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Search results for: 6-Amino-5-nitroso-2-thiouracil C4H4N4O2S CAS: 1672-48-6

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#38500822   2024/03/01 To Up

High-frequency neural activity dysregulation is associated with sleep and psychiatric disorders in BMAL1-deficient animal models.

Sleep disturbance led by BMAL1-deficiency has been recognized both in rodent and non-human primate models. Yet it remained unclear how their diurnal brain oscillations were affected upon BMAL1 ablation and what caused the discrepancy in the quantity of sleep between the two species. Here, we investigated diurnal electroencephalographs of BMAL1-deficient mice and cynomolgus monkeys at young adult age and uncovered a shared defect of dysregulated high-frequency oscillations by Kullback-Leibler divergence analysis. We found beta and gamma oscillations were significantly disturbed in a day versus night manner in BMAL1-deficient monkeys, while in mice the beta band difference was less evident. Notably, the dysregulation of beta oscillations was particularly associated with psychiatric behaviors in BMAL1-deficient monkeys, including the occurrence of self-injuring and delusion-like actions. As such psychiatric phenotypes were challenging to uncover in rodent models, our results offered a unique method to study the correlation between circadian clock dysregulation and psychiatric disorders.
Yu Sun, Mingzhu Zhong, Niannian Xu, Xueting Zhang, Huanhuan Sun, Yan Wang, Yong Lu, Yanhong Nie, Qing Li, Qiang Sun, Jian Jiang, Yun-Chi Tang, Hung-Chun Chang

1087 related Products with: High-frequency neural activity dysregulation is associated with sleep and psychiatric disorders in BMAL1-deficient animal models.

400Tests900 tests0.1ml (1mg/ml)100ug Lyophilized100ug Lyophilized96 assays 100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized

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#38500582   2024/03/04 To Up

Normal distribution of H3K9me3 occupancy co-mediated by histone methyltransferase BcDIM5 and histone deacetylase BcHda1 maintains stable ABA synthesis in TB-31.

Abscisic acid (ABA) is a conserved and important "sesquiterpene signaling molecule" widely distributed in different organisms with unique biological functions. ABA coordinates reciprocity and competition between microorganisms and their hosts. In addition, ABA also regulates immune and stress responses in plants and animals. Therefore, ABA has a wide range of applications in agriculture, medicine and related fields. The plant pathogenic ascomycete has been extensively studied as a model strain for ABA production. Nevertheless, there is a relative dearth of research regarding the regulatory mechanism governing ABA biosynthesis in . Here, we discovered that H3K9 methyltransferase BcDIM5 is physically associated with the H3K14 deacetylase BcHda1. Deletion of and in the high ABA-producing TB-31 led to severe impairment of ABA synthesis. The combined analysis of RNA-seq and ChIP-seq has revealed that the absence of BcDIM5 and BcHda1 has resulted in significant global deficiencies in the normal distribution and level of H3K9me3 modification. In addition, we found that the cause of the decreased ABA production in the Δ and Δ mutants was due to cluster gene repression caused by the emergence of hyper-H3K9me3 in the ABA gene cluster. We concluded that the ABA gene cluster is co-regulated by BcDIM5 and BcHda1, which are essential for the normal distribution of the TB-31 ABA gene cluster H3K9me3. This work expands our understanding of the complex regulatory network of ABA biosynthesis and provides a theoretical basis for genetic improvement of high-yielding ABA strains.
Zhao Wei, Dan Shu, Xiaonan Hou, Tianfu Li, Zhemin Li, Di Luo, Jie Yang, Hong Tan

1872 related Products with: Normal distribution of H3K9me3 occupancy co-mediated by histone methyltransferase BcDIM5 and histone deacetylase BcHda1 maintains stable ABA synthesis in TB-31.

48 assays 96 assays 48 assays 96 assays 48 assays 96 assays 5mg5mg50 ug10mg100 µg10mg

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#38500015   // To Up

The dual roles of dissimilatory iron reduction in the carbon cycle: The "iron mesh" effect can increase inorganic carbon sequestration.

Dissimilatory iron reduction (DIR) can drive the release of organic carbon (OC) as carbon dioxide (CO ) by mediating electron transfer between organic compounds and microbes. However, DIR is also crucial for carbon sequestration, which can affect inorganic-carbon redistribution via iron abiotic-phase transformation. The formation conditions of modern carbonate-bearing iron minerals (IC ) and their potential as a CO sink are still unclear. A natural environment with modern IC , such as karst lake sediment, could be a good analog to explore the regulation of microbial iron reduction and sequential mineral formation. We find that high porosity is conducive to electron transport and dissimilatory iron-reducing bacteria activity, which can increase the iron reduction rate. The iron-rich environment with high calcium and OC can form a large sediment pore structure to support rapid DIR, which is conducive to the formation and growth of IC . Our results further demonstrate that the minimum DIR threshold suitable for IC formation is 6.65 μmol g  dw day . DIR is the dominant pathway (average 66.93%) of organic anaerobic mineralization, and the abiotic-phase transformation of Fe reduces CO emissions by ~41.79%. Our findings indicate that as part of the carbon cycle, DIR not only drives mineralization reactions but also traps carbon, increasing the stability of carbon sinks. Considering the wide geographic distribution of DIR and IC , our findings suggest that the "iron mesh" effect may become an increasingly important vector of carbon sequestration.
Cheng Zhao, Fan Xun, Biao Li, Xiaotong Han, Huan Liu, Yingxun Du, Qinglong L Wu, Peng Xing

1423 related Products with: The dual roles of dissimilatory iron reduction in the carbon cycle: The "iron mesh" effect can increase inorganic carbon sequestration.

1 25 G

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#38499840   2024/03/19 To Up

Ultrasensitive colorimetric detection of Staphylococcus aureus using wheat germ agglutinin and IgY as a dual-recognition strategy.

A novel colorimetric platform was designed for the determination of S. aureus by utilizing a dual-recognition strategy, where wheat germ agglutinin (WGA)-functionalized magnetic beads were served as separation elements to capture and enrich S. aureus efficiently from the matrix. Horseradish peroxidase (HRP) labeled chicken anti-protein A IgY (HRP-IgY) was used to label the captured S. aureus. A chicken IgY was introduced as a signal tracer to bind with staphylococcal protein A (SPA) on the surface of S. aureus, which can circumvent the interference from protein G-producing Streptococcus. Subsequently, the colorimetric signal was achieved by an HRP-catalyzed reaction, which was amplified by HRP-IgY bound by approximately 80,000 SPA molecules on one S. aureus. The entire detection process could be accomplished within 90 min. Under optimal conditions, the linear response of different S. aureus concentrations ranged from 7.8 × 10 to 2.0 × 10 CFU/mL and the limit of detection reached down to 3.9 × 10 CFU/mL. Some common non-target bacteria yielded negative results, indicating the excellent specificity of the method. The developed strategy was successfully applied to the determination of S. aureus in various types of samples with satisfactory recoveries. Therefore, the novel dual-recognition strategy possessed the advantages of high sensitivity, specificity, and low cost and exhibited considerable potential as a promising tool to defend public health.
Yun Zhang, Ge Tian, Xueni Sun, Xiaoli Yang, Yi Zhang, Wenqing Tan, Liangwei Duan, Shunxiang Gao, Junping Yu

2671 related Products with: Ultrasensitive colorimetric detection of Staphylococcus aureus using wheat germ agglutinin and IgY as a dual-recognition strategy.

100tests100tests100tests100tests100tests100tests100tests100tests100tests

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#38499798   2024/03/18 To Up

International nomenclature guidelines for the IL-1 family of cytokines and receptors.


Joseph M Gaballa, Jesper Falkesgaard Højen, Dennis M De Graaf, Jesus Amo-Aparicio, Carlo Marchetti, Giulio Cavalli, Alberto Dinarello, Suzhao Li, Michaele Francesco Corbisiero, Isak W Tengesdal, Jasmina S Redzic, Tania Azam, William S Webber, Karl A Pankratz, Makenna J May, Fabio Cominelli, Elan Z Eisenmesser, Soohyun Kim, Charles A Dinarello, Diana Boraschi

2830 related Products with: International nomenclature guidelines for the IL-1 family of cytokines and receptors.

1 g100ug100μg100 mg 100ul 100ul100ug100ug Lyophilized100ug100ug Lyophilized100ul100ug

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#38499792   2024/03/19 To Up

Nutrient allocation patterns of Picea crassifolia on the eastern margin of the Qinghai-Tibet Plateau.

It can provide a basis for decision making for the conservation and sustainable use of forest ecosystems in mountains to understand the stoichiometric properties and nutrient allocation strategies of major tree species. However, the plant nutrient allocation strategies under different environmental gradients in forest systems of arid and semi-arid mountains are not fully understand. Therefore, three typical regions in the Qilian Mountains on the eastern edge of the Qinghai-Tibet Plateau were selected based on precipitation and temperature gradients, and the stoichiometric characteristics and nutrient allocation strategies of Qinghai spruce (Picea crassifolia) of the dominant tree species under different environmental gradients were investigated. The results showed that (1) the stoichiometric characteristics of plant tissues were different in the three regions. (2) The importance of each tissue in the plant nutrient allocation varied in different regions, showing that the plant roots are more important in the warm-wet region, while the plant leaves, branches and trunks are more important in the transition and hot-dry regions. (3) The influencing factors affecting plant nutrient allocation strategies were inconsistent across regions, which showed that plant nutrient allocation strategies in the warm-wet and transition region were mainly influenced by soil factors, while they were more influenced by climatic factors in the hot-dry region. The patterns of plant nutrient allocation strategies and drivers under different environmental gradients could help us better understand the ecological adaptation mechanism and physiological adjustment mechanism of forest ecosystem in mountains.
Jingjing Wu, Liang Jiao, Xichen Che, Xuli Zhu, Xin Yuan

1669 related Products with: Nutrient allocation patterns of Picea crassifolia on the eastern margin of the Qinghai-Tibet Plateau.

1250 IU100.00 ul 100 G1500 Units 100ul

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#38499771   2024/03/18 To Up

Decomposition of an odorant in olfactory perception and neural representation.

Molecules-the elementary units of substances-are commonly considered the units of processing in olfactory perception, giving rise to undifferentiated odour objects invariant to environmental variations. By selectively perturbing the processing of chemical substructures with adaptation ('the psychologist's microelectrode') in a series of psychophysical and neuroimaging experiments (458 participants), we show that two perceptually distinct odorants sharing part of their structural features become significantly less discernible following adaptation to a third odorant containing their non-shared structural features, in manners independent of olfactory intensity, valence, quality or general olfactory adaptation. The effect is accompanied by reorganizations of ensemble activity patterns in the posterior piriform cortex that parallel subjective odour quality changes, in addition to substructure-based neural adaptations in the anterior piriform cortex and amygdala. Central representations of odour quality and the perceptual outcome thus embed submolecular structural information and are malleable by recent olfactory encounters.
Yuting Ye, Yanqing Wang, Yuan Zhuang, Huibang Tan, Zhentao Zuo, Hanqi Yun, Kaiqi Yuan, Wen Zhou

2145 related Products with: Decomposition of an odorant in olfactory perception and neural representation.

100ug Lyophilized100 μg1 Set1 Set1 Set100ug100ug Lyophilized1 Set1000 TESTS/0.65ml100ug Lyophilized0.1ml (1mg/ml)100 μg

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#38499575   2024/03/18 To Up

Dynamics of extrachromosomal circular DNA in rice.

The genome's dynamic nature, exemplified by elements like extrachromosomal circular DNA (eccDNA), is crucial for biodiversity and adaptation. Yet, the role of eccDNA in plants, particularly rice, remains underexplored. Here, we identify 25,598 eccDNAs, unveiling the widespread presence of eccDNA across six rice tissues and revealing its formation as a universal and random process. Interestingly, we discover that direct repeats play a pivotal role in eccDNA formation, pointing to a unique origin mechanism. Despite eccDNA's prevalence in coding sequences, its impact on gene expression is minimal, implying its roles beyond gene regulation. We also observe the association between eccDNA's formation and minor chromosomal deletions, providing insights of its possible function in regulating genome stability. Further, we discover eccDNA specifically accumulated in rice leaves, which may be associated with DNA damage caused by environmental stressors like intense light. In summary, our research advances understanding of eccDNA's role in the genomic architecture and offers valuable insights for rice cultivation and breeding.
Jundong Zhuang, Yaoxin Zhang, Congcong Zhou, Danlin Fan, Tao Huang, Qi Feng, Yiqi Lu, Yan Zhao, Qiang Zhao, Bin Han, Tingting Lu

2783 related Products with: Dynamics of extrachromosomal circular DNA in rice.

100ug1 Set1 Set1 Set25 mg1 Set500 tests10 10

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#38499551   2024/03/18 To Up

Ultrafast magnetization enhancement via the dynamic spin-filter effect of type-II Weyl nodes in a kagome ferromagnet.

The magnetic type-II Weyl semimetal (MWSM) CoSnS has recently been found to host a variety of remarkable phenomena including surface Fermi-arcs, giant anomalous Hall effect, and negative flat band magnetism. However, the dynamic magnetic properties remain relatively unexplored. Here, we investigate the ultrafast spin dynamics of CoSnS crystal using time-resolved magneto-optical Kerr effect and reflectivity spectroscopies. We observe a transient magnetization behavior, consisting of spin-flipping dominated fast demagnetization, slow demagnetization due to overall half-metallic electronic structures, and an unexpected ultrafast magnetization enhancement lasting hundreds of picoseconds upon femtosecond laser excitation. By combining temperature-, pump fluence-, and pump polarization-dependent measurements, we unambiguously demonstrate the correlation between the ultrafast magnetization enhancement and the Weyl nodes. Our theoretical modelling suggests that the excited electrons are spin-polarized when relaxing, leading to the enhanced spin-up density of states near the Fermi level and the consequently unusual magnetization enhancement. Our results reveal the unique role of the Weyl properties of CoSnS in femtosecond laser-induced spin dynamics.
Xianyang Lu, Zhiyong Lin, Hanqi Pi, Tan Zhang, Guanqi Li, Yuting Gong, Yu Yan, Xuezhong Ruan, Yao Li, Hui Zhang, Lin Li, Liang He, Jing Wu, Rong Zhang, Hongming Weng, Changgan Zeng, Yongbing Xu

2770 related Products with: Ultrafast magnetization enhancement via the dynamic spin-filter effect of type-II Weyl nodes in a kagome ferromagnet.

100 μg96T1 mL1100.00 ug1 mL

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#38499468   2024/03/18 To Up

Optimizing Molecular Crystallinity and Suppressing Electron-Phonon Coupling in Completely Non-fused Ring Electron Acceptors for Organic Solar Cells.

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Tingting Dai, Ailing Tang, Yuhan Meng, Chuanqi Dong, Peiqing Cong, Jiahao Lu, Jimin Du, Yufei Zhong, Erjun Zhou

2799 related Products with: Optimizing Molecular Crystallinity and Suppressing Electron-Phonon Coupling in Completely Non-fused Ring Electron Acceptors for Organic Solar Cells.

2 ml96 tests1.00 flask 1 G-100 µg1x10e7 cells100ug Lyophilized96 wells1 mg1.00 flask

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