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Search results for: Apelin

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#39507838   2024/08/24 To Up

Proprotein convertase subtilisin/kexin type 9 and apelin in fibromyalgia syndrome.

This study aimed to investigate the potential roles of proprotein convertase subtilisin/ kexin type 9 (PCSK9) and apelin in the etiology of fibromyalgia syndrome (FS).
Nevsun Pihtili Taş, Rabia Aydogan Baykara, Ayhan Kamanli, Ali Gürbüz, Erkan Cure, Medine Cumhur Cüre, Mehmet Erdem, Tugce Tasar Yildirim

1581 related Products with: Proprotein convertase subtilisin/kexin type 9 and apelin in fibromyalgia syndrome.

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#39527336   2024/11/11 To Up

Predictors for Irreversibility of Contrast-Induced Acute Kidney Injury in Patients with Obesity After Contrast-Enhanced Computed Tomography Coronary Angiography.

Although contrast-induced (CI) acute kidney injury (AKI) is a common complication in high-risk individuals requiring evaluation with contrast-enhanced angiography, the possible predictors of CI-AKI in patients with obesity are not fully understood. The aim of this study was to elucidate plausible factors associated with the irreversibility of CI-AKI in individuals with obesity undergoing contrast-enhanced computed tomography coronary angiography.
Tetiana A Berezina, Oleksandr O Berezin, Michael Lichtenauer, Alexander E Berezin

1712 related Products with: Predictors for Irreversibility of Contrast-Induced Acute Kidney Injury in Patients with Obesity After Contrast-Enhanced Computed Tomography Coronary Angiography.

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#39524752   2024/10/18 To Up

Multi-omics analysis revealed significant metabolic changes in brain cancer cells treated with paclitaxel and/or topotecan.

Glioblastoma (GBM) stands as the most common primary malignant brain tumor. Despite the best standard therapies, GBM survivors have a brief survival time, about 24 months on average. The treatment is troublesome because the cancer cells may not respond well to specific therapies as they grow within an extensive network of blood vessels. Our study aims to evaluate the impact of paclitaxel 5.3 μg/mL and topotecan 0.26 μM solely and in pairwise combination on the resultant metabolic and proteomic signatures of the U87 cell line while using the precise ultra-high-performance liquid chromatography quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF) analytical technology. The U87 cells wear treated with DMSO, paclitaxel 5.3 μM, topotecan 0.26 μM, and their combinations. Using One-way ANOVA, we observed 14 significantly altered metabolites compared to those cells treated with DMSO. For combination treatment (paclitaxel and topotecan), 11 metabolites were significantly dysregulated. Sparse partial least squares-discriminant analysis (sPLS-DA) revealed minimal overlap, highlighting distinctions among the four groups. While for proteomics, a total of 79 proteins were significantly dysregulated among the groups. These findings can aid in identifying new biomarkers associated with the utilized drugs and creating a map for targeted therapy. EIF3F, GNB2L1, HINT2, and RPA3 were shown to be significantly upregulated in the combination group relative to the control. Moreover, ribosome, apoptosis, HIF-1 signaling, arginine and proline, glutathione, purine metabolism, apelin signaling pathway, and glycolysis were significantly altered in the combination group. Overall, this study underscores the effectiveness of multi-omics approaches in revealing the molecular mechanisms driving chemotherapy responses in cancer cells. Additionally, this work generates a comprehensive list of molecular alterations that can serve as a foundation for further investigations and inform personalized healthcare strategies to enhance patient outcomes.
Ahlam M Semreen, Leen Oyoun Alsoud, Mohammad H Semreen, Munazza Ahmed, Hamza M Al-Hroub, Raafat El-Awady, Wafaa S Ramadan, Ahmad Abuhelwa, Yasser Bustanji, Nelson C Soares, Karem H Alzoubi

2884 related Products with: Multi-omics analysis revealed significant metabolic changes in brain cancer cells treated with paclitaxel and/or topotecan.



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#39519480   2024/10/26 To Up

The Effect of a Multidisciplinary Lifestyle Intervention Program on Apelin-12, Vaspin and Resistin Concentrations in Children and Adolescents with Overweight and Obesity.

Obesity in childhood and adolescence has reached epidemic proportions in recent decades. In the present study, we determined the concentrations of apelin-12, vaspin and resistin in 106 children and adolescents with overweight or obesity before and after the implementation of a multidisciplinary, personalized lifestyle intervention program of diet, sleep and exercise for 1 year. All subjects attended our Center for the Prevention and Management of Overweight and Obesity in Childhood and Adolescence. Following the lifestyle intervention, there were significant decreases in BMI ( < 0.01), apelin-12 ( < 0.05) and resistin ( < 0.01) concentrations, and an increase in vaspin ( < 0.01) concentration. Glucose was the best positive predictor of apelin-12 (b = 0.236, < 0.05), and osteopontin was the best negative predictor of changes in apelin-12 (b = -0.299, < 0.05). Vaspin correlated positively with adiponectin (b = 0.29, < 0.05), while vitamin D (b = 0.621, < 0.05) was the best positive predictor of vaspin. BMI z score (b = -0.794, < 0.05), HDL (b = -0.284, < 0.05) and HbA1C (b = -0.262, < 0.05) were the best negative predictors of changes in vaspin. BMI z score was the best positive predictor of resistin (b = 0.437, < 0.05). These findings suggest that apelin-12, vaspin and resistin correlate with indices of obesity, glucose, lipids and bone metabolism, while interaction with other proteins, such as osteopontin and adiponectin, was also noted. Therefore, apelin-12, vaspin and resistin may be used as biomarkers in children and adolescents with overweight and obesity.
Sofia I Karampatsou, George Paltoglou, Sofia M Genitsaridi, Penio Kassari, Evangelia Charmandari

1350 related Products with: The Effect of a Multidisciplinary Lifestyle Intervention Program on Apelin-12, Vaspin and Resistin Concentrations in Children and Adolescents with Overweight and Obesity.

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#39513765   2024/11/08 To Up

Divergent roles of DRY and NPxxY motifs in selective activation of downstream signalling by the apelin receptor.

G protein-coupled receptors (GPCRs) serve as critical communication hubs, translating a wide range of extracellular signals into intracellular responses that govern numerous physiological processes. In class-A GPCRs, conserved motifs mediate conformational changes of the active states of the receptor, and signal transduction is achieved by selectively binding to Gα proteins and/or adapter protein, arrestin. Apelin receptor (APJR) is a class-A GPCR that regulates a wide range of intracellular signalling cascades in response to apelin and elabela peptide ligands. Understanding how conserved motifs within APJR mediate activation and signal specificity remains unexplored. This study focuses on the functional roles of the DRY and NPxxY motifs within APJR by analyzing their impact on downstream signaling pathways across the receptor's conformational ensembles. Our findings provide compelling evidence that mutations within the conserved DRY and NPxxY motifs of APJR significantly alter its conformational preferences where modification of DRY motif leads to abrogation of G-protein coupling and mutation of NPxxY motif causing abolition of β-arrestin-2 recruitment. These observations shed light on the importance of these motifs in APJR activation and its potential for functional selectivity, highlighting the role of DRY/NPxxY as conformational switches of APJR signalling.
Subhashree Murali, Gopala Krishna Aradhyam

1625 related Products with: Divergent roles of DRY and NPxxY motifs in selective activation of downstream signalling by the apelin receptor.

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#39497115   2024/11/04 To Up

Protective effect of apelin-13 in lens epithelial cells via inhibiting oxidative stress-induced apoptosis.

It is widely accepted that glaucoma-induced oxidative stress expedites cataracts' process. Therefore, we examined the effects of apelin-13 against oxidative stress-induced damage in human lens epithelial cells (HLECs) and investigated the potential pathogenic mechanism of acute primary angle-closure glaucoma.
Xue Li, Chao Gu, Qiumei Hu, Liqin Wang, Ya Zhang, Ling Yu

2648 related Products with: Protective effect of apelin-13 in lens epithelial cells via inhibiting oxidative stress-induced apoptosis.

100 ug5ug100ug1x10e7 cells1 g10 ug4 Membranes/Box96 assays25 mg

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#39493766   2024/10/18 To Up

Age-specific changes in the serum proteome of female anadromous, hilsa a comparative analysis across developmental stages.

The proteome profile of the female (Hamilton, 1822), a species of great ecological and economic importance, across various age groups was investigated to comprehend the functional dynamics of the serum proteome for conservation and aquaculture, as well as sustain the population.
Hena Chakraborty, Hirak Jyoti Chakraborty, Basanta Kumar Das, Joydev Maity

2137 related Products with: Age-specific changes in the serum proteome of female anadromous, hilsa a comparative analysis across developmental stages.

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#39491401   2023/10/19 To Up

Apelin alleviates sepsis-induced acute lung injury in part by modulating the SIRT1/NLRP3 pathway to inhibit endothelial cell pyroptosis.

Sepsis, an intricate systemic inflammatory syndrome, gives rise to various life-threatening complications, with acute lung injury (ALI) being prominently encountered. ALI, clinically characterized by pulmonary infiltration, hypoxemia, and edema, stands as a prevailing consequence of sepsis. This work sought to elucidate the mechanism of Apelin in mitigating sepsis-induced ALI (siALI).
Manyan Zhang, Jiyu Ning, Yu Lu

2302 related Products with: Apelin alleviates sepsis-induced acute lung injury in part by modulating the SIRT1/NLRP3 pathway to inhibit endothelial cell pyroptosis.

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#39488262   2024/10/31 To Up

Activation of the apelin/APJ system by vitamin D attenuates age-related muscle atrophy.

Age-related frailty and reduced physical activity contribute to a degenerative loss of muscle mass, function, and strength, which is known as sarcopenia. Increasing evidence has shown that vitamin D has beneficial effects on the muscle health. However, the molecular mechanisms of vitamin D have not been fully elucidated. In this study, we aimed to demonstrate whether vitamin D can overcome muscle atrophy due to aging, especially with respect to the regulation of myokines.
Yoo Jeong Lee, Gyu Hee Kim, Da Som Lee, Hyeon-Ju Jeong, Joo Hyun Lim

2447 related Products with: Activation of the apelin/APJ system by vitamin D attenuates age-related muscle atrophy.

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#39477221   2024/10/30 To Up

Genomic predictors of fat mass response to the standardized exercise training.

To explore the genetic architecture underlying exercise-induced fat mass change, we performed a genome-wide association study with a Chinese cohort consisting of 442 physically inactive healthy adults in response to a 12-week exercise training (High-intensity Interval Training or Resistance Training). The inter-individual response showed an exercise-induced fat mass change and ten novel lead SNPs were associated with the response on the level of P<1×10. Four of them (rs7187742, rs1467243, rs28629770 and rs10848501) showed a consistent effect direction in the European ancestry. The Polygenic Predictor Score (PPS) derived from ten lead SNPs, sex, baseline body mass and exercise protocols explained 40.3% of the variance in fat mass response, meanwhile importantly the PPS had the greatest contribution. Of note, the subjects whose PPS was lower than -9.301 had the highest response in exercise-induced fat loss. Finally, we highlight a series of pathways and biological processes regarding the fat mass response to exercise, e.g. apelin signaling pathway, insulin secretion pathway and fat cell differentiation biological process.
Xiaolin Yang, Yanchun Li, Dapeng Bao, Bing Yan, Tao Mei, Xiaoxi Liu, Pawel Cięszczyk, IldusI Ahmetov, LarsRobert Mc Naughton, Zihong He

2712 related Products with: Genomic predictors of fat mass response to the standardized exercise training.

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