Search results for: Biomarkers
#35973807 
2022/08/16
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Computed Tomography Embolus Texture Analysis as a Prognostic Marker of Acute Pulmonary Embolism.
Texture analysis is a quantitative imaging analysis that provides novel biomarkers beyond conventional image reading. Our aim was to use texture analysis of pulmonary emboli derived from thoracic computed tomography for prediction of mortality and prognosis of acute pulmonary embolism (PE). Overall, 216 patients (116 female, 53.7%) were included in the analysis. Texture analysis was calculated on axial slices of the contrast enhanced pulmonary angiography of the proximal embolus. Clinical scores, serological parameters, need for intubation, intensive care unit (ICU) admission and mortality was assessed and correlated with the texture features. In the correlation analysis, there were several associations with mortality in days, the highest for the parameter S(0,5)SumVarnc ( = -0.43, < 0.001). Another parameter, S(3,-3)AngScMom correlated with sepsis-related organ failure assessment score (SOFA)-score ( = 0.31, < 0.001). Several texture features correlated with venous lactate and glucose levels. In discrimination analysis, there were significant differences in regard to texture features between survivors and non-survivors and between patients with and without the need for ICU admission ( = 0.02, respectively). These results highlight the potential clinical benefit of texture features in patients with acute PE as novel imaging biomarkers. Further studies are needed to validate these results.Jakob Leonhardi, Nikolaos Bailis, Marianne Lerche, Timm Denecke, Alexey Surov, Hans-Jonas Meyer
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#35973728 2022/08/16
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The Effect of Gender-Affirming Hormone Therapy on Measures of Kidney Function: A Systematic Review and Meta-Analysis.
Gender-affirming hormone therapy modifies body composition and lean muscle mass in transgender persons. We sought to characterize the change in serum creatinine, other kidney function biomarkers, and GFR in transgender persons initiating masculinizing and feminizing gender-affirming hormone therapy.Emily Krupka, Sarah Curtis, Thomas Ferguson, Reid Whitlock, Nicole Askin, Adam C Millar, Marshall Dahl, Raymond Fung, Sofia B Ahmed, Navdeep Tangri, Michael Walsh, David Collister
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#35973657 2022/08/13
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HPV and head and neck cancers: Towards early diagnosis and prevention.
HLuisa Galati, Susanna Chiocca, Daria Duca, Marta Tagliabue, Cindy Simoens, Tarik Gheit, Marc Arbyn, Massimo Tommasino
1635 related Products with: HPV and head and neck cancers: Towards early diagnosis and prevention.
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#35973579 2022/08/13
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Decreases of ethanolamine plasmalogen and phosphatidylcholine in erythrocyte are a common phenomenon in Alzheimer's, Parkinson's, and coronary artery diseases.
Decreased plasma levels of plasmalogens in neurodegenerative diseases have been watched with interest. We previously reported the decreases of erythrocyte ethanolamine plasmalogen (PlsPE) of blood not only in Alzheimer's disease (AD) and Parkinson's disease (PD), but also in coronary artery disease (CAD). In the present study, by using the same high-performance liquid chromatography (HPLC) method, we investigated the pattern of changes in the phospholipid composition of erythrocyte membrane in AD, PD and CAD compared with healthy individuals. The common patten of changes among them was as follows: The decrease of erythrocyte PlsPE was accompanied by a decrease of phosphatidylcholine although phosphatidylethanolamine remained unchanged. The decreases of PlsPE and phosphatidylcholine were replaced by an increase of sphingomyelin (SM) in the total phospholipids. The dissociated change between PlsPE and phosphatidylethanolamine (PE) may be caused by the differences in molecular structure or in location in the cell membrane. Such special changes provide another piece of biochemical evidence that these different diseases are caused by identical pathological mechanism, suggesting potential biomarkers for these chronic diseases due to aging.Shiro Mawatari, Mitsuhiro Fukata, Takeshi Arita, Toru Maruyama, Suminori Kono, Takehiko Fujino