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#34498777   2021/09/09 To Up

Can direct oral anticoagulants be used in kidney transplant recipients?

Kidney transplant recipients(KTRs) are at increased risk of venous thromboembolism (VTE) and atrial fibrillation(AF). Direct oral anticoagulants (DOACs) have shown important advantages over vitamin K antagonists; however, in KTRs concerns regarding interactions and use in severe kidney disease may limit their use. This evaluation describes a large UK kidney transplant center's experience of DOACs in KTRs with CrCl>15ml/min.
Kathrine Parker, Janette Chu, Muir Morton, Shiv Bhutani, Michael Picton, Sandip Mitra, Jecko Thachil

2405 related Products with: Can direct oral anticoagulants be used in kidney transplant recipients?



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#34310212   2021/07/26 To Up

A renal and hepatic toxicity analysis of remdesivir formulations: Does what is on the inside really count?

It has been postulated that the injectable solution formulation of remdesivir could be more nephrotoxic than the lyophilized powder since it contains twice as much sulfobutylether-β-cyclodextrin (SBECD). Therefore, we evaluated 1000 hospitalized patients with SARS-CoV-2 who received remdesivir lyophilized powder or solution. A logistic regression model accounting for baseline confounders identified that neither the use of the injectable solution (OR = 1.05; 95% CI = 0.49-2.29; P=0.901) nor a Creatinine Clearance < 30ml/min at the time of remdesivir initiation (OR = 1.39; 95% CI = 0.51-3.5; P=0.499) were significantly associated with acute kidney injury. Regarding hepatoxicity, there was no significant difference in early discontinuation of remdesivir due to abnormal Liver Function Tests between patients who received the lyophilized powder versus solution (0.9% vs 2.3%, P= 0.09).
Sunish Shah, Tyler W Ackley, Jeffrey E Topal

1331 related Products with: A renal and hepatic toxicity analysis of remdesivir formulations: Does what is on the inside really count?

100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized

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#34305226   2021/07/12 To Up

[Remdesivir in kidney transplant patients with SARS-CoV-2 pneumonia].

Remdesivir is the only antiviral treatment that has been shown to be useful against SARS-CoV-2 infection. It shorts hospitalization time compared to placebo. Its effects in Kidney transplant (KT) patients are limited to some published cases.
Judit Cacho, Elena Burgos, María Molina, Andrés Villegas, Mónica Pérez, Laura Cañas, Omar Taco, Javier Juega, Ricardo Lauzurica

2419 related Products with: [Remdesivir in kidney transplant patients with SARS-CoV-2 pneumonia].

20mg 500 G200ul20000 Units 5 G2000 Units

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#34293394   2021/07/19 To Up

Upper Reference Limits for High-Sensitivity Cardiac Troponin T and N-Terminal Fragment of the Prohormone Brain Natriuretic Peptide in Patients With CKD.

The utility of conventional upper reference limits (URL) for N-terminal pro-brain natriuretic peptide (NT-proBNP) and high-sensitivity cardiac troponin T (hsTnT) in chronic kidney disease (CKD) remains debated. We analyzed the distribution of hsTnT and NT-proBNP in people with CKD in ambulatory settings to examine the diagnostic value of conventional URL in this population.
Nisha Bansal, Leila R Zelnick, Christie M Ballantyne, Paulo H M Chaves, Robert H Christenson, Josef Coresh, Christopher R deFilippi, James A de Lemos, Lori B Daniels, Alan S Go, Jiang He, S Susan Hedayati, Kunihiro Matsushita, Vijay Nambi, Michael G Shlipak, Jonathan J Taliercio, Stephen L Seliger,

2326 related Products with: Upper Reference Limits for High-Sensitivity Cardiac Troponin T and N-Terminal Fragment of the Prohormone Brain Natriuretic Peptide in Patients With CKD.

96T96 tests0.02ml96 tests250 TESTS0.1 mg1 mg96T100ug Lyophilized

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#34246421   // To Up

Incidence of contrast-induced nephropathy after a computed tomography scan.

The term contrast-induced nephropathy is used to describe acute deterioration of renal function after the intravenous administration of iodinated contrast material. We aimed to estimate the incidence of contrast-induced nephropathy and to analyze the evolution of different biomarkers of renal function in patients who underwent computed tomography with intravenous contrast administration after premedication with oral hydration and N-acetylcysteine.
A Barrios López, F García Martínez, J I Rodríguez, B Montero-San-Martín, R Gómez Rioja, J Diez, C Martín-Hervás

1101 related Products with: Incidence of contrast-induced nephropathy after a computed tomography scan.

50 ul50 ul100ug 100ul100ug96 assays100 ul100 ul100ug Lyophilized100ug100ug Lyophilized100μl

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#34238459   // To Up

Neuroimaging of central diabetes insipidus.

Central diabetes insipidus (CDI) occurs secondary to deficient synthesis or secretion of arginine vasopressin peptide from the hypothalamo-neurohypophyseal system (HNS). It is characterized by polydipsia and polyuria (urine output >30mL/kg/day in adults and >2l/m/24h in children) of dilute urine (<250mOsm/L). It can result from any pathology affecting one or more components of the HNS including the hypothalamic osmoreceptors, supraoptic or paraventricular nuclei, and median eminence of the hypothalamus, infundibulum, stalk or the posterior pituitary gland. MRI is the imaging modality of choice for evaluation of the hypothalamic-pituitary axis (HPA), and a dedicated pituitary or sella protocol is essential. CT can provide complimentary diagnostic information and is also of value when MRI is contraindicated. The most common causes are benign or malignant neoplasia of the HPA (25%), surgery (20%), and head trauma (16%). No cause is identified in up to 30% of cases, classified as idiopathic CDI. Knowledge of the anatomy and physiology of the HNS is crucial when evaluating a patient with CDI. Establishing the etiology of CDI with MRI in combination with clinical and biochemical assessment facilitates appropriate targeted treatment. This chapter illustrates the wide variety of causes and imaging correlates of CDI on neuroimaging, discusses the optimal imaging protocols, and revises the detailed neuroanatomy required to interpret these studies.
Terence Patrick Farrell, Niamh Catherine Adams, Seamus Looby

2109 related Products with: Neuroimaging of central diabetes insipidus.

50 UG 100 ml 100 UG 50 UG 50 UG 5 G

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#34089984   2021/05/31 To Up

Application of the Southwell Plot method to determine equilibrium time in phosphate adsorption.

Among the different factors that influence the liquid-solid adsorption technique, equilibrium time is one of the most relevant and requires a large number of experiments over a long period of time for its determination. This work evaluates the Southwell Plot as a further tool that can contribute to determining the equilibrium time in adsorption processes. It can also optimize the operating conditions in a batch system for the removal of phosphate in adsorbents produced from domestic sewage sludge and clam shell residue. Sewage sludge and clam shell residues were ground, sieved and sintered at 700 °C for 1 h. The material was characterized by thermal analyses (TG/DTG), chemical analysis (EDX), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR) and adsorption studies. The kinetic studies were investigated by varying the initial concentration of the phosphate solution and mass of the adsorbent. The equilibrium time was determined by applying the Southwell Plot method to the kinetic data and the results showed some fluctuations as a function of the adsorbent mass. At 0.30 g of the adsorbent in 30 mL of the phosphate solution, regardless of the initial phosphate concentration, the equilibrium time determined by the Southwell Plot was 4 h. The maximum phosphate adsorption capacity in this condition, determined by the Langmuir equation, was 49.45 mg g.
Maíra Luane S de Almeida, Adriano C P Lima, Koji de J Nagahama, Tereza S M Santos

1853 related Products with: Application of the Southwell Plot method to determine equilibrium time in phosphate adsorption.

100 mg96 wells0.1ml 100ul 100ul500 gm.100ug Lyophilized 100ul

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#34044224   2021/05/13 To Up

Pneumothorax in critically ill patients with COVID-19 infection: Incidence, clinical characteristics and outcomes in a case control multicenter study.

The clinical features and outcomes of mechanically ventilated patients with COVID-19 infection who develop a pneumothorax has not been rigorously described or compared to those who do not develop a pneumothorax.
Amit Chopra, Ali Hani Al-Tarbsheh, Nidhi J Shah, Hamid Yaqoob, Kurt Hu, Paul J Feustel, Ronaldo Ortiz-Pacheco, Kinner M Patel, Jozef Oweis, Natalya Kozlova, Spyridon Zouridis, Sahar Ahmad, Oleg Epelbaum, Woon H Chong, John T Huggins, Biplab K Saha, Edward Conuel, Hau Chieng, Jeannette Mullins, Divyansh Bajaj, Boris Shkolnik, Rachel Vancavage, Nagendra Madisi, Marc A Judson

2190 related Products with: Pneumothorax in critically ill patients with COVID-19 infection: Incidence, clinical characteristics and outcomes in a case control multicenter study.



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#33952656   2021/05/05 To Up

Kidney Function, Kidney Function Decline, and the Risk of Dementia in Older Adults: A Registry-Based Study.

Community-based reports regarding the association between the estimated glomerular filtration rate (eGFR) and dementia risk show conflicting results. This study aims is to investigate the links between kidney function, kidney function decline and dementia incidence.
Hong Xu, Sara Garcia-Ptacek, Marco Trevisan, Marie Evans, Bengt Lindholm, Maria Eriksdotter, Juan Jesus Carrero Pharm

1767 related Products with: Kidney Function, Kidney Function Decline, and the Risk of Dementia in Older Adults: A Registry-Based Study.



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#33945595   2021/04/22 To Up

A sono-anatomical and cadaveric study of ultrasound-guided retrolaminar block.

Retrolaminar block (RB) is known to confer chest wall analgesia but, its mechanism has not been established. Our primary objective was to determine if the spread of injectate following RB extends to the paravertebral space (PVS). Second-ary objectives were to determine the predefined anatomical areas and nervous tissues contacted by injectate; the effect of volume on spread; and the extent to which experts can predict PVS spread based on examination of US videos of the injection.
Fahd Aamir, Michael Cronin, Peter Lee, Gabriella Iohom, George Shorten

2743 related Products with: A sono-anatomical and cadaveric study of ultrasound-guided retrolaminar block.

10 mg100 mg100.00 ul10 mg200ug50 ug 5mg1 mg 15 ml 100ug1,000 tests

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