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Search results for: Anti DDC(Netrin receptor DCC precursor) (Tumor suppressor protein DCC)

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#18439993   2008/03/26 To Up

Netrin-1 inhibits sprouting angiogenesis in developing avian embryos.

Netrin-1 is a bifunctional axonal guidance cue, capable of attracting or repelling developing axons via activation of receptors of the deleted in colorectal cancer (DCC) and uncoordinated 5 (UNC5) families, respectively. In addition to its role in axon guidance, Netrin-1 has been implicated in angiogenesis, where it may also act as a bifunctional cue. Attractive effects of Netrin-1 on endothelial cells appear to be mediated by an as yet unknown receptor, while repulsion of developing blood vessels in mouse embryos is mediated by the UNC5B receptor. To explore evolutionary conservation of vascular UNC5B expression and function, we have cloned the chick unc5b homologue. Chick and quail embryos showed unc5b expression in arterial EC and sprouting angiogenic capillaries. To test if Netrin-1 displayed pro- or anti-angiogenic activities in the avian embryo, we grafted cell lines expressing recombinant chick or human Netrin-1 at different stages of development. Netrin-1 expressing cells inhibited angiogenic sprouting of unc5b expressing blood vessels, but had no pro-angiogenic activity at any stage of development examined. Netrin-1 also had no effect on the recruitment of circulating endothelial precursor cells. Taken together, these data indicate that vascular unc5b expression and function is conserved between chick and mice.
Karine Bouvrée, Bruno Larrivée, Xiang Lv, Li Yuan, Benjamin DeLafarge, Catarina Freitas, Thomas Mathivet, Christiane Bréant, Marc Tessier-Lavigne, Andreas Bikfalvi, Anne Eichmann, Luc Pardanaud

2066 related Products with: Netrin-1 inhibits sprouting angiogenesis in developing avian embryos.

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#12668624   // To Up

Netrin 1 mediates spinal cord oligodendrocyte precursor dispersal.

In spinal cord, oligodendrocyte precursors that give rise to myelin-forming cells originate in a restricted domain of the ventral ventricular zone. During development, these cells migrate widely throughout the spinal cord. Netrin 1 is expressed at the ventral ventricular zone during oligodendrocyte precursors emigration, and, in vitro, netrin 1 acts as chemorepellent and antagonizes platelet-derived growth factor (PDGF) chemoattraction. Oligodendrocyte precursors express the netrin receptors DCC and UNC5 and function-blocking anti-DCC antibody inhibits chemorepulsion of ventral spinal cord explants and netrin-secreting cells. In spinal cord slice preparations, addition of function-blocking anti-DCC antibody or netrin 1 dramatically inhibits oligodendrocyte precursor migration from the ventral ventricular zone. These data indicate the initial dispersal of oligodendrocyte precursors from their localized origin is guided by a chemorepellent response to netrin 1.
Hui-Hsin Tsai, Marc Tessier-Lavigne, Robert H Miller

2418 related Products with: Netrin 1 mediates spinal cord oligodendrocyte precursor dispersal.

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#12174360   // To Up

Profiling of differentially expressed genes in human gastric carcinoma by cDNA expression array.

To investigate the expression of cancer related genes in gastric carcinoma (GC) through the use of Atlas Human Cancer Array membranes with 588 well-characterized human genes related to cancer and tumor biology.
Lian-Xin Liu, Zhi-Hua Liu, Hong-Chi Jiang, Xin Qu, Wei-Hui Zhang, Lin-Feng Wu, An-Long Zhu, Xiu-Qin Wang, Min Wu

1150 related Products with: Profiling of differentially expressed genes in human gastric carcinoma by cDNA expression array.