Gentaur Pub

#38652440   2024/04/23 To Up

CRISPR-Cas13a-Triggered DNAzyme Signal Amplification-Based Colorimetric miRNA Detection Method and Its Application in Evaluating the Anxiety.

The development of a bio-sensing strategy based on CRISPR/Cas that is exceptionally sensitive is crucial for the identification of trace molecules. Colorimetric miRNA detection utilizing CRISPR/Cas13a-triggered DNAzyme signal amplification was described in this article. The developed strategy was implemented for miRNA-21 detection as a proof of concept. The cleavage activity of Cas13a was triggered when the target molecule bonded to the Cas13a-crRNA complex and cleaved uracil ribonucleotides (rU) in the substrate probe. As a consequence, the S chain was liberated from the T chain that had been modified on magnetic beads (MB). The G-rich sections were then exposed when the catalytic hairpin assembly between the H1 and H2 probes was activated by the released T@MB. G-rich section can fold into G-quadruplex. By catalyzing the formation of green ABTS- via HRP-mimicking G-quadruplex/hemin complexes, colorimetric measurements of miRNA can be achieved visually through DNAzyme-mediated signal amplification. The method demonstrated a low limit of detection of 27 fM and a high selectivity towards target miRNA eventually. As a result, the developed strategy provides a clinical application platform for the detection of miRNAs that is both ultrasensitive and extremely specific.
Na Yan, Zhiwei Hu, Lingling Zhang

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100tests100tests100tests100tests100tests100tests100tests100tests100tests100tests100tests 100ul

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#38652321   2024/04/23 To Up

Advances in miniature CRISPR-Cas proteins and their applications in gene editing.

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Huimin Wu, Yixiang Sun, Yimai Wang, Liqiang Luo, Yizhi Song

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101 Set100 7 x 25 ul

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#38652294   2024/04/23 To Up

Plant diversity increases spatial stability of aboveground productivity in alpine grasslands.

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Zeng Cui, Jian Sun, Gao-Lin Wu

2501 related Products with: Plant diversity increases spatial stability of aboveground productivity in alpine grasslands.

4/120 Packing /sleeve/bo4/120 Packing /sleeve/bo96tests4/120 Packing /sleeve/bo1 Set1 Set5 mg 0.1 mg

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#38652293   2024/04/23 To Up

Intraspecific alternative phenotypes contribute to variation in species' strategies for growth.

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Samantha J Worthy, María N Umaña, Caicai Zhang, Luxiang Lin, Min Cao, Nathan G Swenson

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100 μg 100ul25 µg4 Membranes/Box100 ml50 ug 96T 100ul1 kit96T 100 G

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#38652189   2024/04/23 To Up

Siderophore-producing bacteria from Spitsbergen soils-novel agents assisted in bioremediation of the metal-polluted soils.

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Małgorzata Majewska, Anna Słomka, Agnieszka Hanaka

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1

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#38652094   2024/04/23 To Up

Sulfonic Acid Functionalized Ionic Liquids for Defect Passivation via Molecular Interactions for High-Quality Perovskite Films and Stable Solar Cells.

The high photoelectric conversion efficiency and low cost of perovskite solar cells (PSCs) have further inspired people's determination to push this technology toward industrialization. The high-quality perovskite films and high-efficiency and stable PSCs are the crucial factors. Ionic liquids have been proven to be an effective strategy for regulating high-quality perovskite films and high-performance PSCs. However, the regulation mechanism between ionic liquids and perovskites still needs further clarification. In this study, a novel sulfonic acid-functionalized ionic liquid, 1-butyl-3-methylimidazolium trifluoromethanesulfonate (BSOHMImOTf), was used as an effective additive to regulate high-quality perovskite films and high-performance devices. Microscopic mechanism studies revealed strong interactions between BSOHMImOTf and Pb ions as well as halogens in the perovskite. The perovskite film is effectively passivated with the controlled crystal growth, suppressed ion migration, facilitating to the greatly improved photovoltaic performance, and superior long-term stability. This article reveals the regulatory mechanism of sulfonic acid type ionic liquids through testing characterization and mechanism analysis, providing a new approach for the preparation of high-quality perovskite devices.
Junhui Fang, Liang Wang, Zhaoyang Chen, Shuai Wang, Lin Yuan, Aamir Saeed, Iqbal Hussain, Jianwei Zhao, Ruixia Liu, Qingqing Miao

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1 G 500 G 1 G20 ug10 mg 1 G25 g 1 G 2x5L5 g 100 G

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#38651920   2024/04/23 To Up

Biomechanical effects of clear aligner with different shape design at extraction space area during anterior teeth retraction.

This study aimed to investigate the biomechanical effects of clear aligner (CA) with different shape designs at extraction space (CAES) area during space closing.
Bochun Mao, Yajing Tian, Yujia Xiao, Jiayi Liu, Dawei Liu, Jing Li, Yanheng Zhou

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#38651836   2024/04/23 To Up

Machine Learning for Experimental Reactivity of a Set of Metal Clusters toward C-H Activation.

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Xi-Guan Zhao, Qi Yang, Ying Xu, Qing-Yu Liu, Zi-Yu Li, Xiao-Xiao Liu, Yan-Xia Zhao, Sheng-Gui He

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#38651620   2024/04/23 To Up

Acceptor-Reactivity-Controlled Stereoconvergent Synthesis and Immunological Activity of a Unique Pentasaccharide from the Cell Wall Polysaccharide of Cutibacterium acnes C7.

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Tianhui Hao, Ke Feng, Hongzhen Jin, Jiawei Li, Chenkai Zhou, Xingbang Liu, Wei Zhao, Fan Yu, Tiehai Li

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#38651538   2024/04/23 To Up

A wafer scale thin film of ultra-small ScO nanocrystals on a 2D COF with high rigidity.

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Xin Guan, Xiaohui Xu, Zhongliang Yu, Junjie Xiong, Yanhong Chang, Bowen Liu, Bin Wang

2131 related Products with: A wafer scale thin film of ultra-small ScO nanocrystals on a 2D COF with high rigidity.

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