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Human mitochondrial protein complexes revealed by large-scale coevolution analysis and deep learning-based structure modeling.
Recent development of deep-learning methods has led to a breakthrough in the prediction accuracy of 3-dimensional protein structures. Extending these methods to protein pairs is expected to allow large-scale detection of protein-protein interactions and modeling protein complexes at the proteome level.Jimin Pei, Jing Zhang, Qian Cong