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Search results for: (5α)-Androstane-3,11,17-trione C19H26O3 CAS: 1482-70-8

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#34525229   2021/09/15 To Up

Altered albedo dominates the radiative forcing changes in a subtropical forest following an extreme snow event.

Subtropical forests are important ecosystems globally due to their extensive role in carbon sequestration. Extreme climate events are known to introduce disturbances in the ecosystem that cause long-term changes in carbon balance and radiation reflectance. However, how these ecosystem function changes contribute to global warming in terms of radiative forcing (RF), especially in the years following a disturbance, still needs to be investigated. We studied an extreme snow event that occurred in a subtropical evergreen broad-leaved forest in southwestern China in 2015 and used 9 years (2011-2019) of net ecosystem CO exchange (NEE) and surface albedo (α) data to investigate the effect of the event on the ecosystem RF changes. In the year of the disturbance, leaf area index (LAI) declined by 40% and α by 32%. The annual NEE was -718 ± 128 gC m as a sink in the pre-disturbance years (2011-2014), but after the event, the sink strength dropped significantly by 76% (2015). Both the vegetation, indicated by LAI, and α recovered to pre-disturbance levels in the fourth post-disturbance year (2018). However, the NEE recovery lagged and occurred a year later in 2019, suggesting a more severe and lasting impact on the ecosystem carbon balance. Overall, the extreme event caused a positive (warming effect) net RF which was predominantly caused by changes in α (90-93%) rather than those in NEE. This result suggests that, compared to the climate effect caused by forest carbon sequestration changes, the climate effect of α alterations can be more sensitive to vegetation damage induced by natural disturbances. Moreover, this study demonstrates the important role of vegetation recovery in driving canopy reflectance and ecosystem carbon balance during the post-disturbance period, which determines the ecosystem feedbacks to the climate change.
Gnanamoorthy Palingamoorthy, Qing-Hai Song, Zhao Junbin, Yiping Zhang, Yuntong Liu, Wenjun Zhou, Liqing Sha, Zexin Fan, Pramit Kumar Deb Burman

2017 related Products with: Altered albedo dominates the radiative forcing changes in a subtropical forest following an extreme snow event.

100 μg4 Arrays/Slide1.00 mg1 Set1 Set

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#34525158   2021/09/15 To Up

Unidirectional water transport on a two-dimensional hydrophilic channel with anisotropic superhydrophobic barriers.

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Qier An, Jinshu Wang, Feng Zhao, Peiliu Li, Lei Wang

1108 related Products with: Unidirectional water transport on a two-dimensional hydrophilic channel with anisotropic superhydrophobic barriers.

50μl100ug40 LB0.1 ml100ug Lyophilized0.1ml (1mg/ml)1 mg0,5 ML100ug0.2 mg100ug Lyophilized

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#34524845   2021/09/15 To Up

TIPE2 is a checkpoint of natural killer cell maturation and antitumor immunity.

[Figure: see text].
Jiacheng Bi, Chen Cheng, Chaoyue Zheng, Chen Huang, Xiaohu Zheng, Xiaochun Wan, Youhai H Chen, Zhigang Tian, Haoyu Sun

2313 related Products with: TIPE2 is a checkpoint of natural killer cell maturation and antitumor immunity.

200 100ug Lyophilized100ug Lyophilized100ug Lyophilized 100ul100ug Lyophilized0.1 mg100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized

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#34524826   2021/09/15 To Up

Impact of Lipid Peroxidation on the Response of Cell Membranes to High-Speed Equibiaxial Stretching: A Computational Study.

The difference between diseased and healthy cellular membranes in response to mechanical stresses is crucial for biology, as well as in the development of medical devices. However, the biomolecular mechanisms by which mechanical stresses interact with diseased cellular components remain largely unknown. In this work, we focus on the response of diseased cellular membranes with lipid peroxidation to high-speed tensile loadings. We find that the critical areal strain (ξ, when the pore forms) is highly sensitive to lipid peroxidation. For example, ξ of a fully oxidized bilayer is only 64 and 69% of the nonoxidized one at the stretching speed of 0.1 and 0.6 m/s, respectively. ξ decreases with the increase in the oxidized lipid ratio, regardless of the speeds. Also, the critical rupture tension of membranes exhibits a similar change. It is obvious that the oxidized membranes are more easily damaged than normal ones by high-speed stretching, which coincides with experimental findings. The reason is that peroxidation introduces a polar group to the tail of lipids, increases the hydrophilicity of tails, and warps the tails to the membrane-water interface, which causes loose accumulation and disorder of lipid tails. This can be deduced from the variation in the area per lipid and order parameter. In addition, the lowering stretching modulus and line tension of membranes (i.e., softening) after lipid peroxidation is also a significant factor. We reveal the difference between the peroxidized (diseased) and normal membrane in response to high-speed stretching, give the ξ value in the pore formation of membranes and analyze the influence of the stretching speed, peroxidation ratio, and molecular structure of phospholipids. We hope that the molecular-level information will be useful for the development of biological and medical devices in the future.
Lingzhi Gu, Tong Wei, Mi Zhou, Hong Yang, Yang Zhou

1860 related Products with: Impact of Lipid Peroxidation on the Response of Cell Membranes to High-Speed Equibiaxial Stretching: A Computational Study.

1 kit100 assays100 extractions1 kit

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#34524792   2021/09/15 To Up

Microplastics in a Remote Lake Basin of the Tibetan Plateau: Impacts of Atmospheric Transport and Glacial Melting.

Plastic pollution is fast becoming one of the most pressing global issues that we currently face. Remote areas, such as the polar regions and the Tibetan Plateau, are now also exposed to microplastic contamination. However, with the impact of global warming, the transport of microplastics within the glacier-lake basins in such regions remains unclear. In this work, the Nam Co Basin in the Tibetan Plateau was selected to study the characteristics of microplastics in the rain fallout, lake water, glacial runoff, and non-glacial runoff. Fiber and films were the most common microplastic morphologies in all water samples; a higher proportion (37%) of light-weighing polypropylene and small-size (50-300 μm, ∼30%) microplastics were found in the glacial runoff. Air mass trajectory analysis showed that microplastics could be transported through the atmosphere over a distance of up to 800 km. For microplastic loading in lakes, the atmospheric fallout was estimated to be 3.3 tons during the monsoon season, whereas the contributions of glacial runoff (∼41 kg) and non-glacial runoff (∼522 kg) were relatively low. For the microplastic loading in glaciers, the atmospheric deposition was ∼500 kg/yr, and the output caused by glacial melting only accounted 8% of the total atmospheric input. All these results suggested that the dominant pathway through which microplastics enter remote mountainous lake basins is atmospheric deposition, and once deposited on glaciers, microplastics will be stored for a long time. This work provides quantitative evidence elucidating the fate of microplastics in alpine lake environments.
Huike Dong, Lanxiang Wang, Xiaoping Wang, Li Xu, Mengke Chen, Ping Gong, Chuanfei Wang

1562 related Products with: Microplastics in a Remote Lake Basin of the Tibetan Plateau: Impacts of Atmospheric Transport and Glacial Melting.

1100 μg100 μg

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#34524661   // To Up

Isolation and Detection of Murine iNKT Cells in Different Organs.

The invariant NKT (iNKT) cells are innate-like lymphocytes that share phenotypic and functional characteristics with NK cells and T cells, playing an important role in both human and mouse physiology and disease and bridging the gap between the innate and adaptive immune responses. The frequency and subtypes of iNKT cells in major immune organs are different, which also determines the regional immune characteristics of iNKT cells. Here, we report a protocol about the isolation of iNKT cells in the thymus, spleen, and liver of C57BL/6, CD1d, and Jα18 mice.
Mengqing Cong, Xiang Li, Haopeng Fang, Li Bai, Xucai Zheng, Bofeng Li

2868 related Products with: Isolation and Detection of Murine iNKT Cells in Different Organs.

1 mg10 ug1x10e7 cells5 x 50 ug1x10e7 cells1.00 flask

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#34524446   2021/09/15 To Up

The repair of topoisomerase 2 cleavage complexes in Arabidopsis.

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Leonie Hacker, Annika Dorn, Janina Enderle, Holger Puchta

2824 related Products with: The repair of topoisomerase 2 cleavage complexes in Arabidopsis.

1mg15mg25mg5mg1020ug

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#34524200   // To Up

Bacteriophages against enteropathogens: rediscovery and refinement of novel antimicrobial therapeutics.

Alarming rates of antibiotic resistance in bacteria and gastrointestinal dysbiosis associated with traditional antimicrobial therapy have led to renewed interests in developing bacteriophages as novel therapeutics. In this review, we highlight some of the recent advances in bacteriophage therapeutic development targeting important enteropathogens of the gastrointestinal tract.
Yrvin León, Christina S Faherty

1225 related Products with: Bacteriophages against enteropathogens: rediscovery and refinement of novel antimicrobial therapeutics.

200ul2.5 mg10 mg100ug Lyophilized100 mg100ug25 mg50 ug 100 mg100ug Lyophilized 25 MG100ul

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#34523920   2021/09/15 To Up

Life Cycle Exposure to Environmentally Relevant Concentrations of Diphenyl Phosphate (DPhP) Inhibits Growth and Energy Metabolism of Zebrafish in a Sex-Specific Manner.

Due to commercial uses and environmental degradation of aryl phosphate esters, diphenyl phosphate (DPhP) is frequently detected in environmental matrices and is thus of growing concern worldwide. However, information on potential adverse effects of chronic exposure to DPhP at environmentally realistic concentrations was lacking. Here, we investigated the effects of life cycle exposure to DPhP on zebrafish at environmentally relevant concentrations of 0.8, 3.9, or 35.6 μg/L and employed a dual-omics approach (metabolomics and transcriptomics) to characterize potential modes of action. Exposure to DPhP at 35.6 μg/L for 120 days resulted in significant reductions in body mass and length of male zebrafish, but did not cause those same effects to females. Predominant toxicological mechanisms, including inhibition of oxidative phosphorylation, down-regulation of fatty acid oxidation, and up-regulation of phosphatidylcholine degradation, were revealed by integrated dual-omics analysis and successfully linked to adverse outcomes. Activity of succinate dehydrogenase and protein content of carnitine -palmitoyltransferase 1 were significantly decreased in livers of male fish exposed to DPhP, which further confirmed the proposed toxicological mechanisms. This study is the first to demonstrate that chronic, low-level exposure to DPhP can retard growth via inhibiting energy output in male zebrafish.
Qiliang Chen, Xiaolong Lian, Jingjing An, Ningbo Geng, Haijun Zhang, Jonathan K Challis, Yun Luo, Yaxin Liu, Guanyong Su, Yuwei Xie, Yingwen Li, Zhihao Liu, Yanjun Shen, John P Giesy, Yufeng Gong

1142 related Products with: Life Cycle Exposure to Environmentally Relevant Concentrations of Diphenyl Phosphate (DPhP) Inhibits Growth and Energy Metabolism of Zebrafish in a Sex-Specific Manner.

4 Membranes/Box2 Pieces/Box2 Pieces/Box2 Pieces/Box2 Pieces/Box2 Pieces/Box100.00 ug4 Membranes/Box4 Arrays/Slide2.50 nmol4 Arrays/Slide2 Pieces/Box

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#34523916   2021/09/15 To Up

Structural Transformation of Heterogeneous Materials for Electrocatalytic Oxygen Evolution Reaction.

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Hui Ding, Hongfei Liu, Wangsheng Chu, Changzheng Wu, Yi Xie

2902 related Products with: Structural Transformation of Heterogeneous Materials for Electrocatalytic Oxygen Evolution Reaction.

50000 Units500 20 ml100ug100ul100 mg1 kit10 mg 1000 ml 250 Units 1 G

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