Search results for: Benzyl (2S,3S,5S)-2-Hexyl-3-benzyloxy-5-[[(S)-2-(formylamino)-4-(methyl-d3)-pe ntanoyl]oxy]hexadecanoate C43H64D3NO6 CAS: 1356931-00-4
#38604579 2024/04/10 To Up
RIFM fragrance ingredient safety assessment, 4-allyl-2-methoxyphenyl benzyl ether, CAS Registry Number 57371-42-3.
A M Api, A Bartlett, D Belsito, D Botelho, M Bruze, A Bryant-Freidrich, G A Burton, M A Cancellieri, H Chon, M L Dagli, W Dekant, C Deodhar, K Farrell, A D Fryer, L Jones, K Joshi, A Lapczynski, M Lavelle, I Lee, H Moustakas, J Muldoon, T M Penning, G Ritacco, N Sadekar, I Schember, T W Schultz, F Siddiqi, I G Sipes, G Sullivan, Y Thakkar, Y Tokura
2908 related Products with: RIFM fragrance ingredient safety assessment, 4-allyl-2-methoxyphenyl benzyl ether, CAS Registry Number 57371-42-3.
1 G 5 G10 mg 1 G 1 G 5 G 1KG 25 G 5 G 25 G 100 G 100 GRelated Pathways
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#38553235 2024/03/12 To Up
Unraveling interplay between lignocellulosic structures caused by chemical pretreatments in enhancing enzymatic hydrolysis.
To investigate the interplay between substrate structure and enzymatic hydrolysis (EH) efficiency, poplar was pretreated with acidic sodium-chlorite (ASC), 3 % sodium-hydroxide (3-SH), and 3 % sulfuric acid (3-SA), resulting in different glucose yields of 94.10 %, 74.35 %, and 24.51 %, respectively, of pretreated residues. Residues were fractionated into cellulose, lignin and unhydrolyzed residue after EH (for lignin-carbohydrate complex (LCC) analysis) and analyzed using HPLC, FTIR, XPS, CP MAS C NMR and 2D-NMR (Lignin and LCC analysis). After delignification, holocellulose exhibited a dramatic increase in glucose yield (74.35 % to 90.82 % for 3-SH and 24.51 % to 80.0 % for 3-SA). Structural analysis of holocellulose suggested the synergistic interplay among cellulose allomorphs to limit glucose yield. Residual lignin analysis from un/pretreated residues indicated that higher β-β' contents and S/G ratios were favorable to the inhibitory effect but unfavourable to the holocellulose digestibility and followed the trend in the following order: 3-SA (L3) > 3-SH (L2) > native-lignin (L1). Analysis of enzymatically unhydrolyzed pretreated residues revealed the presence of benzyl ether (BE) LCC and phenyl glycoside (PG) bond linking to xylose (X) and mannose (M), which yielded a xylan-lignin-glucomannan network. The stability, steric hindrance and hydrophobicity of this network may play a central role in defining poplar recalcitrance.Usama Shakeel, Yu Zhang, Evangelos Topakas, Wen Wang, Cuiyi Liang, Wei Qi
1972 related Products with: Unraveling interplay between lignocellulosic structures caused by chemical pretreatments in enhancing enzymatic hydrolysis.
100 assays100 μg1 pce96 wells (1 kit)100ug Lyophilized1 L.1 Set 1 G1 SetRelated Pathways
#38513663 2024/03/20 To Up
Transport mechanism and pharmacology of the human GlyT1.
TYiqing Wei, Renjie Li, Yufei Meng, Tuo Hu, Jun Zhao, Yiwei Gao, Qinru Bai, Na Li, Yan Zhao
1072 related Products with: Transport mechanism and pharmacology of the human GlyT1.
0.1 ml100ul0.1 mg0.1 mg5mg1mg200 0.1ml (1mg/ml)0.1 ml1 ml101000Related Pathways
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#38419383 2024/02/28 To Up
2D Graphene Oxide Membrane Nanoreactors for Rapid Directional Flow Ring-Opening Reactions with Dominant Same-Configuration Products.
Nanoconfinement within enzymes can increase reaction rate and improve selectivity under mild conditions. However, it remains a great challenge to achieve chemical reactions imitating enzymes with directional molecular motion, short reaction time, ≈100% conversion, and chiral conversion in artificial nanoconfined systems. Here, directional flow ring-opening reactions of styrene oxide and alcohols are demonstrated with ≈100% conversion in <120 s at 22 °C using graphene oxide membrane nanoreactors. Dominant products have the same configuration as chiral styrene oxide in confined reactions, which is dramatically opposed to bulk reactions. The unique chiral conversion mechanism is caused by spatial confinement, limiting the inversion of benzylic chiral carbon. Moreover, the enantiomeric excess of same-configuration products increased with higher alkyl charge in confined reactions. This work provides a new route to achieve rapid flow ring-opening reactions with specific chiral conversion within 2D nanoconfined channels, and insights into the impact of nanoconfinement on ring-opening reaction mechanisms.Jiangwei Fu, Shuai Pang, Yuhui Zhang, Xiang Li, Bo Song, Daoling Peng, Xiqi Zhang, Lei Jiang
1003 related Products with: 2D Graphene Oxide Membrane Nanoreactors for Rapid Directional Flow Ring-Opening Reactions with Dominant Same-Configuration Products.
1 kit1 kit1 kit100ug Lyophilized100ug Lyophilized5.0ml (200 PCR reactions)100μg 1 G25 ml100ug Lyophilized100ug Lyophilized100ug LyophilizedRelated Pathways
#38373587 2024/02/17 To Up
RIFM fragrance ingredient safety assessment, isoeugenyl benzyl ether, CAS Registry Number 120-11-6.
A M Api, A Bartlett, D Belsito, D Botelho, M Bruze, A Bryant-Freidrich, G A Burton, M A Cancellieri, H Chon, M L Dagli, W Dekant, C Deodhar, K Farrell, A D Fryer, L Jones, K Joshi, A Lapczynski, M Lavelle, I Lee, H Moustakas, J Muldoon, T M Penning, G Ritacco, N Sadekar, I Schember, T W Schultz, F Siddiqi, I G Sipes, G Sullivan, Y Thakkar, Y Tokura
1922 related Products with: RIFM fragrance ingredient safety assessment, isoeugenyl benzyl ether, CAS Registry Number 120-11-6.
100 G 5 MG 25 G 5 G 5 G 1 G 5 G 1 G 1KG 25 G 1 G 5 GRelated Pathways
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#38359754 2024/02/07 To Up
1,3-Disubstituted-1,2,4-triazin-6-ones with potent activity against androgen receptor-dependent prostate cancer cells.
Synthesis and biological evaluation of a small, focused library of 1,3-disubstituted-1,2,4-triazin-6-ones for in vitro inhibitory activity against androgen-receptor-dependent (22Rv1) and androgen-receptor independent (PC3) castration-resistant prostate cancer (CRPC) cells led to highly active compounds with in vitro IC values against 22Rv1 cells of <200 nM, and with apparent selectivity for this cell type over PC3 cells. From metabolic/PK evaluations of these compounds, a 3-benzyl-1-(2,4-dichlorobenzyl) derivative had superior properties and showed considerably stronger activity, by nearly an order of magnitude, against AR-dependent LNCaP and C4-2B cells compared to AR-independent DU145 cells. This lead compound decreased AR expression in a dose and time dependent manner and displayed promising therapeutic effects in a 22Rv1 CRPC xenograft mouse model. Computational target prediction and subsequent docking studies suggested three potential known prostate cancer targets: p38a MAPK, TGF-β1, and HGFR/c-Met, with the latter case of c-Met appearing stronger, owing to close structural similarity of the lead compound to known pyridazin-3-one derivatives with potent c-Met inhibitory activity. RNA-seq analysis showed dramatic reduction of AR signalling pathway and/or target genes by the lead compound, subsequently confirmed by quantitative PCR analysis. The lead compound was highly inhibitory against HGF, the c-Met ligand, which fitted well with the computational target prediction and docking studies. These results suggest that this compound could be a promising starting point for the development of an effective therapy for the treatment of CRPC.Shiting Zhao, Abdelsalam S Ali, Xiaomin Liu, Zhiwei Yu, Xinyu Kong, Yan Zhang, G Paul Savage, Yong Xu, Bin Lin, Donghai Wu, Craig L Francis
2042 related Products with: 1,3-Disubstituted-1,2,4-triazin-6-ones with potent activity against androgen receptor-dependent prostate cancer cells.
96T100ug100ug100.00 ul1.00 flask200ug100ul1 mlRelated Pathways
#38228780 2024/01/16 To Up
Semi-synthesis and structure-activity relationship study yield antibacterial vicenistatin derivatives with low cytotoxicity.
VJun Li, Zhenye Yang, Chuanling Shi, Xiaoyun Wu, Le Zhou, Yongqian Liang, Qinglian Li, Jianhua Ju
1469 related Products with: Semi-synthesis and structure-activity relationship study yield antibacterial vicenistatin derivatives with low cytotoxicity.
100 assays2x96 well plates 25 MG100ug100ul100 assays5ml25 mg 96 Tests 40 assaysRelated Pathways
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#38126374 2024/01/17 To Up
Exploring the impact of alignment media on RDC analysis of phosphorus-containing compounds: a molecular docking approach.
RMarkéta Christou Tichotová, Lucie Tučková, Hugo Kocek, Aleš Růžička, Michal Straka, Eliška Procházková
1044 related Products with: Exploring the impact of alignment media on RDC analysis of phosphorus-containing compounds: a molecular docking approach.
3 modules 100 UG1 module0.2 mg50 ug2 modules1 module 120 ml 1 module1 moduleRelated Pathways
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#38097085 2023/12/12 To Up
Insight into modified CeMn based catalysts for efficient degradation of toluene by in situ infrared.
TXuelian Li, Rujie Chen, Min Yang, Yongfang Niu, Jing Li, Dan Shao, Xinmei Zheng, Chuanwei Zhang, Yanxing Qi
1671 related Products with: Insight into modified CeMn based catalysts for efficient degradation of toluene by in situ infrared.
1 kit 5 G1 mg1 kit500 MG1 mg250 mg 100 G1 mg 1 GRelated Pathways
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#38090068 2023/12/11 To Up
The preparation and characterization of self-healing hydrogels based on polypeptides with a dual response to light and hydrogen peroxide.
ICongwei Wang, Dinglei Zhao, Yongjun Xie, Qiang Zhou, Haiyang Yang
1395 related Products with: The preparation and characterization of self-healing hydrogels based on polypeptides with a dual response to light and hydrogen peroxide.
100ul100ug1,000 tests1 mg100 mg1000 1000 tests100ug25 mg2.5 mgRelated Pathways
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