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#33624934   2021/02/24 To Up

Association of MACROD2 gene variants with obesity and physical activity in a Korean population.

Obesity is a serious and common complex disease caused by the influence of genetic and environmental factors. Therefore, we aimed to evaluate the effect of genetic variants on obesity and the possibility of preventing obesity through physical activity using association analysis.
Hye-Rim Kim, Hyun-Seok Jin, Yong-Bin Eom

1441 related Products with: Association of MACROD2 gene variants with obesity and physical activity in a Korean population.

1 kit0.1ml (1mg/ml)900 tests96 assays 1 kit96T100ug400Tests48 assays

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#33624538   2021/02/24 To Up

Effects of resistance training combined with a ketogenic diet on body composition: a systematic review and meta-analysis.

We evaluated the effects of ketogenic diets (KDs) on body mass (BM), fat mass (FM), fat-free mass (FFM), body mass index (BMI), and body fat percentage (BFP) compared to non-KDs in individuals performing resistance training (RT). Online electronic databases including PubMed, the Cochrane Library, Web of Science, Embase, SCOPUS, and Ovid were searched to identify initial studies until February 2021. Data were pooled using both fixed and random-effects methods and were expressed as weighted mean difference (WMD) and 95% confidence intervals (CI). Out of 1372 studies, 13 randomized controlled trials (RCTs) that enrolled 244 volunteers were included. The pooled results demonstrated that KDs significantly decreased BM [(WMD = -3.67 kg; 95% CI: -4.44, -2.90,  < 0.001)], FM [(WMD = -2.21 kg; 95% CI: -3.09, -1.34,  < 0.001)], FFM [(WMD = -1.26 kg; 95% CI: -1.82, -0.70,  < 0.001)], BMI [(WMD = -1.37 kg.m; 95% CI: -2.14, -0.59,  = 0.022)], and BFP [(WMD = -2.27%; 95% CI: -3.63, -0.90,  = 0.001)] compared to non-KDs. We observed beneficial effects of KDs compared to non-KDs on BM and body fat (both FM and BFP) in individuals performing RT. However, adherence to KDs may have a negative effect on FFM, which is not ameliorated by the addition of RT.
Damoon Ashtary-Larky, Reza Bagheri, Omid Asbaghi, Grant M Tinsley, Wesam Kooti, Amir Abbasnezhad, Reza Afrisham, Alexei Wong

2607 related Products with: Effects of resistance training combined with a ketogenic diet on body composition: a systematic review and meta-analysis.

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#33623708   2021/01/25 To Up

Reassessing species demarcation criteria in viroid taxonomy by pairwise identity matrices.

With a small, circular and non-protein coding RNA genome, viroids are the smallest infectious agents. They invade plants, which in turn may develop symptoms. Since their discovery about 50 years ago, more than thirty viroids have been reported and classified using as species demarcation less than 90 per cent sequence identity on the overall genome and evidence of biological divergence with respect to the closest related viroids. In the last few years, new viroids have been identified that infect latently their (frequently) woody hosts and have a narrow experimental hosts range, complicating and slowing down studies on their biology. As a consequence, several viroids are still waiting for classification. Moreover, the number of new viroids is expected to increase in the next years due to the use of high-throughput sequencing technologies with diagnostics purposes. Therefore, establishment of reliable species demarcation criteria mainly based on molecular features of viroids is needed. Here, viroid classification is reassessed and a scheme based on pairwise sequence identity matrices is developed. After identifying a threshold pairwise identity score (PWIS) for each viroid genus, to be used as a species demarcation criterion, we show that most of those yet unclassified viroids can be assigned to a known or to a new species, thus limiting the need for additional biological evidence to only a few more complex situations. The advantages of this PWIS-based method are that the proposed identity thresholds for species demarcations are not arbitrarily established and evidence for biological divergence is not mandatory. Importantly, the current classification is not essentially modified. A protocol for a tentative fast classification of new viroids according to the proposed approach is also provided.
Michela Chiumenti, Beatriz Navarro, Thierry Candresse, Ricardo Flores, Francesco Di Serio

1916 related Products with: Reassessing species demarcation criteria in viroid taxonomy by pairwise identity matrices.

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#33621520   2021/02/20 To Up

What do transcription factors interact with?

Although we have made significant progress, we still possess a limited understanding of how genomic and epigenomic information directs gene expression programs through sequence-specific transcription factors (TFs). Extensive research has settled on three general classes of TF targets in metazoans: promoter accessibility via chromatin regulation (e.g., SAGA), assembly of the general transcription factors on promoter DNA (e.g., TFIID) , and recruitment of RNA polymerase (Pol) II (e.g., Mediator) to establish transcription pre-initiation complex (PIC). Here we discuss TFs and their targets. We also place this in the context of our current work with Saccharomyces (yeast), where we find that promoters typically lack an architecture that supports TF function. Moreover, yeast promoters that support TF binding also display interactions with cofactors like SAGA and Mediator, but not TFIID. It is unknown to what extent all genes in metazoans require TFs and their cofactors.
Haining Chen, B Franklin Pugh

1720 related Products with: What do transcription factors interact with?

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#33612630   // To Up

Effects of High-Fiber Biscuits on Lipid and Anthropometric Profile of Patients with Type 2 Diabetes.

This study aimed to evaluate the efficacy of two types of high-fiber biscuits on the lipid and anthropometric profile of patients with type 2 diabetes mellitus (DM). This study involved a pre- and posttest randomized controlled trial design conducted on 33 subjects of the first first group given caromma biscuit (made from modified cassava flour mixed with koro sword flour and date jam) and 31 subjects of the second first group given temma biscuit (made from a mixture of tempeh flour with date jam). Each group consumed 100 g of biscuit each day for 4 wk. The anthropometric data collected included body mass index (BMI), waist-hip circumference ratio (WHCR), body fat percentage (BFP), blood pressure, and fasting blood glucose (FBG). The lipid profile included total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triglyceride collected before and after the study. The two types of biscuits had similar nutritional contents in terms of energy, carbohydrate, and fat contents, and their glycemic indices were low. However, the fiber content of caromma was higher than that of temma. After 4 wk, the anthropometric profiles, such as BMI (24.47+5.62 to 24.56+5.55; p=0.008), BFP (32.18+6.83 to 32.68+7.22; p=0.4), and WHCR (0.85+0.67 to 0.86+0.65; p=0.015), were unchanged in the caromma and temma groups (BMI 26.68+3.82 to 26.75+3.92; p=0.072; BFP 35.96+5.34 to 35.90+5.15; p=0.907; WHCR 0.86+0.66 to 0.88+0.4; p=0.006), except reducing FBG (167.06+82.8 to 154.85+95.0; p=0.150 in the caromma group and 173.19+92.72 to 150.06+73.64; p=0.095 in the temma group). A significant improvement was observed in the lipid profile of the caromma group (cholesterol, 239.73+35.3 to 195.70+34.13, p=0.000; LDL, 145.18+29.89 to 122.24+29.00, p=0.000; HDL, 61.00+17.76 to 51.12+15.40, p=0.000; triglyceride 175.09+112.64 to 123.67+73.89, p=0.000) and temma group (cholesterol, 264.42+75.10 to 204.68+37.11, p=0.000; LDL, 154.97+53.59 to 125.45+30.56, p=0.001; HDL, 59.68+1,328 to 49.48+11.52, p=0.000; triglyceride, 226.00+172.56 to 152.48+99.88, p=0.007). Lipid and animal protein intake should be limited among patients with type 2 DM. A high lipid profile, which is dangerous for patients with type 2 DM, can be prevented. Originality: Caromma and temma biscuits can be consumed by patients with diabetes. Although these biscuits cannot improve the anthropometric profiles of the subjects, their consumption has positive effects on the blood lipid profile.
Fatmah

1890 related Products with: Effects of High-Fiber Biscuits on Lipid and Anthropometric Profile of Patients with Type 2 Diabetes.

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#33585341   2021/01/29 To Up

Severe Headache, Paraesthesias, Facial Diplegia and Pleocytosis: A Misleading Presentation of Guillain-Barré Syndrome.

Guillain-Barré syndrome (GBS) is an acute inflammatory polyradiculoneuropathy. Progressive limb weakness, diminished/absent reflexes, sensory disturbance, and variable autonomic dysfunction are its core clinical manifestations. Bifacial weakness with paraesthesias (BFP) is a rare regional variant of GBS and is characterized by simultaneous facial diplegia, distal paraesthesias and minimal or no motor weakness. The association of headache with classic GBS has been rarely reported in the literature, and has not yet been described in the BFP variant. Here we report a misleading case of BFP variant associated with severe headache and mild pleocytosis. The repetition of nerve conduction studies (NCS) was extremely beneficial in this confusing case.
Mohamed Reda Belkhribchia, Abderrahim Chekabab, Yahya Naji, Latifa Hadrane, Soufiane Hassar, Nissrine Louhab, Najib Kissani

2224 related Products with: Severe Headache, Paraesthesias, Facial Diplegia and Pleocytosis: A Misleading Presentation of Guillain-Barré Syndrome.

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#33584046   2019/08/30 To Up

Management of Large Oroantral Fistulas Caused by Medication-Related Osteonecrosis with the Combined Sequestrectomy, Buccal Fat Pad Flap and Platelet-Rich Fibrin.

The aim of this retrospective study was to describe the efficacy of management of bisphosphonate-related maxillary osteonecrosis, which had resulted in an oroantral fistula formation, by performing sequestrectomy, platelet-rich fibrin (PRF) and buccal fat pad (BFP) flap.
Alparslan Esen, Sebnem Akkulah

1572 related Products with: Management of Large Oroantral Fistulas Caused by Medication-Related Osteonecrosis with the Combined Sequestrectomy, Buccal Fat Pad Flap and Platelet-Rich Fibrin.

1 ml100 ug100ug Lyophilized500IU10ml1 ml 6 ml Ready-to-use 1,000 tests10 mg100ug100ug

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#33577525   // To Up

Tunable sub-300  fs soliton and switchable dual-wavelength pulse generation from a mode-locked fiber oscillator around 2.8  µm.

In this Letter, we demonstrate, for the first time, to the best of our knowledge, tunable soliton and switchable dual-wavelength pulse generation from a nonlinear polarization rotation mode-locked -doped fluoride fiber oscillator around 2.8 µm, employing a birefringent plate (BFP)-based Lyot filter. In the single soliton state, the wavelength can be continuously tuned in the region of 2752.4∼2807.2 (∼55) with a pulse width between 199 and 270 fs, by rotating the BFP with the aid of its spectral filtering effect. At higher pump levels, two kinds of dual-wavelength synchronous mode-locking states (i.e., 2746.4/2782.0 and 2787.2/2825.2 nm) are observed, and can be flexibly switched by adjusting the rotation angle of the BFP. This approach opens up new opportunities for the development of versatile mid-infrared ultrashort laser sources.
Hongyu Luo, Jian Yang, Jianfeng Li, Yong Liu

1265 related Products with: Tunable sub-300  fs soliton and switchable dual-wavelength pulse generation from a mode-locked fiber oscillator around 2.8  µm.

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#33575144   2021/01/08 To Up

Tailoring Body Mass Index for Prediction of Obesity in Young Adults: A Multi-Centric Study on MBBS Students of Southeast India.

Body mass index (BMI) has been used for a long period as a surrogative measure for obesity. But BMI does not differentiate between fat and nonfat tissue (blood, bone, and muscle) due to which it is not considered accurate anymore. But since BMI is easier to estimate and used widely for assessment of obesity, it is better if it is re-standardized according to the body fat percentage (BFP) of a specific population, community, and their ethnicity.
Swikruti Behera, Alpana Mishra, Angeleena Esther, Ayaskant Sahoo

1849 related Products with: Tailoring Body Mass Index for Prediction of Obesity in Young Adults: A Multi-Centric Study on MBBS Students of Southeast India.

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#33548099   2021/02/06 To Up

The effect of different adiposity factors on insulin resistance in obese children and adolescents.

Insulin resistance (IR) has been common in obese children, but the effect of different adiposity factors on IR is still unclear.
Yang Niu, Xuelin Zhao, Huijun He, Xiaomeng Mao, Jinye Sheng, Jing Zou, Qingya Tang, Wei Cai

2004 related Products with: The effect of different adiposity factors on insulin resistance in obese children and adolescents.

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