Search results for: 2-Acetamido-3-O-acetyl-2-deoxy-D-glucopyranose C10H17NO7 CAS: 51449-93-5
#38648296 
2024/04/22
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Polyphenol-Assisted Biomineralization of Metal-Organic Framework Nanoparticles for Precision Delivery of Therapeutic Proteins to Cancer Cells.
The delivery of proteins into the cytosol holds great promise for cell signaling manipulation and the development of precision medicine. However, this potency is challenged by achieving targeted and controlled delivery, specifically within diseased cells. In this study, we introduce a versatile and effective method for the precision delivery of therapeutic proteins to cancer cells by designing polyphenol-assisted biomineralization of zeolite imidazole framework-8 (ZIF-8). We demonstrate that by leveraging the strong noncovalent binding affinity of epigallocatechin gallate (EGCG) with both proteins and ZIF-8, our approach significantly enhances the biomineralization of ZIF-8, which in turn improves the efficiency of protein encapsulation and intracellular delivery. Moreover, the incorporation of EGCG within ZIF-8 enables controlled degradation of the nanoparticles and the selective release of the encapsulated proteins in cancer cells. This selective release is triggered by the oxidation of EGCG in response to the high levels of reactive oxygen species (ROS) found within cancer cells that destabilize the EGCG/ZIF-8 nanoparticles. We have further demonstrated the ability of EGCG/ZIF-8 to deliver a wide range of proteins into cancer cells, including bacterial virulence protein, to rewire cell signaling and prohibit tumor cell growth in a mouse xenograft model. Our strategy and findings underscore the potential of designing the EGCG/ZIF-8 interface for specific and controlled protein delivery for targeted cancer therapy.Tianli Luo, Qizhen Zheng, Ji Liu, Rui Yao, Ming Wang
1398 related Products with: Polyphenol-Assisted Biomineralization of Metal-Organic Framework Nanoparticles for Precision Delivery of Therapeutic Proteins to Cancer Cells.
10501mg1mg1 mg1002101.00 flask100
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#38648198 2024/04/22
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The impact of phage and phage resistance on microbial community dynamics.
WEllinor O Alseth, Rafael Custodio, Sarah A Sundius, Rachel A Kuske, Sam P Brown, Edze R Westra
1614 related Products with: The impact of phage and phage resistance on microbial community dynamics.
0.25 mL 25 MG1000 tests100ug100ug 6 ml 100 mg25 mg
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#38648173 2024/04/22
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How to use CRISPR/Cas9 in plants - from target site selection to DNA repair.
AAdéla Přibylová, Lukáš Fischer
1695 related Products with: How to use CRISPR/Cas9 in plants - from target site selection to DNA repair.
0.1ml (1.3mg/ml)100 100 1 mg500 gm.10 1 mg
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#38647965 2023/09/15
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Thermophilic Moorella thermoacetica as a platform microorganism for C1 gas utilization: physiology, engineering, and applications.
IDechen Jia, Wangshuying Deng, Peng Hu, Weihong Jiang, Yang Gu
1212 related Products with: Thermophilic Moorella thermoacetica as a platform microorganism for C1 gas utilization: physiology, engineering, and applications.
250 ml5 g0.2 mg10 mg25 mg10 mg0.1 mg10 mg1 mg1 LITRE96 Tests1 ml
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#38647893 2022/07/30
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Production of free fatty acids from various carbon sources by Ogataea polymorpha.
EYunxia Li, XiaoXin Zhai, Wei Yu, Dao Feng, Aamer Ali Shah, Jiaoqi Gao, Yongjin J Zhou
1665 related Products with: Production of free fatty acids from various carbon sources by Ogataea polymorpha.
1,000 tests100tests1001KG500gm1kg100gm500g50gm
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#38647886 2023/06/28
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Construction of Cupriavidus necator displayed with superoxide dismutases for enhanced growth in bioelectrochemical systems.
IKe Chen, Chunling Ma, Xiaolei Cheng, Yuhua Wang, Kun Guo, Ranran Wu, Zhiguang Zhu
1975 related Products with: Construction of Cupriavidus necator displayed with superoxide dismutases for enhanced growth in bioelectrochemical systems.
20ug500 MG2 Pieces/Box100.00 ug10ug100.00 ug0.1ml (1mg/ml)10ug 100 G100.00 ug
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#38647878 2023/03/02
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Secretory expression of β-1,3-glucomannanase in the oleaginous yeast Rhodosporidium toruloides for improved lipid extraction.
LShiyu Liang, Yue Zhang, Liting Lyu, Shuang Wang, Zongbao K Zhao
2736 related Products with: Secretory expression of β-1,3-glucomannanase in the oleaginous yeast Rhodosporidium toruloides for improved lipid extraction.
1 G 1 G100 mg300 units 5 G10 mg
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#38647822 2022/05/26
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Microbial synthesis of long-chain α-alkenes from methanol by engineering Pichia pastoris.
�Peng Cai, Yunxia Li, Xiaoxin Zhai, Lun Yao, Xiaojun Ma, Lingyun Jia, Yongjin J Zhou
2639 related Products with: Microbial synthesis of long-chain α-alkenes from methanol by engineering Pichia pastoris.
1 mg100 µg1 mL100ug100ug100ug Lyophilized500 1mg2 mg100.00 ug0.5 mg200
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#38647771 2022/10/22
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Combinatorial strategies for production improvement of anti-tuberculosis antibiotics ilamycins E/E from deep sea-derived Streptomyces atratus SCSIO ZH16 ΔilaR.
IYunfei Zhu, Gaofan Zheng, Xiujuan Xin, Junying Ma, Jianhua Ju, Faliang An
1910 related Products with: Combinatorial strategies for production improvement of anti-tuberculosis antibiotics ilamycins E/E from deep sea-derived Streptomyces atratus SCSIO ZH16 ΔilaR.
1 mg100μg0.1ml (1mg/ml)500 500 μg500 100ug100ug Lyophilized100ug100ug Lyophilized1 mL100μg
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#38647747 2022/05/18
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A facile and robust T7-promoter-based high-expression of heterologous proteins in Bacillus subtilis.
TJing Ye, Yunjie Li, Yuqing Bai, Ting Zhang, Wei Jiang, Ting Shi, Zijian Wu, Yi-Heng P Job Zhang
2556 related Products with: A facile and robust T7-promoter-based high-expression of heterologous proteins in Bacillus subtilis.
50 25mg400Tests
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