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#32455340   2020/05/04 To Up

Correlating Digestion-Driven Self-Assembly in Milk and Infant Formulas with Changes in Lipid Composition.

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Anna C Pham, Kang-Yu Peng, Malinda Salim, Gisela Ramirez, Adrian Hawley, Andrew J Clulow, Ben J Boyd

1734 related Products with: Correlating Digestion-Driven Self-Assembly in Milk and Infant Formulas with Changes in Lipid Composition.

96T32-50 Sample Kit 1 G 5 G16 Arrays/Slide10mg1 ml5 mg

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#32455334   2020/03/02 To Up

Urinary Estrogen Metabolites and Long-Term Mortality Following Breast Cancer.

Estrogen metabolite concentrations of 2-hydroxyestrone (2-OHE) and 16-hydroxyestrone (16-OHE) may be associated with breast carcinogenesis. However, no study has investigated their possible impact on mortality after breast cancer.
Tengteng Wang, Hazel B Nichols, Sarah J Nyante, Patrick T Bradshaw, Patricia G Moorman, Geoffrey C Kabat, Humberto Parada, Nikhil K Khankari, Susan L Teitelbaum, Mary Beth Terry, Regina M Santella, Alfred I Neugut, Marilie D Gammon

2773 related Products with: Urinary Estrogen Metabolites and Long-Term Mortality Following Breast Cancer.

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#32455252   2020/05/05 To Up

Cell shape, and not 2D migration, predicts extracellular matrix-driven 3D cell invasion in breast cancer.

Metastasis, the leading cause of death in cancer patients, requires the invasion of tumor cells through the stroma in response to migratory cues, in part provided by the extracellular matrix (ECM). Recent advances in proteomics have led to the identification of hundreds of ECM proteins, which are more abundant in tumors relative to healthy tissue. Our goal was to develop a pipeline to easily predict which ECM proteins are more likely to have an effect on cancer invasion and metastasis. We evaluated the effect of four ECM proteins upregulated in breast tumor tissue in multiple human breast cancer cell lines in three assays. There was no linear relationship between cell adhesion to ECM proteins and ECM-driven 2D cell migration speed, persistence, or 3D invasion. We then used classifiers and partial-least squares regression analysis to identify which metrics best predicted ECM-driven 2D migration and 3D invasion responses. We find that ECM-driven 2D cell migration speed or persistence did not predict 3D invasion in response to the same cue. However, cell adhesion, and in particular cell elongation and shape irregularity, accurately predicted the magnitude of ECM-driven 2D migration and 3D invasion. Our models successfully predicted the effect of novel ECM proteins in a cell-line specific manner. Overall, our studies identify the cell morphological features that determine 3D invasion responses to individual ECM proteins. This platform will help provide insight into the functional role of ECM proteins abundant in tumor tissue and help prioritize strategies for targeting tumor-ECM interactions to treat metastasis.
Janani P Baskaran, Anna Weldy, Justinne Guarin, Gabrielle Munoz, Polina H Shpilker, Michael Kotlik, Nandita Subbiah, Andrew Wishart, Yifan Peng, Miles A Miller, Lenore Cowen, Madeleine J Oudin

2675 related Products with: Cell shape, and not 2D migration, predicts extracellular matrix-driven 3D cell invasion in breast cancer.

24 tests96 samples96 samples96 tests24 tests96 samples24 tests96 samples24 tests

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#32455032   2020/05/11 To Up

A Case of Unresectable Papillary Thyroid Carcinoma Treated with Lenvatinib as Neoadjuvant Chemotherapy.

A 75-year-old woman visited a nearby clinic with complaints of right clavicle discomfort, and she underwent diagnostic thoracoscopic lung biopsy, being diagnosed with lung metastasis and a right-upper mediastinal mass. The superior mediastinum mass was extrapulmonary and covered by the pleura, and it was not biopsied. Papillary thyroid carcinoma was diagnosed following biopsy of the lung metastasis. Only a small tumor, with a maximum diameter of 70 mm from the right neck to the superior mediastinum, in the thyroid gland invades the internal jugular vein and subclavian vein, forming a tumor embolus in the right brachiocephalic vein and reaching the vicinity of the superior vena cava. For life-saving purposes, we obtained approval from the Cancer Board of Kanagawa Cancer Center and used lenvatinib according to unresectable undifferentiated cancer IRB approval number 28-41. The tumor had shrunk after 4 months, and surgery was performed. The postoperative course has been good, and the patient is being followed up. The patient is alive three months after surgery, and lung metastases have disappeared on CT images. This case is reported as a successful case of neoadjuvant chemotherapy and interval debulking surgery.
Hiroyuki Iwasaki, Soji Toda, Hiroyuki Ito, Daiji Nemoto, Daisuke Murayama, Yoichiro Okubo, Hiroyuki Hayashi, Tomoyuki Yokose

2856 related Products with: A Case of Unresectable Papillary Thyroid Carcinoma Treated with Lenvatinib as Neoadjuvant Chemotherapy.



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#32455010   2020/05/12 To Up

Prevalence of Severe Depression in Iranian Women with Breast Cancer: A Meta-Analysis.

Breast cancer is one of the most common cancers in women and has mental and emotional effects, which lead to a decline in their quality of life. This study is aimed at determining the prevalence of severe depression in Iranian women with breast cancer.
Parvaneh Isfahani, Marziye Arefy, Monire Shamsaii

1204 related Products with: Prevalence of Severe Depression in Iranian Women with Breast Cancer: A Meta-Analysis.



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#32454975   2020/04/27 To Up

Predictors for upstaging of ductal carcinoma (DCIS) to invasive carcinoma in non-mass-type DCIS.

Preoperatively diagnosed ductal carcinoma (DCIS) is sometimes upstaged to invasive cancer by postoperative pathological examination. Various preoperative factors associated with upstaging to invasive cancer have been reported; however, this subject remains to be clarified. DCIS takes various forms on imaging, but many cases show non-mass-type lesions. In non-mass-type DCIS, recognizing the presence of invasion is difficult. To investigate predictors associated with upstaging to invasive cancer more precisely, we examined only non-mass-type DCIS. The present study retrospectively analyzed 101 patients diagnosed with non-mass-type DCIS preoperatively on breast biopsy at our institution between 2007 and 2017. Data were analyzed using Fisher's exact probability test and two-sample t-tests. Multivariate analysis was performed using logistic regression. The results showed that 27 patients (27%) were finally diagnosed with invasive cancer. Univariate analysis revealed abnormal result of palpation on breast examination (P=0.05), comedo necrosis (P=0.05), and HER2 status (P=0.02) as significant predictors. Multivariate analysis revealed an abnormal result of palpation as an independent predictor of invasive cancer underestimation (odds ratio 4.76; confidence interval 1.44-15.7; P=0.01). In conclusion, preoperatively diagnosed non-mass-type DCIS represented an underestimation in approximately 27% of cases. In particular, the presence of a clinically abnormal palpation increases the chance of upstaging to invasive cancer.
Goshi Oda, Tsuyoshi Nakagawa, Ayumi Ogawa, Yuichi Kumaki, Tokuko Hosoya, Hitoshi Sugimoto, Toshiyuki Ishiba, Mori Mio, Tomoyuki Fujioka, Kazunori Kubota, Iichiroh Onishi, Hiroyuki Uetake

1861 related Products with: Predictors for upstaging of ductal carcinoma (DCIS) to invasive carcinoma in non-mass-type DCIS.



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#32454974   2020/05/05 To Up

Association of matrix metalloproteinases 3 and 9 single nucleotide polymorphisms with breast cancer risk: A case-control study.

Two single nucleotide polymorphisms (SNPs) of matrix metalloproteinase (MMPs) 3 and 9 are functionally implicated in the progression of various types of cancer, including breast cancer (BC). However, the roles of these SNPs remain controversial. In addition, they also vary between one population and another. Therefore, the present study aimed to investigate the possible association between MMP3-1171 5A/6A and MMP9-1562 CT SNPs and the risk of BC among Egyptians, and to elucidate the alteration of MMP3 and MMP9 gene expression in patients with BC. The present case-control study enrolled 162 patients with BC and 146 control subjects. Restriction fragment length polymorphism-PCR was performed for analysis of the selected SNPs, gene expression of MMP3 and MMP9 was also assessed in 50 patients and 50 control subjects by reverse transcription-quantitative PCR. The frequencies of 5A/6A genotype and 5A allele of MMP3 were significantly higher in patients with BC compared with in healthy subjects. On the other hand, the distributions of MMP9 genotypes and alleles were not significantly different among patients and healthy subjects. Compared with healthy subjects, the expression levels of the two genes were found to be upregulated in patients with BC. Therefore, the present study indicated that MMP3-1171 5A/6A SNP, not MMP9-1562 C>T SNP may be a risk factor for developing BC among Egyptian females.
Fawziya Abd Elmaogoud Ragab Ibrahim, Shaymaa Essam Elfeky, Medhat Haroun, Mohamed Abd Elrahman Ahmed, Mostafa Elnaggar, Nada Abd Elfatah Ismail, Nadia Ahmed Abd El Moneim

2987 related Products with: Association of matrix metalloproteinases 3 and 9 single nucleotide polymorphisms with breast cancer risk: A case-control study.



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