Search results for: CA11
#39254690 
2024/09/10
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The system of radiological protection and the UN sustainable development goals.
In 2015 the United Nations issued 17 Sustainable Development Goals (SDGs) addressing a wide range of global social, economic, and environmental challenges. The main goal of this paper is to provide an understanding of how the current System of Radiological Protection relates to these SDGs. In the first part it is proposed that the current System of Radiological Protection is implicitly linked to sustainable development. This is substantiated by analysing the features of the current System as set out by the International Commission on Radiological Protection (ICRP) in its publications. In the second part it is proposed that sustainability should be considered and more explicitly addressed in the next ICRP general recommendations, as part of the currently ongoing review and revision of the current System. A few examples are given of how this could be realised, and it is proposed that this issue should be discussed and developed together with the international community interested in radiological protection.W Rühm, K Applegate, F Bochud, D Laurier, T Schneider, S Bouffler, K Cho, C Clement, O German, G Hirth, M Kai, S Liu, A Mayall, S Romanov, A Wojcik
2525 related Products with: The system of radiological protection and the UN sustainable development goals.
500 Units500 Units500 Units200 units200 units500 Units11mg 100 G12000 IU
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#38802288 2024/05/10
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Application of essential oils as natural antimicrobials in lactic acid bacteria contaminating fermentation for the production of organic cachaça.
Sugarcane-based fermentation is an essential process for different sectors of economic importance, such as the food industry with fermented and distilled beverages. However, this process can suffer from high contamination by wild yeasts and bacteria, especially lactic acid bacteria (LAB). This makes it necessary to use decontamination strategies and search for new methods that have a low environmental impact and contribute to the production of organic products. Among the options, oregano and thyme essential oils stand out for their antibacterial compounds. The aim of this study was to use oregano and thyme essential oils as natural antimicrobials in the alcoholic fermentation of sugar cane juice. Initially, the minimum inhibitory concentration of the essential oils in the fermentation was assessed through turbidity in the sensitivity test, which allowed us to determine which concentrations of essential oils would inhibit the contaminants, 3 morphologically selected LAB strains, as well as assessing the viability of CA-11. For LAB, 3 concentrations of each essential oil were tested, ranging from 0.1 to 0.4 μl/mL, while for CA-11 it was 0.06, to 0.1 μl/mL. The results indicated a maximum total value of essential oils per ml of 0.06 μl. Based on this result, a 2 fractional factorial was established, with 8 conditions +3 central points, with 4 variables, oregano essential oil (0, 0.03 and 0.06 μl/ml), thyme (0, 0.03 and 0.06 μl/ml), initial soluble solids (14, 16 and 18°Brix) and initial yeast concentration (2.5, 3 and 3.5 g/l), with the temperature set at 32 °C for a period of 12 h. The results showed that the center point condition with 0.03 μl/ml of oregano EO, 0.03 μl/ml of thyme controlled the proliferation of contaminating bacteria compared to the control condition. In the experimental validation, the treatment with essential oils had a lower final population of LAB (5.95 log) than the final population of the control treatment (6.53 log), and it was also observed that the treatment with EOs had an alcohol production around 3 % higher than the treatment without antimicrobials. The experimental validation phase confirmed the synergistic action of oregano and thyme essential oils in controlling the proliferation of contaminating bacteria. In conclusion, it was possible to determine the synergistic antimicrobial action of essential oils against LAB during alcoholic fermentation based on organic sugar cane.A C D Oliveira, C Gobato, K N Pereira, M V Carvalho, J V Santos, G D Pinho, C B C Zumpano, R G Bastos, E S Kamimura
1536 related Products with: Application of essential oils as natural antimicrobials in lactic acid bacteria contaminating fermentation for the production of organic cachaça.
100ug Lyophilized100tests100Tests0.1ml (1mg/ml)100ug Lyophilized100 μg100ug Lyophilized 100ul250 mg96 assays
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#38558079 2024/04/01
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Characterization and genomic analysis of the Lyme disease spirochete bacteriophage ϕBB-1.
Lyme disease is a tick-borne infection caused by the spirochete Borrelia (Borreliella) burgdorferi. Borrelia species have highly fragmented genomes composed of a linear chromosome and a constellation of linear and circular plasmids some of which are required throughout the enzootic cycle. Included in this plasmid repertoire by almost all Lyme disease spirochetes are the 32-kb circular plasmid cp32 prophages that are capable of lytic replication to produce infectious virions called ϕBB-1. While the B. burgdorferi genome contains evidence of horizontal transfer, the mechanisms of gene transfer between strains remain unclear. While we know that ϕBB-1 transduces cp32 and shuttle vector DNA during in vitro cultivation, the extent of ϕBB-1 DNA transfer is not clear. Herein, we use proteomics and long-read sequencing to further characterize ϕBB-1 virions. Our studies identified the cp32 pac region and revealed that ϕBB-1 packages linear cp32s via a headful mechanism with preferential packaging of plasmids containing the cp32 pac region. Additionally, we find ϕBB-1 packages fragments of the linear chromosome and full-length plasmids including lp54, cp26, and others. Furthermore, sequencing of ϕBB-1 packaged DNA allowed us to resolve the covalently closed hairpin telomeres for the linear B. burgdorferi chromosome and most linear plasmids in strain CA-11.2A. Collectively, our results shed light on the biology of the ubiquitous ϕBB-1 phage and further implicates ϕBB-1 in the generalized transduction of diverse genes and the maintenance of genetic diversity in Lyme disease spirochetes.Dominick R Faith, Margie Kinnersley, Diane M Brooks, Dan Drecktrah, Laura S Hall, Eric Luo, Andrew Santiago-Frangos, Jenny Wachter, D Scott Samuels, Patrick R Secor
1796 related Products with: Characterization and genomic analysis of the Lyme disease spirochete bacteriophage ϕBB-1.
1 mg1 mL1 mL1 mL50 assays1 module500 mg 15 ml
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#38460427 2024/02/27
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Efficacy of greater occipital nerve block treatment for migraine and potential impact of patient positioning during procedure: Results of randomised controlled trial.
Assess the efficacy, and potential impact of patient positioning for 10 minutes immediately post-procedure, of greater occipital nerve (GON) block for treatment of migraine.Jitka Vanderpol, Gina Kennedy, Fayyaz Ahmed, Leon Jonker
2853 related Products with: Efficacy of greater occipital nerve block treatment for migraine and potential impact of patient positioning during procedure: Results of randomised controlled trial.
5 G50 ug50 ug50 ug2.5 mg50 ug50 ug50 ug50 ug100μg25 μg
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#38309588 2024/02/02
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The underlying mechanism of nuclear and mitochondrial DNA damages in triggering cancer incidences: Insights into proteomic and genomic sciences.
The attempt of this review article is to determine the impact of nuclear and mitochondrial damages on the propagation of cancer incidences. This review has advanced our understanding to altered genes and their relevant cancerous proteins. The progressive raising effects of free reactive oxygen species ROS and toxicogenic compounds contributed to significant mutation in nuclear and mitochondrial DNA where the incidence of gastric cancer is found to be linked with down regulation of some relevant genes and mutation in some important cellular proteins such as AMP-18 and CA-11. Thereby, the resulting changes in gene mutations induced the apparition of newly polymorphisms eventually leading to unusual cellular expression to mutant proteins. Reduction of these apoptotic growth factors and nuclear damages is increasingly accepted by cell reactivation effect, enhanced cellular signaling and DNA repairs. Acetylation, glycation, pegylation and phosphorylation are among the molecular techniques used in DNA repair for rectifying mutation incidences. In addition, the molecular labeling based fluorescent materials are currently used along with the bioconjugating of signal molecules in targeting disease translocation site, particularly cancers and tumors. These strategies would help in determining relevant compounds capable in overcoming problems of down regulating genes responsible for repair mechanisms. These issues of course need interplay of both proteomic and genomic studies often in combination of molecular engineering to cible the exact expressed gene relevant to these cancerous proteins.Sami Saadi, Nor Elhouda Nacer, Nazamid Saari, Abdulkarim Sabo Mohammed, Farooq Anwar
1487 related Products with: The underlying mechanism of nuclear and mitochondrial DNA damages in triggering cancer incidences: Insights into proteomic and genomic sciences.
5mg100ug50 ug 100.00 ul10mg
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#38300768 //
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Appraisal of National Institute for Health and Care Research activity in primary care in England: cross-sectional study.
The National Institute for Health and Care Research (NIHR) was set up to enhance clinical and health research activity in a variety of National Health Service (NHS) healthcare settings, including primary care.Leon Jonker, Stacey Jayne Fisher
2137 related Products with: Appraisal of National Institute for Health and Care Research activity in primary care in England: cross-sectional study.
96 assays 5 G100ug0.1ml (1mg/ml)48 assays 500 MG100ug
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#38260690 2024/01/13
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Characterization and genomic analysis of the Lyme disease spirochete bacteriophage ϕBB-1.
Lyme disease is a tick-borne infection caused by the spirochete () . species have highly fragmented genomes composed of a linear chromosome and a constellation of linear and circular plasmids some of which are required throughout the enzootic cycle. Included in this plasmid repertoire by almost all Lyme disease spirochetes are the 32-kb circular plasmid cp32 prophages that are capable of lytic replication to produce infectious virions called ϕBB-1. While the genome contains evidence of horizontal transfer, the mechanisms of gene transfer between strains remain unclear. While we know that ϕBB-1 transduces cp32 and shuttle vector DNA during cultivation, the extent of ϕBB-1 DNA transfer is not clear. Herein, we use proteomics and long-read sequencing to further characterize ϕBB-1 virions. Our studies identified the cp32 region and revealed that ϕBB-1 packages linear cp32s via a headful mechanism with preferentially packaging of plasmids containing the cp32 region. Additionally, we find ϕBB-1 packages fragments of the linear chromosome and full-length plasmids including lp54, cp26, and others. Furthermore, sequencing of ϕBB-1 packaged DNA allowed us to resolve the covalently closed hairpin telomeres for the linear chromosome and most linear plasmids in strain CA-11.2A. Collectively, our results shed light on the biology of the ubiquitous ϕBB-1 phage and further implicates ϕBB-1 in the generalized transduction of diverse genes and the maintenance of genetic diversity in Lyme disease spirochetes.Dominick R Faith, Margie Kinnersley, Diane M Brooks, Dan Drecktrah, Laura S Hall, Eric Luo, Andrew Santiago-Frangos, Jenny Wachter, D Scott Samuels, Patrick R Secor
1984 related Products with: Characterization and genomic analysis of the Lyme disease spirochete bacteriophage ϕBB-1.
1 mg1 mL1 mL1 mL50 assays1 module500 mg 15 ml
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#37881618 2023/10/10
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Genetic control of flowering time and fruit yield in citron watermelon.
Flowering time and fruit yield are important traits in watermelon crop improvement. There is limited information on the inheritance and genomic loci underlying flowering time and yield performance, especially in citron watermelon. A total of 125 citron watermelon accessions were evaluated in field trials over two growing seasons for days to male and female flowers, fruit count, fruit weight, and fruit yield. The germplasm was genotyped with more than two million single-nucleotide polymorphism (SNP) markers generated via whole-genome resequencing. Trait mapping was conducted using a genome-wide association study (GWAS). Broad-sense heritability for all traits ranged from moderate to high, indicating that genetic improvement through breeding and selection is feasible. Significant marker-trait associations were uncovered for days to female flower (chromosomes Ca04, Ca05, Ca08, and Ca09), fruit count (on Ca02, Ca03, and Ca05), fruit weight (on Ca02, Ca06, Ca08, Ca10, and Ca11), and fruit yield on chromosomes Ca05, Ca07, and Ca09. The phenotypic variation explained by the significant SNPs ranged from 1.6 to 25.4, highlighting the complex genetic architecture of the evaluated traits. Candidate genes relevant to flowering time and fruit yield component traits were uncovered on chromosomes Ca02, Ca04, Ca05, Ca06, Ca09, and Ca11. These results lay a foundation for marker-assisted trait introgression of flowering time and fruit yield component traits in watermelons.Dennis N Katuuramu, Amnon Levi, William P Wechter
1830 related Products with: Genetic control of flowering time and fruit yield in citron watermelon.
2.50 nmol
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#37352719 2023/06/21
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Chornobyl radiation spikes are not due to military vehicles disturbing soil.
On 25 February 2022, increased gamma radiation dose rates were reported within the Chornobyl Exclusion Zone (CEZ). This coincided with Russian military vehicles entering the Ukrainian part of the CEZ from neighbouring Belarus. It was speculated that contaminated soil resuspension by vehicle movements or a leak from the Chornobyl Nuclear Power Plant complex may explain these spikes in radiation dose rates. The gamma dose rate monitoring network in the CEZ provides a crucial early warning system for releases of radioactivity to the environment and is part of the international safeguards for nuclear facilities. With the potential for further military action in the CEZ and concerns over nuclear safety, it is essential that such anomalous readings are investigated. We evaluate the hypotheses suggested to explain the apparent gamma dose rate increases, demonstrating that neither military vehicle-induced soil resuspension nor a leak from the Chornobyl Nuclear Power Plant are plausible. However, disruption of the Chornobyl base-station's reception of wireless signals from the gamma dose rate monitoring network in the CEZ may potentially explain the dose rate increases recorded.M D Wood, N A Beresford, C L Barnett, P H Burgess, S Mobbs
2217 related Products with: Chornobyl radiation spikes are not due to military vehicles disturbing soil.
1 modulecase25 mg1 kit(96 Wells)100 2.5 mg 1 G1 ml51 module 5 G
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#36585114 2022/03/12
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TRPM1 promotes tumor progression in acral melanoma by activating the Ca/CaMKIIδ/AKT pathway.
Acral melanoma is a predominant and aggressive subtype of melanoma in non-Caucasian populations. There is a lack of genotype-driven therapies for over 50% of patients. TRPM1 (transient receptor potential melastatin 1), a nonspecific cation channel, is mainly expressed in retinal bipolar neurons and skin. Nonetheless, the function of TRPM1 in melanoma progression is poorly understood.Chi-Che Hsieh, Yue-Chiu Su, Kuan-Ying Jiang, Takamichi Ito, Ting-Wei Li, Yumiko Kaku-Ito, Shih-Tsung Cheng, Li-Tzong Chen, Daw-Yang Hwang, Che-Hung Shen