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#32432778   // To Up

Sesame lignans suppress age-related disorders of the kidney in mice.

Sesamin is a functional ingredient in sesame (Sesamum indicum) seeds and has many physiological effects. This study investigated whether sesame lignans, sesamin and episesamin (1:1), can suppress age-related disorders of the kidney.
S Shimoyoshi, D Takemoto, Y Kishimoto, A Amano, A Sato, Y Ono, T Rogi, H Shibata, A Ishigami

1058 related Products with: Sesame lignans suppress age-related disorders of the kidney in mice.

96 tests2 Pieces/Box

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#32266309   2019/10/01 To Up

Perianal Disease and Granulomas: Think Out of the Box….

Chronic granulomatous disease (CGD) is a primary immunodeficiency due to a malfunction of NADPH oxidase. It is characterized by recurrent and severe infections caused by catalase-positive microorganisms and autoinflammatory manifestations. Recently, there has been described an gene variant that causes a deficiency of p40, a subunit of NADPH oxidase. Patients with this deficiency appear to have a less severe clinical form as compared to classic CGD.
Ana Reis-Melo, Maria do Céu Espinheira, Isabel Pinto-Pais, Artur Bonito Vitor, Jacinta Bustamante, Eunice Trindade

2470 related Products with: Perianal Disease and Granulomas: Think Out of the Box….

10 mg0.1 ml500 Units1000 tests600 Tests / Kit1-99 mg/ml/ea price x 2100ul

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#32264971   2020/04/07 To Up

Deterioration of cognitive function after transient cerebral ischemia with amyloid-β infusion-possible amelioration of cognitive function by AT receptor activation.

To promote understanding of the pathogenesis of cognitive impairment or dementia, we explored the potential interaction between transient cerebral ischemia and amyloid-β (Aβ) infusion in mediating cognitive decline and examined the possible ameliorative effect of angiotensin II type 2 (AT) receptor activation in vascular smooth muscle cells (VSMC) on this cognitive deficit.
Li-Juan Min, Jun Iwanami, Masachika Shudou, Hui-Yu Bai, Bao-Shuai Shan, Akinori Higaki, Masaki Mogi, Masatsugu Horiuchi

2610 related Products with: Deterioration of cognitive function after transient cerebral ischemia with amyloid-β infusion-possible amelioration of cognitive function by AT receptor activation.

1 kit(96 Wells)200.00 ug1 kit(96 Wells)200.00 ug50.00 ug200ul200.00 ug1 kit(96 Wells)1 kit(96 Wells)200.00 ug200ul

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#32181279   2019/07/27 To Up

Recent advances in chronic granulomatous disease.

Chronic granulomatous disease (CGD) is an inherited defect of phagocyte function due to defective NADPH oxidase. Patients with CGD are not able to effectively clear the infections because of the defect in the phagocyte production of oxygen free radicals and are prone to recurrent bacterial and fungal infections. Inflammatory complications are also noted in CGD such as colitis, non-infective granulomas causing gastrointestinal or urinary tract obstruction, hemophagocytic lymphohistiocytosis, and arthritis. Studies on toll-like receptor pathways and neutrophil extracellular traps in CGD have shed light on the role of NADPH oxidase in the innate immunity and pathogenesis of infections in CGD. Some reports also indicate a reduction of memory B cells and defective production of functional antibodies in CGD. Though the exact mechanisms for non-infective inflammatory complications in CGD are not yet clear, studies on efferocytosis and defective autophagy with inflammasome activation have made a substantial contribution to our understanding of the pathogenesis of inflammation in CGD. We also discuss the clinical and molecular features of p40 defects and a newer genetic defect, . Clinical phenotypes of X-linked carriers of are also discussed.
Gummadi Anjani, Pandiarajan Vignesh, Vibhu Joshi, Jitendra Kumar Shandilya, Dharmagat Bhattarai, Jyoti Sharma, Amit Rawat

1224 related Products with: Recent advances in chronic granulomatous disease.

50 UG96 tests1-99 mg/ml/ea price x 2

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#31949464   2019/12/26 To Up

Granule of BU-XIN RUAN-MAI Attenuates the Patients' Angina Pectoris of Coronary Heart Disease via Regulating miR-542-3p/GABARAP Signaling.

Coronary heart disease (CHD) has been regarded as a serious and common disease in the modern society. This study aims to investigate the effect of Granule of BU-XIN RUAN-MAI (BXRM) on angina pectoris of coronary heart disease and to explore the molecular mechanisms underlying Granule of BU-XIN RUAN-MAI-mediated protective activity against this disease.
Dong Yan, Li-Li Zhao, Bo-Wen Yue, Hui Qian, Zi-Han Zhang, Ning Wang, Shi-Hai Yan, Yu-Liang Qian

1473 related Products with: Granule of BU-XIN RUAN-MAI Attenuates the Patients' Angina Pectoris of Coronary Heart Disease via Regulating miR-542-3p/GABARAP Signaling.

N/A 5 GN/A 500 tests500 Units100 per bag, 10 bags per1 mg

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#31815003   2019/12/04 To Up

CD40 induces renal cell carcinoma-specific differential regulation of TRAF proteins, ASK1 activation and JNK/p38-mediated, ROS-dependent mitochondrial apoptosis.

A unique feature of CD40 among the TNF receptor (TNFR) superfamily is its exquisitely contextual effects, as originally demonstrated in normal and malignant B-lymphocytes. We studied renal cell carcinoma (RCC) in comparison to normal (human renal proximal tubule) cells, as a model to better understand the role of CD40 in epithelial cells. CD40 ligation by membrane-presented CD40 ligand (mCD40L), but not soluble CD40 agonist, induced extensive apoptosis in RCC cells; by contrast, normal cells were totally refractory to mCD40L. These findings underline the importance of CD40 'signal-quality' on cell fate and explain the lack of pro-apoptotic effects in RCC cells previously, while confirming the tumour specificity of CD40 in epithelial cells. mCD40L differentially regulated TRAF expression, causing sustained TRAF2/TRAF3 induction in RCC cells, yet downregulation of TRAF2 and no TRAF3 induction in normal cells, observations strikingly reminiscent of TRAF modulation in B-lymphocytes. mCD40L triggered reactive oxygen species (ROS) production, critical in apoptosis, and NADPH oxidase (Nox)-subunit p40phox phosphorylation, with Nox blockade abrogating apoptosis thus implying Nox-dependent initial ROS release. mCD40L mediated downregulation of Thioredoxin-1 (Trx-1), ASK1 phosphorylation, and JNK and p38 activation. Although both JNK/p38 were essential in apoptosis, p38 activation was JNK-dependent, which is the first report of such temporally defined JNK-p38 interplay during an apoptotic programme. CD40-killing entrained Bak/Bax induction, controlled by JNK/p38, and caspase-9-dependent mitochondrial apoptosis, accompanied by pro-inflammatory cytokine secretion, the repertoire of which also depended on CD40 signal quality. Previous reports suggested that, despite the ability of soluble CD40 agonist to reduce RCC tumour size in vivo via immunocyte activation, RCC could be targeted more effectively by combining CD40-mediated immune activation with direct tumour CD40 signalling. Since mCD40L represents a potent tumour cell-specific killing signal, our work not only offers insights into CD40's biology in normal and malignant epithelial cells, but also provides an avenue for a 'double-hit' approach for inflammatory, tumour cell-specific CD40-based therapy.
Khalidah Ibraheem, Albashir M A Yhmed, Tahir Qayyum, Nicolas P Bryan, Nikolaos T Georgopoulos

1855 related Products with: CD40 induces renal cell carcinoma-specific differential regulation of TRAF proteins, ASK1 activation and JNK/p38-mediated, ROS-dependent mitochondrial apoptosis.

2 Pieces/Box2 Pieces/Box50 ug5ug1 kit1 kit22 Pieces/Box

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#31172470   // To Up

Soluble Regulatory Proteins for Activation of NOX Family NADPH Oxidases.

NOX family NADPH oxidases deliberately produce reactive oxygen species and thus contribute to a variety of biological functions. Of seven members in the human family, the three oxidases NOX2, NOX1, and NOX3 form a heterodimer with p22 and are regulated by soluble regulatory proteins: p47, its related organizer NOXO1; p67, its related activator NOXA1; p40; and the small GTPase Rac. Activation of the phagocyte oxidase NOX2 requires p47, p67, and GTP-bound Rac. In addition to these regulators, p40 plays a crucial role when NOX2 is activated during phagocytosis. On the other hand, NOX1 activation prefers NOXO1 and NOXA1, although Rac is also involved. NOX3 constitutively produces superoxide, which is enhanced by regulatory proteins such as p47, NOXO1, and p67. Here we describe mechanisms for NOX activation with special attention to the soluble regulatory proteins.
Hideki Sumimoto, Reiko Minakami, Kei Miyano

2614 related Products with: Soluble Regulatory Proteins for Activation of NOX Family NADPH Oxidases.

250,1 mg52 Pieces/Box0.1mg100 1001 mg 100 UG31

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#31172463   // To Up

Intersecting Stories of the Phagocyte NADPH Oxidase and Chronic Granulomatous Disease.

Neutrophils serve as the circulating cells that respond early and figure prominently in human host defense to infection and in inflammation in other settings. Optimal oxidant-dependent antimicrobial activity by neutrophils relies on the ability of stimulated phagocytes to utilize a multicomponent NADPH oxidase to generate oxidants. The frequent, severe, and often fatal infections experienced by individuals with chronic granulomatous disease (CGD), an inherited disorder in which one of the NADPH oxidase components is absent or dysfunctional, underscore the link between a functional phagocyte NADPH oxidase and robust host protection against microbial infection.The history of the discovery and characterization of the normal neutrophil NADPH oxidase and the saga of recognizing CGD and its underlying causes together illustrate how the observations of astute clinicians and imaginative basic scientists synergize to forge new understanding of both basic cell biology and pathogenesis of human disease.In this chapter, we review the events in the stepwise evolution of our understanding of the phagocyte NADPH oxidase, both in the context of normal human neutrophil function and in the setting of CGD. The phagocyte oxidase complex employs a heterodimeric transmembrane protein composed of gp91phox and p22phox to relay electrons from NADPH to molecular oxygen, while other cofactors contribute to localization and regulation of the activity of the assembled oxidase. The b-type cytochrome gp91phox, also known as NOX2, serves as the catalytic component of this multicomponent enzyme complex. Although many of the features of the composition and regulation of the phagocyte oxidase may apply as well to NOX2 expressed in non-phagocytes and to other members of the NOX protein family, exceptions exist and pose special challenges to investigators exploring the biology of NADPH oxidases.
William M Nauseef, Robert A Clark

2450 related Products with: Intersecting Stories of the Phagocyte NADPH Oxidase and Chronic Granulomatous Disease.

50 UG25 mg250/kit25000 units1 mL1000 tests100 μg96 tests1

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#31109945   // To Up

Intracellular Neutrophil Oxidants: From Laboratory Curiosity to Clinical Reality.

The phagocyte NADPH oxidase is responsible for the neutrophil's great capacity to produce reactive oxygen species (ROS). The NADPH oxidase can be assembled in the plasma membrane, as well as in membranes of intracellular vesicles, giving neutrophils the ability to direct ROS production to distinct subcellular sites. Neutrophil ROS contribute to microbial killing, trigger formation of neutrophil extracellular traps and appear to partake in inflammation control. Consequently, function-disrupting mutations in the NADPH oxidase lead to chronic granulomatous disease, characterized by severe infections and inflammatory disorders. Recent experimental data and description of a novel chronic granulomatous disease subtype (p40-deficiency) imply that ROS generated in intracellular compartments are key for NETosis and for controlling inflammatory signaling. We foresee boosted interest in intracellular ROS production. To fully understand where and how such ROS function, however, limitations of assay systems to measure ROS need to be appreciated, and the development of novel techniques/reagents would be highly useful.
Claes Dahlgren, Anna Karlsson, Johan Bylund

1618 related Products with: Intracellular Neutrophil Oxidants: From Laboratory Curiosity to Clinical Reality.

1 kit1 kit 500 ml 1 mL1 module

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