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#33091960   2020/10/22 To Up

Epithelial-to-mesenchymal transition in Oral Squamous Cell Carcinoma: challenges and opportunities.

Oral squamous cell carcinoma (OSCC) is the most common malignancy representing 90% of all forms of oral cancer worldwide. Although great efforts have been made in the past decades, the five-year survival rate of OSCC patients is no more than 60% due to tumor metastasis and subsequent recurrence. The metastasis from the primary site is due to a complex process known as epithelial-to-mesenchymal transition (EMT). During the EMT, epithelial cells gradually acquire the structural and functional characteristics of mesenchymal cells, leading to the upregulation of cell migration and the promotion of tumor cell dissemination. Therefore, EMT attracted broad attention due to its close relationship with cancer invasion and metastasis. Therefore, in the present review, an extensive description of the current research on OSCC and the role of EMT in this cancer type is provided, including diverse EMT markers, regulatory networks and crucial EMT-inducing transcription factors in OSCC. Moreover, a brief summary was made regarding the current application of EMT-correlated indexes in the prognostic analysis of OSCC patients, and the potential therapeutic approaches against OSCC and difficulties in the development of an effective anti-EMT treatment are discussed. Our aim is to provide novel insights to develop new strategies to combat OSCC by targeting EMT.
Zihang Ling, Bin Cheng, Xiaoan Tao

1386 related Products with: Epithelial-to-mesenchymal transition in Oral Squamous Cell Carcinoma: challenges and opportunities.



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#33091955   2020/10/22 To Up

Prognostic value of qAnti-HBc in hepatitis B virus related acute-on-chronic liver failure.

It has been reported that serum quantification of anti-HBc (qAnti-HBc) could predict antiviral response in chronic hepatitis B (CHB) patients, while its role in hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) remains unclear. Its implication in HBV-ACLF was evaluated in this study.
Jing Li, Qi-Ming Gong, Pei-Lin Xie, Jun-Yu Lin, Jia Chen, Dong Wei, De-Min Yu, Yue Han, Xin-Xin Zhang

2509 related Products with: Prognostic value of qAnti-HBc in hepatitis B virus related acute-on-chronic liver failure.

100ug Lyophilized100ug50 ug2ug 2 ml Ready-to-use 50 UG96T100ug Lyophilized

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#33091948   2020/10/22 To Up

Challenges in Detecting Clinically Relevant Heparin-Induced Thrombocytopenia Antibodies.

Heparin-induced thrombocytopenia (HIT) is an antibody-mediated hypercoagulable state featuring high thrombosis risk and distinct pathogenesis involving immunoglobulin G-mediated platelet activation. The target of the immune response is a cationic "self" protein, platelet factor 4 (PF4), rendered antigenic by heparin. A key problem is that only a minority of anti-PF4/polyanion antibodies induced by heparin are pathogenic, i.e., capable of causing platelet activation and thereby clinical HIT. Since thrombocytopenia occurs frequently in hospitalized, heparin-treated patients, testing for "HIT antibodies" is common; thus, the problem of distinguishing between pathogenic and nonpathogenic antibodies is important. The central concept is that those antibodies that have platelet-activating properties demonstrable in vitro correlate well with pathogenicity, as shown by platelet activation tests such as the serotonin-release assay (SRA) and heparin-induced platelet activation assay. However, in most circumstances, immunoassays are used for first-line testing, and so it is important for clinicians to appreciate which immunoassay result profiles-in the appropriate clinical context-predict the presence of platelet-activating antibodies (Bayesian analysis). Clinicians with access to rapid, on-demand HIT immunoassays (e.g., particle gel immunoassay, latex immunoturbidimetric assay, chemiluminescent immunoassay) can look beyond simple dichotomous result interpretation ("negative"/"positive") and incorporate semiquantitative interpretation, where, for example, a strong-positive immunoassay result (or even combination of two immunoassays) points to a greater probability of detecting platelet-activating antibodies, and hence supporting a diagnosis of HIT. Recent recognition of "SRA-negative HIT" has increased the importance of semiquantitative interpretation of immunoassays, given that strong immunoassay reactivity is a potential clue indicating possible HIT despite a (false) negative platelet activation assay.
Theodore E Warkentin

2764 related Products with: Challenges in Detecting Clinically Relevant Heparin-Induced Thrombocytopenia Antibodies.

100 μg100 μg100 μg4 Membranes/Box100.00 ug100.00 ug100 μg20 100 μg4 Arrays/Slide100 μg100 μg

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#33091917   2020/10/22 To Up

Efficacy of bandage contact lenses versus eye patching in early postoperative period of Müller's muscle-conjunctival resection.

Patients with blepharoptosis who are treated with Müller's muscle-conjunctival resection (MMCR) may experience postoperative pain and discomfort related to the suture material on the palpebral conjunctiva. This study aims to compare the postoperative subjective complaints, such as pain and discomfort, with a visual analog scale (VAS) and objectively evaluate the cornea with a tear break-up time (TBUT) test and fluorescein staining following MMCR that was managed by either a bandage contact lens (BCL) or eye patching.
Mehmet Serhat Mangan, Hatice Tekcan, Serap Yurttaser Ocak

1786 related Products with: Efficacy of bandage contact lenses versus eye patching in early postoperative period of Müller's muscle-conjunctival resection.

1 Set100ul500 tests500 ml 100ul1 Set

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#33091916   2020/10/22 To Up

Tissue Inhibitor of Metalloproteinases-2 Mediates Kidney Injury during Sepsis.

Urinary tissue inhibitor of metalloproteinases (TIMP)-2 has been identified as a predictive marker for acute kidney injury (AKI), including sepsis-associated AKI (S-AKI). Whether TIMP-2 might be causally related to AKI and hence represent a viable drug target is unclear.
Xiaoyan Wen, Jicheng Zhang, Xiaojian Wan, Alicia A Frank, Xin Qu, John A Kellum

2476 related Products with: Tissue Inhibitor of Metalloproteinases-2 Mediates Kidney Injury during Sepsis.

100.00 ug100 ul10mg96T100 μg20mg

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#33091857   2020/10/08 To Up

A standardized polyphenol mixture extracted from poplar-type propolis for remission of symptoms of uncomplicated upper respiratory tract infection (URTI): A monocentric, randomized, double-blind, placebo-controlled clinical trial.

The most common symptoms of mild upper respiratory tract infections (URTIs) are sore throat, muffled dysphonia, and swelling and redness of the throat, which result from the inflammation process following acute bacterial or viral infection.
Cristina Esposito, Emanuele Ugo Garzarella, Bruno Bocchino, Maria D'Avino, Giuseppe Caruso, Antonio Riccardo Buonomo, Roberto Sacchi, Fabio Galeotti, Gian Carlo Tenore, Vincenzo Zaccaria, Maria Daglia

2526 related Products with: A standardized polyphenol mixture extracted from poplar-type propolis for remission of symptoms of uncomplicated upper respiratory tract infection (URTI): A monocentric, randomized, double-blind, placebo-controlled clinical trial.

0.2 mg25 µg100 ml25 µg0.25 mg0.1 ml1 g100 TESTS

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#33091855   2020/10/13 To Up

Antileukemic effect of caffeic acid 3,4-dihydroxyphenetyl ester. Evidences for its mechanisms of action.

Caffeic acid 3,4-dihydroxyphenethyl ester (CADPE) is a natural polyphenolic ester isolated as a minor component from a water extract of the Chinese medicine Zhongjiefeng [Sarcandra glabra (Thunb.) Nakai (Chloranthaceae)] and has previously shown to have activity against solid tumors through the modulation of multiple targets or signal pathways. However, the activity and potential mechanism of CADPE against leukemia cells have not yet been characterized.
Mingmin Tang, Xin Xie, Muran Shi, Wenxiu Xin, Guowan Zheng, Yanhua Zhang, Zhizhen Zhang, Xiaoyuan Lian

2692 related Products with: Antileukemic effect of caffeic acid 3,4-dihydroxyphenetyl ester. Evidences for its mechanisms of action.

5 mg250 mg10 mg10 mg10 mg250 mg25 mg10 mg50 mg250 mg10 mg 1 G

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#33091854   2020/10/15 To Up

Total flavonoids of astragalus attenuates experimental autoimmune encephalomyelitis by suppressing the activation and inflammatory responses of microglia via JNK/AKT/NFκB signaling pathway.

Microglia-mediated neuroinflammation is one of the most prominent characteristics of multiple sclerosis (MS), a chronic demyelination disease. As one of the main active ingredients in Astragali radix, total flavonoids of Astragalus (TFA) has multiple pharmacological effects such as immunomodulation, anti-inflammation and and anti-tumor. However, little is known about whether TFA could inhibit microglia-mediated neuroinflammation in MS.
Liu Yang, Xinyan Han, Faping Xing, Hui Wu, Hailian Shi, Fei Huang, Qi Xu, Xiaojun Wu

2052 related Products with: Total flavonoids of astragalus attenuates experimental autoimmune encephalomyelitis by suppressing the activation and inflammatory responses of microglia via JNK/AKT/NFκB signaling pathway.

1.5 x 10^6 cells2 Pieces/Box2 Pieces/Box2 Pieces/Box1 mg1.5x10(6) cells2 Pieces/Box2 Pieces/Box2 Pieces/BoxInhibitors

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