Search results for: (S)-Azelastine Hydrochloride C22H25Cl2N3O CAS: 153408-27-6
#38648899 
2024/04/20
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Pre-eclamptic foetal programming predisposes offspring to hepatic steatosis via DNA methylation.
Gamete and embryo-foetal origins of adult diseases hypothesis proposes that adulthood chronic disorders are associated with adverse foetal and early life traits. Our study aimed to characterise developmental changes and underlying mechanisms of metabolic disorders in offspring of pre-eclampsia (PE) programmed pregnancy.Huixi Chen, Sisi Luo, Xiuyu Deng, Sisi Li, Yiting Mao, Jing Yan, Yi Cheng, Xia Liu, Jiexue Pan, Hefeng Huang
1286 related Products with: Pre-eclamptic foetal programming predisposes offspring to hepatic steatosis via DNA methylation.
100ug/vial10 1g1 module100 ug/vial100 ul100ug Lyophilized25 mg1 kit(96 Wells)200 ug300 units2.5 mg
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#38618031 2024/01/31
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Constipation anti-aging effects by dairy-based lactic acid bacteria.
Constipation, which refers to difficulties in defecation and infrequent bowel movement in emptying the gastrointestinal system that ultimately produces hardened fecal matters, is a health concern in livestock and aging animals. The present study aimed to evaluate the potential effects of dairy-isolated lactic acid bacteria (LAB) strains to alleviate constipation as an alternative therapeutic intervention for constipation treatment in the aging model. Rats were aged via daily subcutaneous injection of D-galactose (600 mg/body weight [kg]), prior to induction of constipation via oral administration of loperamide hydrochloride (5 mg/body weight [kg]). LAB strains ( USM 4189 or USM 4187) were administered daily via oral gavage (1 × 10 Log CFU/day) while the control group received sterile saline. Aged rats as shown with shorter telomere lengths exhibited increased fecal bulk and soften fecal upon administration of LAB strains amid constipation as observed using the Bristol Stool Chart, accompanied by a higher fecal moisture content as compared to the control ( < 0.05). Fecal water-soluble metabolite profiles showed a reduced concentration of threonine upon administration of LAB strains compared to the control ( < 0.05). Histopathological analysis also showed that the administration of LAB strains contributed to a higher colonic goblet cell count as compared to the control ( < 0.05). The present study illustrates the potential of dairy-sourced LAB strains as probiotics to ameliorate the adverse effect of constipation amid aging, and as a potential dietary intervention strategy for dairy foods including yogurt and cheese.Mohamad Hafis Jaafar, Pei Xu, Uma-Mageswary Mageswaran, Shandra-Devi Balasubramaniam, Maheswaran Solayappan, Jia-Jie Woon, Cindy Shuan-Ju Teh, Svetoslav Dimitrov Todorov, Yong-Ha Park, Guoxia Liu, Min-Tze Liong
1873 related Products with: Constipation anti-aging effects by dairy-based lactic acid bacteria.
100ug Lyophilized 10 UG100ug Lyophilized100ug Lyophilized100.00 ug100ug Lyophilized100 µl100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized
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#38578703 2024/04/05
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-Fluorosulfonyl Guanidine: An Entry to -Guanyl Sulfamides and Sulfamates.
Here, we present the straightforward synthesis of -fluorosulfonyl guanidine () from two industrial feedstocks, guanidine hydrochloride and sulfuryl fluoride (SOF), using SuFEx chemistry. Compound exhibits excellent stability under ambient conditions and displays unique SuFEx reactivity toward amines and phenols to generate -guanyl sulfamides and sulfamates that have rarely been accessed. Notably, water serves as an effective solvent in this process. Our protocol provides a reliable pathway for the synthesis and investigation of these novel guanidine-containing molecules.Wei Wang, Jingyuan Li, Long Xu, Jiajia Dong
2851 related Products with: -Fluorosulfonyl Guanidine: An Entry to -Guanyl Sulfamides and Sulfamates.
1 module100 ug2.5 mg1 kit(96 Wells)1 module1 mg100ul100 mg100ug1 mg200 ug20
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#38574538 2024/04/01
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Highly sensitive "off-on" sensor based on MXene and magnetic microspheres for simultaneous detection of lung cancer biomarkers - Neuron specific enolase and carcinoembryonic antigen.
In this work, a highly sensitive lung cancer biomarkers detection probe was developed based on Ag and MXene co-functionalized magnetic microspheres. By using carboxyl magnetic microspheres as carrier, MXene was coated repeatedly by Poly (allylamine hydrochloride) (PAH) as interlayer adhesive, and silver particles grown on the surface of MXene in situ can efficiently improve the sensitivity of the probe. The detection of neuron specific enolase (NSE) is mainly through the formation of a specific complex between NSE antigen and antibody, and the release of antibody labeled with amino carbon quantum dots (CQDs) from the surface of Ag nanoparticles (AgNPs), so that the fluorescence is restored and "OFF-ON" is formed. The biosensor exhibits excellently wide linear range (0.0001-1500 ng/mL) and the limit of detection (LOD) is up to 0.03 pg/mL, which is superior to most tumor marker probes based on fluorescence mechanism. Furthermore, we constructed dual detection strategy for NSE and carcinoembryonic antigen (CEA) simultaneously.Chenyu Yin, Xiang Zhao, Zhizhou Liu, Le Ma, Pengyun Sun, Liang He, Huajie Huang, Pengli Bai
2515 related Products with: Highly sensitive "off-on" sensor based on MXene and magnetic microspheres for simultaneous detection of lung cancer biomarkers - Neuron specific enolase and carcinoembryonic antigen.
1 mg96T0.2 mg2 Pieces/Box96 tests0.1 mg4 Membranes/Box4 Arrays/Slide
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#38528777 2024/03/25
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In Situ Synthesized Low-Dimensional Perovskite for >25% Efficiency Stable MA-Free Perovskite Solar Cells.
DYong Li, Yuwei Duan, Zhike Liu, Lu Yang, Hongxiang Li, Qunping Fan, Hui Zhou, Yiqiao Sun, Meizi Wu, Xiaodong Ren, Ningyi Yuan, Jianning Ding, Shaoming Yang, Shengzhong Liu
2397 related Products with: In Situ Synthesized Low-Dimensional Perovskite for >25% Efficiency Stable MA-Free Perovskite Solar Cells.
96 assays96 tests10 ugOne Vial: 5 X 10^6 Cells5 ml500 MG1 mg2 ml1.00 flask
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#37965749 2023/11/15
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Atomically Precise Metal Nanocluster Photosystem: Electron Relay Boosts Photocatalytic Organic Transformation.
AQing Chen, Xing-Zu Ge, Linhui Yu, Fang-Xing Xiao
1327 related Products with: Atomically Precise Metal Nanocluster Photosystem: Electron Relay Boosts Photocatalytic Organic Transformation.
100μg100ug100μg100ug250 g100μg100ug100μg96T100μg100μg100μg
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#37866592 2023/10/20
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Contamination of water, soil, and plants by micropollutants from reclaimed wastewater and sludge from a wastewater treatment plant.
SRadka Kodešová, Helena Švecová, Aleš Klement, Miroslav Fér, Antonín Nikodem, Ganna Fedorova, Oleksandra Rieznyk, Martin Kočárek, Alina Sadchenko, Alica Chroňáková, Roman Grabic
1856 related Products with: Contamination of water, soil, and plants by micropollutants from reclaimed wastewater and sludge from a wastewater treatment plant.
100 mg 25 MG100ug200 25 mg0.1 mg100ug10 mg1000 tests100ul200ul
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#37802505 2023/12/07
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Optimizing the Buried Interface in Flexible Perovskite Solar Cells to Achieve Over 24% Efficiency and Long-Term Stability.
TRuoyao Xu, Fang Pan, Jinyu Chen, Jingrui Li, Yingguo Yang, Yulu Sun, Xinyi Zhu, Peizhou Li, Xiangrong Cao, Jun Xi, Jie Xu, Fang Yuan, Jinfei Dai, Chuantian Zuo, Liming Ding, Hua Dong, Alex K-Y Jen, Zhaoxin Wu
2659 related Products with: Optimizing the Buried Interface in Flexible Perovskite Solar Cells to Achieve Over 24% Efficiency and Long-Term Stability.
100 μg 0.1 mg 1x10e7 cells1.00 flask100 μg
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#37757611 2023/07/22
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Blocking sphingosine 1-phosphate receptor 1 with modulators reduces immune cells infiltration and alleviates endometriosis in mice.
Do sphingosine 1-phosphate (S1P) modulators have therapeutic effects on endometriosis in mice and, if they do, which receptor is responsible for these effects?Fengrui Zhang, Mingyi Peng, Xufen Zheng, Xiaofang Wang, Xiaoxiao Liu, Chun Chen, Yuan Lu
2012 related Products with: Blocking sphingosine 1-phosphate receptor 1 with modulators reduces immune cells infiltration and alleviates endometriosis in mice.
100ug100ug Lyophilized100ug100ug100ug Lyophilized100ul100ug100ug100ug100ug Lyophilized 1 G100ug
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#37531764 2023/07/26
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Dissipation of twelve organic micropollutants in three different soils: Effect of soil characteristics and microbial composition.
The dissipation kinetics and half-lives of selected organic micropollutants, including pharmaceuticals and others, were systematically investigated and compared among different soil types. While some pollutants (e.g., atorvastatin, valsartan, and bisphenol S) disappeared rapidly in all the tested soils, many of them (e.g., telmisartan, memantine, venlafaxine, and azithromycin) remained persistent. Irrespective of the soil characteristics, venlafaxine showed the lowest dissipation kinetics and the longest half-lives (250 to approximately 500 days) among the stable compounds. The highest first and second-order kinetics were, however, recorded for valsartan (k; 0.262 day) and atorvastatin (k; 33.8 g μg day) respectively. Nevertheless, more than 90% (i.e., DT) of all the rapidly dissipated compounds (i.e., atorvastatin, bisphenol S, and valsartan) disappeared from the tested soils within a short timescale (i.e., 5-36 days). Dissipation of pollutants that are more susceptible to microbial degradation (e.g., atorvastatin, bisphenol S, and valsartan) seems to be slower for soils possessing the lowest microbial biomass C (C) and total phospholipid fatty acids (PLFA), which also found statistically significant. Our results revealing the persistence of several organic pollutants in agricultural soils, which might impact the quality of these soils, the groundwater, and eventually on the related biota, is of high environmental significance.Sunil Paul M Menacherry, Radka Kodešová, Ganna Fedorova, Alina Sadchenko, Martin Kočárek, Aleš Klement, Miroslav Fér, Antonín Nikodem, Alica Chroňáková, Roman Grabic