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#36944570 
2023/03/21
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Altered GABA receptor function in women with endometriosis: a possible pain-related mechanism.
The mechanism underlying endometriosis-related pain remains poorly understood. Previous studies have indicated that γ-aminobutyric acid (GABA) type A (GABA ) receptors and GABAergic substances (eg endogenous neurosteroids) play important mechanistic roles in various pain conditions. Our primary objective was to compare GABA receptor function between women with endometriosis and healthy controls by performing a challenge test with diazepam, a GABA receptor agonist, using the saccadic eye velocity as the main outcome. The secondary objective was to investigate the relationship between GABA receptor function and serum levels of allopregnanolone, an endogenous positive modulator of the GABA receptor, in the participating women.Anton Sandström, Marie Bixo, Torbjörn Bäckström, Anna Möller, Sahruh Turkmen