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#34525476   2021/09/15 To Up

Expression and clinical significance of lncRNA OSER1-AS1 in peripheral blood of patients with non-small cell lung cancer.


Peirui Chen, Zhen Qin, Xiaokang Sun, Junrong Yang, Jing Lv, Mingqiang Diao

1301 related Products with: Expression and clinical significance of lncRNA OSER1-AS1 in peripheral blood of patients with non-small cell lung cancer.



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#34525474   2021/09/15 To Up

Patients with Severe Lactic Acidosis in the Intensive Care Unit: A Retrospective Study of Contributing Factors and Impact of Renal Replacement Therapy.

Hyperlactatemia is a regular condition in the intensive care unit, which is often associated with adverse outcomes. Control of the triggering condition is the most effective treatment of hyperlactatemia, but since this is mostly not readily possible, extracorporeal renal replacement therapy (RRT) is often tried as a last resort. The present study aims to evaluate the factors that may contribute to the decision whether to start RRT or not and the potential impact of the start of RRT on the outcome in patients with severe lactic acidosis (SLA) (lactate ≥5 mmol/L).
Lyssa Van De Ginste, Floris Vanommeslaeghe, Eric A J Hoste, Jan M Kruse, Wim Van Biesen, Francis Verbeke

1665 related Products with: Patients with Severe Lactic Acidosis in the Intensive Care Unit: A Retrospective Study of Contributing Factors and Impact of Renal Replacement Therapy.

100 μg25 Bags/Unit1100 μg

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#34525457   2021/09/15 To Up

Medical management of heavily exposed victims: An experience at the Tokaimura criticality accident.

A criticality accident occurred at the uranium conversion plant in Tokaimura, Ibaraki Prefecture, Japan on September 30, 1999. When uranyl nitrate was overloaded to a critical mass level, uncontrolled fission reaction occurred. A procedure was carried out according to the JCO manual, although not an officially approved manual. Three workers were heavily exposed to neutrons and -rays produced by nuclear fission, and they subsequently developed acute radiation syndrome (ARS). The average doses to the whole body of the three workers were approximately 25, 9, and 3 GyEq (biologically equivalent dose of γ-exposure), respectively; dose distribution analysis later revealed extreme heterogeneity of these doses in 2 workers. They were triaged according to the predicted clinical needs. Two of these workers developed severe bone marrow failure and received hematopoietic stem cell transplantation: one with peripheral stem cell transplantation from his HLA compatible sister and the other with umbilical cord blood transplantation. The graft was initially successful in both workers; autologous hematopoietic recovery was observed after donor/recipient mixed chimerism in one of them. Despite of all medical efforts available including hematopoietic stem cell transplantation, investigational drugs, skin graft, two workers died of multiple organ involvement and failure 83 and 211 days after the accident, respectively. Clinically as well as pathologically, the direct cause of death was deemed to be intractable GI bleeding in one, and thoraco-abdominal compartment syndrome due to dermal fibrosis/sclerosis in the other. The third worker also developed bone marrow suppression but was treated with granulocyte colony-stimulating factor (G-CSF). He recovered without major complications and is now under periodical medical follow-up. These experiences suggest that treatment of bone marrow is not a limiting factor for saving the life of ARS victims severely exposed. Successful treatment of other organs such as lungs, skin, and gastrointestinal tract is also essential. Furthermore, the whole-body dose may not always reflect the prognosis of ARS victims because of the nature of accidental exposure, heterogenous exposure.
Makoto Akashi, Kazuhiko Maekawa

2795 related Products with: Medical management of heavily exposed victims: An experience at the Tokaimura criticality accident.

100μl 100ul50 ug 100 ul100ug Lyophilized100ug1 ml100ul1 Set8 Sample Kit100ug Lyophilized

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#34525443   2021/04/27 To Up

Phosphorus equivalency of phytase with various evaluation indicators of meat duck.

The objective of the present experiment was to determine the efficacy and the phosphorus (P) equivalency of phytase in the corn-soybean meal-rapeseed meal diets of Cherry Valley ducks from 1 to 35 d of age. 320 ducks were randomly divided into 8 blocks of 5 cages with 8 ducks per cage. This experiment included eight treatments diets. The available P levels of I to IV treatments were respectively 0.25%, 0.32%, 0.39%, 0.46% (d 1-14) and 0.20%, 0.27%, 0.34%, 0.41% (d 15-35). And 4 levels of phytase added to low-P basal diet (treatment I) with 300, 600, 900, and 1,200 U/kg (treatment V to VIII). Among them, treatment IV was a P-adequate positive control, treatment I was a low-P negative control. The ratio of calcium (Ca) to P was 1.3:1 for all diets. The other nutritional indexes in all diets were basically the same. Ducks were provided ad libitum access to water and experimental diets. The negative control diet reduced (P < 0.05) body weight, carcase weight, eviscerated weigh, breast muscle weight, leg muscle weight, bone ash, tibia Ca and tibia P, and increasing levels of available P and supplementary phytase significantly (P < 0.05) improved the growth performance and slaughtering performance of meat ducks. Phytase supplementation at a dose of 900 U/kg in the low-P basal diet increased the growth performance of ducks to a level comparable to that of a P-adequate diet. The available P level of 0.39% (1-14 d) and 0.34% (15-35 d) could meet the nutritional needs of meat ducks for P, and the apparent P utilization rate was high, and the effective utilization effect of P was the best. In addition, with the evaluation indexes of feed intake, body weight gain, tibia ash, tibia Ca, tibia P, content of blood Ca and P, the addition of 500 U/kg phytase could release available P of 0.02%, 0.02%, 0.02%, 0.02%, 0.01%, 0.04%, and 0.03%, respectively. In the same way, the addition of 1,000 U/kg phytase could release available phosphorus of 0.14%, 0.04%, 0.04%, 0.05%, 0.02%, 0.12%, and 0.01%, respectively.
Yan Wu, Shujing Xu, Xinhui Wang, Hongyang Xu, Peiyao Liu, Xiaoguang Xing, Zhili Qi

1314 related Products with: Phosphorus equivalency of phytase with various evaluation indicators of meat duck.

5 G0.12 mL250 250 25 G200 480/kit 1L

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#34525440   2021/09/12 To Up

Rapid Risk Stratification of Acute Ischemic Stroke Patients in the Emergency Department: The Incremental Prognostic Role of Left Atrial Reservoir Strain.

To determine the prognostic value of positive global left atrial strain (LA-GSA+), measured by two-dimensional speckle tracking echocardiography (2D-STE) in a population of acute ischemic stroke (AIS) patients without atrial fibrillation (AF), in the setting of Emergency Department (ED).
Andrea Sonaglioni, Marianna Di Cara, Gian Luigi Nicolosi, Alessandro Eusebio, Marco Bordonali, Paola Santalucia, Michele Lombardo

1138 related Products with: Rapid Risk Stratification of Acute Ischemic Stroke Patients in the Emergency Department: The Incremental Prognostic Role of Left Atrial Reservoir Strain.

1100 U100.00 ul1 ml

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#34525406   2021/09/12 To Up

Methodological challenges for living systematic reviews conducted during the COVID-19 pandemic: a concept paper.

A living systematic review (LSR) is an emerging review type that makes use of continual updating. In the COVID-19 pandemic, we were confronted with a shifting epidemiological landscape, clinical uncertainties and evolving evidence. These unexpected challenges compelled us to amend standard LSR methodology. Objective and outline: Our primary objective is to discuss some challenges faced when conducting LSRs in the context of the COVID-19 pandemic, and to provide methodological guidance for others doing similar work. Based on our experience and lessons learned from two Cochrane LSRs and challenges identified in several non-Cochrane LSRs, we highlight methodological considerations, particularly with regards to the study design, interventions and comparators, changes in outcome measure, and the search strategy. We discuss when to update, or rather when not to update the review, and the importance of transparency when reporting changes. Lessons learned and conclusions: We learned that a LSR is a very suitable review type for the pandemic context, even in the face of new methodological and clinical challenges. Our experience showed that the decision for updating a LSR depends not only on the evolving disease or emerging evidence, but also on the individual review question and the review teams' resources.
Claire Iannizzi, Elena Dorando, Jacob Burns, Stephanie Weibel, Clare Dooley, Helen Wakeford, Lise J Estcourt, Nicole Skoetz, Vanessa Piechotta

2167 related Products with: Methodological challenges for living systematic reviews conducted during the COVID-19 pandemic: a concept paper.

1 G25 mg100 mg 5 G 1 G 50 UG0.2 mg 25 MG100 mg 100ul100 mg

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