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#32401908   2020/05/11 To Up

Poly (Lactic Acid) membrane and Sedum dendroideum extract favors the repair of burns in rats.

To evaluate the healing potential of the electrospinning membranes of Poly (Lactic Acid) (PLA) associated with Sedum dendroideum extract in burn injuries in rats.
Juliane Peliçari Binotto, Larissa Giorgetti Mendes, Fernanda Oliveira de Gaspari Gaspi, Marcelo Augusto Marreto Esquisatto, Thiago Antonio Moretti de Andrade, Fernanda Aparecida Sampaio Mendonça, Gláucia Maria Tech Santos

2164 related Products with: Poly (Lactic Acid) membrane and Sedum dendroideum extract favors the repair of burns in rats.

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#23901492   // To Up

Electrospun membranes of poly(lactic acid) (PLA) used as scaffold in drug delivery of extract of Sedum dendroideum.

Biomaterials nanofibrous electrospun with biodegradable polymers have the advantage of the similarity to natural extracellular matrices, showing promising as scaffolds for application in tissue engineering. Sedum dendroideum is a phytotherapic drug that stands out for its healing properties and anti-inflammatory. This study presents the efficacy of PLA electrospun membranes used as support S. dendroideum extract releasing on excisional skin lesions of Wistar rats. The PLA porous membranes, which are nonwoven fibrous mats, were obtained by electrospinning using a conventional apparatus with a flat collector. The animals were randomly divided into nine groups: control (C), animals treated with electrospun membranes of PLA (M), animals treated with extract of S. dendroideum dissolved in saline (F), animals treated with membranes of PLA with 10% S. dendroideum (MF10), animals treated with membranes of PLA with 25% S. dendroideum (MF25). Tissue samples were taken after 2, 6 and 10 days after surgery and were subjected to structural analysis and morphology. The experimental observations showed the application of the phytotherapic incorporated in the membrane promoted a significant response regarding the number of inflammatory cells, percentage of mature collagen fibers and epithelium birrefringent in thickness excisional skin lesions in Wistar rats. It was also demonstrated that the application of the PLA membranes without the extract promoted similar responses tissues.
Larissa G Santos, Daniel C Oliveira, Michele S L Santos, Lia Mara G Neves, Fernanda O G de Gaspi, Fernanda A S Mendonça, Marcelo A M Esquisatto, Gláucia M T Santos, M A d'Avila, Lucia H Innocentini Mei

2821 related Products with: Electrospun membranes of poly(lactic acid) (PLA) used as scaffold in drug delivery of extract of Sedum dendroideum.

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#23632918   2013/05/01 To Up

Waldiomycin, a novel WalK-histidine kinase inhibitor from Streptomyces sp. MK844-mF10.

WalK, a histidine kinase, and WalR, a response regulator, make up a two-component signal transduction system that is indispensable for the cell-wall metabolism of low GC Gram-positive bacteria. WalK inhibitors are likely to show bactericidal effects against methicillin-resistant Staphylococcus aureus . We discovered a new WalK inhibitor, designated waldiomycin, by screening metabolites from actinomycetes. Waldiomycin belongs to the family of angucycline antibiotics and is structurally related to dioxamycin. Waldiomycin inhibits WalK from S. aureus and Bacillus subtilis at IC50s 8.8 and 10.2 μM, respectively, and shows antibacterial activity with MICs ranging from 4 to 8 μg ml(-1) against methicillin-resistant S. aureus and B. subtilis.
Masayuki Igarashi, Takafumi Watanabe, Tomohiro Hashida, Maya Umekita, Masaki Hatano, Yohei Yanagida, Hirokazu Kino, Tomoyuki Kimura, Naoko Kinoshita, Kunio Inoue, Ryuichi Sawa, Yoshio Nishimura, Ryutaro Utsumi, Akio Nomoto

2153 related Products with: Waldiomycin, a novel WalK-histidine kinase inhibitor from Streptomyces sp. MK844-mF10.

5 mg400Tests5 mg5 mg25 mg25 mg100 assays50ug2 ml100ug 100ul100ug

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