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#33080583   2020/10/20 To Up

Cone beam CT multisource configurations: evaluating image quality, scatter, and dose using phantom imaging and Monte Carlo simulations.

To compare various multisource configurations applied to cone beam CT (CBCT) using phantom imaging and Monte Carlo simulations.
Amy E Becker, Andrew M Hernandez, Paul R Schwoebel, John M Boone

1427 related Products with: Cone beam CT multisource configurations: evaluating image quality, scatter, and dose using phantom imaging and Monte Carlo simulations.

5mg1,000 tests200ug1 mg25 mg1000 tests100ug1000 TESTS/0.65ml 5 G2.5 mg2.5 mg

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#33080575   2020/10/20 To Up

A prototype multi-x-ray-source array (MXA) for digital breast tomosynthesis.

The design and testing of a prototype Multi-X-ray-source Array (MXA) for digital breast tomosynthesis is reported. The MXA is comprised of an array of tungsten filament cathodes with focus cup grid-controlled modulation and a common rotating anode housed in a single vacuum envelope. Prototypes consisting of arrays of three-source elements and eleven-source-elements were fabricated and evaluated. The prototype sources demonstrated focal spot sizes of 0.3 mm at 45 kV with 50 mA. Measured X-ray spectra were consistent with the molybdenum anode employed, and the tube output (air kerma) was between 0.6 mGy/100 mAs at 20 kV and 17 mGy/100 mAs at 45 kV with a distance of 100 cm. HVL measurements ranged from 0.5 mmat 30 kV to 0.8 mmat 45 kV, and X-ray pulse widths were varied from 20 ms to 110 ms at operating frequencies ultimately to be limited by source turn-on/off times of ~1 ms. Initial results of reconstructed tomographic data are presented.
Amy E Becker, Andrew M Hernandez, John M Boone, Paul R Schwoebel

2047 related Products with: A prototype multi-x-ray-source array (MXA) for digital breast tomosynthesis.



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#33080569   2020/10/20 To Up

Identification of long-term survival-associated gene in breast cancer.

Breast cancer patients at the same stage may show different clinical prognoses or different therapeutic effects of systemic therapy. Differentially expressed genes of breast cancer were identified from GSE42568. Through survival, receiver operating characteristic (ROC) curve, random forest, GSVA and a Cox regression model analyses, genes were identified that could be associated with survival time in breast cancer. The molecular mechanism was identified by enrichment, GSEA, methylation and SNV analyses. Then, the expression of a key gene was verified by the TCGA dataset and RT-qPCR, Western blot, and immunohistochemistry. We identified 784 genes related to the 5-year overall survival time of breast cancer. Through ROC curve and random forest analysis, 10 prognostic genes were screened. These were integrated into a complex by GSVA, and high expression of the complex significantly promoted the recurrence-free survival of patients. In addition, key genes were related to immune and metabolic-related functions. Importantly, we identified methylation of MEX3A and TBC1D 9 and mutations events. Finally, the expression of UGCG was verified by the TCGA dataset and by experimental methods in our own samples. These results indicate that 10 genes may be potential biomarkers and therapeutic targets for long-term survival in breast cancer, especially UGCG.
Shipeng Ning, Hui Li, Kun Qiao, Qin Wang, Meiying Shen, Yujuan Kang, Yanling Yin, Jiena Liu, Lei Liu, Siyu Hou, Jianyu Wang, Shouping Xu, Da Pang

1688 related Products with: Identification of long-term survival-associated gene in breast cancer.



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#33080548   2020/10/09 To Up

Differential diagnosis of benign and malignant male breast lesions in mammography.

To investigate the mammographic characteristics in discriminating benign and malignant male breast lesions.
Yan Huang, Qin Xiao, Yiqun Sun, Qin Li, Simin Wang, Yajia Gu

1349 related Products with: Differential diagnosis of benign and malignant male breast lesions in mammography.



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#33080334   2020/10/17 To Up

Blood oxygenation level dependent magnetic resonance imaging and diffusion weighted MRI imaging for benign and malignant breast cancer discrimination.

The purpose of this study is to assess Blood oxygenation level dependent Magnetic Resonance Imaging (BOLD-MRI) and Diffusion Weighted Magnetic Resonance Imaging (DW-MRI) in the differentiation of benign and malignant breast lesions.
Roberta Fusco, Vincenza Granata, Paolo Pariante, Vincenzo Cerciello, Claudio Siani, Maurizio Di Bonito, Marika Valentino, Mario Sansone, Gerardo Botti, Antonella Petrillo

1531 related Products with: Blood oxygenation level dependent magnetic resonance imaging and diffusion weighted MRI imaging for benign and malignant breast cancer discrimination.

100ul1 ml10 mg200

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#33080293   2020/10/17 To Up

Low physical activity, fatigue and depression in breast cancer survivors: Moderation by levels of IL-6 and IL-8.

Although previous studies suggested that depressed mood and fatigue among cancer survivors are associated with chronic inflammation, the effect of cytokines on the relation between physical activity and fatigue and depressed mood is characterized by inconsistent results. The aim was to examine levels of pro-inflammatory (IL-6, IL-8, TNFα, IL-12) and anti-inflammatory (IL-10) cytokines in relation to the effects of physical activity on fatigue and depressed mood.
Miri Cohen, Inbar Levkovich, Rina Katz, Georgeta Fried, Shimon Pollack

1495 related Products with: Low physical activity, fatigue and depression in breast cancer survivors: Moderation by levels of IL-6 and IL-8.

25 mg1000 TESTS/0.65ml

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#33080213   2020/10/17 To Up

Biosensor-based diagnostic approaches for various cellular biomarkers of breast cancer: A comprehensive review.

Breast cancer is the most commonly occurring cancer among women which lead to thousands of deaths worldwide. The chances of survival are more if the breast cancer is diagnosed at early stage. At present, mammography, magnetic resonance imaging, ultrasound and tissue biopsies are the main diagnostic techniques available for the detection of breast cancer. However, despite of offering promising results, requirement of expensive setup, skilled supervision, expert analysis, invasive procedure (biopsy) and low capacity of multiplexing are the main limitations of these diagnostic techniques. Due to high cost, these screening tests are out of reach of people belonging to low socioeconomic groups and this poses serious health burden to the society. Recently, biosensor-based diagnostic technology for early detection of various types of cancer and other non-oncological disorders have gained considerable attention this is because of their several advantageous features over existing diagnostic technologies such as high throughput, noninvasive nature, cost effectiveness, easy interpretable results and capacity for multiplexing. Further, biosensors can be designed for biomarkers which are confined to particular type of cancer. In this review we have discussed about various genomic, transcriptomic, proteomic and metabolomic biomarkers associated with breast cancer, various biosensors based diagnostic approaches designed for detection of specific biomarkers associated with breast cancer are also discribed. Further, this review throws insight on various biomarkers linked with breast cancer which can be effectively exploited to develop new diagnostic technology. The assessment of these biomarkers associated with BC using biosensors in large population are cost-effective, non-invasive and high throughput. They help in risk assessment of disease at very initial stage even in backward areas and also help to lower the disease burden of society and economic cost of treatment for a common man. This review would provide new avenues for the development of biosensor based diagnostic technology for the detection of biomarkers associated with breast cancer.
Pushpesh Ranjan, Arpana Parihar, Surbhi Jain, Neeraj Kumar, Chetna Dhand, S Murali, Deepti Mishra, Sunil K Sanghi, J P Chaurasia, Avanish K Srivastava, Raju Khan

2455 related Products with: Biosensor-based diagnostic approaches for various cellular biomarkers of breast cancer: A comprehensive review.

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