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#33662819   2021/03/01 To Up

Histologic evaluation of therapeutic responses in ischemic myocardium elicited by dual growth factor delivery from composite glycosaminoglycan hydrogels.

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Alexander A Xu, Kayle S Shapero, Jared A Geibig, Hsiang-Wei K Ma, Alex R Jones, Marina Hanna, Daniel R Pitts, Elaine Hillas, Matthew A Firpo, Robert A Peattie

2380 related Products with: Histologic evaluation of therapeutic responses in ischemic myocardium elicited by dual growth factor delivery from composite glycosaminoglycan hydrogels.

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#33662386   2021/03/01 To Up

Serotonin Deficiency is Associated with Delayed Gastric Emptying.

Gastrointestinal (GI) motility is regulated by serotonin (5-hydroxytryptamine, 5-HT), which is primarily produced by enterochromaffin (EC) cells in the GI tract. However, the precise roles of EC cell-derived 5-HT in regulating gastric motility remain a major point of conjecture. Using a novel transgenic mouse line, we investigated the distribution of EC cells and the pathophysiological roles of 5-HT deficiency in gastric motility in mice and humans.
Lai Wei, Rajan Singh, Se Eun Ha, Alyce M Martin, Lauren Jones, Byungchang Jin, Brian G Jorgenson, Hannah Zogg, Tyler Chervo, Andres Gottfried-Blackmore, Linda Nguyen, Aida Habtezion, Nick J Spencer, Damien J Keating, Kenton M Sanders, Seungil Ro

1402 related Products with: Serotonin Deficiency is Associated with Delayed Gastric Emptying.

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#33662117   // To Up

Description and Molecular Differentiation of a New Skrjabinoptera (Nematode: Physalopteridae) from Eutropis macularia (Sauria: Scincidae) in North-Central Vietnam.

Skrjabinoptera vietnamensis n. sp. is described from specimens recovered from the stomach of Eutropis macularia in north-central Vietnam. The new species is characterized by the medium-sized male worms (6.7-8.7 mm in length and 154-182 μm in width) relative to known members of the genus, 2 pointed spicules of unequal length (87-112 μm and 56-72 μm in length), and 10 pairs of caudal papillae. Female worms are larger than male worms (10.7-18.4 mm in length and 264-411 μm in width), with the vulva situated in the anterior part, and embryonated, elliptical eggs, 35-46 μm long by 20-24 μm wide. Skrjabinoptera vietnamensis n. sp. represents the ninth species assigned to the genus and the first species recorded from the Oriental region. Partial sequences of the 18S ribosomal RNA gene (rDNA), and cytochrome c oxidase subunit 1 (COI) are provided for the new species. The molecular phylogenetic position of the genus Skrjabinoptera is briefly discussed.
Ong Vinh An, Nguyen Van Ha, Stephen E Greiman, Que Anh Tram, Pham Anh Tuan, Tran Thi Binh

2185 related Products with: Description and Molecular Differentiation of a New Skrjabinoptera (Nematode: Physalopteridae) from Eutropis macularia (Sauria: Scincidae) in North-Central Vietnam.

100 μg20 ug 100 UG1 Set100 μg25 mg16-22 Sample Kit100ug Lyophilized100 μg100ug100 μg100ug Lyophilized

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#33662023   2021/03/04 To Up

Protective porcine influenza virus-specific monoclonal antibodies recognize similar haemagglutinin epitopes as humans.

Pigs are natural hosts for the same subtypes of influenza A viruses as humans and integrally involved in virus evolution with frequent interspecies transmissions in both directions. The emergence of the 2009 pandemic H1N1 virus illustrates the importance of pigs in evolution of zoonotic strains. Here we generated pig influenza-specific monoclonal antibodies (mAbs) from H1N1pdm09 infected pigs. The mAbs recognized the same two major immunodominant haemagglutinin (HA) epitopes targeted by humans, one of which is not recognized by post-infection ferret antisera that are commonly used to monitor virus evolution. Neutralizing activity of the pig mAbs was comparable to that of potent human anti-HA mAbs. Further, prophylactic administration of a selected porcine mAb to pigs abolished lung viral load and greatly reduced lung pathology but did not eliminate nasal shedding of virus after H1N1pdm09 challenge. Hence mAbs from pigs, which target HA can significantly reduce disease severity. These results, together with the comparable sizes of pigs and humans, indicate that the pig is a valuable model for understanding how best to apply mAbs as therapy in humans and for monitoring antigenic drift of influenza viruses in humans, thereby providing information highly relevant to making influenza vaccine recommendations.
Barbara Holzer, Pramila Rijal, Adam McNee, Basudev Paudyal, Veronica Martini, Becky Clark, Tanuja Manjegowda, Francisco J Salguero, Emily Bessell, John C Schwartz, Katy Moffat, Miriam Pedrera, Simon P Graham, Alistair Noble, Marie Bonnet-Di Placido, Roberto M La Ragione, William Mwangi, Peter Beverley, John W McCauley, Rodney S Daniels, John A Hammond, Alain R Townsend, Elma Tchilian

2952 related Products with: Protective porcine influenza virus-specific monoclonal antibodies recognize similar haemagglutinin epitopes as humans.

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#33662021   2021/03/04 To Up

Effects of foliar fungicide on yield, micronutrients, and cadmium in grains from historical and modern hard winter wheat genotypes.

Plant breeding and disease management practices have increased the grain yield of hard winter wheat (Triticum aestivum L.) adapted to the Great Plains of the United States during the last century. However, the effect of genetic gains for seed yield and the application of fungicide on the micronutrient and cadmium (Cd) concentration in wheat grains is still unclear. The objectives of this study were to evaluate the effects of fungicide application on the productivity and nutritional quality of wheat cultivars representing 80 years of plant breeding efforts. Field experiments were conducted over two crop years (2017 and 2018) with eighteen hard winter wheat genotypes released between 1933 and 2013 in the presence or absence of fungicide application. For each growing season, the treatments were arranged in a split-plot design with the fungicide levels (treated and untreated) as the whole plot treatments and the genotypes as split-plot treatments in triplicate. The effects on seed yield, grain protein concentration (GPC), micronutrients, phytic acid, and Cd in grains were measured. While the yield of wheat was found to increase at annualized rates of 26.5 and 13.0 kg ha-1 yr-1 in the presence and absence of fungicide (P < 0.001), respectively, GPC (-190 and -180 mg kg-1 yr-1, P < 0.001), Fe (-35.0 and -44.0 μg kg-1 yr-1, P < 0.05), and Zn (-68.0 and -57.0 μg kg-1 yr-1, P < 0.01) significantly decreased during the period studied. In contrast to the other mineral elements, grain Cd significantly increased over time (0.4 μg kg-1 yr-1, P < 0.01) in the absence of fungicide. The results from this study are of great concern, as many mineral elements essential for human nutrition have decreased over time while the toxic heavy metal, Cd, has increased, indicating modern wheats are becoming a better vector of dietary Cd.
Hollman Motta-Romero, Ferdinand Niyongira, Jeffrey D Boehm, Devin J Rose

2486 related Products with: Effects of foliar fungicide on yield, micronutrients, and cadmium in grains from historical and modern hard winter wheat genotypes.

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#33661993   2021/03/04 To Up

Construction, characterization, and immunization of nanoparticles that display a diverse array of influenza HA trimers.

Current influenza vaccines do not elicit broadly protective immune responses against multiple strains. New strategies to focus the humoral immune response to conserved regions on influenza antigens are therefore required for recognition by broadly neutralizing antibodies. It has been suggested that B-cells with receptors that recognize conserved epitopes would be preferentially stimulated through avidity effects by mosaic particles presenting multiple forms of a variable antigen. We adapted SpyCatcher-based platforms, AP205 virus-like particles (VLPs) and mi3 nanoparticles (NPs), to covalently co-display SpyTagged hemagglutinin (HA) trimers from group 1 and group 2 influenza A strains. Here we show successful homotypic and heterotypic conjugation of up to 8 different HA trimers to both VLPs and NPs. We characterized the HA-VLPs and HA-NPs by cryo-electron tomography to derive the average number of conjugated HAs and their separation distances on particles, and compared immunizations of mosaic and homotypic particles in wild-type mice. Both types of HA particles elicited strong antibody responses, but the mosaic particles did not consistently elicit broader immune responses than mixtures of homotypic particles. We conclude that covalent attachment of HAs from currently-circulating influenza strains represents a viable alternative to current annual influenza vaccine strategies, but in the absence of further modifications, is unlikely to represent a method for making a universal influenza vaccine.
Alexander A Cohen, Zhi Yang, Priyanthi N P Gnanapragasam, Susan Ou, Kim-Marie A Dam, Haoqing Wang, Pamela J Bjorkman

1804 related Products with: Construction, characterization, and immunization of nanoparticles that display a diverse array of influenza HA trimers.

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#33661911   2021/03/04 To Up

Prediction of femoral osteoporosis using machine-learning analysis with radiomics features and abdomen-pelvic CT: A retrospective single center preliminary study.

Osteoporosis has increased and developed into a serious public health concern worldwide. Despite the high prevalence, osteoporosis is silent before major fragility fracture and the osteoporosis screening rate is low. Abdomen-pelvic CT (APCT) is one of the most widely conducted medical tests. Artificial intelligence and radiomics analysis have recently been spotlighted. This is the first study to evaluate the prediction performance of femoral osteoporosis using machine-learning analysis with radiomics features and APCT.
Hyun Kyung Lim, Hong Il Ha, Sun-Young Park, Junhee Han

1150 related Products with: Prediction of femoral osteoporosis using machine-learning analysis with radiomics features and abdomen-pelvic CT: A retrospective single center preliminary study.

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#33661880   // To Up

Eficacia y seguridad del cierre quirúrgico del conducto arterioso permeable por el cirujano pediatra general: ensayo clínico.

El conducto arterioso permeable (CAP) es un defecto cardiaco congénito y se considera un problema de salud pública. Se presenta en un alto porcentaje de recién nacidos y en algunos mayores de 1 mes. El cierre farmacológico es el tratamiento inicial preferido, ya que ha tenido excelentes resultados; sin embargo, en aquellos casos en los que no es posible, está indicado el cierre quirúrgico.
Antonio F Gallardo-Meza, José M González-Sánchez, Francisco Vidrio-Patrón, Irene L Velarde-Briceño, Alejandra Peña-Juárez, Humberto Murguía-Guerrero, María Teresa Martínez-González, Oscar E Ceja-Mejía, Miguel A Medina-Andrade, Paulina Armas-Quiroz, Brenda N Arias-Uribe, Elizabeth López-Villalobos, Humberto Vázquez-Jackson

1262 related Products with: Eficacia y seguridad del cierre quirúrgico del conducto arterioso permeable por el cirujano pediatra general: ensayo clínico.

96TOne 96-Well Strip Micropl96T100ugOne 96-Well Microplate Ki1 kit(96 Wells) 25 G100ug Lyophilized250ul100ug Lyophilized101 kit(96 Wells)

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#33661876   // To Up

Manejo de la insuficiencia cardiaca con estimulación hisiana en bloqueo de rama derecha: reporte de caso.

La terapia de resincronización cardiaca mediante estimulación hisiana ha demostrado ser efectiva en pacientes con bloqueo de rama izquierda del haz de His e insuficiencia cardiaca. Paciente masculino, con 47 años de edad, con insuficiencia cardiaca, fracción de expulsión del 17% y miocardio dilatada idiopática, electrocardiograma en ritmo sinusal, bloqueo auriculoventricular de 1. grado, intervalo PR 400 ms, bloqueo completo de rama derecha del haz de His, bloqueo del fascículo anterior de la rama izquierda del haz de His, duración del QRS 200 ms. Se decidió realizar estimulación selectiva del haz de His. La resincronización cardiaca biventricular convencional en pacientes con presencia de bloqueo completo de la rama derecha del haz de His no está indicada debido a la pobre respuesta al tratamiento. La estimulación hisiana permite reclutar la rama bloqueada y reestablecer la conducción a través de ella, de tal forma que, en ausencia de necrosis, se logre sincronía biventricular. En el caso presentado el reclutamiento de la rama derecha mediante estimulación hisiana se reflejó en el restablecimiento de la sincronía biventricular, medida por rastreo de marcas (speckle tracking) e incremento significativo de la fracción de expulsión del ventrículo izquierdo del 17 al 36.6%, con un incremento absoluto del 19.6%.
Jorge Gómez-Flores, Jovana Pérez-Báez, Guillermo Muñoz, Gabriela Bustillos-García, Alan García, Álvaro E Reyes-Quintero, Rosa M Ávila-Ocampo, Antonio Arias-Godínez, Manlio Márquez, Luis Colin-Lizalde, Moisés Levinstein-Jacinto, José L Morales-Velázquez, Santiago Nava

2409 related Products with: Manejo de la insuficiencia cardiaca con estimulación hisiana en bloqueo de rama derecha: reporte de caso.

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