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#32791577   2020/08/14 To Up

Sublethal concentrations of dichlorvos and paraquat induce genotoxic and histological effects in the Clarias gariepinus.

Non-target aquatic organisms such as fish may be impacted by agricultural activities through the run-off of pesticides from farms into aquatic ecosystems. In this study, the genotoxic (erythrocytic micronuclei) and histological effects of sublethal concentrations (1% and 10% of 96-h median lethal concentration (LC50) values) of two pesticides (dichlorvos and paraquat) were evaluated in Clarias gariepinus (the African Sharptooth Catfish) for 28 days. The 96-h LC50 of dichlorvos and paraquat against fingerlings of C. gariepinus was 730 µg/L and 50 µg/L, respectively. There was a significant dose-dependent increase (p<0.05) in micronuclei in the erythrocytes of exposed C. gariepinus (2.00±0.82 ‰ to 3.25±1.26 ‰ for dichlorvos and 2.25±0.96 ‰ to 4.75±0.96 ‰ for paraquat) compared to control (0.75±0.96 ‰) by day 28. Gill histological alterations such as mild to severe necrosis and blunting of secondary lamellae were observed in C. gariepinus exposed to higher sublethal concentrations of both pesticides. This study showed that non-target aquatic organisms like C. gariepinus may be at risk of adverse biological effects from exposure to pesticides from non-point sources. We recommend environmental monitoring and sensitization on responsible pesticide use to stakeholders. This will forestall potential adverse ecological effects in aquatic ecosystems.
Ebenezer I Oladokun, Temitope O Sogbanmu, Joseph C Anikwe

1949 related Products with: Sublethal concentrations of dichlorvos and paraquat induce genotoxic and histological effects in the Clarias gariepinus.

50 ul1,000 tests200ug50 ug 1 mg1000 tests100ug1 mg100ug25 mg 5 G

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#32791572   2020/08/13 To Up

Practical recommendations for systemic treatment in psoriasis in case of coexisting inflammatory, neurologic, infectious or malignant disorders (BETA-PSO: Belgian Evidence-based Treatment Advice in Psoriasis; part 2).

Psoriasis patients carry an increased risk for associated comorbidities. Dermatologists have to be aware of the effects of systemic treatments not only on psoriasis but also on co-occurring diseases. In case of other coexisting inflammatory diseases, the right psoriasis treatment may improve both disorders. For infectious and malignant disorders, some treatments have to be avoided as they may be harmful.
J L W Lambert, S Segaert, P D Ghislain, T Hillary, A Nikkels, F Willaert, J Lambert, R Speeckaert

2808 related Products with: Practical recommendations for systemic treatment in psoriasis in case of coexisting inflammatory, neurologic, infectious or malignant disorders (BETA-PSO: Belgian Evidence-based Treatment Advice in Psoriasis; part 2).



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#32791571   // To Up

Leaf Wax Lipid Extraction for Archaeological Applications.

Plant wax lipid molecules, chiefly normal (n-) alkanes and n-alkanoic acids, are frequently used as proxies for understanding paleoenvironmental and paleoclimatic change. These are regularly analyzed from marine and lake sediments and even more frequently in archaeological contexts, enabling the reconstruction of past environments in direct association with records of past human behavior. Carbon and hydrogen isotope measurements of these compounds are used to trace plant type and water-use efficiency, relative paleotemperature, precipitation, evapotranspiration of leaf and soil moisture, and other physiological and ecological parameters. Plant wax lipids have great potential for answering questions related to human-environment interactions, being for the most part chemically inert and easily recoverable in terrestrial sediments, including those dating back millions of years. The growing use of this technique, and comparison of such data with other paleoenvironmental proxies such as pollen and phytolith analysis and soil carbonate and tooth enamel isotope records, make it essential to establish consistent, best-practice protocols for extracting n-alkanes and n-alkanoic acids from archaeological sediments to provide comparable information for interpreting past climatic, ecosystem, and hydrological changes and their interaction with human societies. © 2020 The Authors. Basic Protocol 1: Total lipid extraction Support Protocol 1: Weighing the total lipid extract Support Protocol 2: Cleaning the PSE extraction cells Alternate Protocol 1: Soxhlet total lipid extraction Alternate Protocol 2: Ultrasonic total lipid extraction Basic Protocol 2: Separation of lipids by aminopropyl column chromatography Basic Protocol 3: Separation of lipids by silver-nitrate-infused silica gel column chromatography Support Protocol 3: Preparation of silica gel infused with 10% silver nitrate Basic Protocol 4: Methylation of n-alkanoic acids Basic Protocol 5: Gas chromatography mass spectrometry (GC-MS) Basic Protocol 6: Gas chromatography isotope ratio mass spectrometry (GC-IRMS).
Robert Patalano, Jana Zech, Patrick Roberts

2577 related Products with: Leaf Wax Lipid Extraction for Archaeological Applications.

0.2 mg0.1 mg100 ml1 ml25 µg25 µg0.25 mg0.1 ml100 TESTS0.1 mg250 ml1 LITRE

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#32791533   2020/08/13 To Up

Genetics and Hemostatic Potential in Persons with Mild to Moderate Hemophilia A with a Discrepancy between One-Stage and Chromogenic FVIII Assays.

 Factor VIII (FVIII) activity (FVIII:C) can be measured by different methods including one-stage clotting assays (OSAs) and chromogenic assays (CSAs). Discrepancy between FVIII:C assays is known and associated with genetic variations causing mild and moderate hemophilia A (HA). We aimed to study the discrepancy phenomenon and to identify associated genetic alterations. Further, we investigated if hemostatic global assays could discriminate the group with discrepant FVIII:C from them.
Annelie Strålfors, Danijela Mikovic, David Schmidt, Liselotte Onelöv, Nida Mahmoud Hourani Soutari, Maria Berndtson, Roza Chaireti, Margareta Holmström, Jovan P Antovic, Maria Bruzelius

1872 related Products with: Genetics and Hemostatic Potential in Persons with Mild to Moderate Hemophilia A with a Discrepancy between One-Stage and Chromogenic FVIII Assays.

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#32791529   2020/08/13 To Up

In Vitro Whitening Effect of a Hydroxyapatite-Based Oral Care Gel.

 Oral care formulations aim to prevent oral diseases such as dental caries and gingivitis. Additionally, desire for white teeth still exists across all age groups. It is known that most whitening toothpastes are highly abrasive and can be harmful to teeth and gingiva. Therefore, a gel formulation with biomimetic hydroxyapatite (HAP; Ca[PO][OH]) as active ingredient was developed. This formulation was tested with respect to its tooth whitening properties in an study.
Sandra Sarembe, Joachim Enax, Maria Morawietz, Andreas Kiesow, Frederic Meyer

2633 related Products with: In Vitro Whitening Effect of a Hydroxyapatite-Based Oral Care Gel.

50 ug96 tests100 μg100 μg50μl100 μg100.00 ug1 Set

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#32791516   2020/08/13 To Up

JBPOS0101 regulates amyloid beta, tau, and glial cells in an Alzheimer's disease model.

Alzheimer's disease (AD) is the most prevalent neurodegenerative disease characterized by cognitive dysfunction and memory loss as the main symptoms. The deposition of amyloid beta (Aβ) and tau hyperphosphorylation are hallmarks of AD and are major therapeutic targets. However, the exact etiology has not yet been fully elucidated; thus, no drug that cures the disease has been approved. JBPOS0101 is a phenyl carbamate compound that has been tested as a drug for epileptic diseases. In our previous study, we showed that JBPOS0101 attenuated the accumulation of Aβ as well as the deficits in learning and memory in the 5xFAD mouse model. Here, we tested the dose effect (70 or 35 mg/kg) of JBPOS0101 on the memory defect and pathological markers and further investigated the underlying mechanisms in 5xFAD mice. In the behavior tests, JBPOS0101 treatment ameliorated deficits in learning and memory. Moreover, JBPOS0101 attenuated Aβ accumulation and tau phosphorylation. The elevated phosphorylation levels of the active GSK3β form (GSK3β-y216) in 5xFAD, which are responsible for tau phosphorylation, decreased in the JBPOS0101-treated groups. Furthermore, the elevation of reactive astrocytes and microglia in 5xFAD mice was attenuated in JBPOS0101-treated groups. These data suggest that JBPOS0101 may be a new drug candidate to lessen amyloid- and tau-related pathology by regulating glial cells.
Jihoon Jeong, Hyung Joon Park, Bo-Ram Mun, Ju Kyong Jang, Yong Moon Choi, Won-Seok Choi

1456 related Products with: JBPOS0101 regulates amyloid beta, tau, and glial cells in an Alzheimer's disease model.

96 tests96 tests96 tests96 tests 100ul500 tests 100ul2 Pieces/Box500 tests100μg

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#32791515   2020/08/13 To Up

Impact of and risk factors for pediatric acute kidney injury defined by the pROCK criteria in a Chinese PICU population.

The definition of pediatric AKI continues to evolve. We aimed to find a better AKI definition to predict outcomes and identify risk factors for AKI in a Chinese PICU.
Cui Wei, Gao Hongxia, Fang Hui, Qin Xianhui, Jin Danqun, Liu Haipeng

2571 related Products with: Impact of and risk factors for pediatric acute kidney injury defined by the pROCK criteria in a Chinese PICU population.

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#32791513   2020/08/13 To Up

Independent replications and integrative analyses confirm TRANK1 as a susceptibility gene for bipolar disorder.

Genetic analyses for bipolar disorder (BD) have achieved prominent success in Europeans in recent years, whereas its genetic basis in other populations remains relatively less understood. We herein report that the leading risk locus for BD in European genome-wide association studies (GWAS), the single-nucleotide polymorphism (SNP) rs9834970 near TRANK1 at 3p22 region, is also genome-wide significantly associated with BD in a meta-analysis of four independent East Asian samples including 5748 cases and 65,361 controls (p = 2.27×10, odds ratio = 1.136). Expression quantitative trait loci (eQTL) analyses and summary data-based Mendelian randomization (SMR) analyses in multiple human brain samples suggest that lower TRANK1 mRNA expression is a principal BD risk factor explaining its genetic risk signals at 3p22. We also identified another SNP rs4789 in the 3' untranslated region (3'UTR) of TRANK1 showing stronger eQTL associations as well as genome-wide significant association with BD. Despite the relatively unclear neuronal function of TRANK1, our mRNA expression analyses in the human brains and in rat primary cortical neurons reveal that genes highly correlated with TRANK1 are significantly enriched in the biological processes related to dendritic spine, synaptic plasticity, axon guidance, and circadian entrainment and are also more likely to exhibit strong associations in psychiatric GWAS (e.g., the CACNA1C gene). Overall, our results support that TRANK1 is a potential BD risk gene. Further studies elucidating its roles in this illness are needed. Fig. 1 GENETIC ANALYSES OF TRANK1 WITH BD.: a Forest plot of rs9834970 with BD in world populations. b Forest plot of rs4789 with BD in world populations. For the PGC2 study in the meta-analysis of rs4789, only the PGC2 discovery sample was included since rs4789 was not tested in their replication datasets. Fig. 2 EXPRESSION ANALYSES OF TRANK1.: a-c eQTL associations of rs9834970 with TRANK1 mRNA expression in CommonMind, Brain xQTL, and GTEx-cortex datasets. d-f eQTL associations of rs4789 with TRANK1 mRNA expression in CommonMind, Brain xQTL, and GTEx-cortex datasets. g, h eQTL associations of rs9834970 and rs4789 with TRANK1 mRNA expression in Han Chinese sample. CommonMind dataset, N = 467 individuals. Brain xQTL dataset, N = 494 individuals. GTEx-cortex dataset, N = 205 individuals. Han Chinese sample, N = 65 individuals. Fig. 3 Multi-SNP-based SMR analyses through integrating different brain eQTL datasets (CommonMind, Brain xQTL, and GTEx-cortex). Fig. 4 PROTEIN-PROTEIN INTERACTION (PPI) AND KEGG PATHWAY ANALYSES OF TRANK1 CORRELATED GENES.: The pathways marked in red were highlighted by both COGs and DEGs. a One thousand seven hundred and forty-two TRANK1 COGs in human brains. b Five hundred and ninety-four downregulated DEGs in the rat primary cortical neurons. COG correlation gene, DEG differentially expressed gene. Fig. 5 ENRICHMENT OF TRANK1 CORRELATED GENES WITH PSYCHIATRIC GWAS RISK GENES.: a INRICH enrichment analysis of TRANK1 COGs and downregulated DEGs with psychiatric GWAS risk genes, and significant enrichment were observed for GWAS risk genes of BD and schizophrenia. b MAGMA enrichment analysis of TRANK1 COGs with psychiatric GWAS risk genes. c A detailed examination of overlapped genes among TRANK1 COGs, BD GWAS risk genes, and schizophrenia GWAS risk genes. BD bipolar disorder, SCZ schizophrenia, MDD major depressive disorder, AD Alzheimer's disease, COG correlation gene.
Wenqiang Li, Xin Cai, Hui-Juan Li, Meng Song, Chu-Yi Zhang, Yongfeng Yang, Luwen Zhang, Lijuan Zhao, Weipeng Liu, Lu Wang, Minglong Shao, Yan Zhang, Chen Zhang, Jun Cai, Dong-Sheng Zhou, Xingxing Li, Li Hui, Qiu-Fang Jia, Na Qu, Bao-Liang Zhong, Shu-Fang Zhang, Jing Chen, Bin Xia, Yi Li, Xueqin Song, Weixing Fan, Wei Tang, Wenxin Tang, Jinsong Tang, Xiaogang Chen, Weihua Yue, Dai Zhang, Yiru Fang, Xiao Xiao, Ming Li, Luxian Lv, Hong Chang

2554 related Products with: Independent replications and integrative analyses confirm TRANK1 as a susceptibility gene for bipolar disorder.

100 tests100 plates1,000 tests50 assays10 plates1 kit96 assays 10 plates

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