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#35644446   2022/05/26 To Up

Update to RIFM fragrance ingredient safety assessment, 2,4-dimethylbenzyl acetate, CAS Registry Number 62346-96-7.

The MOE is greater than 100. Without adjustment for specific uncertainty factors related to inter-species and intra-species variation, the material exposure by inhalation at 0.0040 mg/day is deemed to be safe under the most conservative consumer exposure scenario.
A M Api, D Belsito, D Botelho, M Bruze, G A Burton, M A Cancellieri, H Chon, M L Dagli, M Date, W Dekant, C Deodhar, A D Fryer, L Jones, K Joshi, M Kumar, A Lapczynski, M Lavelle, I Lee, D C Liebler, H Moustakas, M Na, T M Penning, G Ritacco, J Romine, N Sadekar, T W Schultz, D Selechnik, F Siddiqi, I G Sipes, G Sullivan, Y Thakkar, Y Tokura

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100 MG 5 G 1 G 1 G 25 G 5 G 1 G 100 G 25 G 25 G

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#35640856   2022/05/28 To Up

Update to RIFM fragrance ingredient safety assessment, benzyl acetate, CAS Registry Number 140-11-4.

A M Api, D Belsito, D Botelho, M Bruze, G A Burton, M A Cancellieri, H Chon, M L Dagli, M Date, W Dekant, C Deodhar, A D Fryer, L Jones, K Joshi, M Kumar, A Lapczynski, M Lavelle, I Lee, D C Liebler, H Moustakas, M Na, T M Penning, G Ritacco, J Romine, N Sadekar, T W Schultz, D Selechnik, F Siddiqi, I G Sipes, G Sullivan, Y Thakkar, Y Tokura

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5 MG 5 G 100 G 100 G1 g 25 G 100 G 25 G 5 G 25 G 5 G 100 G

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#35630563   2022/05/11 To Up

Novel and Potent Acetylcholinesterase Inhibitors for the Treatment of Alzheimer's Disease from Natural (±)-7,8-Dihydroxy-3-methyl-isochroman-4-one.

Alzheimer's disease (AD) is a neurodegenerative disease that causes memory and cognitive decline as well as behavioral problems. It is a progressive and well recognized complex disease; therefore, it is very urgent to develop novel and effective anti-AD drugs. In this study, a series of novel isochroman-4-one derivatives from natural (±)-7,8-dihydroxy-3-methyl-isochroman-4-one [(±)-XJP] were designed and synthesized, and their anti-AD potential was evaluated. Among them, compound [()-3-acetyl-1-benzyl-4-((6,7-dimethoxy-4-oxoisochroman-3-ylidene)methyl)pyridin-1-ium bromide] possessed potent anti-acetylcholinesterase (AChE) activity as well as modest antioxidant activity. Further molecular modeling and kinetic investigations revealed that compound was a dual-binding inhibitor that binds to both catalytic anionic site (CAS) and peripheral anionic site (PAS) of the enzyme AChE. In addition, compound exhibited low cytotoxicity and moderate anti-A aggregation efficacy. Moreover, the in silico screening suggested that these compounds could pass across the blood-brain barrier with high penetration. These findings show that compound was a promising lead from a natural product with potent AChE inhibitory activity and deserves to be further developed for the prevention and treatment of AD.
Xinnan Li, Yilin Jia, Junda Li, Pengfei Zhang, Tiantian Li, Li Lu, Hequan Yao, Jie Liu, Zheying Zhu, Jinyi Xu

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96 tests96 tests96 tests96 tests50 mL25 mg 125 ml 1 g

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#35470952   2022/04/26 To Up

Scalable Synthesis of Photoluminescent Single-Chain Nanoparticles by Electrostatic-Mediated Intramolecular Crosslinking.

We report the large-scale synthesis of photoluminescent single-chain nanoparticles (SCNPs) by electrostatic-mediated intramolecular crosslinking in a concentrated solution of 40 mg mL by continuous addition of the free radical initiator. Poly(vinyl benzyl chloride) was charged by quaternization with vinyl-imidazolium for the intramolecular crosslinking by using 2,2-dimethoxy-2-phenylacetophenone (DMAP) as the radical initiator. Under the electrostatic repulsion thus interchain isolation, the intrachain crosslinking experiences the transition from coil through pearl-necklace to globular state. The SCNPs demonstrate strong photoluminescence in the visible range when the non-emissive units are confined thereby. Composition and microstructure of the SCNPs are tunable. The photoluminescent tadpole-like Janus SCNP can be used to selectively illuminate interfacial membranes while stabilizing the emulsions.
Yue Shao, Yong-Lei Wang, Zian Tang, Zhendong Wen, Chiawei Chang, Chunyu Wang, Dayin Sun, Yilan Ye, Dong Qiu, Yubin Ke, Feng Liu, Zhenzhong Yang

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0.1mg1mg10 1mg0.5 mg200 units100 μl 6 ml Ready-to-use 50

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#35447288   2022/04/18 To Up

Update to RIFM fragrance ingredient safety assessment, benzyl butyrate, CAS Registry Number 103-37-7.

A M Api, D Belsito, D Botelho, M Bruze, G A Burton, M A Cancellieri, H Chon, M L Dagli, M Date, W Dekant, C Deodhar, A D Fryer, L Jones, K Joshi, M Kumar, A Lapczynski, M Lavelle, I Lee, D C Liebler, H Moustakas, M Na, T M Penning, G Ritacco, J Romine, N Sadekar, T W Schultz, D Selechnik, F Siddiqi, I G Sipes, G Sullivan, Y Thakkar, Y Tokura

1345 related Products with: Update to RIFM fragrance ingredient safety assessment, benzyl butyrate, CAS Registry Number 103-37-7.

100 G 500 G 25 G 1 G 1 G 5 G 5 G 5 G 100 G500 mg 50G 1 G

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#35429862   2022/04/06 To Up

Aromaticity effect on supramolecular aggregation. Aromatic vs. cyclic monohydroxy alcohols.

In this paper, the steric hindrance effect related to the presence of either a cyclic or aromatic ring on the self-association process in the series of monohydroxy alcohols (MAs), from cyclohexanemethanol to 4-cyclohexyl-1-butanol and from benzyl alcohol to 4-phenyl-1-butanol, was studied using X-Ray Diffraction (XRD), Differential Scanning Calorimetry (DSC), Fourier Transform Infrared (FTIR) spectroscopy, Broadband Dielectric Spectroscopy (BDS) and the Pendant Drop (PD) methods. Based on FTIR results, it was shown that phenyl alcohol (PhA) and cyclohexyl alcohol (CA) derivatives reveal substantial differences in the association degree, the activation energy of dissociation, and the homogeneity of supramolecular nanoassociates suggesting that the phenyl ring exerts a stronger steric impact on the self-assembling of molecules than cyclohexyl one. Additionally, XRD data revealed that phenyl moiety introduces more heterogeneity in the organization of molecules compared to the cyclic one. The changes in the self-association process of alcohols were also reflected in differences in the molecular dynamics of the H-bonded aggregates, as well as in the Kirkwood factor, defining the long-range correlation between dipoles, which were slightly higher for CAs with respect to those determined for PhAs. Unexpectedly it was also found that the surface layers of PhAs were more organized than those formed by CAs. Thus, these findings provided insight into the impact of aromaticity on the self-assembly process, H-bonding pattern, supramolecular structure, and intermolecular dynamics of the studied alcohols.
N Soszka, B Hachuła, M Tarnacka, J Grelska, K Jurkiewicz, M Geppert-Rybczyńska, R Wrzalik, K Grzybowska, S Pawlus, M Paluch, K Kamiński

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2 ml Ready-to-use 5 G2.5 mg1x96 well plate100 MG100ug0.2 mg25 mg5x96 well plate 6 ml Ready-to-use 100.00 ug1 mg

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#35385971   2022/04/07 To Up

Associations of Phthalate Metabolites and Bisphenol A Levels with Obesity in Children: The Korean National Environmental Health Survey (KoNEHS) 2015 to 2017.

Phthalates and bisphenol A (BPA) are synthetic chemicals widely used in daily life. This study investigated urinary phthalate and BPA levels in Korean children and their associations with obesity.
Moon Young Seo, Shinje Moon, Shin-Hye Kim, Mi Jung Park

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#35292984   2022/04/10 To Up

Allergic contact dermatitis from benzyl alcohol mimicking acute generalized exanthematous pustulosis.

Hélène Traineau, Erwin Benassaia, Emmanuelle Diaz, Saskia Ingen-Housz-Oro, Haudrey Assier

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5 G1 g2.5 mg100 mg100 mg10 mg 25 G1 g250 mg 25 G10 mg 25 G

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