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Search results for: 2-(4’-Acetoxy-2-fluoro-biphenyl-4-yl)-propionic Acid Methyl Ester C18H17FO4 CAS: 215175-84-1

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#33722611   2021/03/12 To Up

Polymer-ritonavir derivate nanomedicine with pH-sensitive activation possesses potent anti-tumor activity in vivo via inhibition of proteasome and STAT3 signaling.

Drug repurposing is a promising strategy for identifying new applications for approved drugs. Here, we describe a polymer biomaterial composed of the antiretroviral drug ritonavir derivative (5-methyl-4-oxohexanoic acid ritonavir ester; RD), covalently bound to HPMA copolymer carrier via a pH-sensitive hydrazone bond (P-RD). Apart from being more potent inhibitor of P-glycoprotein in comparison to ritonavir, we found RD to have considerable cytostatic activity in six mice (IC ~ 2.3-17.4 μM) and six human (IC ~ 4.3-8.7 μM) cancer cell lines, and that RD inhibits the migration and invasiveness of cancer cells in vitro. Importantly, RD inhibits STAT3 phosphorylation in CT26 cells in vitro and in vivo, and expression of the NF-κB p65 subunit, Bcl-2 and Mcl-1 in vitro. RD also dampens chymotrypsin-like and trypsin-like proteasome activity and induces ER stress as documented by induction of PERK phosphorylation and expression of ATF4 and CHOP. P-RD nanomedicine showed powerful antitumor activity in CT26 and B16F10 tumor-bearing mice, which, moreover, synergized with IL-2-based immunotherapy. P-RD proved very promising therapeutic activity also in human FaDu xenografts and negligible toxicity predetermining these nanomedicines as side-effect free nanosystem. The therapeutic potential could be highly increased using the fine-tuned combination with other drugs, i.e. doxorubicin, attached to the same polymer system. Finally, we summarize that described polymer nanomedicines fulfilled all the requirements as potential candidates for deep preclinical investigation.
Ladislav Sivák, Vladimír Šubr, Jiřina Kovářová, Barbora Dvořáková, Milada Šírová, Blanka Říhová, Eva Randárová, Michal Kraus, Jakub Tomala, Martin Studenovský, Michaela Vondráčková, Radislav Sedláček, Petr Makovický, Jitka Fučíková, Šárka Vošáhlíková, Radek Špíšek, Libor Kostka, Tomáš Etrych, Marek Kovář

2679 related Products with: Polymer-ritonavir derivate nanomedicine with pH-sensitive activation possesses potent anti-tumor activity in vivo via inhibition of proteasome and STAT3 signaling.

0.1ml (1mg/ml)48 assays 96 assays 100ug

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#33501824   2021/01/27 To Up

Boosting the Thermal Stability of α-Diimine Palladium Complexes in Norbornene Polymerization from Construction of Intraligand Hydrogen Bonding and Simultaneous Increasing Axial/Equatorial Bulkiness.

Increasing the thermostability of α-diimine late-transition-metal complexes and therefore rendering them more active at higher temperatures is of great importance, yet challenging for the olefin polymerization field. In the present research, a new family of α-diimine palladium complexes that can promote norbornene polymerization at high temperatures (up to 140 °C) is disclosed. Because of the conformational restriction caused by increasing the axial and equatorial bulkiness as well as the presence of intraligand H···F hydrogen bonds, -aryl rotations can be efficiently restricted, therefore circumventing the deactivation of the active species at high temperatures. At 80-140 °C, these complexes can efficiently catalyze norbornene homopolymerizations, giving high catalytic activities up to 5.65 × 10 g of PNB per mole Ni per hour and polymers with high molecular weights up to 37.2 × 10 g/mol, which are highly superior to catalytic systems mediated by CF-free complexes. Moreover, these complexes could also afford medium catalytic activities in the presence of polar 5-norbornene-2-carboxylic acid methyl ester (NB-COOCH).
Xiaohua Wang, Bo Dong, Qi Yang, Heng Liu, Yanming Hu, Xuequan Zhang

1214 related Products with: Boosting the Thermal Stability of α-Diimine Palladium Complexes in Norbornene Polymerization from Construction of Intraligand Hydrogen Bonding and Simultaneous Increasing Axial/Equatorial Bulkiness.

1111111 kit

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#33223151   2020/11/13 To Up

Separation and identification of diacylglycerols containing branched chain fatty acids by liquid chromatography-mass spectrometry.

A combination of two chromatographic and two enzymatic methods was used for the analysis of molecular species of lipids from Gram-positive bacteria of the genus Kocuria. Gram-positive bacteria contain a majority of branched fatty acids (FAs), especially iso- and/or anteiso-FAs. Two strains K. rhizophila were cultivated at three different temperatures (20, 28, and 37°C) and the majority phospholipid, i.e., the mixture of molecular species of phosphatidylglycerols (PGs) was separated by means of hydrophilic interaction liquid chromatography (HILIC). After enzymatic hydrolysis of PGs by phospholipase C and derivatization of the free OH group, the sn-1,2-diacyl-3-acetyl triacylglycerols (AcTAGs) were separated by reversed phase HPLC. Molecular species such as i-15:0/i-15:0/2:0, ai-15:0/ai-15:0/2:0, and 15:0/15:0/2:0 (straight chains) were identified by liquid chromatography-positive electrospray ionization mass spectrometry. The tandem mass spectra of both standards and natural compounds containing iso, anteiso and straight chain FAs with the same carbons were identical. Therefore, for identification of the ratio of two regioisomers, i.e. i-15:0/ai-15:0/2:0 vs. ai-15:0/i-15:0/2:0, they were cleavage by pancreatic lipase. The mixture of free fatty acids (FFAs) and 2-monoacylglycerols (2-MAGs) was obtained. After their separation by TLC and esterification and/or transesterification, the fatty acid methyl esters were quantified by GC-MS and thus the ratio of regioisomers was determined. It has been shown that the ratio of PG (containing as majority i-15: 0 / i-15: 0, i-15: 0 / ai-15: 0 and / or ai-15: 0 / i-15: 0 and ai-15: 0 / ai-15: 0 molecular species) significantly affected the membrane flow of bacterial cells cultured at different temperatures.
Andrea Palyzová, Tomáš Řezanka

1236 related Products with: Separation and identification of diacylglycerols containing branched chain fatty acids by liquid chromatography-mass spectrometry.

100 assays100ug10 100ug1,000 tests50 ug1 ml200 assays50 ug150 Tests / Kit1 mg 6 ml Ready-to-use

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#33143281   2020/10/30 To Up

Ultrafast Charge Generation Enhancement in Nanoscale Polymer Solar Cells with DIO Additive.

We study the ultrafast photoexcitation dynamics in PBDTTT-C-T (P51, poly(4,8-bis(5-(2-ethylhexyl)-thiophene-2-yl)-benzo[1,2-b:4,5-b']dithiophene--alkylcarbonyl-thieno[3,4-]thiophene)) film (~100 nm thickness) and PBDTTT-C-T:PCBM (P51:PCBM, phenyl-C-butyric-acid-methyl ester) nanostructured blend (∼100 nm thickness) with/without DIO(1,8-diiodooctane) additives with sub-10 fs transient absorption (TA). It is revealed that hot-exciton dissociation and vibrational relaxation could occur in P51 with a lifetime of ~160 fs and was hardly affected by DIO. However, the introduction of DIO in P51 brings a longer lifetime of polaron pairs, which could make a contribution to photocarrier generation. In P51:PCBM nanostructured blends, DIO could promote the Charge Transfer (CT) excitons and free charges generation with a ~5% increasement in ~100 fs. Moreover, the dissociation of CT excitons is faster with DIO, showing a ~5% growth within 1 ps. The promotion of CT excitons and free charge generation by DIO additive is closely related with active layer nanomorphology, accounting for J enhancement. These results reveal the effect of DIO on carrier generation and separation, providing an effective route to improve the efficiency of nanoscale polymer solar cells.
Tongchao Shi, Zeyu Zhang, Xia Guo, Zhengzheng Liu, Chunwei Wang, Sihao Huang, Tingyuan Jia, Chenjing Quan, Qian Xiong, Maojie Zhang, Juan Du, Yuxin Leng

1240 related Products with: Ultrafast Charge Generation Enhancement in Nanoscale Polymer Solar Cells with DIO Additive.

1.00 flask0.1 ml1x10e7 cells1000 Units2000 Units1x10e7 cells250 Units96 tests100 µg

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#33091557   2020/10/19 To Up

RIFM fragrance ingredient safety assessment, carbonic acid, 2-hydroxyethyl 5-methyl-2-(1-methylethyl)cyclohexyl ester, CAS registry number 156679-39-9.


A M Api, D Belsito, S Biserta, D Botelho, M Bruze, G A Burton, J Buschmann, M A Cancellieri, M L Dagli, M Date, W Dekant, C Deodhar, A D Fryer, S Gadhia, L Jones, K Joshi, M Kumar, A Lapczynski, M Lavelle, I Lee, D C Liebler, H Moustakas, M Na, T M Penning, G Ritacco, J Romine, N Sadekar, T W Schultz, D Selechnik, F Siddiqi, I G Sipes, G Sullivan, Y Thakkar, Y Tokura

2786 related Products with: RIFM fragrance ingredient safety assessment, carbonic acid, 2-hydroxyethyl 5-methyl-2-(1-methylethyl)cyclohexyl ester, CAS registry number 156679-39-9.

100 G25 mg 500 G50 mg2.5 mg10 mg2.5 mg250 mg 100 G 1 G1 mg 100 G

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#32689792   2020/08/04 To Up

Fast Wetting of a Fullerene Capping Layer Improves the Efficiency and Scalability of Perovskite Solar Cells.

Fullerene derivatives, especially [6,6]-phenyl-C-butyric acid methyl ester (PCBM), have been widely applied as electron transport layers of inverted planar heterojunction perovskite solar cells (PSCs). However, the solution-processed PCBM capping layer suffers from limited surface wetting which hinders the improvement in efficiency and scalability of PSCs. Herein, we develop a facile hybrid solvent strategy that enables very fast wetting of the PCBM capping layer atop of the perovskite surface, leading to an improved interfacial contact and electron transport. The significantly enhanced wettability of the PCBM solution fulfilled through blending isopropyl alcohol into the commonly used chlorobenzene (CB) is attributed to the reduced surface tension while retaining viscosity. As a result, the electron mobility and electric conductivity of the PCBM capping layer increase by around two times, and the PSC devices exhibit the highest power conversion efficiency (PCE) of 19.92%, which is improved by ∼18% relative to that of the control device (16.78%). Importantly, this strategy is also applicable for other alcohols (ethanol and methanol) and CB blends. Moreover, the fast wetting approach enables us to deposit the PCBM capping layer using a facile drop-casting method, affording comparable PCEs to those obtained by the conventional spin-coating method, which is not achievable by using the conventional single solvent. This fast wetting PCBM capping layer also contributes to efficiency improvement of large-area (1 cm) devices. These advances hold great potential for other scalable deposition methods such as blade-coating and slot-die coating.
Bairu Li, Xin Yu, Lingbo Jia, Mengmeng Zhang, Wanpei Hu, Yanbo Shang, Xingcheng Li, Liming Ding, Jixian Xu, Shangfeng Yang

2041 related Products with: Fast Wetting of a Fullerene Capping Layer Improves the Efficiency and Scalability of Perovskite Solar Cells.

100 extractions2100 70 Slides 100ul100ug Lyophilized 5 G

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#32508085   2020/06/17 To Up

Fuller-Rylenes: Paving the Way for Promising Acceptors.

The hybridization of different acceptors remains a fertile ground awaiting exploration, to fully promote the properties of both components. The concept of this work is to exploit a new form of fuller-rylene hybrids as promising acceptors by integrating planar rylene dye and spherical fullerene for boosting the power conversion efficiency. The synthesis of the fuller-rylenes via a straightforward synthetic strategy by one-pot Pd-catalyzed cyclization can be scaled-up. Specifically, our strategy allows the supplements and enhancement of absorption in the visible region, much wider structural and electronic variations by installing R groups as well as decorating R on the perylene core at will, and good processability without compromising the superior characteristics of fullerene. Thus, bay-decorated fuller-rylene revealed a ground-breaking efficiency as high as 8.01%, even outperforming [6,6]-phenyl-C-butyric acid methyl ester (PCBM) as a parallel comparison (7.09%). Our exploration paves a new way for the design of high-efficiency acceptors, which are promising alternatives to PCBM in photovoltaic devices.
Jiajing Feng, Huiting Fu, Wei Jiang, Andong Zhang, Hwa Sook Ryu, Han Young Woo, Yanming Sun, Zhaohui Wang

2788 related Products with: Fuller-Rylenes: Paving the Way for Promising Acceptors.

96 Well 1 G 2x5Lmin 2 cartons 5 G0.1 mg100.00 ul500 ml100Tests

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#32144245   2020/03/06 To Up

Ultra-high open-circuit voltage of tin perovskite solar cells via an electron transporting layer design.

Tin perovskite is rising as a promising candidate to address the toxicity and theoretical efficiency limitation of lead perovskite. However, the voltage and efficiency of tin perovskite solar cells are much lower than lead counterparts. Herein, indene-C bisadduct with higher energy level is utilized as an electron transporting material for tin perovskite solar cells. It suppresses carrier concentration increase caused by remote doping, which significantly reduces interface carriers recombination. Moreover, indene-C bisadduct increases the maximum attainable photovoltage of the device. As a result, the use of indene-C bisadduct brings unprecedentedly high voltage of 0.94 V, which is over 50% higher than that of 0.6 V for device based on [6,6]-phenyl-C61-butyric acid methyl ester. The device shows a record power conversion efficiency of 12.4% reproduced in an accredited independent photovoltaic testing lab.
Xianyuan Jiang, Fei Wang, Qi Wei, Hansheng Li, Yuequn Shang, Wenjia Zhou, Cheng Wang, Peihong Cheng, Qi Chen, Liwei Chen, Zhijun Ning

2827 related Products with: Ultra-high open-circuit voltage of tin perovskite solar cells via an electron transporting layer design.

100 ug/vial100 ug/vial250 4 Membranes/Box100ug Lyophilized2 Pieces/Box4 Membranes/Box4 Arrays/Slide100 ug/vial100ug/vial

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