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Impact of carotid atherosclerosis in CHA2DS2-VASc-based risk score on predicting ischemic stroke in patients with atrial fibrillation.

Vascular disease is an established risk factor for stroke in patients with atrial fibrillation (AF), which is included in CHA2DS2-VASc score. However, the role of carotid atherosclerosis remains to be determined.

2566 related Products with: Impact of carotid atherosclerosis in CHA2DS2-VASc-based risk score on predicting ischemic stroke in patients with atrial fibrillation.

Rabbit Anti-FGF3 Oncogene Hyperplasia and carcinoma Prostate cancer, hyperpla Top 4 types of cancer (co Prostate cancer, hyperpla Atherosclerosis (Mouse) A Prostate cancer test tiss Prostate cancer, PIN (pro Atherosclerosis (Human) A Prostate cancer and norma Syringe pump can be contr Multiple prostate cancer

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Small adrenal incidentaloma becoming an aggressive adrenocortical carcinoma in a patient carrying a germline APC variant.

Recent guidelines on adrenal incidentalomas suggested in patients with an indeterminate adrenal mass and no significant hormone excess that follow up with a repeat noncontrast CT or MRI after 6-12 months may be an option.

2230 related Products with: Small adrenal incidentaloma becoming an aggressive adrenocortical carcinoma in a patient carrying a germline APC variant.

Non small cell lung carci Small cell lung carcinoma Lung small cell carcinoma Non small cell lung carci Breast invasive ductal ca Colon carcinoma antibody Breast cancer and matched GI cancer (esophageal, ga Her-2 IHC Bio-marker cont Small intestine carcinoma Hepatocellular carcinoma Colon carcinoma tissue ar

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Analysis of candidate biomarkers and related transcription factors involved in the development and restoration of stress-induced gastric ulcer by transcriptomics.

Stress-induced gastric ulcer is one of the common complications affecting patients after trauma, mainly leading to gastrointestinal bleeding and perforation, and severe cases may be life-threatening. However, the molecular mechanism of stress-induced gastric ulcer remains unclear. In the present study, RNA-sequencing was performed on gastric tissues of normal rats (C), stress-induced gastric ulcer rats (T0), and rats recovered from gastric ulcer for 3 days (T3), and bioinformatics analysis was performed to determine changes in gene expression and biological pathways. The protein-protein interaction (PPI) networks of differentially expressed genes (DEGs) were constructed by STRING and visualized by the Cytoscape software. The associated transcriptional factor (TFs)-gene regulatory network of the hub DEGs was also constructed. Pairwise comparisons obtained 103 (T0_C), 127 (T3_T0), and 13 (T3_C) DEGs, respectively. Gene ontology (GO) enrichment analysis indicated DEGs in T0_C and T3_T0 were significantly enriched in response to oxygen-containing compound, response to organic substance, and response to external stimulus. Pathway analysis suggested that DEGs were enriched in TNF signaling pathway, PPAR signaling pathway, apoptosis, and IL-17 signaling pathway. Seven hub genes (Fos, Jun, Nfkbia, Dusp1, Pim3, Junb, and Fosb) were obtained from the PPI networks of T0_C and T3_T0. Key TFs with close interactions, such as Fos, Jun, Nfkbia, Junb, Egr1, and Fosb, were screened This study used RNA-sequencing and bioinformatics analysis to screen out genes associated with gastric ulcer, which can help reveal the molecular mechanism of gastric ulcer development and restoration, and provide reference for the treatment of human gastric ulcers.

2549 related Products with: Analysis of candidate biomarkers and related transcription factors involved in the development and restoration of stress-induced gastric ulcer by transcriptomics.

Transcription factors: O Androgen Receptor Antibod Chromatin Transcription P Androst-16-en-3-ol C19H30 OxiSelect™ Cellular UV- Androsta-3,5,16-trien-17- CAR,Car,Constitutive andr 17β-Acetoxy-2α-bromo-5 Tissue array of gastric d Androgen Receptor (Ab 650 Androstenedione-19 Antibo Human Epstein-Barr Virus

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Effects of fasting on peripapillary capillary density, peripapillary nerve fiber layer, intraocular pressure and central corneal thickness.

To investigate the effects of fasting on intraocular pressure (IOP), central corneal thickness (CCT), radial peripapillary capillary (RPC) density and retinal nerve fiber layer (RNFL) thickness during Islamic fasting month of Ramadan.

1187 related Products with: Effects of fasting on peripapillary capillary density, peripapillary nerve fiber layer, intraocular pressure and central corneal thickness.



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Characterization of Plant 3D Chromatin Architecture, In Situ Hi-C Library Preparation, and Data Analysis.

In the mammalian nucleus, 3D organization of the chromatin plays an important role in the regulation of gene expression. Similar chromatin structures such as A/B compartments, domains, and loops have now been found in plants, yet their biological function remained to be further elucidated. In this chapter, we present a detailed protocol for examining genome-wide chromatin interaction using in situ Hi-C optimized for plant tissues. We also provide a step-by-step bioinformatic workflow for Hi-C sequencing data alignment, and subsequent compartment, domain, and chromatin loop identification.

2158 related Products with: Characterization of Plant 3D Chromatin Architecture, In Situ Hi-C Library Preparation, and Data Analysis.



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Study of Cell-Type-Specific Chromatin Organization: In Situ Hi-C Library Preparation for Low-Input Plant Materials.

The three-dimensional folding of chromatin contributes to the control of genome functions in eukaryotes, including transcription, replication, chromosome segregation, and DNA repair. In recent decades, many cytological and molecular methods have provided profound structural insights into the hierarchical organization of plant chromatin. With the Hi-C (high-throughput chromosome conformation capture) technique, analyses of global chromatin organization in plants indicate considerable differences across species. However, our knowledge of how chromatin organization at a local level is connected to tissue-specific gene expression is rather limited. This problem can be tackled by performing fluorescence-activated sorting of fixed nuclei followed by Hi-C, which is tailored for a limited number of input nuclei. Here, we describe an approach of isolating Arabidopsis thaliana nuclei with defined endopolyploidy level and subsequent in situ Hi-C library preparation for low-input plant materials. In principle, this method can be applied to any types of fluorescence-labeled nuclei, offering researchers a useful tool to unveil temporal and spatial chromatin dynamics in 3D in a tissue-specific context.

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10x ELISA WASH BUFFER, Pr Cell Cycle Phospho-Specif T-Cell Receptor Signaling MOUSE ANTI APAAP COMPLEX, Multiple lung carcinoma ( PERMANENT AQUEOUS MOUNTIN NATIVE HUMAN PROLACTIN, P NATIVE HUMAN PROLACTIN, P MOUSE ANTI HUMAN CD15, Pr Cell Cycle Control Phosph MOUSE ANTI HUMAN CD15, Pr 10X PHOSPHATE BUFFERED SA

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F-FDG PET/CT in lung adenosquamous carcinoma and its correlation with clinicopathological features and prognosis.

Lung adenosquamous carcinoma (ASC) is a rare histological subtype of non-small cell lung cancer (NSCLC). Due to its rarity, the studies about F-FDG PET/CT in this kind of pulmonary tumor were quite limited. Thus, this study investigated F-FDG PET/CT findings in ASC and its correlation with clinicopathological features and clinical outcomes.

2298 related Products with: F-FDG PET/CT in lung adenosquamous carcinoma and its correlation with clinicopathological features and prognosis.

Lung small cell carcinoma Lung carcinoma and normal Lung carcinoma tissue arr Small cell lung carcinoma Middle advanced stage lun Lung large cell carcinoma Non small cell lung carci Non small cell lung carci Multiple lung carcinoma ( High density non small ce Lung carcinoma and normal Lung carcinoma tissue arr

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A novel sigma class glutathione S-transferase gene in freshwater planarian Dugesia japonica: cloning, characterization and protective effects in herbicide glyphosate stress.

As the top-selling herbicide in the world, glyphosate distributes widely in natural environment and its influence on the ecological security and human health has attracted more and more concern. Glutathione S-transferases (GSTs) are a well-characterized superfamily of isoenzymes for cellular defense against exogenous toxic substances and therefore protect organisms from injury. In this study, the complete cDNA sequence of GST gene (named as Dja-GST) in freshwater planarian Dugesia japonica was firstly cloned by means of RACE method. The full-length Dja-GST comprises of 706 nucleotides which encodes a polypeptide of 200 amino acids. Dja-GST has two representative GST domains at the N- and C-termini. The conservative GST-N domain includes G-site Y8, F9, R14, W39, K43, P52 and S64, while the variable GST-C domain contains H-site K104, V156, D159 and L161. Sequence analysis, phylogenetic tree reconstruction and multiple alignment collectively indicate that Dja-GST belongs to the Sigma class of GST superfamily. Also, GST gene expression profile, GST enzymatic activity and MDA content in response to glyphosate exposure were systematically investigated and the correlations among them were analyzed. The results suggest that glyphosate exposure modified the mRNA transcription and enzymatic activity of GST, as well as the MDA content in planarians, indicating that Dja-GST might play an important part in organisms defending against oxidative stress induced by glyphosate. This work lays a molecular foundation for further exploring the exact functions of Dja-GST and gives an important implication for evaluating the ecological environment effects of herbicide glyphosate.

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Anti beta3 AR Human, Poly Goat Anti-Human Glutathio Goat Anti-Human 14-3-3 si DNA (cytosine 5) methyltr Goat Anti-Human Glutathio Rabbit Anti-Insulin Polyc CRKL & PIK3R1 Protein Pro Multi organ carcinoma tis CUL1 & FBXW11 Protein Pro Embryonal tumor test tiss Goat Anti-Human MDM2 (iso TP53 & MDM2 Protein Prote

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Facile Preparation of PNA-Peptide Conjugates with a Polar Maleimide-Thioether Linkage.

Conjugation of a delivery peptide containing a thiol functionality (e.g., a cysteine residue) with a PNA oligomer displaying a single unprotected aliphatic primary amine (e.g., the N-terminus or a C-terminal lysine residue) can be achieved via a one-pot modification with a bisfunctional maleimide linker also displaying a reactive N-hydroxysuccinimidyl ester group (e.g., Mal-PEG2-OSu). Here, an optimized protocol with respect to ratios between the reactants as well as recommended reaction times is presented. Formation and conversion of the maleimide-PNA intermediate was followed by analytical HPLC as exemplified by its conjugation to (KFF)K-Cys-NH. In addition, the reaction time required for direct conversion of a preformed Mal-(CH)-(C=O)-PNA oligomer in the presence of a slight excess of thiol-modified peptide (with a varying degree of sterical hindrance: HS-(CH)-CONH-(KFF)K-NH, (KFF)K-hCys-NH and (KFF)K-Cys-NH) is provided.

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Culturally-Appropriate Orientation Increases the Effectiveness of Mental Health First Aid Training for Bhutanese Refugees: Results from a Multi-state Program Evaluation.

Poor mental health remains a significant source of morbidity and mortality in the Bhutanese refugee community. Mental Health First Aid (MHFA) is a promising intervention that has been used in other immigrant communities to prepare individuals to recognize and respond to mental health warning signs. This was a non-randomized program evaluation. Using pre- and post-training questionnaires developed for prior evaluations of MHFA, we examined the effectiveness of training offered with and without culturally-appropriate orientation to mental health terminology and concepts (N = 458). Pre- to post-training improvement in ability to recognize schizophrenia, ability to respond to schizophrenia and depression, and the overall mental health literacy was greater for Bhutanese refugees who attended orientation relative to other participants (P < 0.05). In scaling up MHFA training for other immigrant communities, we recommend developing and systematically evaluating culturally-appropriate orientation materials that introduce mental health vocabulary and contextualize mental health concepts.

2414 related Products with: Culturally-Appropriate Orientation Increases the Effectiveness of Mental Health First Aid Training for Bhutanese Refugees: Results from a Multi-state Program Evaluation.

10x ELISA WASH BUFFER, Pr 5 (4 Formyl 3,5 dimethoxy Normal liver tissue array Stomach carcinoma (multi Breast cancer and matched Porcine PAI-1 (wild type Breast cancer tissue arra Liver carcinoma (multi ti Rat Anti-CCT theta Antibo Multi Bio 3D, Programmabl Anti-BMP-1 (Bone Morphoge NATIVE HUMAN PROLACTIN, P

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