Search results for: Native Human SERPINA3 Proteins
#34449972 
2021/08/27
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Highly expressed of SERPINA3 indicated poor prognosis and involved in immune suppression in glioma.
The prognosis of patients with glioma is dismal. It has been reported that Serpin peptidase inhibitor clade A member 3 (SERPINA3) is associated with the mobility and invasion of tumor cells. Our study was designed to explore the value of SERPINA3 messenger RNA (mRNA) expression in the biological process, prognosis, and immune significance in glioma.Qing Yuan, Song-Quan Wang, Guang-Tao Zhang, Jie He, Zhi-Dan Liu, Ming-Rong Wang, Hong-Qing Cai, Jing-Hai Wan
1843 related Products with: Highly expressed of SERPINA3 indicated poor prognosis and involved in immune suppression in glioma.
4 Arrays/Slide 50 UG4 Arrays/Slide2 Pieces/Box4 Membranes/Box2 Pieces/Box4 Membranes/Box4 Arrays/Slide4 Membranes/Box2 Pieces/Box4 Membranes/Box
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#33519818 2021/01/14
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Glycoproteoform Profiles of Individual Patients' Plasma Alpha-1-Antichymotrypsin are Unique and Extensively Remodeled Following a Septic Episode.
Sepsis and septic shock remain the leading causes of death in intensive care units (ICUs), yet the pathogenesis originating from the inflammatory response during sepsis remains ambiguous. Acute-phase proteins are typically highly glycosylated, and the nature of the glycans have been linked to the incidence and severity of such inflammatory responses. To further build upon these findings we here monitored, the longitudinal changes in the plasma proteome and, in molecular detail, glycoproteoform profiles of alpha-1-antichymotrypsin (AACT) extracted from plasma of ten individual septic patients. For each patient we included four different time-points, including post-operative (before sepsis) and following discharge from the ICU. We isolated AACT from plasma depleted for albumin, IgG and serotransferrin and used high-resolution native mass spectrometry to qualitatively and quantitatively monitor the multifaceted glycan microheterogeneity of desialylated AACT, which allowed us to monitor how changes in the glycoproteoform profiles reflected the patient's physiological state. Although we observed a general trend in the remodeling of the AACT glycoproteoform profiles, e.g. increased fucosylation and branching/LacNAc elongation, each patient exhibited unique features and responses, providing a resilient proof-of-concept for the importance of personalized longitudinal glycoproteoform profiling. Importantly, we observed that the AACT glycoproteoform changes induced by sepsis did not readily subside after discharge from ICU.Tomislav Čaval, Yu-Hsien Lin, Meri Varkila, Karli R Reiding, Marc J M Bonten, Olaf L Cremer, Vojtech Franc, Albert J R Heck
2267 related Products with: Glycoproteoform Profiles of Individual Patients' Plasma Alpha-1-Antichymotrypsin are Unique and Extensively Remodeled Following a Septic Episode.
96T96T1 kit(96 Wells)500 ug0.1 ml500 ug 5 G96T100ul0.1 mg550 ug
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#29459363 //
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Heart Failure Stimulates Tumor Growth by Circulating Factors.
Heart failure (HF) survival has improved, and nowadays, many patients with HF die of noncardiac causes, including cancer. Our aim was to investigate whether a causal relationship exists between HF and the development of cancer.Wouter C Meijers, Manuel Maglione, Stephan J L Bakker, Rupert Oberhuber, Lyanne M Kieneker, Steven de Jong, Bernhard J Haubner, Wouter B Nagengast, Alexander R Lyon, Bert van der Vegt, Dirk J van Veldhuisen, B Daan Westenbrink, Peter van der Meer, Herman H W Silljé, Rudolf A de Boer
1295 related Products with: Heart Failure Stimulates Tumor Growth by Circulating Factors.
96 Tests/kit16 Arrays/Slide5 ml1 mL10ug100.1 mg
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