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#33073861   2020/10/19 To Up

Detrimental impacts of climate change may be exacerbated by density dependent population regulation in blue mussels.

The climate on our planet is changing and the range distributions of organisms are shifting in response. In aquatic environments, species might not be able to redistribute poleward or into deeper water when temperatures rise because of barriers, reduced light availability, altered water chemistry, or any combination of these. How species respond to climate change may depend on physiological adaptability, but also on the population dynamics of the species. Density dependence is a ubiquitous force that governs population dynamics and regulates population growth, yet its connections to the impacts of climate change remain little known, especially in marine studies. Reductions in density below an environmental carrying capacity may cause compensatory increases in demographic parameters and population growth rate, hence masking the impacts of climate change on populations. On the other hand, climate-driven deterioration of conditions may reduce environmental carrying capacities, making compensation less likely and populations more susceptible to the effects of stochastic processes. Here we investigate the effects of climate change on Baltic blue mussels using a 17-year data set on population density. Using a Bayesian modelling framework, we investigate the impacts of climate change, assess the magnitude and effects of density dependence, and project the likelihood of population decline by the year 2030. 4. Our findings show negative impacts of warmer and less saline waters, both outcomes of climate change. We also show that density-dependence increases the likelihood of population decline by subjecting the population to the detrimental effects of stochastic processes (i.e., low densities where random bad years can cause local extinction, negating the possibility for random good years to offset bad years). We highlight the importance of understanding, and accounting for both density dependence and climate variation when predicting the impact of climate change on keystone species, such as the Baltic blue mussel.
Kim Jaatinen, Mats Westerbom, Alf Norkko, Olli Mustonen, David N Koons

1495 related Products with: Detrimental impacts of climate change may be exacerbated by density dependent population regulation in blue mussels.

10 10 MG100ug0.1 mg2 Pieces/Box1L100 MG100ug96 tests100ug

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#33073799   2020/10/19 To Up

Velvet antler polypeptide prevents the disruption of hepatic tight junctions inhibiting oxidative stress in cholestatic mice and liver cell lines.

The present study aims to examine the protective effects and mechanism of a velvet antler polypeptide (VAP) against lithocholic acid (LCA)-induced cholestatic liver injury in mice. A 7.0 kDa VAP was orally administered at doses of 10 and 20 mg kg-1 day-1. Hematoxylin and eosin (H&E) staining of the liver showed that VAP7.0 reduced LCA-induced infiltration of inflammatory cells and areas of necrotic hepatocytes. In addition, VAP7.0 greatly reduced the levels of alanine aminotransferase (ALT), total bile acid (TBA) and total bilirubin (TBIL) in LCA mouse serum and prolonged the survival time of mice with LCA. VAP7.0 reduced the production of reactive oxygen species (ROS), decreased malondialdehyde (MDA) and increased the superoxide dismutase (SOD) levels in LCA mice. VAP7.0 also reduced OGG1 expression, which is a biochemical indicator of oxidative stress. Mechanistic analysis revealed that VAP7.0 significantly inhibited LCA-induced disruption of tight junction integrity, as determined by observing the morphology of the bile canaliculus, and this finding was confirmed by observation of the bile canalicular structure and tight junction proteins Occludin and ZO-1 expression. Moreover, we also found that VAP7.0 maintained the stability of hepatic paracellular permeability, as determined by Evans blue dye assays and horseradish peroxidase (HRP) tracer distribution through inhibiting the activation of the PI3K pathway in LCA mouse livers. In addition, VAP7.0 ameliorated H2O2-induced barrier dysfunction and tight junction disruption via inhibiting the PI3K activity in human HepG2 and SMMC7721 cells, which was confirmed by the PI3K activator 740Y-P. H2O2 disturbed the localization of the tight junction proteins ZO-1 and Occludin, resulting in the transfer of these proteins from the membrane to the cytoplasm of cells, whereas pretreatment of cells with VAP7.0 prevented the disruption of the localization of these proteins, as determined by immunofluorescence staining and western blot analysis. These results demonstrate that VAP7.0 reduces liver injury by inhibiting oxidative stress and maintains the stability of hepatic tight junctions via suppressing the activation of the intracellular signaling molecule PI3K in LCA mice and hepatocellular carcinoma cells.
Lihua Li, Fan Yang, Rongjun Jia, Pengfei Yan, Liman Ma

2722 related Products with: Velvet antler polypeptide prevents the disruption of hepatic tight junctions inhibiting oxidative stress in cholestatic mice and liver cell lines.

1 kitcase900 tests100ug Lyophilized2 Pieces/Box96 tests

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#33073570   2020/10/18 To Up

Zirconium Metal-Organic Frameworks Containing a Biselenophene Linker: Synthesis, Characterization, and Luminescent Properties.

The bicyclic ditopic linker 2,2'-biselenophene-5,5'-dicarboxylic acid (), specifically designed for metal-organic framework (MOF) construction, has been synthesized in good yield and fully characterized. The corresponding zirconium MOF (Zr-MOF) [ZrO(OH)(SpSp)Cl] (; where missing linkers are replaced by chloride anions as shown by X-ray fluorescence and elemental analysis) is isostructural with its bithiophene and bithiazole analogues. Starting from , an extension of the biselenophene-based Zr-MOF family has been successfully achieved, exploiting the structural analogy of the five-membered heterocycles selenophene, thiophene, and thiazole. Thus, three mixed-linker MOFs containing variable amounts of different bis(heterocyclic) dicarboxylic acids have been prepared and fully characterized: the two double-mixed [ZrO(OH)(SpSp)(TpTp)Cl] (; = 2,2'-bithiophene-5,5'-dicarboxylic acid) and [ZrO(OH)(SpSp)(TzTz)Cl] (; = 2,2'-bithiazole-5,5'-dicarboxylic acid) materials, as well as the triple-mixed [ZrO(OH)(SpSp)(TpTp)(TzTz)Cl] () compound. The four MOFs are luminescent under UV irradiation, exhibiting emission wavelengths falling in the blue-green visible region, as observed for their constitutive linkers. These materials open new horizons in the preparation of porous luminescent sensors or multicolor emitters for light-emitting diodes.
Giorgio Mercuri, Marco Moroni, Andrea Fermi, Giacomo Bergamini, Simona Galli, Giuliano Giambastiani, Andrea Rossin

1986 related Products with: Zirconium Metal-Organic Frameworks Containing a Biselenophene Linker: Synthesis, Characterization, and Luminescent Properties.

200ug50 ug 10 mg100ug Lyophilized100 mg100 mg0.1 mg10 mg 100ul5mg1 mg100ug

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#33073306   2020/10/19 To Up

Ratiometric persistent luminescence aptasensors for carcinoembryonic antigen detection.

NIR-emitted ZnGaO:Cr persistent luminescence nanoparticles (ZGC NPs) coated with polydopamine ([email protected] NPs) were designed featuring internal reference and quenching ability. Sr-doped ZnGeO persistent luminescence nanorods (ZGO:Sr NRs) served as detection probes, which exhibited blue emission. The decay times and intensity of luminescence of ZGO:Sr NRs were optimized to acquire desired luminescence properties. An aptamer-guided ratiometric persistent luminescence sensor with the LOD (0.46 pg mL) was established to detect carcinoembryonic antigen (CEA). This developed ratiometric aptasensor based on persistent luminescence nanomaterials (PLMs) does not only use the afterglow properties of nanomaterials to avoid the interference of autofluorescence but also precludes the interference of certain factors in the detection environment on the luminescence intensity due to the introduction of a reference signal, and is suitable for early screening of tumor markers in serum samples. Moreover, the optimization of luminescence properties, especially for luminescence decay times, provides a way for the fabrication of multiple persistent luminescence materials in the application of time-resolved fluorescence technology. Graphical abstract Construction of ZGO:Sr NR- and [email protected] NP-driven ratiometric aptasensor for CEA detection.
Lixia Shi, Wangwang Zheng, Hongyan Miao, Han Liu, Xiaohui Jing, Yuan Zhao

1392 related Products with: Ratiometric persistent luminescence aptasensors for carcinoembryonic antigen detection.

96 tests0.1ml (1mg/ml)2x96 well plate96 tests1 mg1 kit(96 Wells)0.2 mg100 µg0.1ml1 mg

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#33073155   2020/10/02 To Up

Pyrido-Fused Deazapurine Bases: Synthesis and Glycosylation of 4-Substituted 9-Pyrido[2',3':4,5]- and Pyrido[4',3':4,5]pyrrolo[2,3-]pyrimidines.

Two isomeric sets of 4-substituted pyridopyrrolopyrimidine nucleobases were prepared through nucleophilic substitutions or cross-coupling reactions of 4-chloropyridopyrrolopyrimidines. The corresponding 4-amino-pyridopyrrolopyrimidines were glycosylated with 5--tritylribose using the modified Mitsunobu protocol. Several examples of the title heterocycles showed blue or green fluorescence. Testing of the pyridopyrrolopyrimidine nucleobases for the cytotoxic effect revealed micromolar activity of 4-benzofuryl derivatives in both series, preferentially in multidrug-resistant cancers.
Lucia Veselovská, Radek Pohl, Eva Tloušt Ová, Soňa Gurská, Petr Džubák, Marián Hajdúch, Michal Hocek

2303 related Products with: Pyrido-Fused Deazapurine Bases: Synthesis and Glycosylation of 4-Substituted 9-Pyrido[2',3':4,5]- and Pyrido[4',3':4,5]pyrrolo[2,3-]pyrimidines.

1 mg25 mg0.5 mg10 mg5 mg25 mg10 mg1 mg10 mg10 mg10 mg0.5 mg

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#33073136   2020/09/29 To Up

Magnesium Silicate Polymer as a Coagulant for Reactive Dye Removal from Wastewater: Considering the Intrinsic pH in Magnesium Silicate Polymer and Coagulation Behavior.

A magnesium silicate polymeric coagulant (MgSiPC), which is an inorganic polymer for dye removal from wastewater, was prepared with different pH by copolymerization. The acidity was a key factor in the preparation of the MgSiPC. In the present research, Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), and scanning electron microscopy (SEM) were used to analyze the characterization of optimum coagulants. Additionally, the response surface method (RSM) was applied to optimize the process of coagulation-flocculation. The results of FT-IR and XRD implied that the main components of the MgSiPC with pH 1.50-2.50 were almost the same. SEM images showed that MgSiPCs with pH 1.50-2.50 exhibited different structures including cluster and lamellar shape structure, compact rod-like and network structure, and a kind of irregular geometry shape structure. In the process of coagulation-flocculation, MgSiPCs with pH 1.50-2.50 showed highly efficient coagulation performance. The removal rate of reactive yellow 2(RY2) could reach above 90% at a dosage of 50-70 mg/L and initial pH 12.00, while the removal rate of reactive blue 2 (RB2) could attain above 93% at a dosage of 50-80 mg/L and initial pH 12.00. Moreover, MgSiPCs with pH 2.00 had the highest efficiency. The results of RSM showed that the optimum combination of the MgSiPC's dosage and initial pH was 62 mg/L and 12.08 for RY2 and 78 mg/L and 12.00 for RB2, respectively. Under optimum experimental conditions, the predicted data from this model were 96% for RY2 and 100% for RB2, which was consistent with the actual experimental data. Therefore, a pH of 2.00 is considered to be the optimal acidity for preparing MgSiPCs.
Yanxin Wei, Xueqing Cheng, Aimin Ding, Juncui Xu

1689 related Products with: Magnesium Silicate Polymer as a Coagulant for Reactive Dye Removal from Wastewater: Considering the Intrinsic pH in Magnesium Silicate Polymer and Coagulation Behavior.

1 kit900 tests250 100 G100 assays100 assays2 Pieces/Box1 kit1 kit50 ug 5 G

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#33073045   2020/10/05 To Up

Diagnosis of early gastric cancer using image enhanced endoscopy: a systematic approach.

This paper provides an overview of the principles of a vessel plus surface (VS) classification system to explain the diagnostic system of early gastric cancer using image-enhanced magnifying endoscopy. Furthermore, this paper introduces the magnifying endoscopy simple diagnostic algorithm for gastric cancer (MEADA-G) developed according to the VS classification system, with a description of the procedures performed for diagnosis. In addition to the diagnostic system, white opaque substance (WOS), light blue crest (LBC), white globe appearance (WGA), and vessels within epithelial circle (VEC) patterns, which are representative findings that can be observed in the gastric mucosa by image-enhanced magnifying endoscopy, are also described. Image-enhanced magnifying endoscopy is particularly useful in the diagnosis of differentiated-type early gastric cancer. It is important to use the appropriate clinical strategies based on a comprehensive understanding of the usefulness and limitations of the diagnostic system described in this paper.
Masaki Miyaoka, Kenshi Yao, Hiroshi Tanabe, Takao Kanemitsu, Kensei Otsu, Kentaro Imamura, Yoichiro Ono, Satoshi Ishikawa, Tatsuhisa Yasaka, Toshiharu Ueki, Atsuko Ota, Seiji Haraoka, Akinori Iwashita

2884 related Products with: Diagnosis of early gastric cancer using image enhanced endoscopy: a systematic approach.



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#33072308   2020/09/22 To Up

Sentinel lymph node biopsy after neoadjuvant treatment of breast cancer using blue dye, radioisotope, and indocyanine green: Prospective cohort study.

The breast cancer treatment paradigm has shifted to neoadjuvant treatment. There are many advantages to neoadjuvant treatment, such as tumor downsizing, tumor biology testing, treating micrometastasis, and achieving complete pathological response (a surrogate marker for overall survival). However, in the post neoadjuvant settings, sentinel lymph node biopsy can be done using a dual staining technique to decrease the false-negative rate (FNR) and increase the detection rate. However, many hospitals are not equipped to use radioisotopes. Here we investigate the detection rate and accuracy of sentinel lymph node biopsy in post neoadjuvant treatment breast cancer, comparing radioisotope, isosulfan blue, and indocyanine green (ICG) approaches.
Prakasit Chirappapha, Tanet Chatmongkonwat, Panuwat Lertsithichai, Wiriya Pipatsakulroj, Chanika Sritara, Thongchai Sukarayothin

2776 related Products with: Sentinel lymph node biopsy after neoadjuvant treatment of breast cancer using blue dye, radioisotope, and indocyanine green: Prospective cohort study.



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