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#35961742   // To Up

Surgical Management of Mycobacterial Infections and Related Complex Pleural Space Problems: From History to Modern Day.

Owing to the advent of effective drugs for tuberculosis in the mid-twentieth century, few cases require surgery for active tuberculosis in the present day in areas where effective drugs are available. However, surgical techniques developed to combat tuberculosis in the predrug era are still useful to manage the challenging chest pathology of our time surgically, such as destroyed lung or postresectional empyema. Thoracoplasty and open window thoracostomy are representative procedures and discussed in detail in this review.
Miyako Hiramatsu, Jun Atsumi, Yuji Shiraishi

1160 related Products with: Surgical Management of Mycobacterial Infections and Related Complex Pleural Space Problems: From History to Modern Day.

50 IU50 mg1 kit(96 Wells)200 ug 125 ml 100 5 G1 module 50 ul1000 5mg

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#35961687   2022/08/12 To Up

Case of idiopathic multicentric Castleman's disease: the master mimicker.

A woman in her 20s with no medical history presented with progressive abdominal distension, right-sided abdominal discomfort, fatigue and nausea. Examination showed multifocal lymphadenopathy and hepatomegaly with tense ascites. Investigations revealed a multisystem inflammatory condition characterised by elevated acute phase reactants, anaemia, thrombocytopenia, acute kidney injury, lymphocytic ascites, hypoalbuminaemia and hypergammaglobulinaemia. HIV and human herpes virus-8 tests were both negative. In the presence of elevated ANA and SS-A/Ro antibodies, the patient was suspected to be carrying a connective tissue disease, most likely systemic lupus erythematosus (SLE). Clinical and laboratory findings fulfilled the diagnostic criteria for SLE. However, lymph node biopsy showed interfollicular plasmacytosis, associated with high interleukin 6 (IL-6) and vascular endothelial growth factor titers, together hinting towards a rare diagnosis of multicentric Castleman's disease (MCD). As we investigated further, renal biopsy was consistent with thrombotic microangiopathy which has been previously reported in MCD. Furthermore, immune staining on the renal biopsy was negative for 'full-house' immunoglobulin and complement staining pattern, which is specific for lupus nephritis, helping us exclude SLE. In light of these new findings, the patient was started on anti-IL-6 therapy which provided a successful outcome.
Larabe Farrukh, Andrea Lightle, Ruben Peredo-Wende, Shannon Murawski

1647 related Products with: Case of idiopathic multicentric Castleman's disease: the master mimicker.