Search results for: Benzyl (2R,3S,5S)-2-Hexyl-3-benzyloxy-5-hydroxyhexadecanoate C36H56O4 CAS:
#38604579 
2024/04/10
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RIFM fragrance ingredient safety assessment, 4-allyl-2-methoxyphenyl benzyl ether, CAS Registry Number 57371-42-3.
A M Api, A Bartlett, D Belsito, D Botelho, M Bruze, A Bryant-Freidrich, G A Burton, M A Cancellieri, H Chon, M L Dagli, W Dekant, C Deodhar, K Farrell, A D Fryer, L Jones, K Joshi, A Lapczynski, M Lavelle, I Lee, H Moustakas, J Muldoon, T M Penning, G Ritacco, N Sadekar, I Schember, T W Schultz, F Siddiqi, I G Sipes, G Sullivan, Y Thakkar, Y Tokura
2347 related Products with: RIFM fragrance ingredient safety assessment, 4-allyl-2-methoxyphenyl benzyl ether, CAS Registry Number 57371-42-3.
1 G 1 G 5 G 1KG 1 G 5 G10 mg 100 G 25 G 100 G 1 G 5 G
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#38553235 2024/03/12
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Unraveling interplay between lignocellulosic structures caused by chemical pretreatments in enhancing enzymatic hydrolysis.
To investigate the interplay between substrate structure and enzymatic hydrolysis (EH) efficiency, poplar was pretreated with acidic sodium-chlorite (ASC), 3 % sodium-hydroxide (3-SH), and 3 % sulfuric acid (3-SA), resulting in different glucose yields of 94.10 %, 74.35 %, and 24.51 %, respectively, of pretreated residues. Residues were fractionated into cellulose, lignin and unhydrolyzed residue after EH (for lignin-carbohydrate complex (LCC) analysis) and analyzed using HPLC, FTIR, XPS, CP MAS C NMR and 2D-NMR (Lignin and LCC analysis). After delignification, holocellulose exhibited a dramatic increase in glucose yield (74.35 % to 90.82 % for 3-SH and 24.51 % to 80.0 % for 3-SA). Structural analysis of holocellulose suggested the synergistic interplay among cellulose allomorphs to limit glucose yield. Residual lignin analysis from un/pretreated residues indicated that higher β-β' contents and S/G ratios were favorable to the inhibitory effect but unfavourable to the holocellulose digestibility and followed the trend in the following order: 3-SA (L3) > 3-SH (L2) > native-lignin (L1). Analysis of enzymatically unhydrolyzed pretreated residues revealed the presence of benzyl ether (BE) LCC and phenyl glycoside (PG) bond linking to xylose (X) and mannose (M), which yielded a xylan-lignin-glucomannan network. The stability, steric hindrance and hydrophobicity of this network may play a central role in defining poplar recalcitrance.Usama Shakeel, Yu Zhang, Evangelos Topakas, Wen Wang, Cuiyi Liang, Wei Qi
1571 related Products with: Unraveling interplay between lignocellulosic structures caused by chemical pretreatments in enhancing enzymatic hydrolysis.
100 μg20 100 μg1 mg10mg10mg100ug100ug
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#38419383 2024/02/28
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2D Graphene Oxide Membrane Nanoreactors for Rapid Directional Flow Ring-Opening Reactions with Dominant Same-Configuration Products.
Nanoconfinement within enzymes can increase reaction rate and improve selectivity under mild conditions. However, it remains a great challenge to achieve chemical reactions imitating enzymes with directional molecular motion, short reaction time, ≈100% conversion, and chiral conversion in artificial nanoconfined systems. Here, directional flow ring-opening reactions of styrene oxide and alcohols are demonstrated with ≈100% conversion in <120 s at 22 °C using graphene oxide membrane nanoreactors. Dominant products have the same configuration as chiral styrene oxide in confined reactions, which is dramatically opposed to bulk reactions. The unique chiral conversion mechanism is caused by spatial confinement, limiting the inversion of benzylic chiral carbon. Moreover, the enantiomeric excess of same-configuration products increased with higher alkyl charge in confined reactions. This work provides a new route to achieve rapid flow ring-opening reactions with specific chiral conversion within 2D nanoconfined channels, and insights into the impact of nanoconfinement on ring-opening reaction mechanisms.Jiangwei Fu, Shuai Pang, Yuhui Zhang, Xiang Li, Bo Song, Daoling Peng, Xiqi Zhang, Lei Jiang
1617 related Products with: 2D Graphene Oxide Membrane Nanoreactors for Rapid Directional Flow Ring-Opening Reactions with Dominant Same-Configuration Products.
1 kit1 kit1 kit1 kit200 Reactions100ug Lyophilized100ug Lyophilized100 reactions0,42 Membrane supply4 Membranes/Box100ug Lyophilized
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#38373587 2024/02/17
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RIFM fragrance ingredient safety assessment, isoeugenyl benzyl ether, CAS Registry Number 120-11-6.
A M Api, A Bartlett, D Belsito, D Botelho, M Bruze, A Bryant-Freidrich, G A Burton, M A Cancellieri, H Chon, M L Dagli, W Dekant, C Deodhar, K Farrell, A D Fryer, L Jones, K Joshi, A Lapczynski, M Lavelle, I Lee, H Moustakas, J Muldoon, T M Penning, G Ritacco, N Sadekar, I Schember, T W Schultz, F Siddiqi, I G Sipes, G Sullivan, Y Thakkar, Y Tokura
2099 related Products with: RIFM fragrance ingredient safety assessment, isoeugenyl benzyl ether, CAS Registry Number 120-11-6.
5 G 25 G 5 MG 100 G 5 G 1 G 5 G 1KG 1 G 1 G 25 G 5 G
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#38359754 2024/02/07
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1,3-Disubstituted-1,2,4-triazin-6-ones with potent activity against androgen receptor-dependent prostate cancer cells.
Synthesis and biological evaluation of a small, focused library of 1,3-disubstituted-1,2,4-triazin-6-ones for in vitro inhibitory activity against androgen-receptor-dependent (22Rv1) and androgen-receptor independent (PC3) castration-resistant prostate cancer (CRPC) cells led to highly active compounds with in vitro IC values against 22Rv1 cells of <200 nM, and with apparent selectivity for this cell type over PC3 cells. From metabolic/PK evaluations of these compounds, a 3-benzyl-1-(2,4-dichlorobenzyl) derivative had superior properties and showed considerably stronger activity, by nearly an order of magnitude, against AR-dependent LNCaP and C4-2B cells compared to AR-independent DU145 cells. This lead compound decreased AR expression in a dose and time dependent manner and displayed promising therapeutic effects in a 22Rv1 CRPC xenograft mouse model. Computational target prediction and subsequent docking studies suggested three potential known prostate cancer targets: p38a MAPK, TGF-β1, and HGFR/c-Met, with the latter case of c-Met appearing stronger, owing to close structural similarity of the lead compound to known pyridazin-3-one derivatives with potent c-Met inhibitory activity. RNA-seq analysis showed dramatic reduction of AR signalling pathway and/or target genes by the lead compound, subsequently confirmed by quantitative PCR analysis. The lead compound was highly inhibitory against HGF, the c-Met ligand, which fitted well with the computational target prediction and docking studies. These results suggest that this compound could be a promising starting point for the development of an effective therapy for the treatment of CRPC.Shiting Zhao, Abdelsalam S Ali, Xiaomin Liu, Zhiwei Yu, Xinyu Kong, Yan Zhang, G Paul Savage, Yong Xu, Bin Lin, Donghai Wu, Craig L Francis
2014 related Products with: 1,3-Disubstituted-1,2,4-triazin-6-ones with potent activity against androgen receptor-dependent prostate cancer cells.
96T100.00 ul1.00 flask100ug100ug50 ug 200ul
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#38228780 2024/01/16
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Semi-synthesis and structure-activity relationship study yield antibacterial vicenistatin derivatives with low cytotoxicity.
Vicenistatin (1) is a 20-membered polyketide macrocyclic antibiotic with potent antimicrobial and cytotoxic activities. In this study, to further explore the potential of 1 as candidates of antibacterial drug development, 4'-N-demethyl vicenistatin (2), a secondary metabolite obtained from the ∆vicG mutant strain of Monodonata labio-associated Streptomyces parvus SCSIO Mla-L010, was utilized as a starting material for modifications of 4'-amino group of vicenistatin. Six new vicenistatin derivatives (3-8) were semi-synthesized through a concise route of amino modification with various aliphatic and aromatic aldehydes. Our study reveals that the bioactivity of vicenistatin is closely related to amino modification in sugar moiety, which results from the length of alkyl side chain as well as the presence of electron withdrawing/denoting group on the benzene ring. Importantly, compounds 4 with a butyl group and 8 with a 3,5-dihydroxyl-benzyl group at 4'-amino group, respectively, exhibited good antimicrobial activities, with MIC values spanning 0.5-4 μg ml to Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus, methicillin-resistant Staphylococcus epidermidis, Micrococcus luteus and Bacillus subtilis, with low cytotoxicity. This research promotes the further exploration of structure-activity relationships of vicenistatin and provides new vicenistatin derivatives for development of future anti-infectious agents with reduced cytotoxicity.Jun Li, Zhenye Yang, Chuanling Shi, Xiaoyun Wu, Le Zhou, Yongqian Liang, Qinglian Li, Jianhua Ju
1297 related Products with: Semi-synthesis and structure-activity relationship study yield antibacterial vicenistatin derivatives with low cytotoxicity.
100ug100ul100 assays5ml25 mg 96 Tests 40 assays100tests100 mg1 kit
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#38126374 2024/01/17
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Exploring the impact of alignment media on RDC analysis of phosphorus-containing compounds: a molecular docking approach.
Residual dipolar couplings (RDCs) are employed in NMR analysis when conventional methods, such as -couplings and nuclear Overhauser effects (NOEs) fail. Low-energy (optimized) conformers are often used as input structures in RDC analysis programs. However, these low-energy structures do not necessarily resemble conformations found in anisotropic environments due to interactions with the alignment medium, especially if the analyte molecules are flexible. Considering interactions with alignment media in RDC analysis, we developed and evaluated a molecular docking-based approach to generate more accurate conformer ensembles for compounds in the presence of the poly-γ-benzyl-L-glutamate alignment medium. We designed chiral phosphorus-containing compounds that enabled us to utilize P NMR parameters for the stereochemical analysis. Using P3D/PALES software to evaluate diastereomer discrimination, we found that our conformer ensembles outperform moderately the standard, low-energy conformers in RDC analysis. To further improve our results, we (i) averaged the experimental values of the molecular docking-based conformers by applying the Boltzmann distribution and (ii) optimized the structures through normal mode relaxation, thereby enhancing the Pearson correlation factor and even diastereomer discrimination in some cases. Nevertheless, we presume that significant differences between -couplings in isotropic and in anisotropic environments may preclude RDC measurements for flexible molecules. Therefore, generating conformer ensembles based on molecular docking enhances RDC analysis for mildly flexible systems while flexible molecules may require applying more advanced approaches, in particular approaches including dynamical effects.Markéta Christou Tichotová, Lucie Tučková, Hugo Kocek, Aleš Růžička, Michal Straka, Eliška Procházková
1574 related Products with: Exploring the impact of alignment media on RDC analysis of phosphorus-containing compounds: a molecular docking approach.
50 ug2 modules1 module 120 ml 3 modules 100 UG1 module0.2 mg100.00 ug1 module
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#38097085 2023/12/12
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Insight into modified CeMn based catalysts for efficient degradation of toluene by in situ infrared.
Trace activated carbon (AC) and diatomaceous earth (DE) were used as structural promoters to be incorporated into Ce-Mn-based solid-solution catalysts by the redox precipitation method. The modified catalysts exhibit superior reducibility, with abundant Ce, Mnand reactive oxygen species, which are facilitated to the migration of oxygen and the generation of oxygen vacancies. In particular, the catalytic combustion temperatures of 90 % toluene (3000 ppm) on CeMnOx-AC/DE were 84 °C (dry) and 123 °C (10 vol% HO), respectively. The role of lattice oxygen and adsorbed oxygen was revealed by in situ DRIFTS. Additionally, in situ DRIFTS was employed to verify that the degradation of toluene by CeMnOx-AC/DE satisfied the Langmuir-Hinshelwood (L-H) mechanism and the Mars-Van Krevelen (MvK) mechanism. The possible reaction pathway was elucidated (toluene → benzyl alcohol → benzoic acid → maleic anhydride → CO + HO). Furthermore, final products attributed to toluene oxidation were detected by in situ DRIFTS at 50 °C in the absence of oxygen, confirming that the catalyst possessed outstanding performance at low temperatures beyond mere adsorption.Xuelian Li, Rujie Chen, Min Yang, Yongfang Niu, Jing Li, Dan Shao, Xinmei Zheng, Chuanwei Zhang, Yanxing Qi
2677 related Products with: Insight into modified CeMn based catalysts for efficient degradation of toluene by in situ infrared.
1 kit 5 G1 mg1 kit500 MG1 mg250 mg 100 G1 mg 1 G
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#38090068 2023/12/11
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The preparation and characterization of self-healing hydrogels based on polypeptides with a dual response to light and hydrogen peroxide.
Injectable self-healing hydrogels are being widely used in drug delivery, tissue engineering, and other fields. Because of their excellent biocompatibility and biodegradability, polypeptides are an ideal candidate for preparing injectable self-healing hydrogels. In this study, a polypeptide-based hydrogel with dual response to hydrogen peroxide and light was obtained by copolymerizing 4-arm PEG-amine, -(-nitrophenoxycarbonyl)-l-methionine, and -(-nitrophenoxycarbonyl)-γ--nitrobenzyl-l-glutamate. The hydrogel exhibits injectable self-healing behavior due to the hydrophobic interactions among peptide blocks, which also act as the reservoir of hydrophobic drug molecules. In the presence of hydrogen peroxide or under light irradiation, the thioether bond in methionine was oxidized to sulfoxide, whereas the -nitro benzyl ester bond was broken to form glutamic acid. As a result, the corresponding hydrophobic blocks of polypeptide become hydrophilic, accelerating the release of drug molecules loaded in the polypeptide hydrophobic blocks. Using this technique, the controlled release of hydrophobic drug molecules was achieved. Our efforts could provide a new strategy for the preparation of self-healing hydrogels based on polypeptides with a dual response to hydrogen peroxide and light. In this view, the practical application of polypeptides in drug delivery, tissue engineering, and other fields, could be expanded and advanced.Congwei Wang, Dinglei Zhao, Yongjun Xie, Qiang Zhou, Haiyang Yang