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#33086414   2020/10/21 To Up

[Disseminated protothecosis with ulcerative granulomatous colitis in a Rhodesian Ridgeback from Germany].

A 10-month-old male Rhodesian Ridgeback was presented to the Clinic of Small Animal Medicine, LMU, Germany, with a 6-month history of chronic diarrhea and hematochezia. The dog lived in Germany and had never traveled abroad. Complete blood count and serum biochemistry performed by the referring veterinarian revealed neutrophilia, hyperkalemia, and hyponatremia, with a basal cortisol of 4.3 µg/dl, which excluded hypoadrenocorticism. Since antibiotic treatment had not resulted in any improvement, a 2 week course of prednisolone administration had been initiated, leading to a marked deterioration of intestinal signs and a significant weight loss of 6 kg. At the time of referral, the patient was markedly emaciated, dehydrated, hypovolemic and had a rectal temperature of 39.6 °C. Abdominal ultrasound showed a thickened and irregular colonic wall. On colonoscopy, an irregular colonic mucosa with ulcerations was observed. Histopathologic examination revealed an ulcerative granulomatous colitis, and on Periodic acid-Schiff reaction (PAS) numerous organisms consistent with spp. were identified. infection was confirmed by culture and MALDI-TOF MS. In order to test for an underlying immunodeficiency, immunoglobulin levels in serum were determined. IgM was decreased, while IgG and IgA levels were within the reference interval. Due to deterioration of general condition, grave prognosis and costs of a treatment trial, the patient was euthanized one week later, and necropsy was performed. spp. were detected on histopathologic examination in the lymphnodes, however not in the eyes or the central nervous system. Protothecosis should be considered an differential diagnosis in dogs with chronic diarrhea and ulcerative granulomatous colitis even in dogs living in Germany. Histopathologic examination of colonic biopsies with special stains such as PAS is recommended in every dog with signs of chronic large bowel disease in order to avoid missing this rare infectious disease.
Vera Geisen, Christian Mayer, Julia Harrer, Katrin Hartmann, Sebastian Ulrich, Stefan Unterer

1107 related Products with: [Disseminated protothecosis with ulcerative granulomatous colitis in a Rhodesian Ridgeback from Germany].

100 μg100 μg100 μg100 μg100ug100ug Lyophilized1 Set1 Set1 Set

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#33086400   2020/10/21 To Up

Pharmacokinetics and Pharmacodynamics of Emicizumab in Persons with Hemophilia A with Factor VIII Inhibitors: HAVEN 1 Study.

Emicizumab, a bispecific monoclonal antibody, bridges activated factor IX (FIXa) and FX, replacing the function of missing FVIIIa to restore effective hemostasis in persons with hemophilia A (PwHA). Here we assess pharmacokinetic (PK) and pharmacodynamic (PD) biomarkers in PwHA with FVIII inhibitors in the Phase III HAVEN 1 study (NCT02622321). Blood samples from 112 PwHA receiving 1.5 mg/kg once-weekly subcutaneous emicizumab were analyzed at central laboratories. Emicizumab concentrations for PK analysis were measured via validated immunoassay. PD effects were assessed using FVIII chromogenic activity assay containing human factors (Hyphen Biophen FVIII:C), and by FXIa-triggered thrombin generation (TG). Activated partial thromboplastin time (aPTT), prothrombin time (PT), antigen levels of FIX and FX, fibrinogen, D-dimer, and prothrombin fragment 1.2 (PF1.2) levels were determined. Emicizumab trough concentrations ≥ 50 µg/mL were maintained throughout the study. FVIII-like activity and TG (peak height) correlated with emicizumab concentrations and remained above 20 U/dL and 100 nM, respectively, with a weekly maintenance dose, theoretically converting persons with severe hemophilia A to a mild disease phenotype. aPTT was normalized at subtherapeutic concentrations of emicizumab. Plasma concentrations of target antigens FIX and FX were not significantly affected by emicizumab treatment; nor were fibrinogen, PT (international normalized ratio), D-dimer, or PF1.2. The PK profile of once-weekly emicizumab in HAVEN 1 provides sustained therapeutic plasma levels, consistent with population PK models. Both the PK profile and the PD and safety biomarkers are consistent with the established efficacy of emicizumab prophylaxis in PwHA with FVIII inhibitors.
Christophe Schmitt, Joanne I Adamkewicz, Jin Xu, Claire Petry, Olivier Catalani, Guy Young, Claude Negrier, Michael U Callaghan, Gallia G Levy

2884 related Products with: Pharmacokinetics and Pharmacodynamics of Emicizumab in Persons with Hemophilia A with Factor VIII Inhibitors: HAVEN 1 Study.

100ug100ug Lyophilized100ug100ug Lyophilized100ug100ul100ug Lyophilized100ug100ug100ug Lyophilized100ug100ug

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#33086398   2020/10/21 To Up

Nonvitamin K Antagonist Oral Anticoagulants in Patients with Extreme Body Weights: One Size Fits All?


So-Ryoung Lee, Eue-Keun Choi

1363 related Products with: Nonvitamin K Antagonist Oral Anticoagulants in Patients with Extreme Body Weights: One Size Fits All?

1 Set25 mg100 μg100.00 ug5 mg2

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#33086389   2020/10/21 To Up

Profiling and Quantification of the Key Phytochemicals from the Drumstick Tree (Moringa oleifera) and Dietary Supplements by UHPLC-PDA-MS.

is known as a drumstick tree and is cultivated in the subtropics and tropics. It exhibits antihypertensive and antidiabetic effects. An ultra-high-performance liquid chromatography method was developed for the determination of 9 phytochemicals in leaves and marketed products. The efficient separation was achieved within 7 min with a temperature of 45 °C by using a C-18 column as the stationary phase and water/acetonitrile with 0.05% formic acid as the mobile phase. The method was validated for linearity, repeatability, limits of detection, and limits of quantification. The limits of detections of phenolic compounds 1:  - 9: were as low as 0.2 µg/mL. The photodiode array detector at 220 and 255 nm wavelengths was recruited for quantification. The key phytochemicals were detected in the range of 0.42 to 2.57 mg/100 mg sample weight in 13 dietary supplements. This study considers the quantitative analysis for lignans in for the first time. Isoquercitrin (5: ) and quercetin 3--(6--malonyl)--D-glucopyranoside (6: ) predominates the leaves of with inherent degradable nature detected for compound 6: . Niazirin (2: ) was detected in amounts between 0.010 - 0.049 mg/100 mg while compound 1: was undetectable and potentially an artifact because of the fractionation process. The characterization and confirmation of components were achieved by liquid chromatography-electrospray ionization-mass spectrometry with extractive ion monitoring for the positive and negative ion modes. The developed and validated method is robust and rapid in the conclusive quantification of phytochemicals and authentication of the samples for quality assurance.
Omer I Fantoukh, Yan-Hong Wang, Abidah Parveen, Mohammed F Hawwal, Gadah A Al-Hamoud, Zulfiqar Ali, Amar G Chittiboyina, Ikhlas A Khan

2651 related Products with: Profiling and Quantification of the Key Phytochemicals from the Drumstick Tree (Moringa oleifera) and Dietary Supplements by UHPLC-PDA-MS.

2.5 mg1000 tests100 100ug1 ml25 mg200 units50 ug 2.5 mg100ug10 mg

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#33086383   2020/10/09 To Up

Grouping of UVCB substances with new approach methodologies (NAMs) data.

One of the most challenging areas in regulatory science is assessment of the substances known as UVCB (Unknown or Variable composition, Complex reaction products and Biological materials). Because the inherent complexity and variability of UVCBs present considerable challenges for establishing sufficient substance similarity based on chemical characteristics or other data, we hypothesized that animal alternatives new approach methodologies (NAMs), including in vitro test-derived biological activity signatures to characterize substance similarity, can be used to support grouping of UVCBs. We tested 141 petroleum substances as representative UVCBs in a compendium of 15 human cell types representing a variety of tissues. Petroleum substances were assayed in dilution series to derive point of departure estimates for each cell type and phenotype. Extensive quality control measures were taken to ensure that only high-confidence in vitro data are used to determine whether current groupings of these petroleum substances, based largely on the manufacturing process and physico-chemical properties, are justifiable. We found that bioactivity data-based groupings of petroleum substances were generally consistent with the manufacturing class-based categories. We also showed that these data, especially bioactivity from human induced pluripotent stem cell (iPSC)-derived and primary cells, can be used to rank substances in a manner highly concordant with their expected in vivo hazard potential based on their chemical compositional profile. Overall, this study demonstrates that NAMs can be used to inform groupings of UVCBs, to assist in identification of representative substances in each group for testing when needed, and to fill data gaps by read-across.
John S House, Fabian A Grimm, William D Klaren, Abigail Dalzell, Srikeerthana Kuchi, Shu-Dong Zhang, Klaus Lenz, Peter J Boogaard, Hans B Ketelslegers, Timothy W Gant, Fred A Wright, Ivan Rusyn

2437 related Products with: Grouping of UVCB substances with new approach methodologies (NAMs) data.



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#33086370   2020/10/20 To Up

Screen-Based Simulation for Training and Automated Assessment of Teamwork Skills: Comparing 2 Modes With Different Interactivity.

The need for teamwork training is well documented; however, teaching these skills is challenging given the logistics of assembling individual team members together to train in person. We designed 2 modes of screen-based simulation for training teamwork skills to assess whether interactivity with nonplayer characters was necessary for in-game performance gains or for player satisfaction with the experience.
Randolph H Steadman, Yue Ming Huang, Markus R Iseli, John J Lee, Areti Tillou, Maria D D Rudolph, Rachel Lewin, Alan D Koenig, Rukhsana Khan, Federica Raia, S Michael Smith, Yen-Yi Juo, Cameron Rice, Sophia P Poorsattar, Noreen M Webb

1036 related Products with: Screen-Based Simulation for Training and Automated Assessment of Teamwork Skills: Comparing 2 Modes With Different Interactivity.

1 G200ul2x96 well plate10 mg200ul200ug 2x5L200ug250 mg20 ug 2x5L

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#33086362   2020/10/19 To Up

Measurement of Free Plasma Concentrations of Beta-Lactam Antibiotics: An Applicability Study in ICU Patients.

To assess the applicability of an ultrafiltration method to determine free plasma concentrations of beta-lactam antibiotics in ICU patients.
Selina Schießer, Florian Hitzenbichler, Martin Georg Kees, Alexander Kratzer, Matthias Lubnow, Bernd Salzberger, Frieder Kees, Christoph Dorn

2799 related Products with: Measurement of Free Plasma Concentrations of Beta-Lactam Antibiotics: An Applicability Study in ICU Patients.

100ug100ug100ug16 Arrays/Slide1 mg100ug500 100ug Lyophilized100ug0.1 mg100ug Lyophilized100ug Lyophilized

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#33086346   // To Up

Effective and Rapid Microbial Identification in Pediatric Osteoarticular Infections Using Blood Culture Bottles.

The detection and identification of pathogenic microorganisms are essential for the treatment of osteoarticular infection. However, obtaining a sufficient amount of specimen from pediatric patients is often difficult. Herein, we aimed to demonstrate the effectiveness of the blood culture bottle (BCB) system in pediatric osteoarticular infections. We hypothesized that our BCB culture method is superior to the conventional swab and tissue culture methods in terms of required specimen size, incubation time, and microbial identification rate.
Chang Ho Shin, Chaemoon Lim, Taek Soo Kim, Eun Hwa Choi, Tae-Joon Cho, In Ho Choi, Won Joon Yoo

1215 related Products with: Effective and Rapid Microbial Identification in Pediatric Osteoarticular Infections Using Blood Culture Bottles.

1 L.96 tests4/120 Packing /sleeve/bo 100 UG50 samples100 extractions400Testscase4/120 Packing /sleeve/bocase

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