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Characterization of stability and nasal delivery systems for immunization with nanoemulsion-based vaccines.
Many infectious diseases that cause significant morbidity and mortality, especially in the developing world, could be preventable through vaccination. The effort to produce safe, thermally stable, and needle-free mucosal vaccines has become increasingly important for global health considerations. We have previously demonstrated that a thermally stable nanoemulsion, a mucosal adjuvant for needle-free nasal immunization, is safe and induces protective immunity with a variety of antigens, including recombinant protein. The successful use of nanoemulsion-based vaccines, however, poses numerous challenges. Among the challenges is optimization of the formulation to maintain thermal stability and potency and another is accuracy and efficiency of dispensing the vaccines to the nasal mucosa in the anterior and turbinate region of the nasal cavity or potentially to the nasopharynx-associated lymphoid tissue.Paul E Makidon, Shraddha S Nigavekar, Anna U Bielinska, Nicholas Mank, Abhishek M Shetty, Julie Suman, Jessica Knowlton, Andrzej Myc, Trent Rook, James R Baker
