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Curcumin attenuates autoimmunity and renal injury in an experimental model of systemic lupus erythematosus.
Systemic lupus erythematosus (SLE) is an autoimmune disorder with prevalent hypertension and renal disease. To avoid side effects of immunosuppressive drugs, alternative therapies are needed. Curcumin has been used in Eastern medicine for its anti-inflammatory and antioxidant properties. This study tested whether oral curcumin administration attenuates autoimmunity and renal injury during SLE. Female NZBWF1 (model of SLE) and NZW/LacJ (control) mice were administered curcumin (500 mg kg day , oral gavage) for 14 days in two separate groups beginning at either 26 or 32 weeks of age. Body weight and composition were monitored throughout the study. Immune activity was assessed by spleen weight, circulating dsDNA autoantibodies, and B lymphocytes. Renal injury (albumin excretion, glomerulosclerosis, blood urea nitrogen (BUN)) was measured as a hemodynamic function (glomerular filtration rate (GFR), mean arterial pressure (MAP)) in conscious mice. Body weight and composition were maintained in curcumin-treated SLE mice, but decreased in vehicle-treated SLE mice. Curcumin-treated SLE mice had lower spleen weight and renal injury (glomerulosclerosis) compared to vehicle-treated SLE mice when treatment started at 26 weeks of age. When curcumin treatment started at 32 weeks of age, renal injury (glomerulosclerosis, BUN) was reduced in SLE mice compared to vehicle-treated SLE mice. GFR was reduced, and MAP was increased in vehicle-treated SLE mice compared to controls; however, these were not improved with curcumin. No significant changes were observed in curcumin-treated control mice. These data suggest that curcumin modulates autoimmune activity and may lessen renal injury in female mice with SLE.Elena L Dent, Erin B Taylor, Hannah R Turbeville, Michael J Ryan
1237 related Products with: Curcumin attenuates autoimmunity and renal injury in an experimental model of systemic lupus erythematosus.
100 μg100 μg100ug Lyophilized100 ug100 μg100 μg1 Set1 Set100ug Lyophilized1 Set4 Arrays/Slide
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#32652833 2020/07/11
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Nicarbazin has no effect on reducing feral pigeon populations in Barcelona.
Nicarbazin is an anti-coccidial product sometimes used as a contraceptive to reduce the size of feral pigeon populations. However, its effectiveness in reducing pigeon population size in cities has generated some controversy. Here, we evaluate its effectiveness in Barcelona city.Juan Carlos Senar, Helena Navalpotro, Jordi Pascual, Tomás Montalvo
1836 related Products with: Nicarbazin has no effect on reducing feral pigeon populations in Barcelona.
1 Set100 μg
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#32652826 2020/07/11
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Sotrastaurin, a PKC inhibitor, attenuates RANKL-induced bone resorption and attenuates osteochondral pathologies associated with the development of OA.
Osteoarthritis (OA) is a common degenerative disease that affects the musculoskeletal structure of the whole joint, which is characterized by progressive destruction of both articular cartilage and subchondral bone. Treatment of the bone pathologies, particularly osteoclast-mediated subchondral bone loss in the early stages of OA, could prevent subsequent cartilage degeneration and progression of OA. In the present study, the PKC inhibitor, Sotrastaurin, was found to inhibit RANKL-induced osteoclast formation in vitro in a dose- and time-dependent manner. In particular, SO exerted its anti-osteoclastic effect predominantly at the early stages of RANKL stimulation, suggesting inhibitory effects on precursor cell fusion. Using mature osteoclasts cultured on bovine bone discs, we showed that SO also exerts anti-resorptive effects on mature osteoclasts bone resorptive function. Mechanistically, SO attenuates the early activation of the p38, ERK and JNK signalling pathways, leeding to impaired induction of crucial osteoclast transcription factors c-Jun, c-Fos and NFATc1. We also showed that SO treatment significantly inhibited the phosphorylation of PKCδ and MARCKS, an upstream regulator of cathepsin K secretion. Finally, in animal studies, SO significantly alleviates the osteochondral pathologies of subchondral bone destruction as well as articular cartilage degeneration following DMM-induced OA, markedly improving OARSI scores. The reduced subchondral bone loss was associated with marked reductions in TRAP(+) osteoclasts in the subchondral bone tissue. Collectively, our data provide evidence for the protective effects of SO against OA by preventing aberrant subchondral bone and articular cartilage changes. Thus, SO demonstrates potential for further development as an alternative therapeutic option against OA.Cong Pang, Liangbao Wen, Haikuo Qin, Bikang Zhu, Xuanyuan Lu, Shixing Luo
2358 related Products with: Sotrastaurin, a PKC inhibitor, attenuates RANKL-induced bone resorption and attenuates osteochondral pathologies associated with the development of OA.
100ug0.1ml (1mg/ml)0.1 mg1000 tests5 ug100ug Lyophilized1 mg100.00 ug50ug100μg200ul20
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#32652783 2020/07/11
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Synthesis of antiviral perfluoroalkyl derivatives of teicoplanin and vancomycin.
The limited scope of antiviral drugs and increasing problem of antiviral drug resistance represent a global health threat. Glycopeptide antibiotics and their lipophilic derivatives have emerged as relevant inhibitors of diverse viruses. Here, we describe a new strategy for the synthesis of dual hydrophobic and lipophobic derivatives of glycopeptides, to produce selective antiviral agents without membrane-disrupting activity. Perfluorobutyl and perfluorooctyl moieties through linkers of different length were attached to azido derivatives of vancomycin aglycone and teicoplanin pseudoaglycone, and the new derivatives were evaluated against a diverse panel of viruses. The teicoplanin derivatives displayed strong anti-influenza virus activity at non-toxic concentrations. Some of the perfluoroalkylated glycopeptides were also active against a few other viruses such as herpes simplex virus or coronavirus. These data encourage further exploration of glycopeptide analogues for broad antiviral application.Ilona Bereczki, Magdolna Csávás, Zsolt Szűcs, Erzsébet Rőth, Gyula Batta, Eszter Ostorházi, Lieve Naesens, Anikó Borbás, Pál Herczegh
1088 related Products with: Synthesis of antiviral perfluoroalkyl derivatives of teicoplanin and vancomycin.
5 G200ul100 mg25 mg1 ml1000 tests100ug100ug10 mg50 ug 100 mg100 Rxns Kit
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#32652763 2020/07/11
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Nuclear β-catenin immunoexpression in scars.
Histopathologically, scars can mimic superficial fibromatoses. Superficial fibromatoses are known to show nuclear β-catenin immunoexpression, although the tumor types do not harbor CTNNB1 or APC alterations. The present study aimed to evaluate nuclear β-catenin immunoexpression in scars compared to that in superficial fibromatoses.Keisuke Goto, Misawo Ishikawa, Daisuke Aizawa, Koji Muramatsu, Miho Naka, Takashi Sugino
1941 related Products with: Nuclear β-catenin immunoexpression in scars.
2 Pieces/Box100 μg5mg100 μg100 μg100ug Lyophilized100 μg100ug
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#32652724 2020/07/11
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The Anti-Racist, Pro-patient Pledge of Emergency Medicine.
RIan B K Martin, Stephen Hargarten
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1 ml1 ml0.1 mg100.00 ul100 100.00 ul
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#32652544 2020/07/11
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Long-Term Efficacy of Certolizumab Pegol for the Treatment of Plaque Psoriasis: Three-Year Results from Two Randomised Phase 3 Trials (CIMPASI-1 and CIMPASI-2).
Certolizumab pegol (CZP) is an Fc-free, PEGylated anti-tumour necrosis factor biologic.K B Gordon, R B Warren, A B Gottlieb, A Blauvelt, D Thaçi, C Leonardi, Y Poulin, M Boehnlein, F Brock, C Ecoffet, K Reich
1999 related Products with: Long-Term Efficacy of Certolizumab Pegol for the Treatment of Plaque Psoriasis: Three-Year Results from Two Randomised Phase 3 Trials (CIMPASI-1 and CIMPASI-2).
100μg100ug100μg100Tests100μg100μg100ug Lyophilized100ul100ug100ug Lyophilized100ug 1 G
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#32652517 2020/07/11
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Penehyclidine hydrochloride inhibits renal ischemia/reperfusion-induced acute lung injury by activating the Nrf2 pathway.
The nuclear factor (NF)-κB and NOD-like receptor protein 3 (NLRP3) pathways promote inflammatory signaling that injures the kidneys, whereas the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway promotes anti-inflammatory signaling that inhibits oxidative damage. Penehyclidine hydrochloride (PHC) inhibits NF-κB and activates Nrf2 signaling. We investigated whether PHC induces communication between the Nrf2 and NF-κB/NLRP3 pathways, thereby protecting against renal ischemia/reperfusion (rI/R)-induced lung inflammation. Rat alveolar macrophages (NR8383 cells) were stimulated for 24 h with PHC with or without brusatol (a Nrf2 antagonist), after which they were treated for 4 h with tert-butyl hydroperoxide (10 mM). PHC Nrf2-dependently alleviated tert-butyl hydroperoxide-induced reactive oxygen species production in alveolar macrophages. Additionally, wild-type and Nrf2 rats were each divided into four groups: (1) sham, (2) PHC (1 mg/kg), (3) rI/R and (4) rI/R + PHC (1 mg/kg). PHC markedly induced the Nrf2 and adenosine monophosphate-activated protein kinase pathways and suppressed rI/R-induced NF-κB and NLRP3 activation in the lungs. Nrf2 deficiency diminished the ability of PHC to ameliorate rI/R-induced histopathological alterations and reactive oxygen species release in the lungs; however, PHC inhibited NLRP3 signaling Nrf2-dependently, while it inhibited NF-κB signaling Nrf2-independently. Our findings demonstrate the beneficial effects of PHC on rI/R-induced lung inflammation.Zhaohui Liu, Yan Li, Lili Yu, Yulin Chang, Jingui Yu
1043 related Products with: Penehyclidine hydrochloride inhibits renal ischemia/reperfusion-induced acute lung injury by activating the Nrf2 pathway.
5 g 5 G1 mg2 Pieces/Box 500 G100ug Lyophilized10 mg10 mg 1 G
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#32652505 2020/07/08
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The natural compound Cirsitakaoside enhances antiviral innate responses against vesicular stomatitis virus in vitro and in vivo.
Cirsitakaoside, isolated and purified from the stems and leaves of Premna szemaoensis and Macaranga denticulata, is a natural compound with potential anti-inflammatory effects. However, the role of Cirsitakaoside in antiviral activity and the underlying mechanism remains largely unknown. In this study, we aimed to identify whether Cirsitakaoside has antiviral activity and investigated the underlying mechanisms. Mouse peritoneal macrophages were pretreated with Cir or DMSO, and then infected by Vesicular Stomatitis Virus (VSV) for indicated hours, Q-PCR and ELISA were used to detect the expression of interferons and pro-inflammatory cytokines, immunoblot assay were employed to investigate the involved signaling pathway in the antiviral effects of Cirsitakaoside. Furthermore, mice infected with VSV were used to investigate the antiviral activities of Cirsitakaoside in vivo. Our study demonstrated that Cirsitakaoside could promote type I IFN expression and inhibit pro-inflammatory cytokines such as IL-6 and TNF-α production in mouse peritoneal macrophages infected by VSV. Suppressive viral replication effects of Cirsitakaoside were observed on VSV-infected mouse peritoneal macrophages as well. Furthermore, Cirsitakaoside significantly increased the VSV-triggered phosphorylation of TBK1, IRF3 and reduced the phosphorylation of IκBα and p65 in mouse peritoneal macrophages. in vivo, the results showed that Cirsitakaoside-treated mice were more resistant to VSV infection by producing more IFN-β and less pro-inflammatory cytokines. Our study indicates that Cirsitakaoside is a good candidate for the treatment of viral infection and inflammation-related diseases.Qianqian Di, Huihui Zhu, Debing Pu, Xibao Zhao, Xiaoli Li, Xingyu Ma, Weilie Xiao, Weilin Chen
1741 related Products with: The natural compound Cirsitakaoside enhances antiviral innate responses against vesicular stomatitis virus in vitro and in vivo.
10mg2550 200 1 mL50ug1001 mg2 50
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#32652503 2020/07/07
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Splenectomy enhances the Ly6C phenotype in hepatic macrophages by activating the ERK1/2 pathway during liver fibrosis.
Splenectomy has been reported to attenuate liver fibrosis. In addition, phenotype transitions of infiltrating macrophages, including Ly6C and Ly6C, play an essential role in the liver fibrosis. However, whether the spleen can regulate the phenotype switch of macrophages and the underlying mechanism still remain unclear.Zhongqiang Zheng, Huan Wang, Liang Li, Shaoying Zhang, Chunyan Zhang, Hailong Zhang, Fanpu Ji, Xi Liu, Kai Zhu, Guangyao Kong, Zongfang Li