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#34847611 2021/11/30 To Up
Visual Diagnosis of Pleural Tuberculosis and its Association with Tissue Biopsy, Culture and Xpert Assay.Ã¢Â€Â‚The diagnosis of pleural tuberculosis remains a clinical challenge due to the paucibacillary nature of disease. Medical thoracoscopy remains the gold standard in diagnosing tuberculous pleuritis.
Kamran Khan Sumalani, Nousheen Akhter, Dimple Chawla, Nadeem Ahmed Rizvi
1497 related Products with: Visual Diagnosis of Pleural Tuberculosis and its Association with Tissue Biopsy, Culture and Xpert Assay.10 mg 5 G100tests2.5 mg100ug4/120 Packing /sleeve/bo200 1 mg10 reactions1,000 tests100ul
#34847571 2021/11/30 To Up
Doping control analysis of small peptides in human urine using LC-HRMS with parallel reaction monitoring mode: screening and confirmation.T
Wei Chang, Genye He, Kuan Yan, Zhanliang Wang, Yufeng Zhang, Tianyu Dong, Yunxi Liu, Lisi Zhang, Liu Hong
1238 related Products with: Doping control analysis of small peptides in human urine using LC-HRMS with parallel reaction monitoring mode: screening and confirmation.1.00 flask100 Î¼g100 Î¼g4 Arrays/Slide100 Î¼g100 Î¼g
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#34847555 2021/11/30 To Up
Clinical Heterogeneity in Acute Symptomatic Seizures due to Autoimmune Encephalitis Related to GAD65 Antibodies.This study aimed to explore the diversity and clinical features of acute symptomatic seizures due to autoimmune encephalitis related to anti-glutamate decarboxylase (GAD) 65 antibodies.
Xuemei Fan, Xinxin Li, Shuai Wang, Yafei Zhu, Songyan Liu, Xuemei Han
2901 related Products with: Clinical Heterogeneity in Acute Symptomatic Seizures due to Autoimmune Encephalitis Related to GAD65 Antibodies.100 Î¼g100 1 ml1 mL2 Pieces/Box1 ml200 ug1 mg0.1 mg100
#34847495 2021/11/22 To Up
Quinazoline-based hydroxamic acid derivatives as dual histone methylation and deacetylation inhibitors for potential anticancer agents.C
Haoting Zheng, Qiuzi Dai, Zigao Yuan, Tingting Fan, Cunlong Zhang, Zijian Liu, Bizhu Chu, Qinsheng Sun, Yan Chen, Yuyang Jiang
1018 related Products with: Quinazoline-based hydroxamic acid derivatives as dual histone methylation and deacetylation inhibitors for potential anticancer agents.96 assays 96 assays 96 assays 100ug Lyophilized25 g 1 G 5 G
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#34847494 2021/11/22 To Up
Dihydroartemisinin improves hypercholesterolemia in ovariectomized mice via enhancing vectorial transport of cholesterol and bile acids from blood to bile.The increase of concentrations of total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) in the serum of postmenopausal women is the important risk factor of the high morbidity of cardiovascular diseases of old women worldwide. To test the anti-hypercholesterolemia function of dihydroartemisinin (DHA) in postmenopausal women, ovariectomized (OVX) mice were generated, and DHA were administrated to OVX mice for 4Ã‚Â weeks. The blood and liver tissues were collected for biochemical and histological tests respectively. The mRNA and protein expression levels of genes related to metabolism and transport of cholesterol, bile acid and fatty acid in the liver or ileum were checked through qPCR and western blot. DHA could significantly reduce the high concentrations of TC and LDL-C in the serum and the lipid accumulation in the liver of ovariectomized mice. The expression of ABCG5/8 was reduced in liver of OVX mice, and DHA could up-regulate the expression of them. Genes of transport proteins for bile salt transport from blood to bile, including Slc10a1, Slco1b2 and Abcb11, were also significantly up-regulated by DHA. DHA also down-regulated the expression of Slc10a2 in the ileum of OVX mice to reduce the absorption of bile salts. Genes required for fatty acid synthesis and uptake, such as Fasn and CD36, were reduced in the liver of OVX mice, and DHA administration could significantly up-regulate the expression of them. These results demonstrated that DHA could improve hypercholesterolemia in OVX mice through enhancing the vectorial transport of cholesterol and bile acid from blood to bile.
Zili Lei, Huijuan Wu, Yanhong Yang, Qing Hu, Yuting Lei, Wanwan Liu, Ya Nie, Lanxiang Yang, Xueying Zhang, Changyuan Yang, Ting Lin, Fengxue Tong, Jiamin Zhu, Jiao Guo
1919 related Products with: Dihydroartemisinin improves hypercholesterolemia in ovariectomized mice via enhancing vectorial transport of cholesterol and bile acids from blood to bile.430 Tests / Kit430 tests600 Tests / Kit100ug/vial1 mg1 mg1,000 tests10 1 kit
#34847433 2021/11/25 To Up
A DAMP-scavenging, IL-10-releasing hydrogel promotes neural regeneration and motor function recovery after spinal cord injury.Spinal cord injury (SCI) creates an inflammatory microenvironment characterized by damage-associated molecular patterns (DAMPs) and immune cell activation that exacerbate secondary damage and impair neurological recovery. Here we develop an immunoregulatory hydrogel scaffold for treating SCI that scavenges DAMPs and slowly releases the anti-inflammatory cytokine interleukin-10 (IL-10). We created this dual-functional scaffold by modifying a photocrosslinked gelatin hydrogel with the cationic, DAMP-binding polymer poly (amidoamine) and with IL-10, and compared the therapeutic activity of this scaffold with that of gelatin-only, gelatinÃ‚Â +Ã‚Â poly (amidoamine), and gelatinÃ‚Â +Ã‚Â IL-10 scaffolds in vitro and in vivo. In vitro, the dual-functional scaffold scavenged anionic DAMPs and exhibited sustained release of IL-10, reduced the proinflammatory responses of macrophages and microglia, and enhanced the neurogenic differentiation of neural stem cells. In a complete transection SCI mouse model, the injected dual-functional scaffold suppressed proinflammatory cytokine production, promoted the M2 macrophage/microglia phenotype, and led to neural regeneration and axon growth without scar formation to a greater extent than the single-function or control scaffolds. This DAMP-scavenging, IL-10-releasing scaffold provides a new strategy for promoting neural regeneration and motor function recovery following severe SCI.
He Shen, Bai Xu, Chao Yang, Weiwei Xue, Zhifeng You, Xianming Wu, Dezun Ma, Dan Shao, Kam Leong, Jianwu Dai
2505 related Products with: A DAMP-scavenging, IL-10-releasing hydrogel promotes neural regeneration and motor function recovery after spinal cord injury.30 reactions100ug1,000 tests100ug100.00 ul1 mg1 kit(96 Wells)1000 tests100ul200.00 ug0.1 ml
#34847432 2021/11/18 To Up
Tailoring the properties of double-crosslinked emulsion gels using structural design principles: Physical characteristics, stability, and delivery of lycopene.Lycopene is claimed to have numerous physiological benefits, but its poor water solubility, chemical instability, and low bioavailability limit its application in functional foods and health care products. In this study, lycopene-loaded emulsions containing oil droplets with different interfacial structures were prepared and then cross-linked using transglutaminase (TG) and/or calcium ions (Ca) to form emulsion gels. The oil droplets were first coated by interfacial layers comprised of whey protein isolate (WPI) and sodium alginate (SA). During emulsion preparation, the SA was added either before or after homogenization to create complex or layer-by-layer coatings, respectively. Subsequently, TG and Ca were used to cross-link WPI and SA to form emulsion gels. The results show that double-crosslinking increased the gel strength and viscosity of the emulsion gels. The layer-by-layer emulsion gels were stronger and more viscous than the complex ones. The photochemical and gastrointestinal stability of lycopene encapsulated within the emulsion gels was higher than that of free lycopene. An MTT toxicity test showed that the emulsion gels exhibited no cytotoxicity to Caco-2Ã‚Â cells. The lycopene-loaded emulsion gels exhibited stronger anti-inflammatory activity on the Caco-2Ã‚Â cells than the control. In addition, the absorption of lycopene by the Caco-2Ã‚Â cells increased after encapsulation. This study provides a new approach of preparing edible soft materials to enhance the application of hydrophobic bioactives (like lycopene) in functional foods.
Fuguo Liu, Xiuping Liang, Jun Yan, Sheliang Zhao, Siqi Li, Xuebo Liu, To Ngai, David Julian McClements
2102 related Products with: Tailoring the properties of double-crosslinked emulsion gels using structural design principles: Physical characteristics, stability, and delivery of lycopene.5 G 125 ml 200ul0.1 mg25 mg500 Units1000 tests100ug100ug
#34847428 2021/11/23 To Up
Euphoesulatin A prevents osteoclast differentiation and bone loss via inhibiting RANKL-induced ROS production and NF-ÃŽÂºB and MAPK signal pathways.Euphoesulatin A (Eup A), a new jatrophane diterpenoid isolated from the Euphorbia esula L. (Euphorbiaceae), was reported to inhibit RANKL-induced osteoclastogenesis. However, the underlying mechanism and the effect in osteoporosis mouse model are still unclear. This study is the first to demonstrate that Eup A inhibits osteoclastogenesis in vitro and in vivo. Mechanistic analysis suggested that Eup A (3, 6, 12Ã‚Â ÃŽÂ¼M) dose-dependently inhibited osteoclastogenesis by down-regulating the activation of NFATc1 and NF-ÃŽÂºB and MAPKs signal pathways. Moreover, Eup A (10Ã‚Â mg/kg) significantly prevented bone loss in ovariectomized mice. This work provides in vitro and in vivo evidence that Eup A could be a potential candidate for the development of anti-osteoporosis agents.
Yu-Ting Zhang, Chen Hu, Song-Xuan Zhang, Hui-Hao Zhou, Jun Xu, Jian-da Ma, Lie Dai, Qiong Gu
2008 related Products with: Euphoesulatin A prevents osteoclast differentiation and bone loss via inhibiting RANKL-induced ROS production and NF-ÃŽÂºB and MAPK signal pathways.5 G 5 G25 mg96 wells (1 kit)100ug100ul1 g10 mg100ul100 mg50 ug 200ul
#34847425 2021/11/26 To Up
Impact of carbamazepine on vitamin D levels: A meta-analysis.There are longstanding concerns about the impact of enzyme-inducing anti-seizure medications (ASMs) on vitamin D, an important molecule in both bone metabolism and inflammation pathways. The relationship between chronic use of carbamazepine and vitamin D levels has been studied, but no comprehensive review to inform practitioners and policymakers is currently available. We performed a meta-analysis on studies that measured 25-hydroxyvitamin D (25OHD) levels in persons taking carbamazepine to determine whether this drug significantly reduces circulating 25OHD.
Carla LoPinto-Khoury, Laura Brennan, Scott Mintzer100 25 mg 25 G10 mg1 mg 5 G1 mg
#34847424 2021/11/24 To Up
Acute treatment with dexketoprofen reduces penicillin induced epileptiform activity in wistar albino rats (dexketoprofen in penicillin induced seizure model).Dexketoprofen trometamol is one of the most commonly used anti-inflammatory analgesic agents for pain control. This study aims to investigate the effect of dexketoprofen on penicillin-induced epileptiform activity in rats.
Mustafa Sami Demirsoy, Aras Erdil, Sefa ÃƒÂ‡olak, Esra Duman, Orhan SÃƒÂ¼mbÃƒÂ¼l, Hatice Aygun