Only in Titles

Search results for: AntiVIP

paperclip

#3398995   // To Up

Vasoactive intestinal polypeptide neuron changes in the senile rat suprachiasmatic nucleus.

The suprachiasmatic nucleus (SCN) is thought to be the main neuronal oscillator underlying circadian rhythmicity of different biological phenomena such as sleep-wakefulness and body temperature. Although numerous studies in old rats showed that circadian organization is clearly disturbed in senescence, no decrease in total SCN cell number has been observed. However, in an earlier study we found a significant decrease of approximately 30% in the number of immunocytochemically-stained vasopressin (VP) neurons in the SCN of the old rat. The aim of the present study was to examine whether another group of SCN neurons, i.e., the vasoactive intestinal polypeptide (VIP) cells, shows age-related changes parallel with disturbances found in sleep/wake parameters. Immunocytochemical staining with antiVIP followed by morphometric analysis revealed a 36% decrease in the number of immunoreactive VIP neurons in the SCN of old rats as compared to young ones. The average size of the remaining VIP cells increased in aged rats. The rapid-eye-movement (REM)-sleep time was negatively correlated with the immunoreactive VIP cell number in the old animals. VP and VIP alterations in the SCN may constitute an anatomical substrate for the circadian disturbances observed in senescence.
C A Chee, B Roozendaal, D F Swaab, E Goudsmit, M Mirmiran

2932 related Products with: Vasoactive intestinal polypeptide neuron changes in the senile rat suprachiasmatic nucleus.

20 100ul100ug96tests100ug Lyophilized96 wells100ug100ug

Related Pathways

paperclip

#3282396   // To Up

[Solid cystic acinar cell tumor of the pancreas. Immunohistologic studies of histogenesis].

A case of a very rare solid and cystic tumor of the pancreas in a 25-year-old woman was examined by immunohistochemical methods, e.g. antiglucagon, antisomatostatin, antivip etc. The stainings by the PAP- or biotin-avidin-method were negative and also those with S-100 protein and especially with chromogranin. A tumor of the endocrine system was therefore excluded. Some areas of the tumor showed positive staining with alpha-1-antitrypsin as is known in acinar cell carcinoma. The classification of the neoplasm as an acinar adenoma of the pancreas seems to be well established, mainly because several authors electronmicroscopically demonstrated structures resembling acini and zymogen granules.
H Lüchtrath, A Adams

1964 related Products with: [Solid cystic acinar cell tumor of the pancreas. Immunohistologic studies of histogenesis].

96 tests 5 G0.1ml (1mg/ml)

Related Pathways