia Helena Barem Rabenhorst

1255 related Products with: Evaluation of HPV and EBV in OSCC and the Expression of p53, p16, E-cadherin, COX-2, MYC and MLH1.

10 mg100ul1 ml100ul10 mg100 mg1,000 tests200ug1 mg100ug200

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#33659783   // To Up

Characterization of the complete genome sequence of the recombinant norovirus GII.P16/GII.4_Sydney_2012 revealed in Russia.

Noroviruses (the Caliciviridae family) are a common cause of acute gastroenteritis in all age groups. These small non-envelope viruses with a single-stranded (+)RNA genome are characterized by high genetic variability. Continuous changes in the genetic diversity of co-circulating noroviruses and the emergence of new recombinant variants are observed worldwide. Recently, new recombinant noroviruses with a novel GII.P16 polymerase associated with different capsid proteins VP1 were reported. As a part of the surveillance study of sporadic cases of acute gastroenteritis in Novosibirsk, a total of 46 clinical samples from children with diarrhea were screened in 2016. Norovirus was detected in six samples from hospitalized children by RT-PCR. The identified noroviruses were classified as recombinant variants GII.P21/GII.3, GII. Pe/GII.4_Sydney_2012, and GII.P16/GII.4_Sydney_2012 by sequencing of the ORF1/ORF2 junction. In Novosibirsk, the first appearance of the new recombinant genotype GII.P16/ GII.4_Sydney_2012 was recorded in spring 2016. Before this study, only four complete genome sequences of the Russian GII.P16/GII.3 norovirus strains were available in the GenBank database. In this work, the complete genome sequence of the Russian strain Hu/GII.P16-GII.4/RUS/Novosibirsk/NS16-C38/2016 (GenBank KY210980) was determined. A comparison of the nucleotide and the deduced amino acid sequences showed a high homology of the Russian strain with GII.P16/GII.4_Sydney_2012 strains from other parts of the world. A comparative analysis showed that several unique substitutions occurred in the GII.P16 polymerase, N-terminal p48 protein, and minor capsid protein VP2 genes, while no unique changes in the capsid VP1 gene were observed. A functional significance of these changes suggests that a wide distribution of the strains with the novel GII.P16 polymerase may be associated both with several amino acid substitutions in the polymerase active center and with the insertion of glutamic acid or glycine in an N-terminal p48 protein that blocks the secretory immunity of intestinal epithelial cells. Further monitoring of genotypes will allow determining the distribution of norovirus recombinants with the polymerase GII.P16 in Russia.
E V Zhirakovskaia, A Y Tikunov, S N Sokolov, B I Kravchuk, E I Krasnova, N V Tikunova

1686 related Products with: Characterization of the complete genome sequence of the recombinant norovirus GII.P16/GII.4_Sydney_2012 revealed in Russia.

2000 IU100 IU200 units1mg50 IU1200 units

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#33651718   2021/03/02 To Up

Computerized tumor multinucleation index (MuNI) is prognostic in p16+ oropharyngeal carcinoma: A multi-site validation study.

p16 positive oropharyngeal squamous cell carcinoma (OPSCC) patients are potentially cured with definitive treatment. However, there are currently no reliable biomarkers of treatment failure in p16 positive OPSCC. Pathologist-based visual assessment of tumor cell multinucleation has been shown to be independently prognostic of disease-free survival in p16 positive OPSCC. However, its quantification is time-intensive, subjective, and at risk of interobserver variability.
Can F Koyuncu, Cheng Lu, Kaustav Bera, Zelin Zhang, Jun Xu, Paula Andrea Toro Castaño, Germán Corredor, Deborah Chute, Pingfu Fu, Wade L Thorstad, Farhoud Faraji, Justin A Bishop, Mitra Mehrad, Patricia D Castro, Andrew G Sikora, Lester D R Thompson, R D Chernock, Krystle A Lang Kuhs, Jingqin Luo, Vlad C Sandulache, David J Adelstein, Shlomo Koyfman, James S Lewis, Anant Madabhushi

1023 related Products with: Computerized tumor multinucleation index (MuNI) is prognostic in p16+ oropharyngeal carcinoma: A multi-site validation study.

100ug Lyophilized100ug Lyophilized100ug Lyophilized100 μg100ug Lyophilized100ug Lyophilized100ug Lyophilized

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#33650689   2021/03/02 To Up

Hyperglycemia accelerates inflammaging in the gingival epithelium through inflammasomes activation.

Diabetes accelerates inflammaging in various tissue with an increase in senescent cell burden and senescence-associated secretory phenotype (SASP) secretion, which is a significant cause of tissue dysfunction and contributes to the diabetic complications. Recently, inflammasomes are thought to contribute to inflammaging. Here, utilizing diabetic models in vivo and in vitro, we investigated the potential association between hyperglycemia-induced inflammaging and gingival tissue dysfunction and the mechanism underlying inflammasome-associated inflammaging.
Peng Zhang, Boyao Lu, Rui Zhu, Dawei Yang, Weiqing Liu, Qian Wang, Ning Ji, Qianming Chen, Yi Ding, Xing Liang, Qi Wang

1478 related Products with: Hyperglycemia accelerates inflammaging in the gingival epithelium through inflammasomes activation.

2 mg100μg100ug1100ug25 Bags/Unit

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#33646558   2021/02/28 To Up

Molecular and Immunohistochemical Cognizance of HPV16 in Oral Leukoplakia, Oral Squamous Cell Carcinoma and Oropharyngeal Squamous Cell Carcinoma.

Prior studies have established the carcinogenic role of HPV16 and also demonstrated its unique biological behavior in cervical and oropharyngeal squamous cell carcinoma (OPSCC) but its role in oral leukoplakia (OL) and oral squamous cell carcinoma (OSCC) is not well explored. Therefore, in the present study, we assessed HPV16 prevalence using PCR and Anti-HPV16 antibodies for the first time and correlated its biological behavior using p16 and Ki67 proliferation index (PI) in OL, OSCC, and OPSCC. This study included 63 subjects comprising of 25 OL, 26 OSCC, and 12 OPSCC cases. Exfoliated cells were collected and processed for PCR followed by immunohistochemistry with primary antibodies p16, Anti-HPV16, and Ki67. The expressions were evaluated and statistical analysis included Chi-square and Spearman's test. Cumulatively 37% (OL-7%, OSCC-14% & OPSCC-16%) of cases showed positive PCR expression. PCR positivity was observed to be significantly higher (p 0.00) in OPSCC (9/12) than OSCC (9/26) and OL (5/25) cases. Overall immunohistochemical expression of p16, Anti-HPV16, and Ki67 were significantly (p 0.02) higher in HPV16 (PCR) positive cases. HPV16 + OSCC cases showed higher grades of p16 and Ki67 expression. We have demonstrated a prevalence of HPV16 in OL, OSCC, and OPSCC through PCR, which may be concluded as a gold standard for the detection of HPV16 DNA.
N Sivakumar, Anjali Narwal, Mala Kamboj, Anju Devi, Sanjay Kumar, Rashmi Bhardwaj

2206 related Products with: Molecular and Immunohistochemical Cognizance of HPV16 in Oral Leukoplakia, Oral Squamous Cell Carcinoma and Oropharyngeal Squamous Cell Carcinoma.



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#33646425   2021/03/01 To Up

Individual characteristics associated with the magnitude of heat acclimation adaptations.

The magnitude of heat acclimation (HA) adaptations varies largely among individuals, but it remains unclear what factors influence this variability. This study compared individual characteristics related to fitness status and body dimensions of low-, medium-, and high responders to HA.
Puck Alkemade, Nicola Gerrett, Thijs M H Eijsvogels, Hein A M Daanen

1457 related Products with: Individual characteristics associated with the magnitude of heat acclimation adaptations.

100 ml500 10 ìg50 IU1000 pcs

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#33645625   2021/03/01 To Up

Defective expression of the peroxisome regulators PPARα receptors and lysogenesis with increased cellular senescence in the venous wall of chronic venous disorder.

The pathogenesis of chronic venous disorder (CVeD) remains partially understood. A marked wall remodeling has been shown with potential accelerated tissue senescence. We have investigated the expression of peroxisome proliferator-activated receptor (PPAR) isoforms transcription factor EB (TFEB) as regulatory molecules of cellular homeostasis and makers of peroxisomal and lysosomal biogenesis. We have also quantified p16 expression as a cellular senescence marker. In specimens of maior safena vein from 35 CVeD and 27 healthy venous controls (HV), we studied the expression of PPAR-α, PPAR-β/δ, PPAR-γ, TFEB and p16 by RT-qPCR and immunohistochemical techniques. We have demonstrated a reduced gene and protein expression of the PPAR-α and PPAR-β/δ isoform as well as that of TFEB in the venous wall of CVeD patients, suggesting an altered peroxisomal and lysosomal biogenesis associated with an increased cellular senescence shown by increased p16 expression.
Miguel A Ortega, Oscar Fraile-Martínez, Leonel Pekarek, Miguel A Alvarez-Mon, Ángel Asúnsolo, Lara Sanchez-Trujillo, Santiago Coca, Julia Buján, Melchor Álvarez-Mon, Natalio García-Honduvilla, Felipe Sainz

1899 related Products with: Defective expression of the peroxisome regulators PPARα receptors and lysogenesis with increased cellular senescence in the venous wall of chronic venous disorder.

1500 Units

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#33637118   2021/02/26 To Up

Acquired radioresistance in cancer associated fibroblasts is concomitant with enhanced antioxidant potential and DNA repair capacity.

Cancer-associated fibroblasts (CAFs) are a major component of the cancer stroma, and their response to therapeutic treatments likely impacts the outcome. We tested the hypothesis that CAFs develop unique characteristics that enhance their resistance to ionizing radiation.
Jason D Domogauer, Sonia M de Toledo, Roger W Howell, Edouard I Azzam

1682 related Products with: Acquired radioresistance in cancer associated fibroblasts is concomitant with enhanced antioxidant potential and DNA repair capacity.

100ug Lyophilized 100ul100 μg100ug Lyophilized1 mg100ug Lyophilized100ug Lyophilized100ug Lyophilized

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#33635430   2021/02/26 To Up

TERT promoter mutations in penile squamous cell carcinoma: high frequency in non-HPV-related type and association with favorable clinicopathologic features.

Penile carcinoma is a rare malignant neoplasm with a largely unknown molecular pathogenesis. Telomerase reverse transcriptase promoter (TERT-p) mutations have been detected in several types of human malignancies. The aim of this study was to investigate the presence of TERT-p mutations in penile squamous cell carcinomas (SCCs) and their associations with clinicopathologic features.
Sang Kyum Kim, Jang-Hee Kim, Jae Ho Han, Nam Hoon Cho, Se Joong Kim, Sun Il Kim, Seol Ho Choo, Ji Su Kim, Bumhee Park, Ji Eun Kwon

1419 related Products with: TERT promoter mutations in penile squamous cell carcinoma: high frequency in non-HPV-related type and association with favorable clinicopathologic features.



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