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Search results for: Anti Human Brain Derived Neurotrophic Factor (BDNF)

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#32466148   2020/05/25 To Up

Effects of Polyphenol-Rich Interventions on Cognition and Brain Health in Healthy Young and Middle-Aged Adults: Systematic Review and Meta-Analysis.

Affecting older and even some younger adults, neurodegenerative disease represents a global public health concern and has been identified as a research priority. To date, most anti-aging interventions have examined older adults, but little is known about the effects of polyphenol interventions on brain-related aging processes in healthy young and middle-aged adults.
Achraf Ammar, Khaled Trabelsi, Omar Boukhris, Bassem Bouaziz, Patrick Müller, Jordan M Glenn, Nicholas T Bott, Notger Müller, Hamdi Chtourou, Tarak Driss, Anita Hökelmann

1680 related Products with: Effects of Polyphenol-Rich Interventions on Cognition and Brain Health in Healthy Young and Middle-Aged Adults: Systematic Review and Meta-Analysis.

500 mg25 mg2.5 mg10 mg200ug25 mg0.1 mg 5 G50 ug 5 G1 g100ug

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#32396921   2020/05/12 To Up

Medial PFC AMPA receptor and BDNF signaling are required for the rapid and sustained antidepressant-like effects of 5-HT receptor stimulation.

We previously reported that the serotonergic system is important for the antidepressant-like effects of ketamine, a non-competitive N-methyl-D-aspartate receptor antagonist, which produces rapid and long-lasting antidepressant effects in patients with major depressive disorder (MDD). In particular, selective stimulation of the 5-HT receptor in the medial prefrontal cortex (mPFC), as opposed to the somatic 5-HT autoreceptor, has been shown to play a critical role in the antidepressant-like actions of ketamine. However, the detailed mechanisms underlying mPFC 5-HT receptor-mediated antidepressant-like effects are not fully understood. Here we examined the involvement of the glutamate AMPA receptor and brain-derived neurotrophic factor (BDNF) in the antidepressant-like effects of 5-HT receptor activation in the mPFC. The results show that intra-mPFC infusion of the 5-HT receptor agonist 8-OH-DPAT induces rapid and long-lasting antidepressant-like effects in the forced swim, novelty-suppressed feeding, female urine sniffing, and chronic unpredictable stress tests. In addition, the results demonstrate that the antidepressant-like effects of intra-mPFC infusion of 8-OH-DPAT are blocked by co-infusion of an AMPA receptor antagonist or an anti-BDNF neutralizing antibody. In addition, mPFC infusion of 8-OH-DPAT increased the phosphorylation of signaling proteins downstream of BDNF, including mTOR, ERK, 4EBP1, and p70S6K. Finally, selective stimulation of the 5-HT receptor increased levels of synaptic proteins and synaptic function in the mPFC. Collectively, these results indicate that selective stimulation of 5-HT receptor in the mPFC exerts rapid and sustained antidepressant-like effects via activation of AMPA receptor/BDNF/mTOR signaling in mice, which subsequently increase synaptic function in the mPFC, and provide evidence for the 5-HT receptor as a target for the treatment of MDD.
Kenichi Fukumoto, Manoela V Fogaça, Rong-Jian Liu, Catharine H Duman, Xiao-Yuan Li, Shigeyuki Chaki, Ronald S Duman

1750 related Products with: Medial PFC AMPA receptor and BDNF signaling are required for the rapid and sustained antidepressant-like effects of 5-HT receptor stimulation.

100ul100ug0.1 mg100ul100ug100.00 ul50 ug 100ug1 ml100ug100ul

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#32206827   2020/03/23 To Up

7,8-Dihydroxyflavone alleviated the high-fat diet and alcohol-induced memory impairment: behavioral, biochemical and molecular evidence.

Alcoholism and obesity impart a deleterious impact on human health and affects the quality of life. Chronic consumption of alcohol and western diet has been reported to cause memory deficits. 7,8-dihydroxyflavone (7,8-DHF), a TrkB agonist, comprises antioxidant and anti-inflammatory properties in treating various neurological disorders.
Surya Narayan Pandey, Mohit Kwatra, Durgesh Kumar Dwivedi, Priyansha Choubey, Mangala Lahkar, Ashok Jangra

2168 related Products with: 7,8-Dihydroxyflavone alleviated the high-fat diet and alcohol-induced memory impairment: behavioral, biochemical and molecular evidence.

6 ml Ready-to-use 10 mg 5 G100ug2.5 mg1,000 tests100ug 2 ml Ready-to-use 1 mg50 ug 1mg

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#32204500   2020/03/19 To Up

The Effect of (Poly)phenol-Rich Interventions on Cognitive Functions and Neuroprotective Measures in Healthy Aging Adults: A Systematic Review and Meta-Analysis.

As the food industry is continually involved in the development of new attractive alternative therapeutic agents, the evaluation of the beneficial impact of (poly)phenols on cognitive and brain function during aging has gained increasing interest.
Achraf Ammar, Khaled Trabelsi, Patrick Müller, Bassem Bouaziz, Omar Boukhris, Jordan M Glenn, Nick Bott, Tarak Driss, Hamdi Chtourou, Notger Müller, Anita Hökelmann

1407 related Products with: The Effect of (Poly)phenol-Rich Interventions on Cognitive Functions and Neuroprotective Measures in Healthy Aging Adults: A Systematic Review and Meta-Analysis.

1 mg100ug50 ug 100.00 ul1,000 tests25 mg100ug1000 tests1000 TESTS/0.65ml10 mg 5 G

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#32158447   2020/02/25 To Up

Interplay Between Human Gut Bacteria and in the Occurrence of Neuropsychiatric Disorders in Mice.

To understand the roles of human gut bacteria in the occurrence of neuropsychiatric disorders, we isolated inflammatory K1 and anti-inflammatory from healthy human feces and examined their effects on the occurrence of altered microbiota, cognitive decline, and depression in mice. Oral gavage of K1 caused colitis, cognitive decline, and depression in mice in the elevated plus maze, tail suspension, and forced swimming tasks. However, NK41 treatment reduced K1-induced cognitive decline and anxiety/depression. Furthermore, NK41 treatment increased K1-suppressed brain-derived neurotrophic factor (BDNF) expression and BDNF/NeuN cell population and suppressed K1-induced NF-κB activation and LPS/Iba1 and NF-κB/Iba1 (microglial) cell populations in the hippocampus. NK41 treatment also suppressed K1-induced TNF-α and LPS levels in the blood and TNF-α expression, myeloperoxidase activity, NF-κB/CD11c and CD11b/CD11c cell populations in the colon. Furthermore, NK41 treatment decreased K1-induced colonic MUC2 expression, gut Proteobacteria population, and fecal LPS levels and modified the bacterial abundance related to polysaccharide breaking and biosynthesis. In conclusion, the overgrowth of inflammatory bacteria such as in the gastrointestinal tract can cause neuropsychiatric disorders with gut microbiota alteration and the superiority of anti-inflammatory bacteria such as can alleviate neuropsychiatric disorders with the attenuation of altered microbiota.
Jeon-Kyung Kim, Kyung-Eon Lee, Sang-Ah Lee, Hyo-Min Jang, Dong-Hyun Kim

1376 related Products with: Interplay Between Human Gut Bacteria and in the Occurrence of Neuropsychiatric Disorders in Mice.

100 μg100 μg100 μg100 μg2 100 μg100 μg4 Arrays/Slide100 μg2

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#32099373   2020/01/31 To Up

The Role of Brain Derived Neurotrophic Factor in HIV-Associated Neurocognitive Disorder: From the Bench-Top to the Bedside.

Human immunodeficiency virus (HIV)-associated neurocognitive disorder (HAND) remains prevalent in the anti-retroviral (ART) era. While there is a complex interplay of many factors in the neuropathogenesis of HAND, decreased neurotrophic synthesis has been shown to contribute to synaptic degeneration which is a hallmark of HAND neuropathology. Brain derived neurotrophic factor (BDNF) is the most abundant and synaptic-promoting neurotrophic factor in the brain and plays a critical role in both learning and memory. Reduced BDNF levels can worsen neurocognitive impairment in HIV-positive individuals across several domains. In this paper, we review the evidence from pre-clinical and clinical studies showing the neuroprotective roles of BDNF against viral proteins, effect on co-morbid mental health disorders, altered human microbiome and ART in HAND management. Potential applications of BDNF modulation in pharmacotherapeutic, cognitive and behavioral interventions in HAND are also discussed. Finally, research gaps and future research direction are identified with the aim of helping researchers to direct efforts to make these BDNF driven interventions improve the quality of life of patients living with HAND.
Henry Michael, Thabisile Mpofana, Suvira Ramlall, Frasia Oosthuizen

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#32020642   2020/02/05 To Up

Memory-enhancing effects of Ishige foliacea extract: In vitro and in vivo study.

Ishige foliacea is used as a functional food in East-Asian countries. We evaluated the memory-enhancing effect of an ethanol extract of I. foliacea (EEI) using in vitro and in vivo models. In vitro acetylcholinesterase and β-secretase inhibitory activities, antioxidant properties, and neuroprotective effects against human neuronal cell death by H O and β-amyloid (Aβ) were investigated. We explored the memory-enhancing effect and its underlying mechanism in a mouse model of scopolamine (SCO)-induced memory deficits. EEI showed free radical scavenging and acetylcholinesterase and β-secretase inhibition activities. Additionally, EEI significantly decreased neuronal cell death induced by H O or Aβ in human neuroblastoma SH-SY5Y cells. In behavior tests, SCO-induced memory deficits was improved by EEI administration. EEI increased the protein expression of brain-derived neurotrophic factor (BDNF) and tropomyosin receptor kinase B (TrkB) and phosphorylated extracellular signal-regulated kinase, which are related to synaptic plasticity in the hippocampus. EEI may ameliorate memory deficits and prevent neurodegenerative disorders. PRACTICAL APPLICATIONS: As the population ages, dementia, a neurodegenerative disease, is becoming an important problem. Various Alzheimer's drugs have been developed based on the disease mechanism, but alternative treatments are required because of the low bioavailability and hepatotoxicity of current medications. Ishige foliacea is a type of brown algae containing various bioactive substances. Phlorotannins, known as brown algae polyphenols, have been studied for their various functionalities such as, anticancer, anti-obesity, antioxidant, and sleep improvement effects, and have attracted attention as raw materials for developing new natural products. We found that the EEI mitigates SCO-induced damage by protecting neurons from oxidative stress-induced cell damage, controlling synthesis mechanisms of the causative agents of AD, and activating BDNF-TrkB-ERK signaling to promote memory function in the hippocampus. The results of this study can serve as a foundation for further research. Additionally, I. foliacea may be useful for treating and improving AD.
Tae-Eun Kim, Hyun Jung Son, Dong Wook Lim, Minseok Yoon, Jaekwang Lee, Yun Tai Kim, Daeseok Han, Changho Lee, Min Young Um

1666 related Products with: Memory-enhancing effects of Ishige foliacea extract: In vitro and in vivo study.

50 ug96 tests1mg400 ug10mg96 tests400 ug1 mg48 samples1 mg

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#32007553   2020/01/31 To Up

2,3,5,4'-Tetrahydroxystilbene-2-O-β-d-glucoside Restores BDNF-TrkB and FGF2-Akt Signaling Axis to Attenuate Stress-induced Depression.

Depression is a long term inhibitory mood that heavily disabled human beings. We have previously demonstrated anti-depression effect of 2,3,5,4'-tetrahydroxystilbene-2-O-β-d-glucoside (THSG) in chronic-restraint stress (CRS) induced depressive-like mice by restoring the oxidative pathway and neuroinflammation. In this study, we examine the conditions of neurotrophins in CRS-induced depressive-like mice and whether THSG could be an antidepressant by ameliorating the neurotrophins and their associated signaling axis. CRS produced downregulation of antioxidants, the decline of brain-derived neurotrophic factor (BDNF), fibroblast growth factor 2 (FGF2) and associated signaling regulators in the hippocampus and prefrontal cortex, corresponding to the behavioral inability and anhedonia. Administration of THSG restored the expression of antioxidants and neurotrophins BDNF, FGF2. Besides, THSG recovered the Akt signaling pathway and antagonistically restored the expression of Bcl-2 and cleaved-caspase-3 to inhibit apoptosis. Consistently, behavioral performances were recovered from CRS-induced motor inability and anhedonia. In summary, THSG is effective to attenuate stress-induced depression by ameliorating the biochemistry of neurotrophins and their related signaling pathways. These results may provide an avenue to take BDNF as a target to explore folk medicine for anti-depression.
Xi-Xi Li, Yun Yu, Xiu-Yuan Lang, Cheng-Yong Jiang, Rongfeng Lan, Xiao-Yan Qin

1965 related Products with: 2,3,5,4'-Tetrahydroxystilbene-2-O-β-d-glucoside Restores BDNF-TrkB and FGF2-Akt Signaling Axis to Attenuate Stress-induced Depression.

100.00 ug1 module100ul1 mg410 30 m Pcs Per Pack10 IU 25 G480/kit1 mg

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