Search results for: ADAM
#34130245 2021/05/20 To Up
Does sponge pads wear affect the distribution of electric field generated by tDCS?
1120 related Products with: Does sponge pads wear affect the distribution of electric field generated by tDCS?min 2 cartons100.00 ul 50 UG200 units1 100 G1500 Units
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#34130123 2021/06/11 To Up
Single and double modified salinomycin analogs target stem-like cells in 2D and 3D breast cancer models.Breast cancer remains one of the leading cancers among women. Cancer stem cells (CSCs) are tumor-initiating cells which drive progression, metastasis, and reoccurrence of the disease. CSCs are resistant to conventional chemo- and radio-therapies and their ability to survive such treatment enables tumor reestablishment. Metastasis is the main cause of mortality in women with breast cancer, thus advances in treatment will depend on therapeutic strategies targeting CSCs. Salinomycin (SAL) is a naturally occurring polyether ionophore antibiotic known for its anticancer activity towards several types of tumor cells. In the present work, a library of 17 C1-single and C1/C20-double modified SAL analogs was screened to identify compounds with improved activity against breast CSCs. Six single- and two double-modified analogs were more potent (IC range of 1.1Â Â±Â 0.1-1.4Â Â±Â 0.2Â ÂµM) toward the breast cancer cell line MDA-MB-231 compared to SAL (IC of 4.9Â Â±Â 1.6Â ÂµM). Double-modified compound 17 was found to be more efficacious than SAL against the majority of cancer cell lines in the NCI-60 Human Tumor Cell Line Panel. Compound 17 was more potent than SAL in inhibiting cell migration and cell renewal properties of MDA-MB-231 cells, as well as inducing selective loss of the CD44/CD24 stem-cell-like subpopulation in both monolayer (2D) and organoid (3D) culture. The present findings highlight the therapeutic potential of SAL analogs towards breast CSCs and identify select compounds that merit further study and clinical development.
Alicja Urbaniak, Megan R Reed, Daniel Fil, Anika Moorjani, Sarah Heflin, MichaÅ Antoszczak, MichaÅ Sulik, Adam HuczyÅski, Michalina Kupsik, Robert L Eoff, Melanie C MacNicol, Timothy C Chambers, Angus M MacNicol
1135 related Products with: Single and double modified salinomycin analogs target stem-like cells in 2D and 3D breast cancer models.
#34129520 2021/06/15 To Up
Coping with Coronavirus Disease 2019: Developing a Rapid-cycle Frontline Quality-improvement Process to Support Employee Well-being and Drive Institutional Responsiveness in a Tertiary Care Faith-based Hospital in Rural Kenya.The coronavirus disease 2019 (COVID-19) pandemic has demanded rapid institutional responses to meet the needs of patients and employees in the face of a serious new disease. To support the well-being of frontline staff, a series of debriefing sessions was used to drive a rapid-cycle quality-improvement process. The goals were to confidentially determine personal coping strategies used by staff, provide an opportunity for staff cross-learning, identify what staff needed most, and provide a real-time feedback loop for decision-makers to create rapid changes to support staff safety and coping. Data were collected via sticky notes on flip charts to protect confidentiality. Management reviewed the data daily. Institutional responses to problems identified during debrief sessions were tracked, visualized, addressed, and shared with staff. More than 10% of staff participated over a 2-week period. Feedback influenced institutional decisions to improve staff schedules, transportation, and COVID-19 training.
Mary B Adam, Naomi Wambui Makobu, Wilson Karuri Kamiru, Simon Mbugua, Faith Mailu
1879 related Products with: Coping with Coronavirus Disease 2019: Developing a Rapid-cycle Frontline Quality-improvement Process to Support Employee Well-being and Drive Institutional Responsiveness in a Tertiary Care Faith-based Hospital in Rural Kenya.100 1 mg100 μg500 tests2 Pieces/Box
#34128984 2021/06/15 To Up
HoxD transcription factors define monosynaptic sensory-motor specificity in the developing spinal cord.The specificity of monosynaptic connections between proprioceptive sensory neurons and their recipient spinal motor neurons depends on multiple factors, including motor neuron positioning and dendrite morphology, axon projection patterns of proprioceptive sensory neurons in the spinal cord, and the ligand-receptor molecules involved in cell-to-cell recognition. However, with few exceptions, the transcription factors engaged in this process are poorly characterized. Here, we show that members of the HoxD family of transcription factors play a crucial role in the specificity of monosynaptic sensory-motor connections. Mice lacking Hoxd9, Hoxd10 and Hoxd11 exhibit defects in locomotion but have no obvious defects in motor neuron positioning or dendrite morphology through the medio-lateral and rostro-caudal axes. However, we found that quadriceps motor neurons in these mice show aberrant axon development and receive inappropriate inputs from proprioceptive sensory axons innervating the obturator muscle. These genetic studies demonstrate that the HoxD transcription factors play an integral role in the synaptic specificity of monosynaptic sensory-motor connections in the developing spinal cord.
Fumiyasu Imai, Mike Adam, S Steven Potter, Yutaka Yoshida
2227 related Products with: HoxD transcription factors define monosynaptic sensory-motor specificity in the developing spinal cord.100 16962 Pieces/Box96100 μg
#34128555 2021/06/15 To Up
Distress and retaliatory aggression in response to witnessing intergroup exclusion are greater on higher levels of collective narcissism.The negative consequences of personal exclusion have been demonstrated by multiple studies. Less is known about the consequences of witnessing one's own group being excluded by other groups, although studies suggest exclusion can be experienced vicariously and negatively affects members of the excluded group. Results of the present lab-based experiment (NÂ =Â 153) indicate, in line with our predictions, that witnessing intergroup exclusion (a national majority excluded by a minority, manipulated by an adapted intergroup Cyberball paradigm) produced a sense of personal exclusion. It also increased self-reported distress and behavioral aggression measured in the Taylor Aggression Paradigm), especially among participants high on collective narcissism: a belief that the exaggerated greatness of the in-group is not sufficiently appreciated by others. Contrary to expectations, a short mindful decentration intervention (instructing participants to observe thoughts and emotions as transient mental products without engaging with them) delivered while participants were witnessing intergroup exclusion (vs. inclusion) produced changes in heart rate variability reactivity indicative of emotional arousal, especially among collective narcissists. We concluded that collective narcissism is associated with distress in the face of intergroup exclusion, aggressive retaliation, and in consequence, it is a risk-factor predisposing group members to stress-related health and psychosocial problems. Furthermore, a mindful decentration, despite being an effective strategy to reduce maladaptive stress in most people, may be counterproductive in addressing high collective narcissists' responses to threat to the in-group's image.
Adrian Hase, Maciej Behnke, Magdalena Mazurkiewicz, Kamil Kordian Wieteska, Agnieszka Golec de Zavala
1682 related Products with: Distress and retaliatory aggression in response to witnessing intergroup exclusion are greater on higher levels of collective narcissism.96Tcase96 wells (1 kit)case1 mg100ug
#34128394 2021/06/15 To Up
Bidirectional connectivity between Broca's area and Wernicke's area during interactive verbal communication.This investigation aims to advance understanding of the neural dynamics that underlie live and natural interactions during spoken dialogue between two-individuals.
Yumie Ono, Xian Zhang, J Adam Noah, Swethasri Dravida, Joy Hirsch
1502 related Products with: Bidirectional connectivity between Broca's area and Wernicke's area during interactive verbal communication.case1 L.5 per Sleeve, 100 Flasks/case50 ug 100ug50 ug 100ug100ug
#34127850 2021/06/14 To Up
Perinatal stroke: mapping and modulating developmental plasticity.Most cases of hemiparetic cerebral palsy are caused by perinatal stroke, resulting in lifelong disability for millions of people. However, our understanding of how the motor system develops following such early unilateral brain injury is increasing. Tools such as neuroimaging and brain stimulation are generating informed maps of the unique motor networks that emerge following perinatal stroke. As a focal injury of defined timing in an otherwise healthy brain, perinatal stroke represents an ideal human model of developmental plasticity. Here, we provide an introduction to perinatal stroke epidemiology and outcomes, before reviewing models of developmental plasticity after perinatal stroke. We then examine existing therapeutic approaches, including constraint, bimanual and other occupational therapies, and their potential synergy with non-invasive neurostimulation. We end by discussing the promise of exciting new therapies, including novel neurostimulation, brain-computer interfaces and robotics, all focused on improving outcomes after perinatal stroke.
Adam Kirton, Megan J Metzler, Brandon T Craig, Alicia Hilderley, Mary Dunbar, Adrianna Giuffre, James Wrightson, Ephrem Zewdie, Helen L Carlson1000 tests100ug200ul25 mg 50 UG10 mg100ug10 mg100 mg1000 1 ml1,000 tests
#34127549 2021/06/14 To Up
'Ice' flavoured e-cigarette use among young adults.'Ice' e-cigarette flavours-marketed as a combination of fruity/sweet and cooling flavours (eg, 'blueberry ice' or 'melon ice')-recently entered the US market. The prevalence and correlates of ice flavoured e-cigarette use in young adults are unknown.
Adam Leventhal, Hongying Dai, Jessica Barrington-Trimis, Steve Sussman
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#34123262 2019/12/18 To Up
Decoupling the effects of hydrophilic and hydrophobic moieties at the neuron-nanofibre interface.Peptide-based nanofibres are a versatile class of tunable materials with applications in optoelectronics, sensing and tissue engineering. However, the understanding of the nanofibre surface at the molecular level is limited. Here, a series of homologous dilysine-diphenylalnine tetrapeptides were synthesised and shown to self-assemble into water-soluble nanofibres. Despite the peptide nanofibres displaying similar morphologies, as evaluated through atomic force microscopy and neutron scattering, significant differences were observed in their ability to support sensitive primary neurons. Contact angle and labelling experiments revealed that differential presentation of lysine moieties at the fibre surface did not affect neuronal viability; however the mobility of phenylalanine residues at the nanofibre surface, elucidated through solid- and gel-state NMR studies and confirmed through tethered bilayer lipid membrane experiments, was found to be the determining factor in governing the suitability of a given peptide as a scaffold for primary neurons. This work offers new insights into characterising and controlling the nanofibre surface at the molecular level.
Adam D Martin, Jonathan P Wojciechowski, Eric Y Du, Aditya Rawal, Holly Stefen, Carol G Au, Liming Hou, Charles G Cranfield, Thomas Fath, Lars M Ittner, Pall Thordarson
1592 related Products with: Decoupling the effects of hydrophilic and hydrophobic moieties at the neuron-nanofibre interface.100.00 ulmin 2 cartons11 ml1200 units1500 Units1mg
#34126602 2021/06/14 To Up
Iterative material decomposition for spectral CT using self-supervised Noise2Noise prior.Compared to conventional computed tomography (CT), spectral CT can provide the capability of material decomposition, which can be used in many clinical diagnosis applications. However, the decomposed images can be very noisy due to the dose limit in CT scanning and the noise magnification of material decomposition process. To alleviate this situation, we proposed an iterative one-step inversion material decomposition algorithm with a Noise2Noise prior. The algorithm estimated material images directly from projection data and used a Noise2Noise prior for denoising. Different from supervised deep learning methods, the designed Noise2Noise prior was built based on self-supervised learning and did not need external data for training. In our method, the data consistency term and the Noise2Noise network were alternatively optimized in the iterative framework respectively using separable quadratic surrogate (SQS) and Adam algorithm. The proposed iterative algorithm was validated and compared to other methods on simulated spectral CT data, pre-clinical photon-counting CT data and clinical dual-energy CT data. Quantitative analysis showed that our proposed method has promising performance on noise suppression and structure detail recovery.
Wei Fang, Dufan Wu, Kyungsang Kim, Mannudeep K Kalra, Ramandeep Singh, Liang Li, Quanzheng Li
1665 related Products with: Iterative material decomposition for spectral CT using self-supervised Noise2Noise prior.1 mg100ug Lyophilized96 wells (1 kit)1 Set 100 G10100 assays100ug Lyophilized1 Set1 Set100 μg
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