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Stress-mediated increases in systemic and local epinephrine impair skin wound healing: potential new indication for beta blockers.
Stress, both acute and chronic, can impair cutaneous wound repair, which has previously been mechanistically ascribed to stress-induced elevations of cortisol. Here we aimed to examine an alternate explanation that the stress-induced hormone epinephrine directly impairs keratinocyte motility and wound re-epithelialization. Burn wounds are examined as a prototype of a high-stress, high-epinephrine, wound environment. Because keratinocytes express the beta2-adrenergic receptor (beta2AR), another study objective was to determine whether beta2AR antagonists could block epinephrine effects on healing and improve wound repair.Raja K Sivamani, Christine E Pullar, Catherine G Manabat-Hidalgo, David M Rocke, Richard C Carlsen, David G Greenhalgh, R Rivkah Isseroff
