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#32693232   2020/07/15 To Up

Psoas hematoma in the elderly patient, a diagnostic challenge, a case report.

A psoas hematoma is an uncommon condition in patients on anticoagulant therapy and patients with bleeding disorders. It can present itself with non-specific symptoms, as anemia, pain and hemodynamically instability. The CT angioscan is the diagnostic test of choice.
Anne G Posthuma, Mike Hogervorst, Barbara C van Munster

1709 related Products with: Psoas hematoma in the elderly patient, a diagnostic challenge, a case report.



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#32670520   2020/07/01 To Up

Children in Coronaviruses' Wonderland: What Clinicians Need to Know.

Human coronaviruses (HCoVs) commonly cause mild upper-respiratory tract illnesses but can lead to more severe and diffusive diseases. A variety of signs and symptoms may be present, and infections can range in severity from the common cold and sore throat to more serious laryngeal or tracheal infections, bronchitis, and pneumonia. Among the seven coronaviruses that affect humans (SARS)-CoV, the Middle East respiratory syndrome (MERS)-CoV, and the most recent coronavirus disease 2019 (COVID-19) represent potential life-threatening diseases worldwide. In adults, they may cause severe pneumonia that evolves in respiratory distress syndrome and multiorgan failure with a high mortality rate. Children appear to be less susceptible to develop severe clinical disease and present usually with mild and aspecific symptoms similar to other respiratory infections typical of childhood. However, some children, such as infants, adolescents, or those with underlying diseases may be more at-risk categories and require greater caution from clinicians. Available data on pediatric coronavirus infections are rare and scattered in the literature. The purpose of this review is to provide to clinicians a complete and updated panel useful to recognize and characterize the broad spectrum of clinical manifestations of coronavirus infections in the pediatric age.
Giuseppe Lassandro, Valentina Palladino, Anna Amoruso, Viviana Valeria Palmieri, Giovanna Russo, Paola Giordano

2116 related Products with: Children in Coronaviruses' Wonderland: What Clinicians Need to Know.

96 wells (1 kit)1 mg 1 G1mg1 kit500 gm.100 μg100 mg

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#32634617   2020/06/23 To Up

Intramural ectopic pancreatic tissue of the stomach: A case report of an uncommon origin of a non-cancerous gastric tumour.

Ectopic pancreatic tissue is often incidentally encountered during abdominal surgery. We report a case of an incidental finding during a laparoscopic appendectomy, the approach to diagnosis and management of this. The work has been reported in line with the SCARE criteria.
Enrica Chiriatti, Paulina Kuczma, Domenico Galasso, E Koliakos, Edgardo Pezzetta, Olivier Martinet

2940 related Products with: Intramural ectopic pancreatic tissue of the stomach: A case report of an uncommon origin of a non-cancerous gastric tumour.



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#32630815   2020/07/02 To Up

Cell-Mediated Release of Nanoparticles as a Preferential Option for Future Treatment of Melanoma.

Targeted and immune therapies have unquestionably improved the prognosis of melanoma patients. However the treatment of this neoplasm still requires approaches with a higher therapeutic index, in order to reduce shortcomings related to toxic effects and aspecific targeting. This means developing therapeutic tools derived with high affinity molecules for tumor components differentially expressed in melanoma cells with respect to their normal counterpart. Nanomedicine has sought to address this problem owing to the high modulability of nanoparticles. This approach exploits not only the enhanced permeability and retention effect typical of the tumor microenvironment (passive targeting), but also the use of specific "molecular antennas" that recognize some tumor-overexpressed molecules (active targeting). This line of research has given rise to the so-called "smart nanoparticles," some of which have already passed the preclinical phase and are under clinical trials in melanoma patients. To further improve nanoparticles partition within tumors, for some years now a line of thought is exploiting the molecular systems that regulate the innate tumor-homing activity of platelets, granulocytes, monocytes/macrophages, stem cells, endothelial-colony-forming cells, and red blood cells loaded with nanoparticles. This new vision springs from the results obtained with some of these cells in regenerative medicine, an approach called "cell therapy." This review takes into consideration the advantages of cell therapy as the only one capable of overcoming the limits of targeting imposed by the increased interstitial pressure of tumors.
Anastasia Chillà, Francesca Margheri, Alessio Biagioni, Tommaso Del Rosso, Gabriella Fibbi, Mario Del Rosso, Anna Laurenzana

1234 related Products with: Cell-Mediated Release of Nanoparticles as a Preferential Option for Future Treatment of Melanoma.

100tests25 Tests1 kit96 samples1 kit500 assaysEach1000100 tests1 kit1 kit

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#32627327   2020/07/05 To Up

Jejunoileal diverticula: a broad spectrum of complications.

Small bowel diverticula are a rare condition occurring mainly in the elderly. They can be isolated or multiple and can involve the duodenum, jejunum and ileum. Acute complications are extremely rare, with an aspecific pattern of symptoms. The aim of the study is to report the different patterns of presentation of patients with complicated jejunoileal diverticula.
Gabriele Bellio, Hayato Kurihara, Mauro Zago, Dario Tartaglia, Massimo Chiarugi, Sara Coppola, Alan Biloslavo, Nicolò de Manzini

2523 related Products with: Jejunoileal diverticula: a broad spectrum of complications.

100ul

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#32622186   2020/06/20 To Up

Rapidly fatal outcome of Covid-19 after successful emergency surgery during pandemic outbreak in Northern Italy.

A pandemic outbreak of novel coronavirus, named SARS-CoV-2 and responsible of Coronavirus Disease 2019 (COVID-19), has rapidly spread from China to Europe, being Northern Italy the first focus outside Asia. Little is known about the evolution of SARS-CoV-2 infection in patients undergoing surgery.
Filippo Montali, Gerardo Palmieri, Lorenzo Casali, Lorenzo Pagliai, Renato Costi

2080 related Products with: Rapidly fatal outcome of Covid-19 after successful emergency surgery during pandemic outbreak in Northern Italy.

5 mg5mg100 μg25 mg100 μg100ug Lyophilized100 μg100ug Lyophilized1 mg

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#32562382   2020/06/19 To Up

QRS fragmentation as a possible electrocardiographic diagnostic marker in patients with acute myocarditis: preliminary histopathological validation.

We aim to assess the reproducibility of QRS fragmentation (fQRS) on a multi-centre dataset of patients with acute myocarditis (AM), including a histopathological validation in a subgroup with biopsy-proven disease. Electrocardiogram (ECG) in patients with myocarditis is usually considered aspecific. ST changes and conduction anomalies have been commonly reported so far. We have previously described fQRS in patients with AM.
Paolo Ferrero, Isabelle Piazza, Uwe Kühl, Aurelia Grosu, Carsten Tschöpe, Michele Senni

2942 related Products with: QRS fragmentation as a possible electrocardiographic diagnostic marker in patients with acute myocarditis: preliminary histopathological validation.

100 assays24 tests100 assays20 100 assays

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#32557407   2020/06/18 To Up

Ultrasound 2-D and 3-D diagnosis of Rubinstein-Taybi syndrome in a 21-week-old fetus.

Rubinstein-Taybi syndrome is a rare genetic multisystem disorder with an estimated prevalence between 1 per 100,000-125,000 live births. Diagnosis is usually clinical and subsequent to birth. In fact, the rarity of the syndrome and the presence of aspecific morphologic anomalies make prenatal diagnosis challenging. The aim of our work is to analyze ultrasonographic findings, detectable with a combination of 2D and 3D techniques, which may increase the sensitivity of in utero diagnosis of this condition. We report a case of a sonographic prenatal diagnosis of broad and angulated thumbs and halluces and of an abnormal ductus venosus at 21 weeks of gestational age. These findings allowed us to suspect Rubinstein-Taybi syndrome. An accurate ultrasonographic examination may allow a prenatal diagnosis of those syndromes which are usually diagnosed after birth.
Francesco D'Ambrosi, Luisa Ronzoni, Roberta Villa, Stefano De Marinis, Giulia Emily Cetera, Chiara Maria Soldavini, Enrico Ferrazzi

2497 related Products with: Ultrasound 2-D and 3-D diagnosis of Rubinstein-Taybi syndrome in a 21-week-old fetus.

25 mg100ug Lyophilized100 assays100 μg900 tests500 tests1000 tests100 μg20 ul5 mg96 tests

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#32507746   2020/05/16 To Up

Modeling the impact of mass influenza vaccination and public health interventions on COVID-19 epidemics with limited detection capability.

The emerging coronavirus SARS-CoV-2 has caused a COVID-19 pandemic. SARS-CoV-2 causes a generally mild, but sometimes severe and even life-threatening infection, known as COVID-19. Currently, there exist no effective vaccines or drugs and, as such, global public authorities have so far relied upon non pharmaceutical interventions (NPIs). Since COVID-19 symptoms are aspecific and may resemble a common cold, if it should come back with a seasonal pattern and coincide with the influenza season, this would be particularly challenging, overwhelming and straining the healthcare systems, particularly in resource-limited contexts, and would increase the likelihood of nosocomial transmission. In the present study, we devised a mathematical model focusing on the treatment of people complaining of influenza-like-illness (ILI) symptoms, potentially at risk of contracting COVID-19 or other emerging/re-emerging respiratory infectious agents during their admission at the health-care setting, who will occupy the detection kits causing a severe shortage of testing resources. The model is used to assess the effect of mass influenza vaccination on the spread of COVID-19 and other respiratory pathogens in the case of a coincidence of the outbreak with the influenza season. Here, we show that increasing influenza vaccine uptake or enhancing the public health interventions would facilitate the management of respiratory outbreaks coinciding with the peak flu season, especially, compensate the shortage of the detection resources. However, how to increase influenza vaccination coverage rate remains challenging. Public health decision- and policy-makers should adopt evidence-informed strategies to improve influenza vaccine uptake.
Qian Li, Biao Tang, Nicola Luigi Bragazzi, Yanni Xiao, Jianhong Wu

1385 related Products with: Modeling the impact of mass influenza vaccination and public health interventions on COVID-19 epidemics with limited detection capability.

5 G0.1 mg50 mgmin 2 cartons10100 mg1 mg2100 assays50

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#32472706   2020/05/30 To Up

The long-standing history of Corynebacterium parvum, immunity, and viruses.

We report a review of all the experimental and clinical studies performed in the last 60 years on the antiviral activity of inactivated Corynebacterium parvum (Cutibacterium acnes). This bacterium has been originally investigated and used for its oncolytic properties linked to immunomodulating activity, but the interest to successfully prevent and treat bacterial, fungal, and viral infections and lethality, uprising the innate immunity barriers produced many experimental models and very few clinical studies. The dramatic defenseless situation due to impending CoViD-19 pandemic claims to exhume and highlight this aspecific strategy in preventive and therapeutic settings; as a matter of fact, no new or mutated virus can potentially escape to this strong innate immune surveillance strengthened by adequate C. parvum protocols.
Beniamino Palmieri, Maria Vadalà, Luca Roncati, Andrea Garelli, Francesco Scandone, Moreno Bondi, Claudio Cermelli

2491 related Products with: The long-standing history of Corynebacterium parvum, immunity, and viruses.

25 mg2000 IU100 ug 5 G100.00 ul1 mg 5 G100ul1100ug

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