Only in Titles

Search results for: ADAMTS7

paperclip

#33237970   2020/11/25 To Up

Age-associated changes in the transcriptomes of non-cultured adipose-derived stem cells from young and old mice assessed via single-cell transcriptome analysis.

Adipose-derived stem cells (ASCs) exhibit self-renewal and pluripotency. The differentiation potency of ASCs has been reported to deteriorate with aging; however, relevant studies used ASCs that were isolated and subcultured several times. It is still unclear whether subcultured ASCs accurately reflect the in vivo state. To address this question, we used freshly isolated stromal vascular fractions (SVFs) and performed comprehensive single-cell transcriptome analysis. In this study, we identified three cell populations as putative ASC candidates in SVFs and three novel ASC-related genes: Adamts7, Snai2, and Tgfbr1, that are reported to be negative regulators of cell differentiation. Moreover, we identified age-associated high gene expression levels of Adamts7, Egfr, and Igfbp4 in the earliest differentiation stage of ASCs. These results suggest that aging may make it impossible to maintain the stringency of the regulation of the expression of some genes related to ASC differentiation.
Yuta Doshida, Haruka Sano, Sadahiro Iwabuchi, Toshiro Aigaki, Masayuki Yoshida, Shinichi Hashimoto, Akihito Ishigami

2332 related Products with: Age-associated changes in the transcriptomes of non-cultured adipose-derived stem cells from young and old mice assessed via single-cell transcriptome analysis.

1 x 10^6 cells/vial5 x 10A5 cells/vial1 mg10 ug1 mg4 x 96-well plate1x10e7 cells1.00 flaskOne Vial: 5 X 10^6 Cells96 tests3 inhibitors

Related Pathways

paperclip

#33122452   2020/10/29 To Up

Association of polymorphisms in ADAMTS-7 gene with the susceptibility to coronary artery disease - a systematic review and meta-analysis.

To systematically review literature evidence to discover the association of ADAMTS7 (A Disintegrin And Metalloproteinase with Thrombospondin-like motifs 7) polymorphisms and the risk of developing CAD (coronary artery disease).
Davood K Hosseini, Sharareh Ataikia, Hanieh K Hosseini, Baoai Han, Haiying Sun

1353 related Products with: Association of polymorphisms in ADAMTS-7 gene with the susceptibility to coronary artery disease - a systematic review and meta-analysis.

100 1 mg1 module1 module1 module

Related Pathways

paperclip

#32897244   2020/09/07 To Up

Identification of cardiovascular health gene variants related to longevity in a Chinese population.

Cardiovascular disease (CVD) is one of the most important causes of human death, but no attention has been paid to cardiovascular health genes related to healthy longevity. Therefore, we developed a cohort study to explore such genes in healthy, long-lived Chinese subjects. A total of 13275 healthy elderly people were enrolled, including 5107 healthy long-lived individuals and 8168 age-matched control individuals with low CVD risk. Using a combination of whole-exome sequencing (WES) and genome-wide association studies (GWAS), we identified 2 genetic variants (TFPI rs7586970 T, p=0.013, OR=1.100. ADAMTS7 rs3825807 A, p=0.017, OR=1.198) associated with healthy lipid metabolism and longevity. Furthermore, we showed that an interaction among TFPI rs7586970, ADAMTS7 rs3825807 and APOE ɛ3 maintained normal blood lipid levels in centenarians by stratified analysis of CVD risk factors. Finally, through biological function analysis, we revealed clues regarding the mechanism of factor related to cardiovascular health (FCH) such as lipids and longevity. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis indicated that the two variants above may be associated with longevity via FCH lipid metabolism pathways. From a meta-analysis of venous thrombosis patients, we unexpectedly found that rs7586970 T is associated with both longevity and protection against vascular disease.
Li Zhang, Chen Bai, Chao Nie, Xiaoquan Zhu, Huiping Yuan, Liang Sun, Qi Zhou, Xiaoling Li, Xuan Xian, Fan Yang, Guofang Pang, Yuan Lv, Xiaolin Ni, Caiyou Hu, Ze Yang

1224 related Products with: Identification of cardiovascular health gene variants related to longevity in a Chinese population.

2 Pieces/Box25 1 kit300 units2 Pieces/Box100 1 kit1 mg100 μg

Related Pathways

paperclip

#32692461   2020/08/10 To Up

ADAMTS7 degrades Comp to fuel BMP2-dependent osteogenic differentiation and ameliorate oncogenic potential in osteosarcomas.

Osteosarcoma (OS) is the most common primary malignant bone tumor in children and adolescents, with a high metastatic potential. Despite dramatic changes in OS treatments over the past decades, their efficiency still remains limited, with severe complications and adverse side effects. Key mechanisms underlining tumorigenesis, metastasis and chemotherapy resistance are currently lacking, in turn hindering any progress with respect to developing effective and safe therapeutic strategies against OS. Recently, ADAMTS7, a member of the disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) family, was shown to be involved in osteogenic differentiation-related pathological processes. ADAMTS7 promotes vascular calcification via disturbing the balance between osteogenic bone morphogenetic protein (BMP)2 (regulating osteogenic differentiation and bone formation during development) and its natural inhibitor cartilage oligomeric matrix protein (Comp). Hence, in the present study, we aimed to investigate the role of ADAMTS7 in the pathological process of OS. We first revealed that ADAMTS7 was decreased in OS tissues. Lower expression of ADAMTS7 was correlated with poor histological differentiation and an advanced clinical stage of OS. Through loss- and gain-function analysis, we further revealed that ADAMTS7 attenuated cell proliferation, migration and invasion, at the same time as promoting the expression of osteogenic differentiation markers in two OS cell lines: MG63 and SAOS2. Moreover, Comp was responsible for the effects of ADAMTS7 on OS pathogenesis by reinforcing cell osteogenic differentiation mediated by BMP2 in vitro. In conclusion, ADAMTS7-mediated degradation of Comp may provide a potential therapeutic target for the treatment of OS.
Chao Wang, Yunqing Chen, Hongfei Xiang, Xiaolin Wu, Qian Tang, Xuexiao Ma, Lu Zhang

1938 related Products with: ADAMTS7 degrades Comp to fuel BMP2-dependent osteogenic differentiation and ameliorate oncogenic potential in osteosarcomas.

100 μg50 ul24 wells100ug Lyophilized500 gm.100ug Lyophilized100ug Lyophilized10100 μg100ug Lyophilized1600

Related Pathways

paperclip

#32636717   2020/07/02 To Up

The plasma peptides of sepsis.

A practical strategy to discover sepsis specific proteins may be to compare the plasma peptides and proteins from patients in the intensive care unit with and without sepsis. The aim was to discover proteins and/or peptides that show greater observation frequency and/or precursor intensity in sepsis. The endogenous tryptic peptides of ICU-Sepsis were compared to ICU Control, ovarian cancer, breast cancer, female normal, sepsis, heart attack, Alzheimer's and multiple sclerosis along with their institution-matched controls, female normals and normal samples collected directly onto ice.
Thanusi Thavarajah, Claudia C Dos Santos, Arthur S Slutsky, John C Marshall, Pete Bowden, Alexander Romaschin, John G Marshall

2170 related Products with: The plasma peptides of sepsis.

96T100 IU500 μg

Related Pathways

paperclip

#32441044   2020/05/22 To Up

Elevated serum cartilage oligomeric matrix protein and the metalloproteinase-ADAMTS7 levels are associated with vascular calcification in maintenance hemodialysis patients.

Vascular calcification is common in maintenance hemodialysis (HD) patients. Recent studies showed that cartilage oligomeric matrix protein (COMP) could protect blood vessels from calcification, but the role of ADAMTS7 was opposite. We aimed to investigate the relationship between serum COMP, ADAMTS7 levels and vascular calcification scores in HD patients.
Wei Zhao, Yue Wang, Wei Kong, Hai-Dan Zhao

1932 related Products with: Elevated serum cartilage oligomeric matrix protein and the metalloproteinase-ADAMTS7 levels are associated with vascular calcification in maintenance hemodialysis patients.

0.1 mg2 ml96 wells (1 kit)0.1 mg200 1 mL96T1 ml1 Set0.2 mg1 Set100

Related Pathways

paperclip

#32311840   2020/04/20 To Up

Identification of cancer stem cell characteristics in liver hepatocellular carcinoma by WGCNA analysis of transcriptome stemness index.

Cancer stem cells (CSCs) are characterized by self-renewal and -differential potential as compared to common cancer cells and play an important role in the development and therapeutic resistance of liver hepatocellular carcinoma (LIHC). However, the specific pathogenesis of LIHC stem cells is still unclear, and the genes involved in the stemness of LIHC stem cells are currently unknown. In this study, we investigated novel biomarkers associated with LIHC and explored the expression characteristics of stem cell-related genes in LIHC. We found that mRNA expression-based stemness index (mRNAsi) was significantly overexpressed in liver cancer tissues. Further, mRNAsi expression in LIHC increased with the tumor pathological grade, with grade 4 tumors harboring the greatest stem cell features. Upon establishing mRNAsi scores based on mRNA expression of every gene, we found an association with poor overall survival in LIHC. Moreover, modules of interest were determined based on weighted gene co-expression network analysis (WGCNA) inclusion criteria, and three significant modules (red, green, and brown) and 21 key genes (DCN, ECM1, HAND2, PTGIS, SFRP1, SRPX, COLEC10, GRP182, ADAMTS7, CD200, CDH11, COL8A1, FAP, LZTS1, MAP1B, NAV1, NOTCH3, OLFML2A, PRR16, TMEM119, and VCAN) were identified. Functional analysis of these 21 genes demonstrated their enrichment in pathways involved in angiogenesis, negative regulation of DNA-binding transcription factor activity, apoptosis, and autophagy. Causal relationship with proteins indicated that the Wnt, Notch, and Hypoxia pathways are closely related to LIHC tumorigenesis. To our knowledge, this is the first report of a novel CSC biomarker, mRNAsi, to predict the prognosis of LIHC. Further, we identified 21 key genes through mRNA expression network analysis, which could be potential therapeutic targets to inhibit the stemness of cancer cells in LIHC.
Kun-Hao Bai, Si-Yuan He, Ling-Ling Shu, Wei-Da Wang, Shi-Yong Lin, Qian-Yi Zhang, Liang Li, Lei Cheng, Yu-Jun Dai

2158 related Products with: Identification of cancer stem cell characteristics in liver hepatocellular carcinoma by WGCNA analysis of transcriptome stemness index.



Related Pathways

paperclip

#32293292   2020/04/15 To Up

Susceptible gene polymorphism in patients with three-vessel coronary artery disease.

Data of susceptible gene polymorphisms related to progression of coronary atherosclerosis in patients with three-vessel disease (TVD) is limited in China. This case-control study aimed to analyze the differences of variant carrier frequencies between cases and controls, and to explain the possible genetic effects on the progression of TVD.
Ru Liu, Lei Song, Lin Jiang, Xiaofang Tang, Lianjun Xu, Zhan Gao, Xueyan Zhao, Jingjing Xu, Runlin Gao, Jinqing Yuan

2568 related Products with: Susceptible gene polymorphism in patients with three-vessel coronary artery disease.

4/120 Packing /sleeve/bo1-99 mg/ml/ea price x 296 tests1 mg1.00 flask4/120 Packing /sleeve/bo

Related Pathways

paperclip

Error loading info... Pleas try again later.
paperclip

#32148246   2020/02/11 To Up

ADATMS-7 regulates the focal adhesion kinase signaling and promotes invasiveness of trophoblasts in early pregnancy.

ADAMTS-7, a member of the disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) family, was recently identified to be associated with cell migration and invasion. However, its function on trophoblasts remains unknown. In this study, we are aimed to investigate the role of ADAMTS-7 on trophoblasts in human first trimester gestation.
Yu-Han Meng, Jin-Bao Zhang, Ye-Ling Sun, Xing-Long Liu

2907 related Products with: ADATMS-7 regulates the focal adhesion kinase signaling and promotes invasiveness of trophoblasts in early pregnancy.

7 inhibitors2 Pieces/Box14 inhibitors20 ul1 mg20 ul2 Pieces/Box100 μg10mg

Related Pathways