Gentaur Pub

#37469758   2023/07/10 To Up

TMEM100 Regulates Neuropathic Pain by Reducing the Expression of Inflammatory Factors.

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Huifei Cui, Zhaoyang Guo, Zhu Guo, Zuoran Fan, Nana Shen, Xiaoying Qi, Yuanye Ma, Youfu Zhu, Xiaolin Wu, Bohua Chen, Hongfei Xiang

2801 related Products with: TMEM100 Regulates Neuropathic Pain by Reducing the Expression of Inflammatory Factors.

0.1 mg1 ml250ul5 reactions100 IU5 μg0.1mg

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#36607587   2023/01/06 To Up

Total Saponin Fraction of Dioscorea Nipponica Makino Improves Gouty Arthritis Symptoms in Rats via M1/M2 Polarization of Monocytes and Macrophages Mediated by Arachidonic Acid Signaling.

To explore the mechanism of effects of total saponin fraction from Dioscorea Nipponica Makino (TSDN) on M1/M2 polarization of monocytes/macrophages and arachidonic acid (AA) pathway in rats with gouty arthritis (GA).
Qi Zhou, Hui-Juan Sun, Xi-Wu Zhang

1034 related Products with: Total Saponin Fraction of Dioscorea Nipponica Makino Improves Gouty Arthritis Symptoms in Rats via M1/M2 Polarization of Monocytes and Macrophages Mediated by Arachidonic Acid Signaling.

25 mg2 Pieces/Box96tests100ug Lyophilized25 TESTS250 mg2 Pieces/Box100ug Lyophilized100ug Lyophilized500 MG1 kit25 mg

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#35411597   2022/04/11 To Up

Construction and identification of an immortalized rat intestinal smooth muscle cell line.

Although intestinal smooth muscle cells (ISMCs) play an important role in the remodeling of the intestinal structure, considerably less is known about the molecular mechanisms that mediate the development and growth of ISMCs. A possible reason for this lag is the lack of cell lines that recapitulate ISMCs in vivo.
Huiling Chen, Xiaoli Li, Liping Gao, Dekui Zhang, Tiyun Han

2297 related Products with: Construction and identification of an immortalized rat intestinal smooth muscle cell line.

100ul100ul100ul100ul200ul100ul100ul100ul0.1ml (1mg/ml) 100ul100ul100ul

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#34773542   2021/11/13 To Up

Role of Adenosine Kinase in Sphingosine-1-Phosphate Receptor 1-Induced Mechano-Hypersensitivities.

Emerging evidence implicates the sphingosine-1-phosphate receptor subtype 1 (S1PR1) in the development of neuropathic pain. Continued investigation of the signaling pathways downstream of S1PR1 are needed to support development of S1PR1 antagonists. In rodents, intrathecal (i.th.) injection of SEW2871, a selective S1PR1 agonist, activates the nod-like receptor family, pyrin domain containing 3 inflammasome, increases interleukin-1β (IL-1β) and causes behavioral hypersensitivity. I.th. injection of a IL-1β receptor antagonist blocks SEW2871-induced hypersensitivity, suggesting that IL-1β contributes to S1PR1's actions. Interestingly, previous studies have suggested that IL-1β increases the expression/activity of adenosine kinase (ADK), a key regulator of adenosine signaling at its receptors (ARs). Increased ADK expression reduces adenosine signaling whereas inhibiting ADK restores the action of adenosine. Here, we show that SEW287-induced behavioral hypersensitivity is associated with increased expression of ADK in astrocytes of the dorsal horn of the spinal cord. Moreover, the ADK inhibitor, ABT702, blocks SEW2871-induced hypersensitivity. These findings link ADK activation to S1PR1. If SEW2871-induced pain is mediated by IL-1β, which in turn activates ADK and leads to mechano-allodynia, then blocking ADK should attenuate IL-1β effects. In support of this idea, recombinant rat (rrIL-1β)-induced allodynia was blocked by at least 90% with ABT702, functionally linking ADK to IL-1β. Moreover, the selective AAR antagonist, MRS1523, prevents the ability of ABT702 to block SEW2871 and IL-1β-induced allodynia, implicating AAR signaling in the beneficial effects exerted by ABT702. Our findings provide novel mechanistic insight into how S1PR1 signaling in the spinal cord produces hypersensitivity through IL1-β and ADK activation.
Filomena Lauro, Luigino Antonio Giancotti, Grant Kolar, Caron Mitsue Harada, Taylor A Harmon, Timothy J Garrett, Daniela Salvemini

1998 related Products with: Role of Adenosine Kinase in Sphingosine-1-Phosphate Receptor 1-Induced Mechano-Hypersensitivities.

8 inhibitors100ug5 inhibitors96 wells (1 kit)50 ug96T5 mg100ug Lyophilized200ul100ug100 μg

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#34674761   2021/10/21 To Up

Induced pluripotent stem cells can improve thrombolytic effect of low-dose rt-PA after acute carotid thrombosis in rat.

Intravenous thrombolysis using recombinant tissue plasminogen activator (rt-PA) is the standard treatment for acute ischemic stroke. Standard-dose rt-PA (0.9 mg/kg) is known to achieve good recanalization but carries a high bleeding risk. Lower dose of rt-PA has less bleeding risk but carries a high re-occlusion rate. We investigate if induced pluripotent stem cells (iPSCs) can improve the thrombolytic effect of low-dose rt-PA (0.45 mg/kg).
Hsi-Lung Hsieh, Ching-Chung Liang, Cheng-You Lu, Jen-Tsung Yang, Chiu-Yen Chung, Yu-Shien Ko, Tsong-Hai Lee

2177 related Products with: Induced pluripotent stem cells can improve thrombolytic effect of low-dose rt-PA after acute carotid thrombosis in rat.

2 Pieces/Box

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#33612100   2021/02/21 To Up

Interleukin-1β mediates alterations in mitochondrial fusion/fission proteins and memory impairment induced by amyloid-β oligomers.

The lack of effective treatments for Alzheimer's disease (AD) reflects an incomplete understanding of disease mechanisms. Alterations in proteins involved in mitochondrial dynamics, an essential process for mitochondrial integrity and function, have been reported in AD brains. Impaired mitochondrial dynamics causes mitochondrial dysfunction and has been associated with cognitive impairment in AD. Here, we investigated a possible link between pro-inflammatory interleukin-1 (IL-1), mitochondrial dysfunction, and cognitive impairment in AD models.
Andre F Batista, Tayná Rody, Leticia Forny-Germano, Suzana Cerdeiro, Maria Bellio, Sergio T Ferreira, Douglas P Munoz, Fernanda G De Felice

2336 related Products with: Interleukin-1β mediates alterations in mitochondrial fusion/fission proteins and memory impairment induced by amyloid-β oligomers.

96 wells (1 kit) 0.1 mg 250 50 1 mg1mg50μg2 5ug96T2 10

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#30646897   2019/01/15 To Up

Mesenchymal stem cells alleviate the early brain injury of subarachnoid hemorrhage partly by suppression of Notch1-dependent neuroinflammation: involvement of Botch.

Activated microglia-mediated neuroinflammation has been regarded as an underlying key player in the pathogenesis of subarachnoid hemorrhage (SAH)-induced early brain injury (EBI). The therapeutic potential of bone marrow mesenchymal stem cells (BMSCs) transplantation has been demonstrated in several brain injury models and is thought to involve modulation of the inflammatory response. The present study investigated the salutary effects of BMSCs on EBI after SAH and the potential mechanism mediated by Notch1 signaling pathway inhibition.
Wenchao Liu, Ran Li, Jian Yin, Shenquan Guo, Yunchang Chen, Haiyan Fan, Gancheng Li, Zhenjun Li, Xifeng Li, Xin Zhang, Xuying He, Chuanzhi Duan

1427 related Products with: Mesenchymal stem cells alleviate the early brain injury of subarachnoid hemorrhage partly by suppression of Notch1-dependent neuroinflammation: involvement of Botch.

5 G5 x 10A5 cells/vial1.00 flask24 wells24 wells1 x 10^6 cells/vial24 wells1.00 flask1 mg0.1ml (1mg/ml)1 vial1

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#30014637   // To Up

[Effect of Flavonoids from Wang Zaizi on Adjuvant Arthritis in Rats and Its Mechanism].

The therapeutic effect and mechanism of total flavonoids in Isodon amethystoides (Ben-th) Cy Wu et Hsuan (TFIA) on adjuvant arthritis (AA) were investigated.
Cheng-Gui Miao, You-Yi Xiong, Mei-Song Qing, Hao Chen, Jun Chang

1726 related Products with: [Effect of Flavonoids from Wang Zaizi on Adjuvant Arthritis in Rats and Its Mechanism].

100 ug100ug1 Set4 Arrays/Slide1 Set1 Set1 Set2.50 nmol100 μg

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