Search results for: 2-Amino-5-bromopyrazine-3-carboxylic Acid C5H4BrN3O2 CAS: 486424-37-7
#38638229 
2024/03/06
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The superiority of Pd in CO hydrogenation to formic acid.
The hydrogenation of CO to formic acid is an essential subject since formic acid is a promising hydrogen storage material and a valuable commodity chemical. In this study, we report for the first time the hydrogenation of CO to formic acid catalyzed by a Pd catalyst, Pd-V/AC-air. The catalyst exhibited extraordinary catalytic activity toward the hydrogenation of CO to formic acid. The TON and TOF are up to 4790 and 2825 h, respectively, representing the top level among reported heterogeneous Pd catalysts. By combining a study of first-principles density functional theory with experimental results, the superiority of Pd over Pd was confirmed. Furthermore, the presence of V modified the electronic state of Pd, thus promoting the reaction. This study reports the effect of metal valence and electronic state on the catalytic performance for the first time and provides a new prospect for the design of an efficient heterogeneous catalyst for the hydrogenation of CO to formic acid.Yanyan Wang, Minghua Dong, Shaopeng Li, Bingfeng Chen, Huizhen Liu, Buxing Han
1808 related Products with: The superiority of Pd in CO hydrogenation to formic acid.
100ug Lyophilized100ug Lyophilized100ug100ug Lyophilized100ug Lyophilized100ug Lyophilized1
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#38638228 2024/03/13
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Engineering the passivation routes of perovskite films towards high performance solar cells.
Passivation treatment is an effective method to suppress various defects in perovskite solar cells (PSCs), such as cation vacancies, under-coordinated Pb or I, and Pb-I antisite defects. A thorough understanding of the diversified impacts of different defect passivation methods (DPMs) on the device performance will be beneficial for making wise DPM choices. Herein, we choose a hydrophobic Lewis acid tris(pentafluorophenyl)borane (BCF), which can dissolve in both the perovskite precursor and anti-solvent, as the passivation additive. BCF treatment can immobilize organic cations forming hydrogen bonds. Three kinds of DPMs based on BCF are applied to modify perovskite films in this work. It is found that the best DPM with BCF dissolved in anti-solvent can not only passivate multiple defects in perovskite, but also inhibit δ phase perovskite and improve the stability of devices. Meanwhile, DPM with BCF dissolved in both the perovskite precursor and anti-solvent can cause cracks and voids in perovskite films and deteriorate device performance, which should be avoided in practical applications. As a result, PSCs based on optimal DPMs of BCF present an increased efficiency of 22.86% with negligible hysteresis as well as improved overall stability. This work indicates that the selection and optimization of DPMs have an equally important influence on the photovoltaic performance of PSCs as the selection of passivation additives.Liangzheng Zhu, Shendong Xu, Guozhen Liu, Long Liu, Han Zhou, Zhiqiang Ai, Xu Pan, Fapei Zhang
1909 related Products with: Engineering the passivation routes of perovskite films towards high performance solar cells.
100ug Lyophilized101x10e7 cells50ml11mg
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#38637224 2024/04/02
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Piezocatalytically-induced controllable mineralization scaffold with bone-like microenvironment to achieve endogenous bone regeneration.
Orderly hierarchical structure with balanced mechanical, chemical, and electrical properties is the basis of the natural bone microenvironment. Inspired by nature, we developed a piezocatalytically-induced controlled mineralization strategy using piezoelectric polymer poly-L-lactic acid (PLLA) fibers with ordered micro-nano structures to prepare biomimetic tissue engineering scaffolds with a bone-like microenvironment (pcm-PLLA), in which PLLA-mediated piezoelectric catalysis promoted the in-situ polymerization of dopamine and subsequently regulated the controllable growth of hydroxyapatite crystals on the fiber surface. PLLA fibers, as analogs of mineralized collagen fibers, were arranged in an oriented manner, and ultimately formed a bone-like interconnected pore structure; in addition, they also provided bone-like piezoelectric properties. The uniformly sized HA nanocrystals formed by controlled mineralization provided a bone-like mechanical strength and chemical environment. The pcm-PLLA scaffold could rapidly recruit endogenous stem cells, and promote their osteogenic differentiation by activating cell membrane calcium channels and PI3K signaling pathways through ultrasound-responsive piezoelectric signals. In addition, the scaffold also provided a suitable microenvironment to promote macrophage M2 polarization and angiogenesis, thereby enhancing bone regeneration in skull defects of rats. The proposed piezocatalytically-induced controllable mineralization strategy provides a new idea for the development of tissue engineering scaffolds that can be implemented for multimodal physical stimulation therapy.Xi Cui, Lingling Xu, Yizhu Shan, Jiaxuan Li, Jianying Ji, Engui Wang, Baokun Zhang, Xiaozhou Wen, Yuan Bai, Dan Luo, Chunying Chen, Zhou Li
2791 related Products with: Piezocatalytically-induced controllable mineralization scaffold with bone-like microenvironment to achieve endogenous bone regeneration.
100ug Lyophilized100ug100ug100ug Lyophilized100ug5 ug20 100ul100ug Lyophilized
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#38636687 2024/04/16
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Genome-guided discovery of two undescribed 6,6-spiroketal polyketides and stereochemical correction of bafilomycins P and Q from the marine-derived Streptomyces sp. SCSIO 66814.
Bafilomycins are macrocyclic polyketides with intriguing structures and therapeutic value. Genomic analysis of Streptomyces sp. SCSIO 66814 revealed a type I polyketide synthase biosynthetic gene cluster (BGC), namely blm, which encoded bafilomycins and featured rich post-modification genes. The One strain many compounds (OSMAC) strategy led to the discovery of six compounds related to the blm BGC from the strain, including two previously undescribed 6,6-spiroketal polyketides, streptospirodienoic acids D (1) and E (2), and four known bafilomycins, bafilomycins P (3), Q (4), D (5), and G (6). The structures of 1 and 2 were determined by extensive spectroscopic analysis, quantum calculation, and biosynthetic analysis. Additionally, the absolute configurations of the 6/5/5 tricyclic ring moiety containing six consecutive chiral carbons in the putative structures of 3 and 4 were corrected through NOE analysis, DP4+ calculation, and single-crystal X-ray diffraction data. Bioinformatic analysis uncovered a plausible biosynthetic pathway for compounds 1-6, indicating that both streptospirodienoic acids and bafilomycins were derived from the same blm BGC. Additionally, sequence analysis revealed that the KR domains of module 2 from blm BGC was B1-type, further supporting the configurations of 1-4. Notably, compounds 3 and 4 displayed significant cytotoxic activities against A-549 human non-small cell lung cancer cells and HCT-116 human colon cancer cells.Wenping Ding, Yanqun Li, Xingyu Li, Songbiao Shi, Jiajia Yin, Xinpeng Tian, Min Xiao, Si Zhang, Hao Yin
2599 related Products with: Genome-guided discovery of two undescribed 6,6-spiroketal polyketides and stereochemical correction of bafilomycins P and Q from the marine-derived Streptomyces sp. SCSIO 66814.
50 ug 10 mg100ug100ul10 mg50 ug 100ug100ul100ul50 mg100.00 ul96T
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#38636599 2024/04/16
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Update to RIFM fragrance ingredient safety assessment, 2-methylheptanoic acid, CAS Registry Number 1188-02-9.
A M Api, A Bartlett, D Belsito, D Botelho, M Bruze, A Bryant-Freidrich, G A Burton, M A Cancellieri, H Chon, M L Dagli, W Dekant, C Deodhar, K Farrell, A D Fryer, L Jones, K Joshi, A Lapczynski, M Lavelle, I Lee, H Moustakas, J Muldoon, T M Penning, G Ritacco, N Sadekar, I Schember, T W Schultz, F Siddiqi, I G Sipes, G Sullivan, Y Thakkar, Y Tokura
1555 related Products with: Update to RIFM fragrance ingredient safety assessment, 2-methylheptanoic acid, CAS Registry Number 1188-02-9.
25 G 100 G 25 G 1KG 1 G 1 G 1 G 500 G 500 G 1 G 1KG 1 G
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#38636598 2024/04/16
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Update to RIFM fragrance ingredient safety assessment, 2-methylhexanoic acid, CAS Registry Number 4536-23-6.
A M Api, A Bartlett, D Belsito, D Botelho, M Bruze, A Bryant-Freidrich, G A Burton, M A Cancellieri, H Chon, M L Dagli, W Dekant, C Deodhar, K Farrell, A D Fryer, L Jones, K Joshi, A Lapczynski, M Lavelle, I Lee, H Moustakas, J Muldoon, T M Penning, G Ritacco, N Sadekar, I Schember, T W Schultz, F Siddiqi, I G Sipes, G Sullivan, Y Thakkar, Y Tokura
1180 related Products with: Update to RIFM fragrance ingredient safety assessment, 2-methylhexanoic acid, CAS Registry Number 4536-23-6.
25 G 100 G 25 G 1KG 1 G 1 G 1 G 500 G 500 G 1 G 1KG 1 G
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#38636595 2024/04/16
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Update to RIFM fragrance ingredient safety assessment, 4-ethyloctanoic acid, CAS Registry Number 16493-80-4.
A M Api, A Bartlett, D Belsito, D Botelho, M Bruze, A Bryant-Freidrich, G A Burton, M A Cancellieri, H Chon, M L Dagli, W Dekant, C Deodhar, K Farrell, A D Fryer, L Jones, K Joshi, A Lapczynski, M Lavelle, I Lee, H Moustakas, J Muldoon, T M Penning, G Ritacco, N Sadekar, I Schember, T W Schultz, F Siddiqi, I G Sipes, G Sullivan, Y Thakkar, Y Tokura
2657 related Products with: Update to RIFM fragrance ingredient safety assessment, 4-ethyloctanoic acid, CAS Registry Number 16493-80-4.
25 G 100 G 25 G 1KG 1 G 1 G 1 G 500 G 500 G 1 G 1KG 1 G
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#38636594 2024/04/16
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Update to RIFM fragrance ingredient safety assessment, hexanoic acid, 4-methyl-, CAS Registry Number 1561-11-1.
A M Api, A Bartlett, D Belsito, D Botelho, M Bruze, A Bryant-Freidrich, G A Burton, M A Cancellieri, H Chon, M L Dagli, W Dekant, C Deodhar, K Farrell, A D Fryer, L Jones, K Joshi, A Lapczynski, M Lavelle, I Lee, H Moustakas, J Muldoon, T M Penning, G Ritacco, N Sadekar, I Schember, T W Schultz, F Siddiqi, I G Sipes, G Sullivan, Y Thakkar, Y Tokura
2071 related Products with: Update to RIFM fragrance ingredient safety assessment, hexanoic acid, 4-methyl-, CAS Registry Number 1561-11-1.
50G 25 G 500 G 5 G 100 G 500 G 5 G 1 G 100 G 1 G 100 G 25 G
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#38636316 2024/04/16
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A rapid and sensitive one-pot platform integrating fluorogenic RNA aptamers and CRISPR-Cas13a for visual detection of monkeypox virus.
The recent global upsurge in Monkeypox virus (MPXV) outbreaks underscores the critical need for rapid and precise diagnostic solutions, particularly in resource-constrained settings. The gold standard diagnostic method, qRT-PCR, is hindered by its time-consuming nature, requirement for nucleic acid purification, expensive equipment, and the need for highly trained personnel. Traditional CRISPR/Cas fluorescence assays, relying on trans-cleavage of ssDNA/RNA reporters labeled with costly fluorophores and quenchers, pose challenges that limit their widespread application, especially for point-of-care testing (POCT). In this study, we utilized a cost-effective and stable fluorogenic RNA aptamer (Mango III), specifically binding and illuminating the fluorophore TO3-3 PEG-Biotin Fluorophore (TO3), as a reporter for Cas13a trans-cleavage activity. We propose a comprehensive strategy integrating RNA aptamer, recombinase-aided amplification (RAA), and CRISPR-Cas13a systems for the molecular detection of MPXV target. Leveraging the inherent collateral cleavage properties of the Cas13a system, we established high-sensitivity and specificity assays to distinguish MPXV from other Orthopoxviruses (OPVs). A streamlined one-pot protocol was developed to mitigate aerosol contamination risks. Our aptamer-coupled RAA-Cas13a one-pot detection method achieved a Limit of Detection (LoD) of 4 copies of target MPXV DNA in just 40 min. Validation using clinical MPX specimens confirmed the rapid and reliable application of our RAA-Cas13a-Apt assays without nucleic acid purification procedure, highlighting its potential as a point-of-care testing solution. These results underscore the user-friendliness and effectiveness of our one-pot RAA-Cas13a-Apt diagnostic platform, poised to revolutionize disease detection and management.Xiao Wang, Xiaobao Deng, Yidun Zhang, Weiyi Dong, Qiao Rao, Qingmei Huang, Fei Tang, Rong Shen, Hongzhi Xu, Zhen Jin, Youzhi Tang, Dan Du
1203 related Products with: A rapid and sensitive one-pot platform integrating fluorogenic RNA aptamers and CRISPR-Cas13a for visual detection of monkeypox virus.
500 mg25 mg10 mg100ug25 mg 5 G 5 G100ug100ug1 g100ul
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#38635971 2024/04/18
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RNA splicing modulates the postharvest physiological deterioration of cassava storage root.
Rapid postharvest physiological deterioration (PPD) of cassava (Manihot esculenta Crantz) storage roots is a major constraint that limits the potential of this plant as a food and industrial crop. Extensive studies have been performed to explore the regulatory mechanisms underlying the PPD processes in cassava to understand their molecular and physiological responses. However, the exceptional functional versatility of alternative splicing (AS) remains to be explored during the PPD process in cassava. Here, we identified several aberrantly spliced genes during the early PPD stage. An in-depth analysis of AS revealed that the abscisic acid (ABA) biosynthesis pathway might serve as an additional molecular layer in attenuating the onset of PPD. Exogenous ABA application alleviated PPD symptoms through maintaining ROS generation and scavenging. Interestingly, the intron retention transcript of MeABA1 (ABA DEFICIENT 1) was highly correlated with PPD symptoms in cassava storage roots. RNA yeast three-hybrid and RNA immunoprecipitation assays showed that the serine/arginine-rich protein MeSCL33 (SC35-like splicing factor 33) binds to the precursor mRNA of MeABA1. Importantly, overexpressing MeSCL33 in cassava conferred improved PPD resistance by manipulating the AS and expression levels of MeABA1 and then modulating the endogenous ABA levels in cassava storage roots. Our results uncovered the pivotal role of the ABA biosynthesis pathway and RNA splicing in regulating cassava PPD resistance and proposed the essential roles of MeSCL33 for conferring PPD resistance, broadening our understanding of SR proteins in cassava development and stress responses.Jinbao Gu, Xiaowen Ma, Qiuxiang Ma, Zhiqiang Xia, Yan Lin, Jianbo Yuan, Yang Li, Cong Li, Yanhang Chen, Wenquan Wang, Peng Zhang, Zhen-Yu Wang