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Search results for: 2-Amino-5-chloro-α-[(1E)-2-cyclopropylethenyl]-α-(trifluoromethyl)-benzenemethanol C13H13ClF3NO CAS: 221177-51-1

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#33950565   2021/05/05 To Up

Rhodium-terpyridine Catalyzed Transfer Hydrogenation of Aromatic Nitro Compounds in Water.

Rhodium terpyridine complexes catalyzed transfer hydrogenation of nitroarenes to anilines with i -PrOH as hydrogen source and water as solvent has been developed. The catalytic system can work at a substrate/catalyst (S/C) ratio of 2000, with a turnover frequency (TOF) up to 3360 h -1 , which represents one of the most active catalytic transfer hydrogenation systems for nitroarene reduction. The catalytic system is operationally simple and the protocol could scale up to 20 gram scale. The water-soluble catalyst bearing a carboxyl group could be recycled 15 times without significant loss of activity.
Yuxuan Liu, Wang Miao, Weijun Tang, Dong Xue, Jianliang Xiao, Chao Wang, Changzhi Li

2128 related Products with: Rhodium-terpyridine Catalyzed Transfer Hydrogenation of Aromatic Nitro Compounds in Water.

50μl25 g100 μg100ug 25 G100 μg100ug Lyophilized5 g0.1 mg1 Set500 Units

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#33949734   2021/05/05 To Up

Multifunctional Graphdiyne-Cerium Oxide Nanozymes Facilitate MicroRNA Delivery and Attenuate Tumor Hypoxia for Highly Efficient Radiotherapy of Esophageal Cancer.

Radioresistance is an important challenge for clinical treatments. The main causes of radioresistance include hypoxia in the tumor microenvironment, the antioxidant system within cancer cells, and the upregulation of DNA repair proteins. Here, a multiple radiosensitization strategy of high-Z-element-based radiation enhancement is designed, attenuating hypoxia and microRNA therapy. The novel 2D graphdiyne (GDY) can firmly anchor and disperse CeO nanoparticles to form GDY-CeO nanocomposites, which exhibit superior catalase-mimic activity in decomposing H O to O to significantly alleviate tumor hypoxia, promote radiation-induced DNA damage, and ultimately inhibit tumor growth in vivo. The miR181a-2-3p (miR181a) serum levels in patients are predictive of the response to preoperative radiotherapy in locally advanced esophageal squamous cell carcinoma (ESCC) and facilitate personalized treatment. Moreover, miR181a can act as a radiosensitizer by directly targeting RAD17 and regulating the Chk2 pathway. Subsequently, the GDY-CeO nanocomposites with miR181a are conjugated with the iRGD-grafted polyoxyethylene glycol (short for nano-miR181a), which can increase the stability, efficiently deliver miR181a to tumor, and exhibit low toxicity. Notably, nano-miR181a can overcome radioresistance and enhance therapeutic efficacy both in a subcutaneous tumor model and human-patient-derived xenograft models. Overall, this GDY-CeO nanozyme and miR181a-based multisensitized radiotherapy strategy provides a promising therapeutic approach for ESCC.
Xuantong Zhou, Min You, Fuhui Wang, Zhenzhen Wang, Xingfa Gao, Chao Jing, Jiaming Liu, Mengyu Guo, Jiayang Li, Aiping Luo, Huibiao Liu, Zhihua Liu, Chunying Chen

1751 related Products with: Multifunctional Graphdiyne-Cerium Oxide Nanozymes Facilitate MicroRNA Delivery and Attenuate Tumor Hypoxia for Highly Efficient Radiotherapy of Esophageal Cancer.



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#33949719   2021/05/05 To Up

Bmcas-1 plays an important role in response against BmNPV infection in vitro.

Apoptosis, as one kind of innate immune system, is involved in host response against pathogens innovation. Caspases play a vital role in the execution stage of host cell apoptosis. It has been reported that Bmcaspase-1 (Bmcas-1) has a close relationship with Bombyx mori nucleopolyhedrovirus (BmNPV) infection for its differentially expressed patterns after viral infection. However, its underlying response mechanism is still unclear. The significant differential expression of Bmcas-1 in different tissues of differentially resistant strains revealed its vital role in BmNPV infection. To further validate its role in BmNPV infection, budded virus (BV)-eGFP was analyzed after knockdown and overexpression of Bmcas-1 by small interfering RNA and the pIZT-mCherry vector, respectively. The reproduction of BV-eGFP obviously increased at 72 h after knockdown of Bmcas-1, and decreased after overexpression in BmN cells. Moreover, the conserved functional domain of Cas-1 among different species and the closed evolutionary relationship of Cas-1 in Lepidoptera hinted that Bmcas-1 might be associated with apoptosis, and this was also validated by the apoptosis inducer, Silvestrol, and the inhibitor, Z-DEVD-FMK. Therefore, Bmcas-1 plays an essential antiviral role by activating apoptosis, and this result lays a fundament for clarifying the molecular mechanism of silkworm in response against BmNPV infection and breeding of resistant strains.
Xin Wang, Zi-Qin Zhao, Xin-Ming Huang, Xin-Yi Ding, Chun-Xiao Zhao, Mu-Wang Li, Yang-Chun Wu, Qiu-Ning Liu, Xue-Yang Wang

2884 related Products with: Bmcas-1 plays an important role in response against BmNPV infection in vitro.

100 UG100ug Lyophilized1000 100ug100ug100ug Lyophilized100ug Lyophilized100ug100μg100ug Lyophilized100ug Lyophilized 100ul

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