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#34861290   2021/11/30 To Up

RIFM fragrance ingredient safety assessment, cyclohexaneacetic acid, α-methyl-, ethyl ester, CAS Registry Number 2511-00-4.

A M Api, D Belsito, D Botelho, M Bruze, G A Burton, J Buschmann, M A Cancellieri, M L Dagli, M Date, W Dekant, C Deodhar, A D Fryer, L Jones, K Joshi, M Kumar, A Lapczynski, M Lavelle, I Lee, D C Liebler, H Moustakas, M Na, T M Penning, G Ritacco, J Romine, N Sadekar, T W Schultz, D Selechnik, F Siddiqi, I G Sipes, G Sullivan, Y Thakkar, Y Tokura

2109 related Products with: RIFM fragrance ingredient safety assessment, cyclohexaneacetic acid, α-methyl-, ethyl ester, CAS Registry Number 2511-00-4.

25 mg250 mg1 mg25 mg1 mg500 mg10 mg50 mg 1 G 100 G 25 G25 mg

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#34845585   2021/11/30 To Up

Enhanced Dissolution of 7-ADCA in the Presence of PGME for Enzymatic Synthesis of Cephalexin.

Enzymatic catalysis has been recognized as a green alternative to classical chemical route for synthesis of cephalexin (CEX). However, its industrial practice has been severely limited by the low productivity due to the low solubility of 7-amino-3-deacetoxycephalosporanic acid (7-ADCA) and high hydrolysis of D-phenylglycine methyl ester (PGME). In this work, the enhanced dissolution of 7-ADCA in the presence of PGME for efficient enzymatic synthesis of CEX was investigated. Results showed that the solubility of 7-ADCA in water could be improved by PGME. Moreover, supersaturated solution of 7-ADCA could be created in the presence of PGME by a pH shift strategy. The supersaturated solution of 7-ADCA possess good stability, which could be explained in terms of the inhibition of 7-ADCA precipitation due to the presence of PGME. The interaction between 7-ADCA and PGME is explored by spectroscopic determination and DFT analysis and the mechanism of enhanced dissolution of 7-ADCA in the presence of PGME is discussed and proposed. The feasibility of supersaturated solution of 7-ADCA for the enzymatic synthesis of CEX is evaluated. It was demonstrated that high conversion ratio (> 95.0%) and productivity (> 240.0 mmol/L/h) was obtained under a wide range of reaction conditions, indicating that the supersaturated solution system was highly superior to conventional homogeneous solution system. The information obtained in this work will be helpful to industrial production of CEX via enzymatic route.
Yixiao Fan, Yingbo Li, Qingfen Liu

1382 related Products with: Enhanced Dissolution of 7-ADCA in the Presence of PGME for Enzymatic Synthesis of Cephalexin.

5 G96 tests 100 G250 mg96 tests 1 G96 tests

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#34555469   2021/09/20 To Up

RIFM fragrance ingredient safety assessment, cis-3-hexenyl tiglate, CAS Registry Number 67883-79-8.

The existing information supports the use of this material as described in this safety assessment. cis-3-Hexenyl tiglate was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data from read-across analogs 2-methyl-trans-2-butenoic acid (CAS # 80-59-1) and cis-3-hexenol (CAS # 928-96-1) show that cis-3-hexenyl tiglate is not expected to be genotoxic. The repeated dose, reproductive, and local respiratory toxicity endpoints were evaluated using the Threshold for Toxicological Concern (TTC) for a Cramer Class I material; exposure to cis-3-hexenyl tiglate is below the TTC (0.03 mg/kg/day, 0.03 mg/kg/day and 1.4 mg/day, respectively). Data from analog 2-hexenoic acid, 2-methyl-, methyl ester, (2E)- (CAS # 16493-96-2) provided cis-3-hexenyl tiglate a No Expected Sensitization Induction Level (NESIL) of 1100 μg/cm for the skin sensitization endpoint. The phototoxicity/photoallergenicity endpoints were evaluated based on ultraviolet/visible (UV/Vis) spectra; cis-3-hexenyl tiglate is not expected to be phototoxic/photoallergenic. The environmental endpoints were evaluated; cis-3-hexenyl tiglate was found not to be Persistent, Bioaccumulative, and Toxic (PBT) as per the International Fragrance Association (IFRA) Environmental Standards, and its risk quotients, based on its current volume of use in Europe and North America (i.e., Predicted Environmental Concentration/Predicted No Effect Concentration [PEC/PNEC]), are <1.
A M Api, D Belsito, D Botelho, M Bruze, G A Burton, J Buschmann, M A Cancellieri, M L Dagli, M Date, W Dekant, C Deodhar, A D Fryer, L Jones, K Joshi, M Kumar, A Lapczynski, M Lavelle, I Lee, D C Liebler, H Moustakas, M Na, T M Penning, G Ritacco, J Romine, N Sadekar, T W Schultz, D Selechnik, F Siddiqi, I G Sipes, G Sullivan, Y Thakkar, Y Tokura

2514 related Products with: RIFM fragrance ingredient safety assessment, cis-3-hexenyl tiglate, CAS Registry Number 67883-79-8.

500 G 5 MG 5 G 5 G 1 G 25 G 1 G 1 G 1 MG 25 G

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#34555466   2021/09/20 To Up

RIFM fragrance ingredient safety assessment, benzoic acid, 2-[(1-hydroxy-3-phenylbutyl)amino], methyl ester, CAS Registry Number 144761-91-1.

A M Api, D Belsito, D Botelho, M Bruze, G A Burton, J Buschmann, M A Cancellieri, M L Dagli, M Date, W Dekant, C Deodhar, A D Fryer, L Jones, K Joshi, M Kumar, A Lapczynski, M Lavelle, I Lee, D C Liebler, H Moustakas, M Na, T M Penning, G Ritacco, J Romine, N Sadekar, T W Schultz, D Selechnik, F Siddiqi, I G Sipes, G Sullivan, Y Thakkar, Y Tokura

1274 related Products with: RIFM fragrance ingredient safety assessment, benzoic acid, 2-[(1-hydroxy-3-phenylbutyl)amino], methyl ester, CAS Registry Number 144761-91-1.

1 mg10 mg100 mg25 mg5 mg10 mg5 mg10 mg 100 G50 mg5 mg250 mg

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#34547396   2021/09/20 To Up

RIFM fragrance ingredient safety assessment, butanoic acid, 2-methyl-, 5-hexen-1-yl ester, CAS Registry Number 155514-23-1.

A M Api, D Belsito, D Botelho, M Bruze, G A Burton, J Buschmann, M A Cancellieri, M L Dagli, M Date, W Dekant, C Deodhar, A D Fryer, L Jones, K Joshi, M Kumar, A Lapczynski, M Lavelle, I Lee, D C Liebler, H Moustakas, M Na, T M Penning, G Ritacco, J Romine, N Sadekar, T W Schultz, D Selechnik, F Siddiqi, I G Sipes, G Sullivan, Y Thakkar, Y Tokura

1037 related Products with: RIFM fragrance ingredient safety assessment, butanoic acid, 2-methyl-, 5-hexen-1-yl ester, CAS Registry Number 155514-23-1.

100 G10 mg50 mg1 g1 g100 mg100 mg2.5 mg1 g 100 G1 g1 mg

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#34533312   2021/09/17 To Up

An Atom-Economic Inverse Solid-Phase Peptide Synthesis Using Bn or BcM Esters of Amino Acids.

An atom-economic N-to-C-directed solid-phase peptide synthesis is reported that uses benzyl (Bn) or (benzhydryl-carbamoyl)-methyl (BcM) esters of amino acids as the building blocks, which facilitate efficient hydrazinolysis, convenient conversion to acyl azide, and robust amidation with the next amino acid ester. This method is free of coupling reagents and free of protection on the side-chain OH, COH, CONH2, etc., therefore exhibiting a significantly improved atom economy compared to those of BOC- or Fmoc-based C-to-N-directed approaches.
Jian Li, Yue Zhu, Bo Liu, Feng Tang, Xing Zheng, Wei Huang

2779 related Products with: An Atom-Economic Inverse Solid-Phase Peptide Synthesis Using Bn or BcM Esters of Amino Acids.

100 ug100ug1mg100ug Lyophilized100ug0.1mg100ug Lyophilized100μg100μg

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#34486738   2021/09/06 To Up

Heat-induced overexpression of the thermophilic lipase from Bacillus thermocatenulatus in Escherichia coli by fermentation and its application in preparation biodiesel using rapeseed oil.

Due to its simple, less by-product and environment friendly properties, enzymatic transesterification of oil with short-chain alcohol to biodiesel, fatty acid methyl esters (FAMEs) is considered to be a promising way of green production and has attracted much attention. In this study, FAMEs were synthesized by an enzymatic method with recombinant lipase as catalysts. A thermophilic Bacillus thermocatenulatus lipase 2 (BTL2) was overexpressed in Escherichia coli BL21(DE3) through relative and quantitative analysis using real-time quantitative PCR. The results suggested that the BTL2 gene was overexpressed in E. coli at the mRNA level, and the recombinant strain harboring a high-copy number vectors was selected and applied to fermentation to produce BTL2 with enzyme activity of 35.54 U/mg cells. The recombinant BTL2 solution exhibited excellent resistance to neutral pH, high temperature, and organic solvents after a certain treatment. Finally, the effects of enzymatic transesterification for preparing biodiesel were studied, using rapeseed oil as raw material, as well as BTL2 solution as catalysts, which resulted in 86.04% yield of FAMEs under 50°C for 36 h. The liquid BTL2 was directly used to prepare FAMEs at a higher temperature efficiently, making the thermophilic BTL2 had the potential application value in biodiesel reproduction subsequently.
Jun Zhang, Huanjun Chen, Zhiyuan Wang, Huijuan Xu, Wen Luo, Jingliang Xu, Pengmei Lv

1389 related Products with: Heat-induced overexpression of the thermophilic lipase from Bacillus thermocatenulatus in Escherichia coli by fermentation and its application in preparation biodiesel using rapeseed oil.

100ul0.1ml (1mg/ml)0.1ml 100ul1 mg100ug Lyophilized500 ml0.1 mg100ug Lyophilized100 ml

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#34389373   2021/08/11 To Up

RIFM fragrance ingredient safety assessment, 2-pentenoic acid, 2-methyl-, (3Z)-3-hexen-1-yl ester, CAS Registry Number 76649-17-7.

A M Api, D Belsito, D Botelho, M Bruze, G A Burton, J Buschmann, M A Cancellieri, M L Dagli, M Date, W Dekant, C Deodhar, A D Fryer, L Jones, K Joshi, M Kumar, A Lapczynski, M Lavelle, I Lee, D C Liebler, H Moustakas, M Na, T M Penning, G Ritacco, J Romine, N Sadekar, T W Schultz, D Selechnik, F Siddiqi, I G Sipes, G Sullivan, Y Thakkar, Y Tokura

1157 related Products with: RIFM fragrance ingredient safety assessment, 2-pentenoic acid, 2-methyl-, (3Z)-3-hexen-1-yl ester, CAS Registry Number 76649-17-7.

100 G50 mg1 g1 g100 mg100 mg2.5 mg 100 G1 g1 mg25 mg250 mg

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