Search results for: AntiMfn1
#38334845 2024/02/09 To Up
Effect of superficial adipose tissue mitochondrial and cellular functionality induced by extracorporeal shock wave therapy (ESWT).
Due to its regenerative action, extracorporeal shock wave therapy (ESWT) is applied in treating integumentary and musculoskeletal diseases. However, other potential therapeutic interventions are being investigated. It is essential to fully understand its mitochondrial signaling pathway to achieve this, which plays a fundamental role in elucidating the mechanism of action and possible therapeutic interventions. Thus, this study aimed to analyze the effect of ESWT on mitochondrial pathways through the relationship between lipolysis and adipocyte apoptosis, as well as cellular functionality. This is a non-randomized case-control clinical trial where obese women received ESWT sessions in the abdominal region, after which tissue samples were collected for histological and immunohistochemical analyses of adipose tissue. The data demonstrated positivity in the expression of mitochondrial markers related to cell apoptosis, such as FIS1 (p < 0.0203) and OPA1 (p < 0.0283), in addition to the positivity of anti-MFN1, responsible for regulating mitochondrial cell proliferation (p < 0.0003). In summary, this study demonstrates that ESWT was able to activate specific mitochondrial signaling pathways, which may be associated with its ability to stimulate lipolysis and apoptosis in superficial adipose tissue. However, no significant improvements in cellular functionality were observed.Débora Aparecida Oliveira Modena, Ana Paula Ferro, Everton Cazzo, Elaine Caldeira de Oliveira Guirro, Elinton Adami Chaim
1398 related Products with: Effect of superficial adipose tissue mitochondrial and cellular functionality induced by extracorporeal shock wave therapy (ESWT).
96 assays500 MG96/kitRelated Pathways
#36580020 2023/03/29 To Up
Prediction of Erosive Disease Development by Antimitochondrial Antibodies in Rheumatoid Arthritis.
Mitochondria are found in the extracellular space in rheumatoid arthritis (RA). However, whether mitochondria are a source of autoantigens in RA has not been carefully addressed. Thus, we undertook this study to investigate the presence and significance of antimitochondrial antibodies (AMAs) in patients with RA.Richard E Moore, Ting Wang, Bhargavi Duvvuri, Marie L Feser, Kevin D Deane, Joshua J Solomon, J Lee Nelson, M Kristen Demoruelle, Christian Lood
1682 related Products with: Prediction of Erosive Disease Development by Antimitochondrial Antibodies in Rheumatoid Arthritis.
100 μg2 Pieces/Box100 μg100 μg100 μg100 μg100 μg100 μg100 μg100.00 ug1 ml100 μgRelated Pathways
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#35128841 2022/06/06 To Up
Identification of Mitofusin 1 and Complement Component 1q Subcomponent Binding Protein as Mitochondrial Targets in Systemic Lupus Erythematosus.
Mitochondria are organelles that exhibit several bacterial features, such as a double-stranded genome with hypomethylated CpG islands, formylated proteins, and cardiolipin-containing membranes. In systemic lupus erythematosus (SLE), mitochondria and their inner components are released into the extracellular space, potentially eliciting a proinflammatory response from the immune system. While cardiolipin and mitochondrial DNA and RNA are confirmed targets of autoantibodies, other antigenic mitochondrial proteins in SLE remain to be identified. The present study was undertaken to characterize the protein repertoire recognized by antimitochondrial antibodies (AMAs) in patients with SLE.Yann L C Becker, Jean-Philippe Gagné, Anne-Sophie Julien, Tania Lévesque, Isabelle Allaeys, Nadine Gougeard, Vicente Rubio, François-Michel Boisvert, Dominique Jean, Eric Wagner, Guy G Poirier, Paul R Fortin, Éric Boilard
2464 related Products with: Identification of Mitofusin 1 and Complement Component 1q Subcomponent Binding Protein as Mitochondrial Targets in Systemic Lupus Erythematosus.
1000 TESTS/0.65ml100ug Lyophilized100ul100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized10100ug Lyophilized100 μg100ug Lyophilized100ug LyophilizedRelated Pathways
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