Search results for: 3-Amino-6-bromo-4-(2-chlorophenyl)-2(1H)-quinolinone-d5 C15H5D5BrClN2O CAS:
#38635971 
2024/04/18
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RNA splicing modulates the postharvest physiological deterioration of cassava storage root.
Rapid postharvest physiological deterioration (PPD) of cassava (Manihot esculenta Crantz) storage roots is a major constraint that limits the potential of this plant as a food and industrial crop. Extensive studies have been performed to explore the regulatory mechanisms underlying the PPD processes in cassava to understand their molecular and physiological responses. However, the exceptional functional versatility of alternative splicing (AS) remains to be explored during the PPD process in cassava. Here, we identified several aberrantly spliced genes during the early PPD stage. An in-depth analysis of AS revealed that the abscisic acid (ABA) biosynthesis pathway might serve as an additional molecular layer in attenuating the onset of PPD. Exogenous ABA application alleviated PPD symptoms through maintaining ROS generation and scavenging. Interestingly, the intron retention transcript of MeABA1 (ABA DEFICIENT 1) was highly correlated with PPD symptoms in cassava storage roots. RNA yeast three-hybrid and RNA immunoprecipitation assays showed that the serine/arginine-rich protein MeSCL33 (SC35-like splicing factor 33) binds to the precursor mRNA of MeABA1. Importantly, overexpressing MeSCL33 in cassava conferred improved PPD resistance by manipulating the AS and expression levels of MeABA1 and then modulating the endogenous ABA levels in cassava storage roots. Our results uncovered the pivotal role of the ABA biosynthesis pathway and RNA splicing in regulating cassava PPD resistance and proposed the essential roles of MeSCL33 for conferring PPD resistance, broadening our understanding of SR proteins in cassava development and stress responses.Jinbao Gu, Xiaowen Ma, Qiuxiang Ma, Zhiqiang Xia, Yan Lin, Jianbo Yuan, Yang Li, Cong Li, Yanhang Chen, Wenquan Wang, Peng Zhang, Zhen-Yu Wang
1689 related Products with: RNA splicing modulates the postharvest physiological deterioration of cassava storage root.
200ul15 x 20 Boxes/case 500 Units1000 units10 nmol100.1 mg
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#38635336 2024/04/18
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Prevalence of celebrity worship: Development and application of the short version of the Celebrity Attitude Scale (CAS-7) on a large-scale representative sample.
Celebrity worship, defined as an excessive admiration towards celebrities, has generated considerable research and public interest. A widely used assessment instrument to measure celebrity worship is the 23-item Celebrity Attitude Scale. However, concerns have been raised regarding the measurement, including the inconsistent factor structure and lack of a cut-off point to identify "celebrity worshipers". The present study aims to address these concerns by testing the psychometric appropriateness of a short, 7-item version of the CAS (i.e., CAS-7) and estimating the prevalence of individuals with high-level celebrity admiration using a representative sample of Hungarian adults (between 18 and 64 years of age) according to gender, age, geographic location, and size of residence.Ágnes Zsila, Lynn E McCutcheon, Rita Horváth, Róbert Urbán, Borbála Paksi, Gergely Darnai, József Janszky, Zsolt Demetrovics
1548 related Products with: Prevalence of celebrity worship: Development and application of the short version of the Celebrity Attitude Scale (CAS-7) on a large-scale representative sample.
Labels 2 mg of Ab 100ul96T100.00 ul10.1ml (1mg/ml)1 kit1 kit
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#38635331 //
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Correction to: by Burger et al. 2023;7(1):12-28; DOI: 10.1089/crispr.2023.0061.
2120 related Products with: Correction to: by Burger et al. 2023;7(1):12-28; DOI: 10.1089/crispr.2023.0061.
2.5 mg10 mg 500 G100 G 25 G2 100 G1 g 5 G121 mg2.5 mg
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#38635330 //
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Correction to: by Chen et al. 2023;6(6):570-582; DOI: 10.1089/crispr.2023.0048.
1544 related Products with: Correction to: by Chen et al. 2023;6(6):570-582; DOI: 10.1089/crispr.2023.0048.
100 mg 1 G 100 G25 mg2.5 lt2 25 G5 mg 5 G1210 mg500 mg
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#38635326 //
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Diverse Class 2 CRISPR Effectors as Active Nucleases with Expanded Targeting Capabilities.
CRISPR-Cas systems have proven effective in a variety of applications due to their ease of use and relatively high editing efficiency. Yet, any individual CRISPR-Cas system has inherent limitations, necessitating a diversity of RNA-guided nucleases to suit applications with distinct needs. We searched through metagenomic sequences to identify RNA-guided nucleases and found enzymes from diverse CRISPR-Cas types and subtypes, the most promising of which we developed into gene-editing platforms. Based on prior annotations of the metagenomic sequences, we establish the likely taxa and sampling locations where Class 2 CRISPR-Cas systems active in eukaryotes may be found. The newly discovered systems show robust capabilities as gene editors and base editors.Meng Wang, Lila Rieber, Jessica van Baaren, Meaghan Morgan, Stephanie Merrett, Ian McDowell, Tyson Bowen
2644 related Products with: Diverse Class 2 CRISPR Effectors as Active Nucleases with Expanded Targeting Capabilities.
25 assays200ul25 g2500 Tests200ul100 assays200ul1 kit(96 Wells)250tests100 assays
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#38635033 2024/04/18
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Genetic associations of cardiovascular risk genes in European patients with coronary artery spasm.
Coronary artery spasm (CAS) is a frequent finding in patients presenting with angina pectoris. Although the pathogenesis of CAS is incompletely understood, previous studies suggested a genetic contribution. Our study aimed to elucidate genetic variants in a cohort of European patients with angina and unobstructed coronary arteries who underwent acetylcholine (ACh) provocation testing.Roman Tremmel, Valeria Martínez Pereyra, Incifer Broders, Elke Schaeffeler, Per Hoffmann, Markus M Nöthen, Raffi Bekeredjian, Udo Sechtem, Matthias Schwab, Peter Ong
2862 related Products with: Genetic associations of cardiovascular risk genes in European patients with coronary artery spasm.
1.00 flask1.00 flask1.00 flask1.00 flaskInhibitor100ug1roll (50 m)50ul50ul100 ug
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#38634879 2024/04/18
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Zn Single-Atom Catalysts Enable the Catalytic Transfer Hydrogenation of αβ-Unsaturated Aldehydes.
Highly active nonprecious-metal single-atom catalysts (SACs) toward catalytic transfer hydrogenation (CTH) of α,β-unsaturated aldehydes are of great significance but still are deficient. Herein, we report that Zn-N-C SACs containing Zn-N moieties can catalyze the conversion of cinnamaldehyde to cinnamyl alcohol with a conversion of 95.5% and selectivity of 95.4% under a mild temperature and atmospheric pressure, which is the first case of Zn-species-based heterogeneous catalysts for the CTH reaction. Isotopic labeling, FT-IR spectroscopy, and DFT calculations indicate that reactants, coabsorbed at the Zn sites, proceed CTH via a "Meerwein-Ponndorf-Verley" mechanism. DFT calculations also reveal that the high activity over Zn-N moieties stems from the suitable adsorption energy and favorable reaction energy of the rate-determining step at the Zn active sites. Our findings demonstrate that Zn-N-C SACs hold extraordinary activity toward CTH reactions and thus provide a promising approach to explore the advanced SACs for high-value-added chemicals.Jiawen Chen, Yongming Xia, Yuxuan Ling, Xuehui Liu, Shuyuan Li, Xiong Yin, Lipeng Zhang, Minghui Liang, Yi-Ming Yan, Qiang Zheng, Wenxing Chen, Yan-Jun Guo, En-Hui Yuan, Gaofei Hu, Xiaole Zhou, Leyu Wang
1734 related Products with: Zn Single-Atom Catalysts Enable the Catalytic Transfer Hydrogenation of αβ-Unsaturated Aldehydes.
200 units200 units100ug Lyophilized100ug Lyophilized10 ug100ug Lyophilized100ug Lyophilized100ug100ug Lyophilized1
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#38634860 2024/04/18
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Peniditerpenoids A and B: Oxidized Indole Diterpenoids with Osteoclast Differentiation Inhibitory Activity from a Mangrove-Sediment-Derived sp.
An unprecedented di--indole diterpenoid, peniditerpenoid A (), and a rare -oxide-containing indole diterpenoid derivative, peniditerpenoid B (), together with three known ones (-), were obtained from the mangrove-sediment-derived fungus sp. SCSIO 41411. Their structures were determined by the analysis of spectroscopic data, quantum chemical calculations, and X-ray diffraction analyses. Peniditerpenoid A () inhibited lipopolysaccharide-induced NF-κB with an IC value of 11 μM and further effectively prevented RANKL-induced osteoclast differentiation in bone marrow macrophages. studies demonstrated that exerted significant inhibition of NF-κB activation in the classical pathway by preventing TAK1 activation, IκBα phosphorylation, and p65 translocation. Furthermore, effectively reduced the level of NFATc1 activation, resulting in the attenuation of osteoclast differentiation. Our findings suggest that holds promise as an inhibitor with significant potential for the treatment of diseases related to osteoporosis.Jian Cai, Min Li, Chunmei Chen, Bin Yang, Chenghai Gao, Yonghong Liu, Xiaowei Luo, Yanhui Tan, Xuefeng Zhou
1105 related Products with: Peniditerpenoids A and B: Oxidized Indole Diterpenoids with Osteoclast Differentiation Inhibitory Activity from a Mangrove-Sediment-Derived sp.
100ug100 assays1mg100uL100ug Lyophilized 500 G200ul100 assays100ug Lyophilized 96 Tests 0.5 mg
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#38634757 2024/04/18
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Synthesis of Metal-Nitrogen-Carbon Electrocatalysts with Atomically Regulated Nitrogen-Doped Polycyclic Aromatic Hydrocarbons.
Tuning the active site structure of metal-nitrogen-carbon electrocatalysts has recently attracted increasing interest. Herein, we report a bottom-up synthesis strategy in which atomically regulated N-doped polycyclic aromatic hydrocarbons (N-PAHs) of NC ( = 1, 2, 3, 4) were used as ligands to allow tuning of the active site's structures of M-N and establish correlations between the structures and electrocatalytic properties. Based on the synthesis process, detailed characterization, and DFT calculation results, active structures of N-Fe-N in Fe-N/RGO catalysts were constructed. The results demonstrated that the extra uncoordinated N atoms around the Fe-N moieties disrupted the π-conjugated NC ligands, which led to more localized electronic state in the Fe-N moieties and superior catalytic performance. Especially, the Fe-N4/RGO exhibited optimized performance for ORR with increasing by 80 mV and at 0.85 V improved 18 times (compared with Fe-N1/RGO). This synthesis strategy utilizing N-PAHs holds significant promise for enhancing the controllability of metal-nitrogen-carbon electrocatalyst preparation.Shaoqing Chen, Hui-Min Yan, Jochi Tseng, Shijie Ge, Xia Li, Lin Xie, Zian Xu, Pengfei Liu, Chongxuan Liu, Jie Zeng, Yang-Gang Wang, Hsing-Lin Wang
2748 related Products with: Synthesis of Metal-Nitrogen-Carbon Electrocatalysts with Atomically Regulated Nitrogen-Doped Polycyclic Aromatic Hydrocarbons.
400/kit240/kit2 x 96 well plate132/kit66/kit150/kit25 mg 1KG4100 mg100ug10 mg
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#38634689 2024/04/18
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Efficient Homojunction Tin Perovskite Solar Cells Enabled by Gradient Germanium Doping.
P-type self-doping is known to hamper tin-based perovskites for developing high-performance solar cells by increasing the background current density and carrier recombination processes. In this work, we propose a gradient homojunction structure with germanium doping that generates an internal electric field across the perovskite film to deplete the charge carriers. This structure reduces the dark current density of perovskite by over 2 orders of magnitude and trap density by an order of magnitude. The resultant tin-based perovskite solar cells exhibit a higher power conversion efficiency of 13.3% and excellent stability, maintaining 95% and 85% of their initial efficiencies after 250 min of continuous illumination and 3800 h of storage, respectively. We reveal the homojunction formation mechanism using density functional theory calculations and molecular level characterizations. Our work provides a reliable strategy for controlling the spatial energy levels in tin perovskite films and offers insights into designing intriguing lead-free perovskite optoelectronics.Zhenzhu Zhao, Mulin Sun, Yuyang Ji, Kaitian Mao, Zongming Huang, Chengjian Yuan, Yuqian Yang, Honghe Ding, Yingguo Yang, Yu Li, Wenjing Chen, Junfa Zhu, Jing Wei, Jixian Xu, Watcharaphol Paritmongkol, Antonio Abate, Zhengguo Xiao, Lixin He, Qin Hu