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Search results for: N-Acetyl-L-tyrosine Amide C11H14N2O3 CAS: 1948-71-6

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#34417467   2021/08/20 To Up

Saturated very long chain fatty acid configures glycosphingolipid for lysosome homeostasis in long-lived C. elegans.

The contents of numerous membrane lipids change upon ageing. However, it is unknown whether and how any of these changes are causally linked to lifespan regulation. Acyl chains contribute to the functional specificity of membrane lipids. In this study, working with C. elegans, we identified an acyl chain-specific sphingolipid, C22 glucosylceramide, as a longevity metabolite. Germline deficiency, a conserved lifespan-extending paradigm, induces somatic expression of the fatty acid elongase ELO-3, and behenic acid (22:0) generated by ELO-3 is incorporated into glucosylceramide for lifespan regulation. Mechanistically, C22 glucosylceramide is required for the membrane localization of clathrin, a protein that regulates membrane budding. The reduction in C22 glucosylceramide impairs the clathrin-dependent autophagic lysosome reformation, which subsequently leads to TOR activation and longevity suppression. These findings reveal a mechanistic link between membrane lipids and ageing and suggest a model of lifespan regulation by fatty acid-mediated membrane configuration.
Feng Wang, Yuxi Dai, Xufeng Zhu, Qilong Chen, Huanhu Zhu, Ben Zhou, Haiqing Tang, Shanshan Pang

2432 related Products with: Saturated very long chain fatty acid configures glycosphingolipid for lysosome homeostasis in long-lived C. elegans.

100ug100ug100μg25 μg100μg96tests100μg100μg100ug 25 G 1 G

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#34365551   2021/08/08 To Up

Intraoperative detection of human meningioma using a handheld visible resonance Raman analyzer.

To report for the first time the preliminary results for the evaluation of a VRR-LRR™ analyzer based on visible resonance Raman technique to identify human meningioma grades and margins intraoperatively. Unprocessed primary and recurrent solid human meningeal tissues were collected from 33 patients and underwent Raman analysis during surgeries. A total of 1180 VRR spectra were acquired from fresh solid tissues using a VRR-LRR™ analyzer. A confocal HR Evolution (HORIBA, France SAS) Raman system with 532-nm excitation wavelength was also used to collect data for part of the ex vivo samples after they were thawed from - 80 °C for comparison. The preliminary analysis led to the following observations. (1) The intensity ratio of VRR peaks of protein to fatty acid (I/I) decreased with the increase of meningioma grade. (2) The ratio of VRR peaks of phosphorylated protein to amid I (I/I) decreased for the higher grade of meningioma. (3) Three RR vibration modes at 1378, 3174, and 3224 cm which were related to the molecular vibrational bands of oxy-hemeprotein, amide B, and amide A protein significantly changed in peak intensities in the two types of meningioma tissues compared to normal tissue. (4) The changes in the intensities of VRR modes of carotenoids at 1156 and 1524 cm were also found in the meningioma boundary. The VRR-LRR™ analyzer demonstrates a new approach for label-free, rapid, and objective identification of primary human meningioma in quasi-clinical settings. The accuracy for detecting meningioma tissues using support vector machines (SVMs) was over 70% based on Raman peaks of key biomolecules and up to 100% using principal component analysis (PCA).
Liang Zhang, Yan Zhou, Binlin Wu, Shengjia Zhang, Ke Zhu, Cheng-Hui Liu, Xinguang Yu, Robert R Alfano

2207 related Products with: Intraoperative detection of human meningioma using a handheld visible resonance Raman analyzer.

96 tests96 tests96 tests0.1 mg100ug Lyophilized2 mL100 Grams0.1 ml100ug Lyophilized100 100 μg0.1ml (1mg/ml)

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#34347502   2021/08/04 To Up

Nickel-Catalyzed Asymmetric Reductive Dicarbamoylation of Alkenes.

Herein we report a nickel-catalyzed asymmetric reductive dicarbamoylation of alkenes, in which tethered carbamoyl chlorides and isocyanates serve as distinct electrophilic carbamoylating agents, providing new access to chiral oxindoles bearing an amide-substituted quaternary stereogenic center.
Jiaoyang Wu, Chuan Wang

1441 related Products with: Nickel-Catalyzed Asymmetric Reductive Dicarbamoylation of Alkenes.

1 5 G25 ml1 l100 assays100 ml100 ml50 ml25 ml10 ml5 ml100 ml

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#34332063   2021/07/28 To Up

Cyclodextrin-based formulation of carbonic anhydrase inhibitors for ocular delivery - A review.

Carbonic anhydrase inhibitors (CAIs) are used as systemic and topical agents for lowering intraocular pressure (IOP) in patients with glaucoma. Owing to the wide distribution of CAs and their physiological functions in various tissues, systemic administration of CAIs may lead to unwanted side effects. Thus, exploration of drugs targeting the specific CA isoenzyme in ocular tissues and application of the same as topical eye drops would be desirable. However, the anatomical and physiological barriers of the eyes can limit drug availability at the site. The very low aqueous solubility of CAI agents can further hamper drug bioavailability, consequently resulting in insufficient therapeutic efficacy. Solubilization of drugs using cyclodextrin (CD) complexes can enhance both solubility and permeability of the drugs. The use of CD for such purposes and development and testing of topical CAI eye drops containing CD have been discussed in detail. Further, pharmaceutical nanotechnology platforms were discussed in terms of investigation of their IOP-lowering efficacies. Future prospects in drug discovery and the use of CD nanoparticles and CD-based nanocarriers to develop potential topical CAI formulations have also been described here.
Phatsawee Jansook, Hay Marn Hnin, Thorsteinn Loftsson, Einar Stefánsson

2629 related Products with: Cyclodextrin-based formulation of carbonic anhydrase inhibitors for ocular delivery - A review.

100ul100.00 ug100ug50 mg100ug1 g100 TESTS250 mg0.1 mg100ug

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#34319703   2021/07/28 To Up

Iron Cycle Tuned by Outer-Membrane Cytochromes of Dissimilatory Metal-Reducing Bacteria: Interfacial Dynamics and Mechanisms In Vitro.

The biogeochemical cycle of iron is of great importance to living organisms on Earth, and dissimilatory metal-reducing bacteria (DMRB) with the capability of reducing hematite (α-FeO) by outer-membrane (OM) cytochromes play a great role in the iron cycle. However, the dynamic binding of cytochromes to α-FeO at the molecular level and the resulting impact on the photon-to-electron conversion of α-FeO for the iron cycle are not fully understood. To address these issues, two-dimensional IR correlation analysis coupled with molecular dynamics (MD) simulations was conducted for an OmcA-FeO system as OmcA bonds stronger with hematite in a typical DMRB,. The photoelectric response of α-FeO with the OmcA coating was evaluated at three different potentials. Specifically, the binding groups from OmcA to α-FeO were in the sequence of carboxyl groups, amide II, and amide I. Further MD analysis reveals that both electrostatic interactions and hydrogen bonds played essential roles in the binding process, leading to the structural changes of OmcA to facilitate iron reduction. Moreover, the OmcA coating could store the photogenerated electrons from α-FeO like a capacitor and utilize the stored electrons for α-FeO reduction in dark and anoxic environments, further driving the biogeochemical cycle of iron. These investigations give the dynamic information on the OM protein/hematite interaction and provide fundamental insights into the biogeochemical cycle of iron by taking the photon-induced redox chemistry of iron oxide into consideration.
Sheng-Song Yu, Jie-Jie Chen, Rui-Fen Cheng, Yuan Min, Han-Qing Yu

1181 related Products with: Iron Cycle Tuned by Outer-Membrane Cytochromes of Dissimilatory Metal-Reducing Bacteria: Interfacial Dynamics and Mechanisms In Vitro.

5mg5mg5mg4 Membranes/Box50mg4 Membranes/Box4 Membranes/Box5mg10mg10mg20mg

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#34270204   2021/07/16 To Up

Polyacrylamide/Chitosan-Based Conductive Double Network Hydrogels with Outstanding Electrical and Mechanical Performance at Low Temperatures.

Hydrogel-based electronics have received growing attention because of their great flexibility and stretchability. However, the fabrication of conductive hydrogels with high stretchability, excellent toughness, outstanding sensitivity, and low-temperature stability still remains a great challenge. In this study, a type of conductive hydrogels consisting of a double network (DN) structure is synthesized. The dynamically cross-linked chitosan (CS) and the flexible polyacrylamide network doped with polyaniline constitute the DN through the hydrogen bonds between the hydroxyl, amide, and aniline groups. This type of hydrogels displays excellent mechanical performance, striking conductivity, and remarkable freezing tolerance. The flexible electronic sensors based on the double-network hydrogels demonstrate superior strain sensitivity and linear response on various deformations. Additionally, the good antifreezing property of the hydrogels allows the sensors to exhibit excellent performance at -20 °C.
Jing Cong, Zhiwei Fan, Shaoshan Pan, Jie Tian, Weizhen Lian, Shan Li, Sijie Wang, Dongchang Zheng, Chunguang Miao, Weiping Ding, Taolin Sun, Tianzhi Luo

1428 related Products with: Polyacrylamide/Chitosan-Based Conductive Double Network Hydrogels with Outstanding Electrical and Mechanical Performance at Low Temperatures.

100ul96T100 100ug Lyophilized100ul100 µg100ug Lyophilized50 ul100ug1 mg100 ug

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#34239261   // To Up

Trial eligibility in advanced hepatocellular carcinoma: Does it support clinical practice in underrepresented subgroups?

Although hepatocellular carcinoma is considered a highly lethal malignancy, recent therapeutic advances have been achieved during the last 10 years. This scenario resulted in an unprecedented improvement in survival for patients with advanced hepatocellular carcinoma, almost reaching 20-26 mo of overall survival after first-second line sequential treatment. The advent of the combination of atezolizumab with bevacizumab showed, for the first time, superiority over sorafenib with improvement in overall survival. However, first and second-line trials were correctly based on the premise that a strict selection of patients enhances the power to capture the positive effect of treatment by excluding competing risks for mortality such as liver failure, decompensated cirrhosis or other underlying medical conditions. As a result, the inclusion criteria used in clinical trials do not support the use of novel therapies in several real-world scenarios involving underrepresented subgroups, such as patients with unpreserved liver function, other comorbid conditions, a history of solid-organ transplantation, autoimmune disorders and those with a high risk of bleeding. The present text aims at discussing treatment strategies in these subgroups.
Federico Piñero, Leonardo Gomes da Fonseca

1287 related Products with: Trial eligibility in advanced hepatocellular carcinoma: Does it support clinical practice in underrepresented subgroups?



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#34224975   2021/07/03 To Up

Pharmaco-transcriptomic correlation analysis reveals novel responsive signatures to HDAC inhibitors and identifies Dasatinib as a synergistic interactor in small-cell lung cancer.

Histone acetylation/deacetylase process is one of the most studied epigenetic modifications. Histone deacetylase inhibitors (HDACis) have shown clinical benefits in haematological malignancies but failed in solid tumours due to the lack of biomarker-driven stratification.
Haitang Yang, Beibei Sun, Ke Xu, Yunfei He, Tuo Zhang, Sean R R Hall, Swee T Tan, Ralph A Schmid, Ren-Wang Peng, Guohong Hu, Feng Yao

2724 related Products with: Pharmaco-transcriptomic correlation analysis reveals novel responsive signatures to HDAC inhibitors and identifies Dasatinib as a synergistic interactor in small-cell lung cancer.

1 kit1 kit

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