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Search results for: Androst-4-ene-3,17-dion-19-oic Acid Discontinued C19H24O4 CAS: 4757-95-3

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#34555742   2021/09/15 To Up

Intermediate accumulation and toxicity reduction during the selective photoelectrochemical process of atrazine in complex water bodies.

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Baoling Niu, Junzhuo Cai, Wenjing Song, Guohua Zhao

1011 related Products with: Intermediate accumulation and toxicity reduction during the selective photoelectrochemical process of atrazine in complex water bodies.

96 tests100 ul100 ug96 wells50 ul100 ug1 mg1 mg

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#34555696   2021/09/14 To Up

p-Aminostyryl thiazole orange derivatives for monitoring mitochondrial viscosity in live cells.

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Lingling Zhang, Mengwen Yi, Shilong Zhong, Jing Liu, Xiangjun Liu, Tao Bing, Nan Zhang, Yongbiao Wei, Dihua Shangguan

1355 related Products with: p-Aminostyryl thiazole orange derivatives for monitoring mitochondrial viscosity in live cells.

250 mg1 kit

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#34555585   2021/09/16 To Up

Multiple fouling dynamics, interactions and synergistic effects in brackish surface water distribution systems.

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Tahir Muhammad, Lei Li, Yang Xiao, Yunpeng Zhou, Zeyuan Liu, Xin He, Nazir Ahmed Bazai, Yunkai Li

1351 related Products with: Multiple fouling dynamics, interactions and synergistic effects in brackish surface water distribution systems.



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#34555581   2021/09/18 To Up

Reduction of Cu and nitrate leaching risk associated with EDDS-enhanced phytoextraction process by exogenous inoculation of plant growth promoting rhizobacteria.

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Wenliang Ju, Chengjiao Duan, Lei Liu, Xiaolian Jin, Gabriela Bravo-Ruiseco, Yuxia Mei, Linchuan Fang

1871 related Products with: Reduction of Cu and nitrate leaching risk associated with EDDS-enhanced phytoextraction process by exogenous inoculation of plant growth promoting rhizobacteria.

5 ml4/120 Packing /sleeve/bo1 ml1 ml1 ml5 ml4/120 Packing /sleeve/bo5 ml 5 G4/120 Packing /sleeve/boOne 96-Well Strip Micropl

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#34555510   2021/09/20 To Up

Evidence for two distinct thalamocortical circuits in retrosplenial cortex.

Retrosplenial cortex (RSC) lies at the interface between sensory and cognitive networks in the brain and mediates between these, although it is not yet known how. It has two distinct subregions, granular (gRSC) and dysgranular (dRSC). The present study investigated how these subregions differ with respect to their electrophysiology and thalamic connectivity, as a step towards understanding their functions. The gRSC is more closely connected to the hippocampal formation, in which theta-band local field potential oscillations are prominent. We, therefore, compared theta-rhythmic single-unit activity between the two RSC subregions and found, mostly in gRSC, a subpopulation of non-directional cells with spiking activity strongly entrained by theta oscillations, suggesting a stronger coupling of gRSC to the hippocampal system. We then used retrograde tracers to test for differential inputs to RSC from the anteroventral thalamus (AV). We found that gRSC and dRSC differ in their afferents from two AV subfields: dorsomedial (AVDM) and ventrolateral (AVVL). Specifically: (1) as a whole AV projects more strongly to gRSC; (2) AVVL targets both gRSC and dRSC, while AVDM provides a selective projection to gRSC, (3) the gRSC projection is layer-specific: AVDM targets specifically gRSC superficial layers. These same AV projections are topographically organized with ventral AV neurons innervating rostral RSC and dorsal AV neurons innervating caudal RSC. These combined results suggest the existence of two distinct but interacting RSC subcircuits: one connecting AVDM to gRSC that may comprise part of the cognitive hippocampal system, and the other connecting AVVL to both RSC regions that may link hippocampal and perceptual regions. We suggest that these subcircuits are distinct to allow for differential weighting during integration of converging sensory and cognitive computations: an integration that may take place in thalamus, RSC, or both.
Eleonora Lomi, Mathias L Mathiasen, Han Yin Cheng, Ningyu Zhang, John P Aggleton, Anna S Mitchell, Kate J Jeffery

2658 related Products with: Evidence for two distinct thalamocortical circuits in retrosplenial cortex.

1 G 5 G500 MG 100 G250 mg 1 G20

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#34555495   2021/09/20 To Up

Engineering high coenzyme Q tomato.

Coenzyme Q (CoQ) is vital for energy metabolism in living organisms. In humans, CoQ deficiency causes diseases and must be replenished via diet; however, CoQ content in plant foods is primarily low. Here, we report the breeding of high CoQ tomato lines by expressing four enzymes with a fruit-specific promoter, which modifies the chloroplast chorismate pathway, enhances cytosolic isoprenoid biosynthesis, and up-regulates the first two reactions in mitochondrion that construct the CoQ polyisoprenoid tail. We show that, while the level of the aromatic precursor could be markedly elevated, head group prenylation is the key to increasing the final CoQ yield. In the HUCD lines expressing all four transgenes, the highest CoQ content (0.15 mg/g dry weight) shows a seven-fold increase from the wild-type level and reaches an extraordinarily rich CoQ food grade. Overviewing the changes in other terpenoids by transcriptome and metabolic analyses reveals variable contents of carotenoids and α-tocopherol in the HUCD lines. In addition to the enigmatic relations among different terpenoid pathways, high CoQ plants maintaining substantial levels of either vitamin can be selected. Our investigation paves the way for the development of CoQ-enriched crops as dietary supplements.
Hang Fan, Yan Liu, Chen-Yi Li, Yan Jiang, Jiao-Jiao Song, Lei Yang, Qing Zhao, Yong-Hong Hu, Xiao-Ya Chen, Jing-Jing Xu

2337 related Products with: Engineering high coenzyme Q tomato.

200 Tests4 Membranes/Box25 ml. 25 G96 tests4 Arrays/Slide25016 Arrays/Slide10 Plates100ug Lyophilized

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#34555477   2021/09/20 To Up

Co-assembled Nanocomplexes of Peptide Neoantigen Adpgk and Toll-like Receptor 9 Agonist CpG ODN for Efficient Colorectal Cancer Immunotherapy.

Cancer vaccines targeting tumor specific neoantigens derived from nonsynonymous mutations of tumor cells have emerged as an effective approach to induce antitumor T cells responses for personalized cancer immunotherapy. Despite the enormous potential of synthetic peptides as a common modality for neoantigen vaccines, their practical efficacy was limited due to their relatively low immunogenicity. Herein, we modify neoantigen peptide (Adpgk) derived from MC-38 colon carcinoma by supplementing ten consecutive positively-charged lysine (10K-Adpgk) to obtain cationic polypeptide. And then we made them self-assemble with toll-like receptor 9 (TLR-9) agonist CpG oligodeoxynucleotides (CpG ODN) adjuvant directly forming antigen/adjuvant integrated nanocomplexes (PCNPs) through electrostatic interaction for potent tumor immunotherapy. The optimal formed PCNPs were around 175 nm with uniform size distribution and could maintain stable in physiological saline solution. CpG ODN and 10K-Adpgk in the formed PCNPs could be effectively uptake by dendritic cells (DCs) and stimulate the maturation of DCs as well as improving the efficiency of antigen cross-presentation efficiency in vitro. Furthermore, the PCNPs vaccine could markedly improve neoantigen and adjuvant co-delivery efficiency to lymphoid organs and activate cytotoxic T cells. In addition, vaccination with PCNPs could not only offer prophylactic to protect mice from challenged MC-38 colorectal tumors, but also achieve a better anti-tumor effect in an established colorectal tumor model, and significantly prolong the survival rate of tumor-bearing mice. Therefore, this work provided a versatile but effective method for neoantigen peptide and CpG ODN co-assembly vaccine platform for efficient colorectal cancer immunotherapy.
Zhaoyuan Liang, Xinyue Cui, Liqun Yang, Qin Hu, Danyang Li, Xiaofei Zhang, Lu Han, Siwei Shi, Yurong Shen, Weijian Zhao, Qi Ju, Xiongwei Deng, Yan Wu, Wang Sheng

1875 related Products with: Co-assembled Nanocomplexes of Peptide Neoantigen Adpgk and Toll-like Receptor 9 Agonist CpG ODN for Efficient Colorectal Cancer Immunotherapy.

20 96well200ul100.00 ug100ul100ug50 ug 100ug5mg200ug100ul200

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